Difference between revisions of "Bioinformatics Main Page"

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BCH441 - Bioinformatics
 
BCH441 - Bioinformatics
  
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<div class="BIO_2">
 
</div>
 
 
== The Course ==
 
== The Course ==
 +
BCH441H1F is the undergraduate course code.<br>
 +
BCH1441H1F is the cross-listed course code for graduate students.
  
BCH441H1F is the undergraduate course code and BCH1441H1F is the corresponding cross-listed course code for graduate students.
 
  
<div class="BIO_3">
 
</div>
 
 
===Organization===
 
===Organization===
 
;Dates
 
;Dates
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<div class="BIO_3">
 
</div>
 
 
===Grading and Activities===
 
===Grading and Activities===
  
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<div class="BIO_2">
 
</div>
 
 
== Assignments ==
 
== Assignments ==
  
<div class="BIO_alert">
+
<div class="alert">
 
[[Assignment 5]] has been posted.
 
[[Assignment 5]] has been posted.
 
<br>
 
<br>
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<div class="BIO_2">
 
</div>
 
 
== Temporary links for material ==
 
== Temporary links for material ==
  
  
<div class="BIO_3">
 
</div>
 
 
===Lecture slides 2012===
 
===Lecture slides 2012===
  
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<div class="BIO_3">
 
</div>
 
 
===Lecture slides 2011===
 
===Lecture slides 2011===
  
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<div class="BIO_3">
 
</div>
 
 
=== Add this material ===
 
=== Add this material ===
 
* Quantitative evolution: signals of recent change and selective pressure
 
* Quantitative evolution: signals of recent change and selective pressure
  
  
<!--  
+
<!-- * [[Database Identifiers]] -->
== Organization ==
 
  
;Dates
+
<!--
:''Lectures'': Monday and Thursday, 12:00 to 13:00
 
:''Tutorial sessions'': Mondays, 13:00 to 14:00 <small>&nbsp;&nbsp;for in-class quizzes, quiz debriefings, exam preparation and other activities, as the need arises.</small>
 
 
 
;Location
 
:MSB 2173 (Medical Sciences Building)
 
 
 
See the [http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/ Course Web page] for general information.
 
 
 
We are recommending '''[http://www.garlandscience.com/textbooks/0815340249.asp Understanding Bioinformatics]''', Zvelebil &amp; Baum, Garland 2008 as a background textbook for the course. <small>([http://www.amazon.ca/Understanding-Bioinformatics-Market-Zvelebil/dp/0815340249 amazon], [http://www.uoftbookstore.com/online/merchant.ihtml?pid=1051140&step=4 UofT Bookstore])</small>
 
 
 
== Grading and Activities ==
 
 
 
<table cellpadding="5">
 
 
 
<tr class="sh">
 
<td>'''Activity'''</td>
 
<td>'''Weight'''<br><small>(Undergraduates)</small></td>
 
<td>'''Weight'''<br><small>(Graduates)</small></td>
 
</tr>
 
 
 
<tr class="sp"><td colspan="3" style="height: 5px;"></td></tr>
 
 
 
<tr class="s0">
 
<td>[[Assignments|'''5 Assignments''' (drop 1)]]</td>
 
<td>16 marks <small>(4 x 4)</small></td>
 
<td>12 marks <small>(4 x 3)</small></td>
 
</tr>
 
 
 
 
 
<tr class="s1">
 
<td>[[Quizzes|'''5 In-class quizzes''' (drop 1)]]</td>
 
<td>32 marks <small>(4 x 8)</small></td>
 
<td>20 marks <small>(4 x 5)</small></td>
 
</tr>
 
 
 
<tr class="s0">
 
<td>'''[[Group project]]'''</td>
 
<td>10 marks</td>
 
<td>6 marks</td>
 
</tr>
 
 
 
<tr class="s1">
 
<td>'''[[Participation]]'''</td>
 
<td>2 marks</td>
 
<td>2 marks</td>
 
</tr>
 
 
 
<tr class="s0">
 
<td>'''[[Graduate project]]'''</td>
 
<td>&nbsp;</td>
 
<td>20 marks</td>
 
</tr>
 
 
 
<tr class="s1">
 
<td>[[Exam questions|'''Final exam''']]</td>
 
<td>40 marks</td>
 
<td>40 marks</td>
 
</tr>
 
 
 
<tr class="sp"><td colspan="3" style="height: 5px;"></td></tr>
 
 
 
<tr class="s0">
 
<td>'''Total'''</td>
 
<td>100 marks</td>
 
<td>100 marks</td>
 
</tr>
 
 
 
</table>
 
 
 
I will not adjust marks towards a target average for the class ("Belling"). If your classmate gets a great mark because you helped him with a difficult concept, this will have no bearing whatsoever on your own mark. Collaborate as much as possible, it is a great way to learn. The only times I will consider adjusting marks is if we phrase questions ambiguously on quizzes or if I decide that the final exam was too long.
 
