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Canonical Sequence Approximation

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Combined V-k domains

The sequences underlying this analysis have been taken from the Kabat database of sequences of proteins of immunological interest (5th edition). They have been manually edited wherever necessary to align insertions at the respective positions where they have been crystallographically determined. Only the six most frequent residues are given in this table.

ALL KAPPA CHAIN VARIABLE DOMAINS COMBINED
Kappa light chains subgroup I V region - Human
Kappa light chains subgroup II V region - Human
Kappa light chains subgroup III V region - Human
Kappa light chains subgroup IV V region - Human
Kappa light chains I V region - Mouse
Kappa light chains II V region - Mouse
Kappa light chains III V region - Mouse
Kappa light chains IV V region - Mouse
Kappa light chains V V region - Mouse
Kappa light chains VI V region - Mouse
Kappa light chains VII V region - Mouse
Kappa light chains miscellaneous V region - Mouse
Kappa light chains V region - Rat
Kappa light chains V region - Rabbit
Kappa light chains V region
 
 
  +--- Position
  |
  |   +--- Number of observations (not counting gaps)
  |   |
  |   |      +--- Residue type
  |   |      |
  V   V      V v--- Observed frequency in sample
  1 ( 1359): D:0.692 E:0.134 Q:0.095 A:0.039 N:0.019 S:0.009
  2 ( 1397): I:0.752 V:0.165 N:0.020 L:0.015 A:0.009 P:0.008
  3 ( 1415): V:0.683 Q:0.209 L:0.057 K:0.018 D:0.007 T:0.007
  4 ( 1412): M:0.618 L:0.336 I:0.027 V:0.014 T:0.001 X:0.001
  5 ( 1408): T:0.955 S:0.022 I:0.010 N:0.004 A:0.002 X:0.002
  6 ( 1405): Q:0.988 E:0.007 W:0.001 A:0.001 L:0.001 R:0.001
  7 ( 1397): S:0.633 T:0.299 A:0.031 D:0.021 I:0.004 F:0.002
  8 ( 1402): P:0.847 T:0.060 A:0.034 E:0.023 H:0.014 Q:0.012
  9 ( 1364): S:0.330 A:0.301 L:0.177 G:0.050 K:0.043 T:0.032
 10 ( 1395): S:0.622 I:0.133 T:0.127 F:0.066 P:0.017 L:0.014
 11 ( 1390): L:0.635 M:0.183 V:0.091 N:0.035 T:0.021 K:0.011
 12 ( 1379): S:0.552 P:0.199 A:0.162 T:0.027 E:0.022 Y:0.020
 13 ( 1361): V:0.453 A:0.413 L:0.062 T:0.034 M:0.016 E:0.012
 14 ( 1372): S:0.749 T:0.142 A:0.066 P:0.027 V:0.004 F:0.004
 15 ( 1380): L:0.349 P:0.266 V:0.249 A:0.084 S:0.023 I:0.016
 16 ( 1360): G:0.970 S:0.021 R:0.004 E:0.003 V:0.002
 17 ( 1329): E:0.396 D:0.353 Q:0.124 G:0.090 K:0.020 T:0.014
 18 ( 1335): R:0.390 K:0.237 T:0.121 Q:0.121 S:0.076 P:0.037
 19 ( 1349): V:0.663 A:0.307 I:0.021 S:0.004 D:0.003 E:0.001
 20 ( 1350): T:0.715 S:0.263 A:0.007 I:0.005 E:0.002 X:0.002
 21 ( 1342): I:0.662 M:0.190 L:0.119 V:0.015 F:0.010 T:0.001
 22 ( 1318): S:0.548 T:0.358 N:0.046 K:0.026 R:0.004 A:0.003
 23 ( 1280): C:0.997 Y:0.002 X:0.001
 24 ( 1227): R:0.514 K:0.188 S:0.149 Q:0.091 T:0.031 L:0.006
 25 ( 1211): A:0.662 S:0.303 T:0.017 V:0.007 M:0.005 P:0.002
 26 ( 1212): S:0.958 N:0.012 T:0.007 R:0.007 G:0.005 A:0.003
