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| | '''Update Warning!''' | | '''Update Warning!''' |
| − | This page has not been revised yet for the 2007 Fall term. Some of the slides may be reused, but please consider the page as a whole out of date as long as this warning appears here. | + | This page has not been revised yet for the 2008 Fall term. Some of the slides may be reused, but please consider the page as a whole out of date as long as this warning appears here. |
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| | __NOTOC__ | | __NOTOC__ |
| | <small>[[Lecture_16|(Previous lecture)]] ... [[Lecture_18|(Next lecture)]]</small> | | <small>[[Lecture_16|(Previous lecture)]] ... [[Lecture_18|(Next lecture)]]</small> |
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| − | ==Phylogenetic Analysis== | + | ==Functional Annotation== |
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| − | * Summary points
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| − | * Exercises
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| − | * Further reading
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| − | ==Lecture Slides==
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| − | ======Slide 001======
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| − | [[Image:L17_s001.jpg|frame|none|Lecture 17, Slide 001<br>
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| − | ======Slide 002======
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| − | [[Image:L17_s002.jpg|frame|none|Lecture 17, Slide 002<br>
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| − | ======Slide 003======
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| − | [[Image:L17_s003.jpg|frame|none|Lecture 17, Slide 003<br>
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| − | ======Slide 004======
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| − | [[Image:L17_s004.jpg|frame|none|Lecture 17, Slide 004<br>
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| − | ======Slide 005======
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| − | [[Image:L17_s005.jpg|frame|none|Lecture 17, Slide 005<br>
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| − | ======Slide 006======
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| − | [[Image:L17_s006.jpg|frame|none|Lecture 17, Slide 006<br>
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| − | ======Slide 007======
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| − | [[Image:L17_s007.jpg|frame|none|Lecture 17, Slide 007<br>
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| − | ======Slide 008======
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| − | [[Image:L17_s008.jpg|frame|none|Lecture 17, Slide 008<br>
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| − | ======Slide 009======
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| − | [[Image:L17_s009.jpg|frame|none|Lecture 17, Slide 009<br>
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| − | ======Slide 010======
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| − | [[Image:L17_s010.jpg|frame|none|Lecture 17, Slide 010<br>
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| − | ======Slide 011======
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| − | [[Image:L17_s011.jpg|frame|none|Lecture 17, Slide 011<br>
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| − | ======Slide 012======
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| − | [[Image:L17_s012.jpg|frame|none|Lecture 17, Slide 012<br>
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| − | Usually, analysis of confidence implies a "bootstrapping" procedure: rerun the analysis many times with partial data and analyze which features of the tree (branching order -> topology!) are well conserved, and which ones depend critically on unreliable features of the input data.
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| − | ======Slide 013======
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| − | [[Image:L17_s013.jpg|frame|none|Lecture 17, Slide 013<br>
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| − | ======Slide 014======
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| − | [[Image:L17_s014.jpg|frame|none|Lecture 17, Slide 014<br>
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| − | Note that distance methods first reduce the explicit molecular data into a matrix of pairwise distances, then operate on that "summary" to construct the most plausible tree. They are fast, but less accurate than some alternatives.
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| − | ======Slide 015======
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| − | [[Image:L17_s015.jpg|frame|none|Lecture 17, Slide 015<br>
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| − | ======Slide 016======
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| − | [[Image:L17_s016.jpg|frame|none|Lecture 17, Slide 016<br>
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| − | ======Slide 017======
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| − | [[Image:L17_s017.jpg|frame|none|Lecture 17, Slide 017<br>
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| − | ======Slide 018======
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| − | [[Image:L17_s018.jpg|frame|none|Lecture 17, Slide 018<br>
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| − | ======Slide 019======
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| − | [[Image:L17_s019.jpg|frame|none|Lecture 17, Slide 019<br>
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| − | ======Slide 020======
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| − | [[Image:L17_s020.jpg|frame|none|Lecture 17, Slide 020<br>
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| − | ======Slide 021======
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| − | [[Image:L17_s021.jpg|frame|none|Lecture 17, Slide 021<br>
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| − | ======Slide 022======
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| − | [[Image:L17_s022.jpg|frame|none|Lecture 17, Slide 022<br>
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| − | ======Slide 023======
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| − | [[Image:L17_s023.jpg|frame|none|Lecture 17, Slide 023<br>
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| − | Genomes are and always have been exquisitly plastic, malleable entities. That we have long thought this not to be the case is a consequence of our limited personal experience and anthropocentric world view.
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| − | ======Slide 024======
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| − | [[Image:L17_s024.jpg|frame|none|Lecture 17, Slide 024<br>
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| − | ======Slide 025======
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| − | [[Image:L17_s025.jpg|frame|none|Lecture 17, Slide 025<br>
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| − | ======Slide 026======
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| − | [[Image:L17_s026.jpg|frame|none|Lecture 17, Slide 026<br>
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| − | ======Slide 027======
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| − | [[Image:L17_s027.jpg|frame|none|Lecture 17, Slide 027<br>
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| − | ]] | + | * Lecture slides linked [http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/2007/17_FunctionalAnnotation.pdf '''here''' (PDF format, 9.9 Mb)]. |