 
 
== Lecture Schedule ==
 
<small>This section is currently under construction.</small>
 
 
 
 
 
<table cellpadding="5">
 
 
 
<tr class="st">
 
<td colspan="7">'''I n t r o d u c t i o n'''</td>
 
</tr>
 
 
 
<tr class="sh">
 
<td>'''#'''</td>
 
<td>'''Date'''</td>
 
<td>'''Lecturer'''</td>
 
<td>'''Topic'''</td>
 
<td>'''Handout'''</td>
 
<td>'''Book'''</td>
 
<td>'''Note'''</td>
 
</tr>
 
 
 
<tr class="s1">
 
<td>1</td>
 
<td>Mon. Sept 8</td>
 
<td>Steipe</td>
 
<td>Organisation and Orientation</td>
 
<td>[[Introduction]]</td>
 
<td>Ch 1, 2</td>
 
<td>-</td>
 
</tr>
 
 
 
 
 
 
 
 
 
--><!--  ===================    TOPIC    ===================  --><!--
 
<tr class="sp"><td colspan="7" style="height: 10px;"></td></tr>
 
<tr class="st">
 
<td colspan="7">'''A b s t r a c t i o n s'''</td>
 
</tr>
 
 
 
<tr class="sh">
 
<td>'''#'''</td>
 
<td>'''Date'''</td>
 
<td>'''Lecturer'''</td>
 
<td>'''Topic'''</td>
 
<td>'''Handout'''</td>
 
<td>'''Book'''</td>
 
<td>'''Note'''</td>
 
</tr>
 
 
 
<tr class="sp"><td colspan="7" style="height: 5px;"></td></tr>
 
 
 
<tr class="s1">
 
<td>2</td>
 
<td>Thu. Sept 11</td>
 
<td>Steipe</td>
 
<td>Sequence abstraction and sequence databases</td>
 
<td>[[Sequence data]]</td>
 
<td>Ch 3</td>
 
<td>[[Assignment 1|Assignment 1 to be handed out]]</td>
 
</tr>
 
 
 
<tr class="s2">
 
<td>3</td>
 
<td>Mon. Sept 15</td>
 
<td>Steipe</td>
 
<td>Protein Structure Data</td>
 
<td>[[Structure data]]</td>
 
<td>-</td>
 
<td>-</td>
 
</tr>
 
 
 
--><!--  ===================    TOPIC    ===================  --><!--
 
<tr class="sp"><td colspan="7" style="height: 10px;"></td></tr>
 
<tr class="st">
 
<td colspan="7">'''A n a l y s i s'''</td>
 
</tr>
 
 
 
<tr class="sh">
 
<td>'''#'''</td>
 
<td>'''Date'''</td>
 
<td>'''Lecturer'''</td>
 
<td>'''Topic'''</td>
 
<td>'''Handout'''</td>
 
<td>'''Book'''</td>
 
<td>'''Note'''</td>
 
</tr>
 
 
 
<tr class="sp"><td colspan="7" style="height: 5px;"></td></tr>
 
 
 
<tr class="s1">
 
<td>3</td>
 
<td>Thu. Sept 18</td>
 
<td>Steipe</td>
 
<td>Sequence properties</td>
 
<td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/SequenceProperties.pdf Raw lecture PDF]</small></td>
 
<td>Ch 4.9, 11, 12</td>
 
<td>-</td>
 
</tr>
 
 
 
<tr class="s2">
 
<td>4</td>
 
<td>Mon. Sept 22</td>
 
<td>Steipe</td>
 
<td> Sequence Analysis and Bioinformatics methods</td>
 
<td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/SequenceAnalysis.pdf Raw lecture PDF]</small></td>
 
<td>-</td>
 
<td>-</td>
 
</tr>
 
 
 
<tr class="s1">
 
<td>5</td>
 
<td>Thu. Sept 25.</td>
 
<td>Steipe</td>
 
<td>Interpreting protein structure</td>
 
<td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/InterpretingProteinStructure.pdf Raw lecture PDF]</td>
 
