Expected Preparations:

  [BIN-EXPR]
DE 		  [FND-STA]
Significance 		 
  The units listed above are part of this course and contain important preparatory material.  
Keywords: Multiple testing problem: concepts; Bonferroni correction and FDR
Objectives:

This unit will …

  • … introduce the concepts of probability correction with Family Wise Error rate and False Discovery Rate.

 Outcomes:

After working through this unit you …

  • … are aware of the need to correct significance levels in situations with multiple observations;

  • … are familar with the ideas of the Bonferroni correction and control with the False Discovery Rate (FDR).

Deliverables:

Time management: Before you begin, estimate how long it will take you to complete this unit. Then, record in your course journal: the number of hours you estimated, the number of hours you worked on the unit, and the amount of time that passed between start and completion of this unit.

Journal: Document your progress in your Course Journal. Some tasks may ask you to include specific items in your journal. Don’t overlook these.

Insights: If you find something particularly noteworthy about this unit, make a note in your insights! page.

Evaluation:

NA: This unit is not evaluated for course marks.

Contents

Searching for significant effects in high-throughput experiments changes the statistical odds of finding highly unusual outcomes. This needs to be properly corrected, especially in situations like expression analysis where we observe tens of thousands of measurements simultaneously and need to determine which ones should be followed up on.

 

Task…

 

Questions, comments

If in doubt, ask! If anything about this contents is not clear to you, do not proceed but ask for clarification. If you have ideas about how to make this material better, let’s hear them. We are aiming to compile a list of FAQs for all learning units, and your contributions will count towards your participation marks.

Improve this page! If you have questions or comments, please post them on the Quercus Discussion board with a subject line that includes the name of the unit.

References

Page ID: BIN-EXPR-Multiple_testing

Author:
Boris Steipe ( <boris.steipe@utoronto.ca> )
Created:
2017-08-05
Last modified:
2022-09-14
Version:
1.1
Version History:
–  1.1 Maintainance
–  1.0 First live version
–  0.1 First stub
Tagged with:
–  Unit
–  Live
–  Has lecture slides

 

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