User:Boris/tmp1
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Strategic Errors
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- Hiding problems, rather than addressing them
MSA for Homology Modeling
>14426_COPCI QKKLIADL------------------K---------------AAASSKKP------A-------------------DTVK ---E-------D----DDQ-------------------------QM-EEEGQGPSKLKRIRQDE-------EKPLQF--- EFKEPER-------------------------------------------EERQIATNRRVG--RFDM------------ ----------------------------------------------------------------QPERKS--LA------ -WGIAA--FAF--GMTAITY---L-------PN----------------------------------------------- -----------------------------------F---------L--------------------------------- >02840_CRYNE AKQLVKDL------------------R---------------QEIQLRNE------A-------------------GDSL ---E-------D----QGV-------------------------AV-ADDVRG---VKRGKHED-------EA-V-V--- ISGGAGG-------------------------------------------KDRVVRTNKRIP--QTAG------------ ----------------------------------------------------------------GDVGQR--FG------ -WGAFV--FSI--GLGASLT---L-------FS----------------------------------------------- -----------------------Q-----------Y---------ASSLL----------------------------- >SWI4_SACCE NDHHNE----------------YCDS------NGSNNNNNTVASNGSSIEVFSSNENDNS-------------------- -------------------MNMSSRSMTP----FSA----------------GNT---SSQNKLE--NKMTDQEYKQTIL TILSSERSSDVDQALLATLYPAPKNFNI--NFEIDDQGHTPLHWATAMANIPLI----------KMLI-----TLNA--N ALQCNKLGFNCITKSIFYNNCYKENA------F-----------DEIISILKI-------CLITPDVNGRLPFH------ -YLIELSVNKSKNPMIIKSYMDSIILSLGQQDY--------------------------------NLLKICLNYQDNI-- GNTPLHLSALN-L------NFEVYNR---LVYLGA-----------------------STDI-LNLDNESPASIMNKFN ...
CLUSTAL W format. MBP1_BATDE DSSVFCAVYSNVPVYETIKH---NVVVMRRIEDDQLNATQILKLAGLAKSQRT-KVLESQ 1SW6 NDDINKG-----PSGDNENN---GTDDNDRTAGPIITFTHDLTSDFLSSPLKIMKALPSP MBP1_NEUCR EPGIYSATYSGIPVWEYQFGVDLKEHVMRRRHDDWVNATHILKAAGFDKPART-RILERE MBP1_ASPNI FSNVYSATYSSVPVYEFKIG---TDSVMRRRSDDWINATHILKVAGFDKPART-RILERE MBP1_BIPOR DGKIYSATYSNVPVYECNVN---GHHVMRRRADDWINATHILKVADYDKPART-RILERE MBP1_SACCE SNQIYSARYSGVDVYEFIHS---TGSIMKRKKDDWVNATHILKAANFAKAKRT-RILEKE MBP1_SCHPO SSAVHVAVYSGVEVYECFIK---GVSVMRRRRDSWLNATQILKVADFDKPQRT-RVLERQ MBP1_PUCGR TTTIYKATYSGVPVLEMPCE---GIAVMRRRSDSWLNATQILKVAGFDKPQRT-RVLERE MBP1_USTMA DKTIFKATYSGVPVYECIIN---NVAVMRRRSDDWLNATQILKVVGLDKPQRT-RVLERE MBP1_CRYNE PNTIYKATYSGVPVYEMVCR---DVAVMRRRSDAYLNATQILKVAGFDKPQRT-RVLERE MBP1_COPCI EAQIFKATYSGIPVYEMMCK---GVAVMRRRSDSWLNATQILKVAGFDKPQRT-RVLERE MBP1_WALME APPIYKACYSGVPVYEFNCK---NVAVMKRRSDSWMNATQILKVANFDKPQRT-RILERE MBP1_BATDE VHSGEHEKVQGGYGKYQGTWVPFETGRNLAIQFKVYDLIEPLLTFTS--GTDPLYKRASY 1SW6 VVNDNEQKMK------------------------LEAFLQRLL----------------- MBP1_NEUCR VQKDTHEKIQGGYGRYQGTWIPLEQAEALARRNNIYERLKPIFEFQP--GNE-------- MBP1_ASPNI VQKGVHEKVQGGYGKYQGTWIPLQEGRQLAERNNILDKLLPIFDYVA--GDR-------- MBP1_BIPOR VQKGVHEKVQGGYGKYQGTWIPLEEGRGLAERNGVLDKMRAIFDYVP--GDR-------- MBP1_SACCE