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Canonical Sequence Approximation

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Murine V-l domains

The sequences underlying this analysis have been taken from the Kabat database of sequences of proteins of immunological interest (5th edition). They have been manually edited wherever necessary to align insertions at the respective positions where they have been crystallographically determined. Only the six most frequent residues are given in this table.

MURINE LAMBDA LIGHT CHAIN VARIABLE DOMAINS
Lambda light chains V region - Mouse
 
 
  +--- Position
  |
  |   +--- Number of observations (not counting gaps)
  |   |
  |   |      +--- Residue type
  |   |      |
  V   V      V v--- Observed frequency in sample
  1 (  35): Q:0.971 D:0.029
  2 (  35): A:0.971 L:0.029
  3 (  35): V:1.000
  4 (  35): V:0.971 L:0.029
  5 (  35): T:1.000
  6 (  35): Q:1.000
  7 (  35): E:0.751 Q:0.221 S:0.029
  8 (  35): S:1.000
  9 (  35): A:0.971 S:0.029
 10 (   0): -:1.000
 11 (  35): L:0.971 A:0.029
 12 (  35): T:0.971 S:0.029
 13 (  35): T:0.971 F:0.029
 14 (  35): S:1.000
 15 (  35): P:0.971 L:0.029
 16 (  35): G:0.971 R:0.029
 17 (  35): E:0.714 G:0.257 A:0.029
 18 (  35): T:0.971 S:0.029
 19 (  35): V:0.971 A:0.029
 20 (  35): T:0.714 I:0.257 K:0.029
 21 (  35): L:1.000
 22 (  35): T:1.000
 23 (  35): C:1.000
 24 (  35): R:0.971 T:0.029
 25 (  35): S:0.971 L:0.029
 26 (  35): S:0.886 N:0.057 T:0.057
 27 (  35): T:0.971 S:0.029
 28 (  35): G:0.971 Q:0.029
 29 (  35): A:0.971 H:0.029
 30 (  35): V:0.971 S:0.029
 31 (  35): T:1.000
 31a(  35): T:0.971 Y:0.029
 31b(  34): S:0.914 G:0.057 -:0.029
 31c(  34): N:0.971 -:0.029
 31d(   0): -:1.000
 31e(   0): -:1.000
 31f(   0): -:1.000
 32 (  35): Y:0.971 T:0.029
 33 (  35): A:0.971 I:0.029
 34 (  35): N:0.971 E:0.029
 35 (  35): W:1.000
 36 (  35): V:0.857 I:0.114 Y:0.029
 37 (  35): Q:1.000
 38 (  32): E:0.650 Q:0.350
 39 (  32): K:0.969 Q:0.031
 40 (  32): P:1.000
 41 (  35): D:0.971 L:0.029
 42 (  35): H:0.971 K:0.029
 43 (  35): L:0.971 P:0.029
 44 (  35): F:0.971 P:0.029
 45 (  35): T:0.971 K:0.029
 46 (  35): G:0.971 Y:0.029
 47 (  35): L:0.971 V:0.029
 48 (  35): I:0.943 L:0.029 M:0.029
 49 (  35): G:0.971 E:0.029
 50 (  35): G:0.943 L:0.029 N:0.029
 51 (  35): T:0.971 K:0.029
 52 (  35): N:0.714 S:0.257 K:0.029
 53 (  35): N:0.913 D:0.087
 54 (  35): R:0.971 X:0.029
 55 (  35): A:0.943 G:0.029 V:0.029
 56 (  35): P:0.971 D:0.029
 57 (  35): G:1.000
 58 (  35): V:0.971 I:0.029
 59 (  35): P:1.000
 60 (  35): A:0.714 V:0.257 D:0.029
 61 (  35): R:1.000
 62 (  35): F:1.000
 63 (  35): S:1.000
 64 (  35): G:1.000
 65 (  35): S:1.000
 66 (  35): L:0.971 S:0.029
 67 (  35): I:0.971 S:0.029
 68 (  35): G:1.000
 69 (  35): D:0.706 N:0.265 A:0.029
 70 (  35): K:0.971 D:0.029
 71 (  35): A:0.971 R:0.029
 72 (  35): A:0.971 Y:0.029
 73 (  35): L:1.000
 74 (  35): T:0.971 S:0.029
 75 (  35): I:1.000
 76 (  35): T:0.971 S:0.029
 77 (  35): G:0.971 N:0.029
 78 (  35): A:0.943 I:0.029 T:0.029
 79 (  35): Q:1.000
 80 (  32): T:0.969 P:0.031
 81 (  32): E:1.000
 82 (  32): D:1.000
 83 (  35): E:0.743 D:0.257
 84 (  35): A:1.000
 85 (  35): I:0.714 M:0.286
 86 (  35): Y:1.000
 87 (  35): F:0.971 I:0.029
 88 (  35): C:1.000
 89 (  35): A:0.971 G:0.029
 90 (  35): L:0.971 V:0.029
 91 (  35): W:0.971 G:0.029
 92 (  35): Y:0.829 F:0.114 C:0.029 D:0.029
 93 (  35): S:0.857 R:0.114 T:0.029
 94 (  35): N:0.829 T:0.143 I:0.029
 95 (  35): H:0.914 K:0.029 Q:0.029 R:0.029
 95a(   1): -:0.971 E:0.029
 95b(   1): -:0.971 Q:0.029
 95c(   1): -:0.971 F:0.029
 95d(   1): -:0.971 V:0.029
 95e(   0): -:1.000
 95f(   0): -:1.000
 96 (  35): W:0.629 F:0.286 Y:0.086
 97 (  35): V:0.886 I:0.114
 98 (  35): F:1.000
 99 (  35): G:1.000
100 (  35): G:0.914 S:0.086
101 (  35): G:1.000
102 (  35): T:1.000
103 (  35): K:1.000
104 (  35): L:0.657 V:0.343
105 (  34): T:1.000
106 (  34): V:1.000
106a(  34): L:1.000
107 (  33): G:1.000
108 (  24): Q:0.958 X:0.042
109 (  23): P:1.000

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