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Canonical Sequence Approximation

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Human V-l domains

The sequences underlying this analysis have been taken from the Kabat database of sequences of proteins of immunological interest (5th edition). They have been manually edited wherever necessary to align insertions at the respective positions where they have been crystallographically determined. Only the six most frequent residues are given in this table.

HUMAN LAMBDA LIGHT CHAIN VARIABLE DOMAINS
Lambda light chains subgroup I V region - Human
Lambda light chains subgroup II V region - Human
Lambda light chains subgroup III V region - Human
Lambda light chains subgroup IV V region - Human
Lambda light chains subgroup V V region - Human
Lambda light chains subgroup VI V region - Human
 
 
  +--- Position
  |
  |   +--- Number of observations (not counting gaps)
  |   |
  |   |      +--- Residue type
  |   |      |
  V   V      V v--- Observed frequency in sample
  1 (   95): Q:0.589 S:0.158 N:0.095 H:0.074 D:0.053 F:0.021
  2 (  139): S:0.446 Y:0.388 F:0.101 V:0.043 L:0.014 T:0.007
  3 (  140): V:0.307 E:0.243 A:0.207 M:0.093 D:0.064 I:0.043
  4 (  140): L:0.971 V:0.029
  5 (  141): T:0.915 A:0.021 S:0.021 I:0.014 K:0.007 L:0.007
  6 (  140): Q:0.993 E:0.007
  7 (  139): P:0.906 D:0.029 S:0.029 A:0.022 E:0.014
  8 (  139): P:0.741 A:0.137 H:0.072 R:0.029 L:0.007 S:0.007
  9 (  139): S:0.964 A:0.014 V:0.014 R:0.007
 10 (    0): -:1.000
 11 (  138): V:0.790 A:0.138 L:0.058 M:0.014
 12 (  139): S:0.978 F:0.007 T:0.007 E:0.004 Q:0.004
 13 (  138): V:0.406 G:0.348 A:0.138 E:0.087 L:0.014 D:0.007
 14 (  135): S:0.630 A:0.230 T:0.111 D:0.007 F:0.007 G:0.007
 15 (  135): P:0.881 L:0.089 A:0.022 S:0.007
 16 (  134): G:0.978 E:0.015 L:0.007
 17 (  133): Q:0.811 K:0.098 A:0.045 E:0.024 G:0.015 H:0.008
 18 (  133): T:0.504 S:0.263 R:0.135 K:0.068 E:0.008 G:0.008
 19 (  130): V:0.454 A:0.385 I:0.146 G:0.008 L:0.008
 20 (  128): T:0.531 R:0.188 S:0.148 K:0.047 I:0.031 M:0.016
 21 (  121): I:0.901 V:0.050 L:0.017 A:0.008 F:0.008 M:0.008
 22 (  120): S:0.492 T:0.475 A:0.008 G:0.008 I:0.008 N:0.008
 23 (  117): C:1.000
 24 (  112): S:0.536 T:0.259 G:0.089 A:0.045 Q:0.033 I:0.018
 25 (  108): G:0.870 L:0.056 R:0.028 A:0.019 I:0.009 P:0.009
 26 (  108): D:0.339 S:0.250 T:0.213 N:0.087 E:0.037 G:0.037