<td>-</td>
 
<td>[[Assignment 1]] due<br>
 
<hr>
 
'''First quiz''' in class<br>
 
<hr>
 
[[Assignment 2]] to be posted
 
</td>
 
</tr>
 
 
 
<tr class="s1">
 
<td>12</td>
 
<td>Thu. Oct 23.</td>
 
<td>Steipe</td>
 
<td>Structural domains</td>
 
<td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/StructuralDomains.pdf Raw lecture PDF]</small></td>
 
<td>-</td>
 
<td>[[Assignment 3]] due</td>
 
</tr>
 
 
 
<tr class="s1">
 
<td>6</td>
 
<td>Mon. Sept 29</td>
 
<td>Steipe</td>
 
<td>Homology I: the principles</td>
 
<td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/Homology_I_Principles.pdf Raw lecture PDF]</small></td>
 
<td>Ch. 14</td>
 
<td>-</td>
 
</tr>
 
 
 
<tr class="s1">
 
<td>7</td>
 
<td>Thu. Oct 2</td>
 
<td>Parkinson</td>
 
<td>Genome sequencing, genome browsers</td>
 
<td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/Genome_sequencing.pdf Lecture slide PDFs (1.8 MB)]</small></td>
 
<td>Ch. 9, 10</td>
 
<td>-</td>
 
</tr>
 
 
 
<tr class="s2">
 
<td>8</td>
 
<td>Mon. Oct 6</td>
 
<td>Parkinson</td>
 
<td>Genomes and genome structure</td>
 
<td>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/Genomes.pdf Lecture slide PDFs (2.4 MB)]</td>
 
<td>-</td>
 
<td>-</td>
 
</tr>
 
 
 
--><!--  ===================    TOPIC    ===================  --><!--
 
<tr class="sp"><td colspan="7" style="height: 10px;"></td></tr>
 
<tr class="st">
 
<td colspan="7">'''H o m o l o g y'''</td>
 
</tr>
 
 
 
<tr class="sh">
 
<td>'''#'''</td>
 
<td>'''Date'''</td>
 
<td>'''Lecturer'''</td>
 
<td>'''Topic'''</td>
 
<td>'''Handout'''</td>
 
<td>'''Book'''</td>
 
<td>'''Note'''</td>
 
</tr>
 
 
 
<tr class="sp"><td colspan="7" style="height: 5px;"></td></tr>
 
 
 
<tr class="s1">
 
<td>9</td>
 
<td>Thu. Oct 9.</td>
 
<td>Steipe</td>
 
<td>Lecture: Homology II: Sequence alignment</td>
 
<td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/Homology_II_Alignment.pdf Raw lecture PDF]</small></td>
 
<td></td>
 
<td>[[Assignment 2]] due<br>
 
<hr>
 
[[Assignment 3]] to be posted
 
<hr>
 
</td>
 
</tr>
 
 
 
 
 
<tr class="s2">
 
<td>10</td>
 
<td>'''Thu. Oct 16'''</td>
 
<td>Steipe</td>
 
<td>Lecture: Homology III: Fast sequence database searches</td>
 
<td>[[BLAST]]</td>
 
<td>Ch. 5</td>
 
<td>-</td>
 
</tr>
 
 
 
<tr class="s1">
 
<td>11</td>
 
<td>Mo. Oct 20</td>
 
<td>Steipe</td>
 
<td>Homology IV: Multiple sequence alignment</td>
 
<td>[[Multiple Sequence Alignment]]</td>
 
<td>Ch. 6</td>
 
<td>'''Second quiz''' in class (13:00 tutorial time slot)</td>
 
</tr>
 
 
 
<tr class="s2">
 
<td>18</td>
 
<td>Thu. Nov 13</td>
 
<td>Steipe</td>
 
<td>Homology modeling and structure prediction (Part 1)</td>
 
<td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/PredictingProteinStructure_I.pdf Raw lecture PDF]</small></td>
 
<td>-</td>
 
<td>-</td>
 
</tr>
 
 
 
<tr class="s1">
 
<td>19</td>
 
<td>Mon. Nov 17</td>
 
<td>Steipe</td>
 
<td>Homology modeling and structure prediction (Part 2)</td>
 
<td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/PredictingProteinStructure_II.pdf Raw lecture PDF]</small></td>
 
<td>-</td>
 
<td>[[Assignment 4]] due.
 
<hr>
 
'''Fourth quiz''' in class: 13:00 in tutorial time slot.
 