VLKETHEKVQGGFGKYQGTWVPLNIAKQLAEKFSVYDQLKPLFDFTQTDGSA-------- MBP1_SCHPO VQIGAHEKVQGGYGKYQGTWVPFQRGVDLATKYKVDGIMSPILSLDIDEGKA-------- MBP1_PUCGR IQKGTHEKIQGGYGKYQGTWVPLDRGIDLAKQYGVDHLLSALFNFQPS-SNE-------- MBP1_USTMA IQKGIHEKVQGGYGKYQGTWIPLDVAIELAERYNIQGLLQPITSYVPSAAD--------- MBP1_CRYNE VQKGEHEKVQGGYGKYQGTWIPIERGLALAKQYGVEDILRPIIDYVP--TSV-------- MBP1_COPCI VQKGEHEKVQGGYGKYQGTWIPLERGMQLAKQYNCEHLLRPIIEFTP--AAK-------- MBP1_WALME VQKGTHEKVQGGYGKYQGTWIPMERSVELARQYRIELLLDPIINYLP--GPQ-------- MBP1_BATDE SKIDSNFLEFEPRRRGRPRKFLSPDFKDAIMTSPELPPIH-TLASNSISISPRSVLKSTH 1SW6 --------------------------------FPEI------------------------ MBP1_NEUCR --------------------------------SPPPAPRHASKPKAPKVK---------- MBP1_ASPNI --------------------------------SPPPAPKHTSAASKPRAP---------- MBP1_BIPOR --------------------------------SPPPAPKH-ATAASNRMK---------- MBP1_SACCE --------------------------------SPPPAPKHHHASKVDRKK---------- MBP1_SCHPO --------------------------------IAPKKKQTKQKKPSVRGR---------- MBP1_PUCGR --------------------------------SPPLAPKH-VTALSTRVKVSKVSAASAA MBP1_USTMA --------------------------------SPPPAPKH-TISTSNRSK---------- MBP1_CRYNE --------------------------------SPPPAPKH-SVAPPSKAR---------- MBP1_COPCI --------------------------------SPPLAPKHLVATAGNRPV---------- MBP1_WALME --------------------------------SPPLAPKH-ATNVGSRAR---------- MBP1_BATDE ALKSKSHSASVSTPSTAFATPLYSKTVTPPKSHVSSHNETRSSSARKSWGAPRSTATSLR 1SW6 ------------------------------------------------------------ MBP1_NEUCR --PAVPTWGSKSAKNANPPQPGTFLPPGRKGLPAQAPDYN-------------------- MBP1_ASPNI ----------KINKRVVKEDVFSAVNHHRSMGPPSFHHEHY------------------- MBP1_BIPOR --PPRQTAAAVAAAAVAAAAAAAAVANHNALMSNSRSQASEDPYEN-------------- MBP1_SACCE AIRSASTSAIMETKRNNKKAEENQFQSSKILGNPTAAPRKRGRPVGSTRGSRRKLGVNLQ MBP1_SCHPO RGRKPSSLSSSTLHSVNEKQPNSSISP--------------------------------- MBP1_PUCGR RAARAVVPSLPSTSGLGGRNTNNSWSNFDSDNEPGLPPAASSRESNGNWATQSKLARSSN MBP1_USTMA ----KIIPADPGALGRSRRATSIETESEVIGAAPNNVSEG-------------------- MBP1_CRYNE RDKEKETGRTKATPSRTGPTSAAALQAQAQLNRAKMHDSTPDADA--------------- MBP1_COPCI --RKPLTTDLSAAVINTRSTRKQVADGVGEESDHDTHSLRGSEDG--------------- MBP1_WALME KSTAPAAQTLPSTSKVFHPLSSTKHPAKLAAATNAKAEISDGEDA--------------- MBP1_BATDE ASTHNSLSVNIDSHWEG-------------DLSMDASNSEQQPAPTKHSTGQKSRKYAAD 1SW6 ---------------------------------------QEMPTSLNNDSSNRNS----- MBP1_NEUCR ---------------------------------DADTHMHDDDTPDNLTVASASY----- MBP1_ASPNI ---------------------------------DVNTGLDEDESIEQATLESSSM----- MBP1_BIPOR ---------------------------------SQRSQIYREDTPDNETVISESM----- MBP1_SACCE RS-------------------------------QSDMGFPRPAIPNSSISTTQLPSIRST MBP1_SCHPO ---------------------------------TIESSMNKVNLPGAEEQVSATP----- MBP1_PUCGR LARARANINNSHPEDLPVPAPDQLQASPLPSMQTADPENDNSLTPSELSLPSRTP----- MBP1_USTMA ---------------------------------------SMSPSPSDISSSSRTP----- MBP1_CRYNE ---------------------------------SFRSFEERVSLTPEDDSSSDTP----- MBP1_COPCI ---------------------------------------SMTPSPSEASSSSRTP----- MBP1_WALME ---------------------------------------SIPSSPSFKSNSSRTP----- MBP1_BATDE LSNTSSMSSPEDIFGGESSDNSIGSTVVSSYSNHDSPDQLSASDDPDTELYESKRKGNPK 1SW6 ------------------------------------------------------------ MBP1_NEUCR ------------------------------MAEDDRYDHSHF------------------ MBP1_ASPNI ------------------------------IADEDMISMSQN------------------ MBP1_BIPOR ------------------------------LGDADLMDMSQY------------------ MBP1_SACCE MGPQSPTLGILEEERHDSRQQQPQQNNSAQFKEIDLEDGLSSDVEPSQQLQQVFNQ---- MBP1_SCHPO -----------------------------------LPASPNA------------------ MBP1_PUCGR ----SPIEDLPLTVNTASSQ-----STRNKGKSRDLPDDEDL------------------ MBP1_USTMA ------------------------------------------------------------ MBP1_CRYNE ----SPVASVMTDQDMEVDKMGMHMSMPNVTLSQNMEEL--------------------- MBP1_COPCI ----SPIHS------------------PGTYHSNGLDGPSSG------------------ MBP1_WALME ------------------------------------------------------------ MBP1_BATDE RPSRRTSKTTSRTISPVHSEAALEPTNISNLMLATPADLSKSVDIENVSCPTKSKSKYRG 1SW6 --EGGSSNQQQQHV---------------------------------------------- MBP1_NEUCR --STGHRKRKRDELIED---------------------MTEQQHA--------------- MBP1_ASPNI --GPYSSRKRKRGINEVAA-----------------MSLSEQEHI--------------- MBP1_BIPOR --SADGNRKRKRGMDQ--------------------MSLLDQQHQ--------------- MBP1_SACCE --NTGFVPQQQSSLIQTQQTESMATSVSSSPSLPTSPGDFADSNPFEERFPGGGTSPIIS MBP1_SCHPO --LLSPNDNTIKPVEE--------------------LGMLEAPLD--------------- MBP1_PUCGR --SRGQKRKYDTSLVEDTS----------------YSDGADDQYINGNPSNAASA----- MBP1_USTMA --SPLPADRAHPLHANHA--------------LAGYNGRDANNHA--------------- MBP1_CRYNE --GAGSRKRSAAMMMEDEDQFGQLRSIRGNSAVHTPHGTPRHLGIGMPPEPIGPE----- MBP1_COPCI --GRNRYRQSNDRYDEDDD-------------------ASRHNGMGDPR----------- MBP1_WALME --SPIRINARKRKLEDEAT----------------IPSSAIDGSI--------------- MBP1_BATDE RPNGSGSTKKSKESHYRSQKSTLSYYENAPPEIMVM-PE----TPVTENISILENPTLPS 1SW6 ------------------------SFDSLLQEV----ND-----AFP------------- MBP1_NEUCR ------------------------VYGDELLDYFLL-SR----NEQP---AVRPDP---- MBP1_ASPNI ------------------------LYGDQLLDYFMTVGDAPEATRIP-----PPQP---- MBP1_BIPOR ------------------------IWADQLLDYFML-LD----HEAA---VSWPEP---- MBP1_SACCE MIPRYPVTSRPQTSDINDKVN---KYLSKLVDYFIS-NEMKSNKSLP---QVLLHP---- MBP1_SCHPO ------------------------KYEESLLDFFLHPEE----GRIP---SFLYSP---- MBP1_PUCGR ------------------------KYAKLILDYFVS-ES----SQIP---NFLNDP---- MBP1_USTMA ------------------------RYADIILDYFVT-EN----TTVP---SLLINP---- MBP1_CRYNE ------------------------QYTDIILNYFVS-ET----SQIP---SILVSP---- MBP1_COPCI ------------------------SYGDQILEYFIS-DT----NQIP---PILITP---- MBP1_WALME ------------------------SYEDIILDYFIS-ES----TQIP---ALLIHP---- MBP1_BATDE KESVSSMHQCLSDLEDITAVPSHASPAAPLSLTLDNPPLHRLLFDEGDFSAPQTAPFVDP 1SW6 ------------------------------------------------------------ MBP1_NEUCR ------------------------------------------------------------ MBP1_ASPNI ------------------------------------------------------------ MBP1_BIPOR ------------------------------------------------------------ MBP1_SACCE ------------------------------------------------------------ MBP1_SCHPO ------------------------------------------------------------ MBP1_PUCGR ------------------------------------------------------------ MBP1_USTMA ------------------------------------------------------------ MBP1_CRYNE ------------------------------------------------------------ MBP1_COPCI ------------------------------------------------------------ MBP1_WALME ------------------------------------------------------------ MBP1_BATDE IELGEDSAKRSPSTFIPAPISKSAQVATPAERCREIILGIYVYGDDYVYETFQYLRDQNS 1SW6 -----------NTQLNL------------------------------------------- MBP1_NEUCR -----------PPNFKP------------------------------------------- MBP1_ASPNI -----------PANFQV------------------------------------------- MBP1_BIPOR -----------PPSINL------------------------------------------- MBP1_SACCE -----------PPHSAPY------------------------------------------ MBP1_SCHPO -----------PPDFQV------------------------------------------- MBP1_PUCGR -----------PSDFDP------------------------------------------- MBP1_USTMA -----------PPDFNP------------------------------------------- MBP1_CRYNE -----------PHDFDP------------------------------------------- MBP1_COPCI -----------PPDFDP------------------------------------------- MBP1_WALME -----------PSDFNP------------------------------------------- MBP1_BATDE QTGYDFNLVLDNQGCRAIHWAAACARVKMLRMLIYRGANTCLRSNGGETPLMRAVGSHNN 1SW6 ------NIPVDEHGNTPLHWLTSIANLELVKHLVKHGSNRLYGDNMGESCLVKAVKSVNN MBP1_NEUCR ------DWPIDNERHTCLHWASAMGDVDVMRQLKKFGASLDAQNVRGETPFMRAVNFTNC MBP1_ASPNI ------DRPIDDSGNTALHWACAMGDLEIVKDLLRRGADMKALSIHEETPLVRAVLFTNN MBP1_BIPOR ------DRPIDEKGHAAMHWAAAMGDVGVVKELIHRGARLDCLSNNLETPLMRAVMFTNN MBP1_SACCE -----IDAPIDPELHTAFHWACSMGNLPIAEALYEAGTSIRSTNSQGQTPLMRSSLFHNS MBP1_SCHPO ------NSVIDDDGHTSLHWACSMGHIEMIKLLLRANADIGVCNRLSQTPLMRSVIFTNN MBP1_PUCGR ------NVVIDDDGHTALHWACAMGRIKIIKLLLTCGADIFRANNAGQTALMRAVMFTNN MBP1_USTMA ------DMSIDDDEHTALHWACAMGRIRVVKLLLSAGADIFRVNSNQQTALMRATMFSNN MBP1_CRYNE ------NAPIDDDGHTALHWACAMGRVRVVKLLLTAGASIFAGNNAEQTPLMRSVMFSNN MBP1_COPCI ------NMAIDDDGHTSLHWACAMGRIRIVKLLLSAGADIFKVNKAGQTALMRSVMFANN MBP1_WALME ------NMSIDDEGHTAMHWACAMGKVRVVKLLLSAGADIFRVNHSEQTALMRSVMFSNN MBP1_BATDE YTLETFPDILGLLMPSLFSTDISGRTVLHYICFVGGHR-SKRAQAKYYMHYVLKYMSYAQ 1SW6 YDSGTFEALLDYLYPCLILEDSMNRTILHHIIITSGMT-GCSAAAKYYLDILMGWIVKKQ MBP1_NEUCR FEKQTFPQVMKELFSTIDCRDLSGCTVIHHAAVMKIGRVNSQSCSRYYLDIIL------- MBP1_ASPNI YEKRTFPALLDLLLDTISFRDWFGATLFHHIAQTTKSK-GKWKSSRYYCEVAL------- MBP1_BIPOR FDKETMPSMVKIFQQTVHRTDWFGSTVFHHIAATTSSS-NKYVCARWYLDCII------- MBP1_SACCE YTRRTFPRIFQLLHETVFDIDSQSQTVIHHIVK---RK-STTPSAVYYLDVVL------- MBP1_SCHPO YDCQTFGQVLELLQSTIYAVDTNGQSIFHHIVQSTSTP-SKVAAAKYYLDCIL------- MBP1_PUCGR HDLRTFPELFESFSGSVINIDRTDRTVFHYVIDIALTK-GKVPAARYYLETIL------- MBP1_USTMA