 27 ( 1211): Q:0.619 S:0.166 E:0.099 K:0.091 T:0.007 H:0.005
 28 ( 1199): S:0.698 D:0.167 N:0.065 G:0.032 T:0.016 R:0.006
 29 ( 1200): V:0.361 I:0.351 L:0.259 T:0.007 S:0.006 F:0.003
 30 ( 1188): S:0.375 L:0.157 V:0.137 Y:0.076 N:0.064 G:0.058
 31 ( 1008): S:0.225 N:0.222 H:0.158 -:0.136 T:0.073 Y:0.063
 31a(  607): -:0.477 S:0.370 N:0.042 Y:0.038 K:0.031 G:0.009
 31b(  501): -:0.568 N:0.179 G:0.106 D:0.063 K:0.029 S:0.028
 31c(  475): -:0.592 G:0.224 N:0.088 H:0.028 Y:0.023 T:0.013
 31d(  452): -:0.611 N:0.151 S:0.067 K:0.065 Q:0.057 I:0.020
 31e(  357): -:0.692 T:0.181 K:0.076 V:0.026 N:0.014 R:0.007
 31f(  157): -:0.864 N:0.070 T:0.036 H:0.024 Y:0.003 K:0.001
 32 ( 1174): Y:0.734 N:0.069 F:0.054 W:0.031 S:0.026 A:0.020
 33 ( 1158): L:0.694 M:0.205 V:0.058 I:0.030 F:0.008 A:0.003
 34 ( 1138): A:0.276 H:0.259 N:0.208 S:0.067 Y:0.062 E:0.061
 35 ( 1149): W:0.997 L:0.003 Y:0.001
 36 ( 1093): Y:0.848 F:0.111 L:0.025 H:0.011 N:0.003 Q:0.001
 37 ( 1088): Q:0.765 L:0.222 R:0.006 E:0.002 H:0.002 D:0.001
 38 ( 1086): Q:0.950 H:0.023 K:0.011 E:0.007 R:0.003 L:0.002
 39 ( 1061): K:0.893 R:0.084 E:0.006 T:0.005 X:0.003 Y:0.003
 40 ( 1073): P:0.805 S:0.143 Q:0.021 L:0.010 A:0.009 T:0.008
 41 ( 1040): G:0.825 D:0.091 E:0.028 W:0.016 H:0.011 S:0.009
 42 ( 1021): Q:0.547 T:0.134 K:0.119 G:0.097 S:0.040 E:0.023
 43 ( 1019): S:0.568 P:0.172 A:0.130 T:0.105 G:0.016 R:0.003
 44 ( 1017): P:0.891 V:0.082 I:0.014 N:0.005 L:0.003 F:0.002
 45 ( 1013): K:0.761 R:0.113 Q:0.095 N:0.009 T:0.008 E:0.007
 46 ( 1022): L:0.743 R:0.121 P:0.047 T:0.028 V:0.022 A:0.012
 47 ( 1007): L:0.811 W:0.176 V:0.005 I:0.002 Q:0.002 S:0.002
 48 ( 1009): I:0.950 V:0.030 L:0.007 M:0.006 F:0.003 T:0.003
 49 ( 1004): Y:0.907 H:0.021 S:0.021 K:0.019 F:0.012 W:0.004
 50 (  998): K:0.149 Y:0.149 D:0.132 G:0.119 R:0.111 A:0.078
 51 ( 1004): A:0.418 T:0.296 V:0.174 M:0.048 I:0.032 G:0.018
 52 ( 1000): S:0.922 T:0.037 K:0.013 N:0.013 I:0.004 D:0.003
 53 (  993): N:0.416 T:0.168 K:0.157 S:0.106 R:0.090 Y:0.028
 54 (  996): L:0.582 R:0.374 S:0.016 Q:0.014 V:0.006 H:0.002
 55 (  993): A:0.390 E:0.161 F:0.152 H:0.079 Y:0.058 Q:0.045
 56 (  992): S:0.756 T:0.125 D:0.051 P:0.024 A:0.008 I:0.007
 57 (  991): G:0.994 E:0.002 S:0.002 D:0.001 V:0.001
 58 (  977): V:0.851 I:0.134 F:0.007 A:0.002 T:0.002 M:0.001
 59 (  992): P:0.959 S:0.030 T:0.005 L:0.003 Q:0.002 V:0.001
 60 (  978): D:0.410 S:0.281 A:0.257 G:0.012 K:0.010 V:0.010
 61 (  977): R:0.990 S:0.003 K:0.002 F:0.001 G:0.001 N:0.001
 62 (  979): F:0.994 L:0.003 K:0.001 Q:0.001 V:0.001
 63 (  994): S:0.798 T:0.132 K:0.041 I:0.013 A:0.004 X:0.004
 64 (  990): G:0.977 S:0.015 D:0.004 R:0.004
 65 (  974): S:0.976 G:0.005 D:0.004 R:0.003 T:0.003 N:0.002
 66 (  991): G:0.964 R:0.020 A:0.003 E:0.003 T:0.003 I:0.002
 67 (  958): S:0.972 Y:0.011 A:0.005 F:0.003 W:0.003 E:0.001
 68 (  979): G:0.934 R:0.038 A:0.011 E:0.004 S:0.004 D:0.003