<hr>
 
[[Assignment 5]] to be posted.</td>
 
</tr>
 
 
 
 
 
 
 
--><!--  ===================    TOPIC    ===================  --><!--
 
<tr class="sp"><td colspan="7" style="height: 10px;"></td></tr>
 
<tr class="st">
 
<td colspan="7">'''P h y l o g e n y'''</td>
 
</tr>
 
 
 
<tr class="sh">
 
<td>'''#'''</td>
 
<td>'''Date'''</td>
 
<td>'''Lecturer'''</td>
 
<td>'''Topic'''</td>
 
<td>'''Handout'''</td>
 
<td>'''Book'''</td>
 
<td>'''Note'''</td>
 
</tr>
 
 
 
<tr class="sp"><td colspan="7" style="height: 5px;"></td></tr>
 
 
 
<tr class="s1">
 
<td>13</td>
 
<td>Mon. Oct 27</td>
 
<td>Steipe</td>
 
<td>Phylogenetic analysis I</td>
 
<td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/PhylogeneticAnalysis_I.pdf Raw lecture PDF]</small></td>
 
<td>Ch. 7,8</td>
 
<td>'''Third quiz''' in class, 13:00 in tutorial time-slot</td>
 
</tr>
 
 
 
<tr class="s2">
 
<td>14</td>
 
<td>Thu. Oct 30</td>
 
<td>Steipe</td>
 
<td>Phylogenetic analysis II</td>
 
<td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/PhylogeneticAnalysis_II.pdf Raw lecture PDF]</small></td>
 
<td>Ch. 7,8</td>
 
<td>-</td>
 
</tr>
 
 
 
<tr class="s1">
 
<td>15</td>
 
<td>Mon. Nov 3</td>
 
<td>Parkinson</td>
 
<td>Comparative genomics</td>
 
<td>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/ComparativeGenomics.pdf Lecture slide PDFs (1.6 MB)]</td>
 
<td>Ch. 9.8, 10.8</td>
 
<td>-</td>
 
</tr>
 
 
 
<tr class="s2">
 
<td>17</td>
 
<td>Mon. Nov 10</td>
 
<td>Steipe</td>
 
<td>Human population genomics</td>
 
<td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/HumanPopulationGenomics.pdf Raw lecture PDF]</small></td>
 
<td>-</td>
 
<td>[[Assignment 4]] to be posted</td>
 
</tr>
 
 
 
--><!--  ===================    TOPIC    ===================  --><!--
 
<tr class="sp"><td colspan="7" style="height: 10px;"></td></tr>
 
<tr class="st">
 
<td colspan="7">'''I n t e r a c t i o n s'''</td>
 
</tr>
 
 
 
<tr class="sh">
 
<td>'''#'''</td>
 
<td>'''Date'''</td>
 
<td>'''Lecturer'''</td>
 
<td>'''Topic'''</td>
 
<td>'''Handout'''</td>
 
<td>'''Book'''</td>
 
<td>'''Note'''</td>
 
</tr>
 
 
 
<tr class="sp"><td colspan="7" style="height: 5px;"></td></tr>
 
 
 
<tr class="s1">
 
<td>20</td>
 
<td>Thu. Nov 20</td>
 
<td> Wodak </td>
 
<td>Gene regulation (Part 1)</td>
 
<td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/GeneRegulation.pdf Lecture slide PDFs (2.1 MB)]</small></td>
 
<td>Ch. 15</td>
 
<td>-</td>
 
</tr>
 
 
 
<tr class="s2">
 
<td>21</td>
 
<td>Mon. Nov 24</td>
 
<td>Wodak</td>
 
<td>Gene regulation (Part 2)</td>
 
<td>-</td>
 
<td>-</td>
 
<td>-</td>
 
</tr>
 
 
 
<tr class="s1">
 
<td>22</td>
 
<td>Thu. Nov 27</td>
 
<td>Wodak</td>
 
<td>Functional annotation</td>
 
<td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/FunctionalAnnotations.pdf Lecture slide PDFs ('''10.6 MB''')]</small></td>
 
<td>Appendix A</td>
 
<td>-</td>
 
</tr>
 
 
 
 
 
<tr class="s2">
 
<td>23</td>
 
<td>Mon. Dec 1</td>
 
<td>Wodak</td>
 
<td>Metabolic networks</td>
 
<td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/PathwaysAndNetworks.pdf Lecture slide PDFs (3.1 MB)]</small></td>
 
<td>Ch. 17.1</td>
 
<td>[[Assignment 5]] due<br>
 
<hr>
 
'''Fifth quiz''' in class: 13:00 in tutorial time slot
 
</td>
 
</tr>
 
 
 