YDLRKFPELFELLHRSILNIDRNDRTVFHHVVDLALSR-GKPHAARYYMETMI------- MBP1_CRYNE YDMRKFPELYELLHRSTLNIDKQNRTVFHHIANLALTK-GKTHAAKYYMETIL------- MBP1_COPCI YDVRKFPELYELLHRSTLNIDNSNRTVFHHVVDVAMSK-GKTHAARYYMETIL------- MBP1_WALME YDIRKFPQLYELLHRSTLNLDKHDRTVLHHIVDLALTK-SKTHAARYYMECVL------- MBP1_BATDE PCLNITTDLKME------------NHTETNSVAAMIEEFVNAQDSFGQTALHVAVRFRNH 1SW6 NRPIQSGTNEKESKPNDKNGERKDSILENLDLKWIIANMLNAQDSNGDTCLNIAARLGNI MBP1_NEUCR ------------------------NRLQETHHPEFVQQLLDAQDNDGNTAVHLAAMRDAR MBP1_ASPNI ------------------------EKLRTTFSPEEVDLLLSCQDSVGDTAVLVAARNGVF MBP1_BIPOR ------------------------NKLSETWIPEEVTRLLNAADQNGDTAIMIAARNGAR MBP1_SACCE ------------------------SKIKDFSPQYRIELLLNTQDKNGDTALHIASKNGDV MBP1_SCHPO ------------------------EKLISIQPFENVVRLVNLQDSNGDTSLLIAARNGAM MBP1_PUCGR ------------------------SQLSEY--PKELIDILNFQDEDGETALTLAARCRSK MBP1_USTMA ------------------------NRLADY--GDQLADILNFQDDEGETPLTMAARARSK MBP1_CRYNE ------------------------ARLADY--PQELADVINFQDEEGETALTIAARARSR MBP1_COPCI ------------------------TRLADY--PKELADVINFQDEDGETALTMAARCRSK MBP1_WALME ------------------------SKLANY--PDELADVINFQDDEGESALTLAARARSK MBP1_BATDE RLIQMLLRAGARR-DICDKNGDTPLGIAGSSLRTILLLNRSVERLLVPELYDIDDFSDAA 1SW6 SIVDALLDYGADP-FIANKSGLRPVD---------F------------------------ MBP1_NEUCR KCIRALLGRGAST-DIPNKQGIRAEE---------LIKELN-----ASISKSRSNLPQRS MBP1_ASPNI RLVDLLLSRCPRAGDLVNKRGETASS---------IMQRAHLAERDIPPPPSSI------ MBP1_BIPOR KCVRSLLGRNVAV-DIPNKKGETADD---------LIRELNQRRR----MHGRTRQASSS MBP1_SACCE VFFNTLVKMGALT-TISNKEGLTANE---------IM--NQQYEQ-MMIQNGTNQHVNSS MBP1_SCHPO DCVNSLLSYNANP-SIPNRQRRTASE---------YLLEADKKPH-SLLQSNSN------ MBP1_PUCGR KLVKILLDHGANP-KTANRDGKSAED---------YILEDDKFRALSPTPCSSGPIRQLD MBP1_USTMA RLVRLLLEHGADP-KIRNKEGKNAED---------YIIEDERFRS-SPSRTGPA------ MBP1_CRYNE RLVKALLDHGANP-KIKNRDSRSAED---------YILEDERFRS-SPVPAPNG------ MBP1_COPCI RLVKLLIDHGADP-KINNHDGKNAED---------YILEDERFRS-SPAPSSRV------ MBP1_WALME RLVKLLLEHGADS-KLPNKDGKTAED---------YILEDERFRQ-SPLLNSNHLRLH-- MBP1_BATDE TSIASVESDDDISTAKDGMASKNTGPFASVRNSFSCVLSQKALDAITRHDAAPTTNRLAS 1SW6 ------------------------------------------------------------ MBP1_NEUCR SSPFAPDTQRHDAFH-----EAISESMVTSRKNSQPNYSSDAANTVQNRITPLVLQKLKD MBP1_ASPNI ----TMGNDHIDG-------EVGAPTSLEPQSVTLHHESSPATAQLLSQIGAIMAEASRK MBP1_BIPOR PFAPAPEHRLNGHVPHFDGGPLMSVPVPSMAVRESVQYRSQTASHLMTKVAPTLLEKCEE MBP1_SACCE NTDLNIHVNTNNIETKN---DVNSMVIMSPVSPSDYITYPSQIATNISRNIPNVVNSMKQ MBP1_SCHPO ----ASHS------------AFSFSGISPA------IISPSCSSHAFVKAIPSISSKFSQ MBP1_PUCGR QNSPGGTSNRSDFVDLVDPVPIDSNLIPQRSPNASPPHYSETGQRVTKQLLPEVTSMIEL MBP1_USTMA ----GIEL------------GADGLPVLPTSS----LHTSEAGQRTAGRAVTLMSNLLHS MBP1_CRYNE ----GIGKASTSA-------AAEKPLFAPQ------LYFSEAARLCGGQALTDITSHMQS MBP1_COPCI ----AAMSYRNAQVAYPPPGAPSTYSFAPANHDRPPLHYSAAAQKASTRCVNDMASMLDS MBP1_WALME --------------------PPDTSIYAPPAH----LFNSETSQNIANTSMSSVANLLES MBP1_BATDE --SRYEVTAILKRQ-SQLDGLVKVAQDV-GRKCSAVMYARRSTDIPLGIDALNSIKTTAI 1SW6 ------------------------------------------------------------ MBP1_NEUCR LTATYDSE-FKEKD-DAEKEARRILNKT-QSELKALTASIDDYNSRLDTDDVAAKTAAEM MBP1_ASPNI LTSSYGAAKPSQKDSDDVANPEALYEQL-EQDRQKI---------RRQYDALAAKEAA-- MBP1_BIPOR LATAYEAE-LQEKE-AEFFDAERVVKRR-QAELEAV---------RKQVAELQSMSKG-- MBP1_SACCE MASIYNDL-HEQHD-NEIKSLQKTLKSISKTKIQVS---------LKTLEVLKESSKD-- MBP1_SCHPO LAEEYESQ-LREKE-EDLIRANRLKQDT-LNEISRT---------YQELTFLQKNNPT-- MBP1_PUCGR LATTFDTE-LQDKE-RDLDHAVGLLSNI-EKEYLEG---------QRKILNYERMLSD-- MBP1_USTMA LADSYDSE-INTAE-KKLTQAHGLLKQI-QTEIEDS---------AKVAEALHHEAQG-- MBP1_CRYNE LARSFDAE-LQGKE-RDILQAKALLTNI-HTEVTEN---------GRSITAITNQAAP-- MBP1_COPCI LAASFDQE-LRDKE-RDMAQAQALLTNI-QAEILES---------QRTVLQLRQQAEG-- MBP1_WALME LAQSYDKE-ITQKE-RDYQQAQVILRNI-KTDIVEA---------KSNIEKMTIDSSE-- MBP1_BATDE CQDGVPSDPASTLLFFHQVACTHMQPAISTEQ-SSNKRGLNADDPTEHDAKRICVLPNNP 1SW6 ------------------------------------------------------------ MBP1_NEUCR ATARHKVLAFVTHQNRISVQEAVKQELAALDRANAVTNGTSTKSKSSSPSKKPKLSPIPD MBP1_ASPNI -------------------EESSDAQLGRYEQMRDNYESLLEQIQRARLKERLASTPVPT MBP1_BIPOR ------------LHIDLNDEEAERQQEDELRLLVEEAESLLEIEQKAEL-RRLC------ MBP1_SACCE -------------------ENGEAQTNDDFEILSRLQEQNTKKLRKRLI-RYKR----LI MBP1_SCHPO -------------------YSQSMENLIREAQ--ETYQQLSKRLL-----IWLEARQIFD MBP1_PUCGR -------------------FGEKKLALGDLEK--ELNDKLGKRYRFGWE-KYVRDEEERA MBP1_USTMA -------------------VDEERKRVDSLQL--ALKHAINKRARDDLERRWSEGKQAIK MBP1_CRYNE -------------------LEEKRRELEALQA--SLKTRVKDALKKGYI-GWLEGELVRE MBP1_COPCI -------------------LSQAKQRLADLEN--ALQDKMGRRYRLGFE-KWIKDEETRE MBP1_WALME -------------------FEHLKHKLRELEM--KLEEHSNDVYNKGWE-EYSR------ MBP1_BATDE MYTLVEGIESTSFE------FTKPYQPCLMG---------DEKQANPDQPSSTYQPLLSS 1SW6 ------------------------------------------------------------ MBP1_NEUCR QKDKPPKDENETES------EAEHPDPPAAQ-----------AHQQQPGPSSQDTEVEDQ MBP1_ASPNI QTAVIG------------------------------------------------------ MBP1_BIPOR ------------------------------------------------------SSMPQQ MBP1_SACCE KQKLEYRQTVLL----------------------------------NKLIEDETQATTNN MBP1_SCHPO LERSLKPHTSLSIS------FPSDFLKKEDG---------------LSLNNDFKKPACNN MBP1_PUCGR RRITEQRSKYLQEL------SIEDRKLLDSSNLRFADPSKQEVLMKLQADERENSDLLNL MBP1_USTMA RARLQAGLEPGALS------TSNATNAPATG--------------DQKSKDDAKSLIEAL MBP1_CRYNE QRWENGE--------------LEG----------------------NEEEKAAVQALRDV MBP1_COPCI KVIRDAANGDLVLTPATTSYTVDEDGDSDSGSNGDKNKGKRKAQVQQEEVSDLVELYSNI MBP1_WALME ---------------------------------------------------NVDDPAIDA MBP1_BATDE QLETVEHLQNQVAVLQMQSEILQTNNNALIQAVHKLHEQRHL-----------------K 1SW6 ------------------------------------------------------------ MBP1_NEUCR DREEEEDDYTHRLSLAAELRSILQEQRSAENDYVEARGMLGTGE---------------R MBP1_ASPNI SSSPEQDRLLTTFQLSRALCSEQKIRRAAVKELAQQRADAGVST---------------K MBP1_BIPOR NSDSSPVDITEKMRLALLLHRAQLERRELVREVVGNLSVAGMSE---------------K MBP1_SACCE TVEKDN-NTLERLELAQELTMLQLQRKNKLSSLVKKFEDNA------------------K MBP1_SCHPO VTNSD-----EYEQLINKLTSLQASRKKDTLYIRKLYEELGIDD---------------T