 69 (  969): T:0.905 Q:0.027 R:0.018 N:0.017 A:0.012 S:0.011
 70 ( 1002): D:0.676 S:0.198 Q:0.044 E:0.043 A:0.021 K:0.008
 71 (  996): F:0.643 Y:0.338 C:0.005 H:0.004 L:0.002 S:0.002
 72 ( 1006): T:0.599 S:0.380 I:0.005 P:0.005 A:0.004 V:0.003
 73 ( 1001): L:0.934 F:0.060 T:0.002 M:0.001 P:0.001 S:0.001
 74 (  993): T:0.651 K:0.193 N:0.049 R:0.037 S:0.034 E:0.015
 75 ( 1002): I:0.980 V:0.011 S:0.003 T:0.002 K:0.001 L:0.001
 76 (  985): S:0.817 N:0.068 H:0.045 G:0.015 T:0.015 D:0.014
 77 (  988): S:0.419 R:0.289 N:0.124 P:0.075 G:0.033 D:0.028
 78 (  997): V:0.467 L:0.321 M:0.187 A:0.011 I:0.008 T:0.002
 79 ( 1002): E:0.721 Q:0.234 K:0.028 L:0.004 G:0.003 H:0.003
 80 (  962): A:0.527 P:0.164 Q:0.077 S:0.076 E:0.048 C:0.044
 81 ( 1000): E:0.859 D:0.095 A:0.032 G:0.008 Q:0.002 Y:0.002
 82 ( 1013): D:0.989 N:0.003 V:0.003 A:0.002 C:0.002 E:0.001
 83 (  956): L:0.264 A:0.257 F:0.157 V:0.131 I:0.103 T:0.031
 84 (  977): A:0.702 G:0.266 V:0.015 T:0.009 S:0.005 Q:0.002
 85 (  992): T:0.434 V:0.368 I:0.055 D:0.047 M:0.031 S:0.026
 86 ( 1013): Y:0.991 F:0.005 D:0.001 E:0.001 H:0.001 K:0.001
 87 (  997): Y:0.749 F:0.227 L:0.011 H:0.008 C:0.002 D:0.001
 88 ( 1015): C:0.996 L:0.002 Q:0.001 S:0.001
 89 ( 1004): Q:0.616 L:0.090 F:0.080 S:0.067 M:0.039 A:0.028
 90 (  980): Q:0.873 H:0.047 N:0.040 G:0.019 A:0.005 L:0.003
 91 (  997): G:0.204 Y:0.180 S:0.168 W:0.148 H:0.090 D:0.040
 92 (  991): S:0.245 N:0.185 Y:0.132 T:0.116 D:0.071 G:0.060
 93 (  988): S:0.343 H:0.168 E:0.154 T:0.110 N:0.058 G:0.042
 94 (  993): Y:0.177 L:0.164 V:0.154 N:0.118 S:0.109 F:0.055
 95 (  943): P:0.848 -:0.048 L:0.034 S:0.025 A:0.009 T:0.009
 95a(   85): -:0.903 P:0.031 X:0.015 R:0.011 N:0.008 S:0.007
 95b(   25): -:0.971 G:0.006 T:0.005 V:0.005 M:0.004 Y:0.004
 95c(   18): -:0.979 D:0.005 S:0.004 F:0.002 G:0.002 T:0.002
 95d(    6): -:0.993 S:0.004 D:0.001 G:0.001 Y:0.001
 95e(    3): -:0.996 N:0.001 P:0.001 S:0.001
 95f(    2): -:0.998 G:0.001 Y:0.001
 96 (  850): L:0.250 Y:0.219 W:0.164 R:0.137 F:0.058 P:0.046
 97 (  854): T:0.949 S:0.012 V:0.012 A:0.008 -:0.005 G:0.002
 98 (  865): F:0.992 L:0.002 E:0.001 I:0.001 R:0.001 V:0.001
 99 (  863): G:0.994 A:0.002 D:0.001 R:0.001 -:0.001
100 (  856): G:0.547 A:0.256 Q:0.098 S:0.069 T:0.013 P:0.009
101 (  824): G:0.988 A:0.006 P:0.002 D:0.001 T:0.001 -:0.001
102 (  820): T:0.993 S:0.004 F:0.001 K:0.001 Q:0.001
103 (  806): K:0.922 E:0.040 R:0.025 T:0.004 A:0.002 G:0.002
104 (  788): L:0.831 V:0.165 G:0.001 Q:0.001 X:0.001
105 (  734): E:0.925 V:0.040 D:0.018 L:0.007 G:0.004 S:0.003
106 (  725): I:0.666 L:0.263 V:0.052 M:0.007 K:0.003 N:0.003
106a(    1): -:0.999 K:0.001
107 (  677): K:0.965 R:0.012 I:0.006 T:0.006 N:0.004 E:0.003
108 (  419): R:0.912 G:0.069 C:0.005 S:0.005 V:0.005 E:0.002
109 (  138): T:0.399 A:0.326 D:0.202 L:0.022 N:0.015 S:0.014

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