 27 (  104): S:0.415 N:0.118 K:0.113 A:0.104 T:0.066 G:0.047
 28 (  104): L:0.346 S:0.346 I:0.115 G:0.067 A:0.058 D:0.019
 29 (  100): G:0.243 N:0.239 D:0.159 S:0.078 P:0.068 H:0.058
 30 (  103): I:0.291 V:0.165 D:0.136 N:0.107 E:0.058 S:0.049
 31 (  101): G:0.356 K:0.168 A:0.099 E:0.084 Q:0.084 D:0.069
 31a(   54): -:0.438 S:0.167 G:0.104 N:0.083 Y:0.063 D:0.052
 31b(   49): -:0.495 N:0.227 Y:0.155 S:0.041 G:0.021 H:0.021
 31c(   23): -:0.760 N:0.134 S:0.031 K:0.021 D:0.012 E:0.010
 31d(    0): -:1.000
 31e(    0): -:1.000
 31f(    0): -:1.000
 32 (   94): Y:0.515 S:0.134 F:0.093 A:0.072 T:0.052 H:0.041
 33 (   97): V:0.680 A:0.186 I:0.082 Y:0.021 F:0.010 P:0.010
 34 (   92): S:0.380 H:0.120 A:0.109 Y:0.098 N:0.076 Q:0.076
 35 (   98): W:0.990 Y:0.010
 36 (   96): Y:0.844 F:0.073 H:0.073 W:0.010
 37 (   95): Q:0.916 R:0.042 E:0.011 H:0.011 K:0.011 Y:0.011
 38 (   94): Q:0.862 H:0.053 L:0.053 E:0.011 K:0.011 V:0.011
 39 (   93): K:0.333 L:0.172 R:0.161 H:0.151 Q:0.086 V:0.043
 40 (   93): P:0.946 S:0.022 A:0.011 L:0.011 R:0.011
 41 (   93): G:0.871 H:0.065 D:0.022 R:0.022 P:0.011 V:0.011
 42 (   92): Q:0.424 T:0.217 K:0.163 R:0.087 S:0.054 G:0.022
 43 (   92): A:0.717 S:0.174 G:0.065 T:0.022 L:0.011 V:0.011
 44 (   93): P:0.978 A:0.011 M:0.011
 45 (   92): K:0.391 V:0.315 R:0.109 L:0.065 T:0.065 A:0.033
 46 (   92): L:0.728 V:0.076 F:0.065 T:0.043 A:0.022 M:0.022
 47 (   91): V:0.484 L:0.374 I:0.077 M:0.055 N:0.011
 48 (   91): I:0.791 V:0.110 M:0.077 L:0.011 S:0.011
 49 (   91): Y:0.769 F:0.110 R:0.066 H:0.022 D:0.011 I:0.011
 50 (   89): D:0.303 E:0.210 Q:0.093 V:0.067 G:0.056 K:0.056
 51 (   88): D:0.364 N:0.205 V:0.159 H:0.068 T:0.068 G:0.034
 52 (   89): N:0.393 T:0.213 S:0.202 D:0.101 A:0.022 F:0.011
 53 (   88): K:0.307 D:0.193 Q:0.182 N:0.080 E:0.057 S:0.057
 54 (   88): R:0.875 X:0.068 K:0.034 L:0.011 W:0.011
 55 (   86): P:0.851 G:0.080 S:0.023 A:0.011 H:0.011 R:0.011
 56 (   85): S:0.837 D:0.081 P:0.023 A:0.012 L:0.012 T:0.012
 57 (   86): G:0.920 E:0.034 S:0.011 T:0.011 W:0.011 -:0.011
 58 (   84): I:0.600 V:0.353 A:0.012 G:0.012 T:0.012 -:0.012
 59 (   84): P:0.847 S:0.106 A:0.012 L:0.012 V:0.012 -:0.012
 60 (   85): D:0.488 E:0.325 N:0.047 A:0.035 H:0.023 L:0.023
 61 (   87): R:0.977 D:0.011 -:0.011
 62 (   88): F:0.943 I:0.034 L:0.011 R:0.011
 63 (   87): S:0.989 F:0.011
 64 (   87): G:0.885 A:0.069 S:0.023 V:0.023
 65 (   87): S:0.977 G:0.011 Y:0.011