MBP1_PUCGR IRTNSTDVESECDLLRESVQKLSEERERLFKEFINLSSENTGGENEEDDGANHTSANTSR MBP1_USTMA PAGTN--VKTAIAELRKQLSQVQANKTELVDKFVARAREQGTGR---------------T MBP1_CRYNE PTGGQEVVQAEEEKLRWEIEEKRKRRAMFVEKFVRAQTEAGTSE---------------Q MBP1_COPCI PTDPEE-LRKQCEALREEVSQSRKRRKAMFDELVTFQAEAGTSG---------------R MBP1_WALME PSDN---VQEECASLRNKIKDLQEKRISSMQELIKRQKEVGTGK---------------K MBP1_BATDE SSRYKTLIAWCM-GVTTH 1SW6 -------------GAGLE MBP1_NEUCR IDKYKHLLMSCLPPDEQE MBP1_ASPNI FDVHRKLVALAT-GLKEE MBP1_BIPOR QGTYKKLIAKAL-GEREE MBP1_SACCE IHKYRRIIREGT-EMNIE MBP1_SCHPO VNSYRRLIAMSC-GINPE MBP1_PUCGR LNNYRKLISLGCGGIGLD MBP1_USTMA MAAYRRLIAAGCGGIAPD MBP1_CRYNE IAKYRKLVSAGLGGVSTN MBP1_COPCI MSDYRRLIAAGCGGLEPL MBP1_WALME MSEYRKLISVGC-GIPTT
CLUSTAL W (1.83) multiple sequence alignment
NP_010227.1 MS------------------------------------------------
NP_593032.1 MAP-----------------------------------------------
XP_001837394.2 MPE-----------------------------------------------
XP_003327086.2 MAYGGSIQPLRPPSRESATLHLHQPDLTVTSPPLSLTHCPPCVYSHFTHT
XP_006957051.1 MSA-----------------------------------------------
XP_007682304.1 MPPA----------------------------------------------
XP_007734318.1 MAPH----------------------------------------------
XP_011392621.1 MSG-----------------------------------------------
XP_569090.1 MGK--------------------------------------KV---IASG
XP_660758.1 MAAV----------------------------------------------
XP_955821.1 MVKE--------------------------------------N---V--G
*
NP_010227.1 -------------------------------------NQIYSARYSGVDV
NP_593032.1 -----------------------------------RSSAVHVAVYSGVEV
XP_001837394.2 -------------------------------------AQIFKATYSGIPV
XP_003327086.2 PTSLIVIQVSLHSLLDQETYHLLPSRSPPTVSVRMGTTTIYKATYSGVPV
XP_006957051.1 -------------------------------------PPIYKACYSGVPV
XP_007682304.1 -----------------------------------PDGKIYSATYSNVPV
XP_007734318.1 ------------------------------------DKEIYSATYSNVPV
XP_011392621.1 ------------------------------------DKTIFKATYSGVPV
XP_569090.1 --------------GD------------------NGPNTIYKATYSGVPV
XP_660758.1 -----------------------------------DFSNVYSATYSSVPV
XP_955821.1 --------------G-------------------NPEPGIYSATYSGIPV
:. * **.: *
NP_010227.1 YEFIHS---TGSIMKRKKDDWVNATHILKAANFAKAKRTRILEKEVLKET
NP_593032.1 YECFIK---GVSVMRRRRDSWLNATQILKVADFDKPQRTRVLERQVQIGA
XP_001837394.2 YEMMCK---GVAVMRRRSDSWLNATQILKVAGFDKPQRTRVLEREVQKGE
XP_003327086.2 LEMPCE---GIAVMRRRSDSWLNATQILKVAGFDKPQRTRVLEREIQKGT
XP_006957051.1 YEFNCK---NVAVMKRRSDSWMNATQILKVANFDKPQRTRILEREVQKGT
XP_007682304.1 YECNVN---GHHVMRRRADDWINATHILKVADYDKPARTRILEREVQKGV
XP_007734318.1 YELKIG---SDHIMRRRSDDWVNATHILKVAGFDKPARTRILEREVQKGV
XP_011392621.1 YECIIN---NVAVMRRRSDDWLNATQILKVVGLDKPQRTRVLEREIQKGI
XP_569090.1 YEMVCR---DVAVMRRRSDAYLNATQILKVAGFDKPQRTRVLEREVQKGE
XP_660758.1 YEFKIG---TDSVMRRRSDDWINATHILKVAGFDKPARTRILEREVQKGV
XP_955821.1 WEYQFGVDLKEHVMRRRHDDWVNATHILKAAGFDKPARTRILEREVQKDT
* :*:*: * ::***:***... *. ***:**:::