<tr class="s1">
 
<td>24</td>
 
<td>Thu. Dec 4</td>
 
<td>Parkinson</td>
 
<td>Computational systems biology</td>
 
<td>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/ComputationalSystemsBiology.pdf Lecture slide PDFs (3.4 MB)]</td>
 
<td>Ch. 17</td>
 
<td>-</td>
 
</tr>
 
 
 
 
 
</table>
 
 
 
<div class="BIO_2">
 
</div>
 
==In depth...==
 
 
 
* [[Glossary]]
 
* [[Mutation Data Matrices]]
 
* [http://en.wikipedia.org/wiki/List_of_standard_amino_acids Amino acids]
 
 
 
--><!-- * [[Database Identifiers]] --><!--
 
  
 
&nbsp;
 
&nbsp;
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-->
 
 
 
<!--
 
;Course Wiki
 
*[[Help:Introduction|Introduction:]] Concept and contents of the Course Wiki
 
*[[Soapbox]]: A page to commmunicate. Do you want to leave a message? Alert the course members? Voice an opinion? Praise or flame? Use this page.
 
*[[Help:Editing| Editing:]] Editing principles and Wiki markup syntax for the Course Wiki pages
 
*[[Sandbox]]: A page for your editing experiments. Content added to this page will not stay permanently.
 
*[[Feedback]]: Share your views on the course, suggest improvements.
 
 
-->
 
-->
  
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[[Category:Bioinformatics]]
 
[[Category:Bioinformatics]]
 +
</div>

Revision as of 16:29, 5 January 2012

BCH441 - Bioinformatics

Welcome to the BCH441 Course Wiki.

These wiki pages are provided to coordinate information, activities and projects in the introductory bioinformatics course taught by Boris Steipe at the University of Toronto. If you are not one of my students, you can still browse this site, however only users with a login account can edit or contribute or edit material. If you are here because you are interested in general aspects of bioinformatics or computational biology, you may want to review the Wikipedia article on bioinformatics, or visit Wikiomics. Contact boris.steipe(at)utoronto.ca with any questions you may have.



The Course

BCH441H1F is the undergraduate course code.
BCH1441H1F is the cross-listed course code for graduate students.


Organization

Dates

The course will be next held in the Fall Term - September to December 2012.

Lectures: Monday, 13:00 to 14:00 and Thursday, 12:00 to 13:00
Tutorial sessions: Mondays, 12:00 to 13:00 for in-class quizzes, quiz debriefings, exam preparation and other activities, as the need arises.
Location
MSB 2173 (Medical Sciences Building)
General

See the Course Web page for general information.

We are recommending Understanding Bioinformatics, Zvelebil & Baum, Garland 2008 as a background textbook for the course. (buy used at AbeBooks)

This is an electronic submission only course; but if you must print material, you might consider printing double-sided. Learn how, at the Print-Double-Sided Student Initiative.


Grading and Activities

Activity Weight
(Undergraduates)
Weight
(Graduates)
5 Assignments 15 marks (5 x 3) 10 marks (5 x 2)
5 In-class quizzes 35 marks (5 x 7) 25 marks (5 x 5)
Open project 7 marks 5 marks
"Classroom" participation 3 marks 3 marks
Graduate project   17 marks
Final exam 40 marks 40 marks
Total 100 marks 100 marks


Activity Weight
(Undergraduates)
Weight
(Graduates)
9 In-class quizzes 35 marks (9 x 6) 25 marks (9 x 5)
Open project 18 marks 18 marks
"Classroom" participation 8 marks 8 marks
Graduate project   9 marks
Final exam 20 marks 20 marks
Total 100 marks 100 marks



A note on marking

It is not my policy to adjust marks towards a target mean and variance (i.e. there will be no "belling" of grades). I feel strongly that such "normalization" detracts from a collaborative and mutually supportive learning environment. If your classmate gets a great mark because you helped him with a difficult concept, this should never have the effect that it brings down your mark through class average adjustments. Collaborate as much as possible, it is a great way to learn. However I may adjust marks is if we phrase questions ambiguously on quizzes or if I decide that the final exam was too long.


Assignments

Assignment 5 has been posted.
Due Monday, Dec. 5.


Temporary links for material

Lecture slides 2012

None yet.


Lecture slides 2011


A selection of Lecture recordings of the 2011 course is available.


Add this material

  • Quantitative evolution: signals of recent change and selective pressure




 

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