 66 (   86): K:0.430 N:0.186 S:0.186 T:0.081 X:0.070 R:0.035
 67 (   85): S:0.953 T:0.024 K:0.012 L:0.012
 68 (   85): G:0.859 S:0.071 A:0.035 D:0.024 Q:0.012
 69 (   85): N:0.434 T:0.318 A:0.129 D:0.036 G:0.024 K:0.024
 70 (   85): T:0.529 S:0.341 E:0.082 A:0.024 K:0.024
 71 (   85): A:0.847 R:0.082 V:0.059 S:0.012
 72 (   85): T:0.447 S:0.424 Y:0.082 A:0.035 I:0.012
 73 (   85): L:0.988 S:0.012
 74 (   85): T:0.706 A:0.165 G:0.106 I:0.012 L:0.012
 75 (   85): I:0.929 V:0.047 A:0.012 L:0.012
 76 (   85): S:0.718 T:0.200 N:0.035 I:0.024 G:0.012 R:0.012
 77 (   85): G:0.765 R:0.129 S:0.094 E:0.012
 78 (   85): L:0.588 V:0.224 T:0.106 A:0.071 G:0.012
 79 (   85): Q:0.659 E:0.153 R:0.071 K:0.047 L:0.024 A:0.012
 80 (   85): A:0.459 S:0.235 T:0.200 V:0.047 P:0.035 N:0.012
 81 (   85): E:0.541 G:0.235 M:0.071 D:0.047 L:0.024 N:0.024
 82 (   85): D:0.964 N:0.024 E:0.012
 83 (   85): E:0.976 D:0.012 T:0.012
 84 (   85): A:0.941 T:0.035 E:0.012 S:0.012
 85 (   85): D:0.859 E:0.082 H:0.024 A:0.012 I:0.012 M:0.012
 86 (   85): Y:0.976 F:0.012 H:0.012
 87 (   85): Y:0.894 F:0.106
 88 (   85): C:0.988 H:0.012
 89 (   85): Q:0.482 A:0.153 S:0.141 G:0.094 C:0.059 N:0.035
 90 (   85): S:0.388 T:0.271 A:0.212 V:0.118 L:0.012
 91 (   85): W:0.576 Y:0.247 A:0.059 F:0.035 R:0.035 D:0.012
 92 (   84): D:0.606 G:0.095 A:0.071 N:0.061 T:0.048 E:0.024
 93 (   84): S:0.405 D:0.179 G:0.107 N:0.095 P:0.071 T:0.060
 94 (   84): S:0.536 G:0.155 N:0.073 R:0.060 D:0.058 T:0.048
 95 (   82): S:0.265 L:0.253 G:0.108 N:0.096 T:0.084 A:0.036
 95a(   60): -:0.268 S:0.183 D:0.159 N:0.110 T:0.073 Q:0.049
 95b(   40): -:0.512 A:0.098 G:0.098 H:0.085 E:0.049 R:0.037
 95c(    5): -:0.939 P:0.037 A:0.012 G:0.012
 95d(    1): -:0.988 G:0.012
 95e(    0): -:1.000
 95f(    0): -:1.000
 96 (   80): V:0.305 G:0.098 P:0.098 W:0.098 A:0.073 N:0.073
 97 (   85): V:0.788 I:0.118 L:0.047 M:0.035 G:0.012
 98 (   86): F:0.988 V:0.012
 99 (   89): G:0.989 F:0.011
100 (   89): G:0.831 T:0.124 A:0.022 S:0.022
101 (   89): G:1.000
102 (   89): T:0.989 G:0.011
103 (   88): K:0.739 N:0.091 R:0.068 Q:0.034 T:0.034 E:0.011
104 (   87): L:0.667 V:0.322 Q:0.011
105 (   87): T:0.954 S:0.023 I:0.011 L:0.011
106 (   85): V:0.988 T:0.012
106a(   84): L:0.952 V:0.024 P:0.012 Q:0.012
107 (   78): G:0.782 S:0.103 R:0.090 C:0.013 L:0.013
108 (   46): Q:0.957 P:0.022 R:0.022
109 (   46): P:0.957 K:0.022 Q:0.022

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