NP_010227.1 HEKVQGGFGKYQGTWVPLNIAKQLAEKFSVYDQLKPLFDFTQTDG-SASP
NP_593032.1 HEKVQGGYGKYQGTWVPFQRGVDLATKYKVDGIMSPILSLDI----DEGK
XP_001837394.2 HEKVQGGYGKYQGTWIPLERGMQLAKQYNCEHLLRPIIEFTP--A-AKSP
XP_003327086.2 HEKIQGGYGKYQGTWVPLDRGIDLAKQYGVDHLLSALFNFQP--SSNESP
XP_006957051.1 HEKVQGGYGKYQGTWIPMERSVELARQYRIELLLDPIINYLP--G-PQSP
XP_007682304.1 HEKVQGGYGKYQGTWIPLEEGRGLAERNGVLDKMRAIFDYVP--G-DRSP
XP_007734318.1 HEKIQGGYGKYQGTWIPLTEGRMLAEKHGVVARISNIFDFVP--G-DRSP
XP_011392621.1 HEKVQGGYGKYQGTWIPLDVAIELAERYNIQGLLQPITSYVP--SAADSP
XP_569090.1 HEKVQGGYGKYQGTWIPIERGLALAKQYGVEDILRPIIDYVP--T-SVSP
XP_660758.1 HEKVQGGYGKYQGTWIPLQEGRQLAERNNILDKLLPIFDYVA--G-DRSP
XP_955821.1 HEKIQGGYGRYQGTWIPLEQAEALARRNNIYERLKPIFEFQP--G-NESP
***:***:*:*****:*: . ** : : : . .
NP_010227.1 PPAPKHHHASKV----DRKKAIRSA-STSAIM------------ETKRNN
NP_593032.1 AIAPKKKQTKQKKPSVRGRRGRKPS-SLSSST------------LHSV--
XP_001837394.2 PLAPKHLVATAG----NRPVRKPLTTDLSAAV------------INT---
XP_003327086.2 PLAPKHVTALST----RVKVSKVSAASAARAARAVVPSLPSTSGLGGRNT
XP_006957051.1 PLAPKHATNVGS----RARKSTAPA-AQTLPS-------------TS---
XP_007682304.1 PPAPKHATAASN----RMKPPRQTA-AAVAAA------------A-VAAA
XP_007734318.1 PPAPKHTTAASN----RTKQAKQPA-HPKKTA------------P-APAP
XP_011392621.1 PPAPKHTISTSN----RSKKIIPADPGALGRS--------------R---
XP_569090.1 PPAPKHSVAPPS----KARRDKEKETGRTKAT--------------P---
XP_660758.1 PPAPKHTSAASK----PRAPKINKR-VV----------------K-ED--
XP_955821.1 PPAPRHASKPKA----PKVKPAVPT-WGSK-S--------------AKNA
. **::
NP_010227.1 KKAEENQFQSSKILGNPTAAPRKRG-RPVGSTRGSRRK-LGVNLQRSQSD
NP_593032.1 ----------------------NEKQPN-S---SIS---PT-IE------
XP_001837394.2 ---------------------RSTR-KQ-V---ADGV--G-------E--
XP_003327086.2 NNSW-SNFDSDNEPGLPPAASSRES-NGNWAT-QSKLARSS-NLARARAN
XP_006957051.1 ---------------------KVFH-PL-S---STKH--PA-KL---AA-
XP_007682304.1 A-----AAA-------------------------------AVANH-----
XP_007734318.1 A-----PPQ-------------------------------PV--------
XP_011392621.1 ---------------------RATS-IE-T---ESEV--I-------G--
XP_569090.1 ---------------------SRTG-PT-S---AAAL--QA-QAQLNRAK
XP_660758.1 ------VFS-------------------------------AVNHH-----
XP_955821.1 N-----PPQ-------------------------------PG--------
NP_010227.1 MGFP------RPA------IPNSSISTTQLPSIRSTMGPQSPTLGILEEE
NP_593032.1 -------------------SSM-------------------N-----K--
XP_001837394.2 -------------------ESD-------------------H----DT--
XP_003327086.2 INNSHPEDLPVPAPDQLQASPL-------------------P-----S--
XP_006957051.1 -------------------ATN-------------------A-----K--
XP_007682304.1 ----------------------NAL-----MSNSRSQASEDPYENSQRSQ
XP_007734318.1 ----------------------QAY----------Q-PAES-YYESASVQ
XP_011392621.1 ---A---------------APN----------------------------
XP_569090.1 MHDS---------------TPD-------------------A-----D--
XP_660758.1 ----------------------RSM----------GPPSFHHEHYDVNTG
XP_955821.1 ----------------------TFL-----PPGRKGLPAQAPDYNDADTH
NP_010227.1 RHDSRQQQ-P-QQNNSAQFKEIDLEDGLSSDVEP-SQQLQQVFNQNTGFV
NP_593032.1 ----VNLPGA-E--------------------------------------
XP_001837394.2 ----HSLRGSEDGSMTPSP-------------------------------
XP_003327086.2 ----MQTADP-ENDNSLTP-------------------------------
XP_006957051.1 ----AEISDGEDASIPSSP-------------------------------
XP_007682304.1 IYRE------------------DTPDN--E-T-VIS----ESMLGDAD--
XP_007734318.1 YNGT------------------ES-RD--G-S-PET----ASFMAEDD--
XP_011392621.1 -------NVS-EGSMSPSP-------------------------------
XP_569090.1 ----ASFRSF-EERVSLTP-------------------------------
XP_660758.1 LDED------------------ESIEQ--A-T-LES----SSMIADED--
XP_955821.1 MHDD------------------DTPDN--L-T-VAS----ASYMAEDD--
NP_010227.1 PQQQSSLIQTQQTESMATSVSSSPSLPTSPGDFA----------------
NP_593032.1 -----------------EQVSATPLPASPN-------------------A
XP_001837394.2 --------------SEASSSSRTPSPIHSPGTYH----------------
XP_003327086.2 --------------SELSLPSRTPSPIEDL--------------------
XP_006957051.1 --------------SFKSNSSRTPSPIR----------------------
XP_007682304.1 --------------------------------------------------
XP_007734318.1 --------------------------------------------------
XP_011392621.1 --------------SDISSSSRTPSPLPAD----RA-------------H
XP_569090.1 --------------ED-DSSSDTPSPVASVMTDQDMEVDKMGMHMSMPNV
XP_660758.1 --------------------------------------------------
XP_955821.1 --------------------------------------------------
NP_010227.1 -DSNPFEERFPG-GGT----SPIISMIPRYPVTSRPQ-------------
NP_593032.1 LLSPN---------D--------------------NTIKPV-EE------
XP_001837394.2 SNGLDG--PSSG-GR--------------------NRYRQSNDRYDEDDD
XP_003327086.2 PLTVNT--ASSQSTRNKGKSRDLPDDEDLSR-GQ-KRKYDT-SL-VEDTS
XP_006957051.1 ----------IN-AR--------------------KRKLED-EA------
XP_007682304.1 ----------------------LMDMSQYSADGNRKRKRGMDQ-------
XP_007734318.1 ----------------------FLPLSQNS-TASRKRKRELEEQ------
XP_011392621.1 PLHANH--ALAG-YN--------------------GR-------------
XP_569090.1 TLSQNMEELGAG-SR--------------------KRSAAM-MM--EDED
XP_660758.1 ----------------------MISMSQNGPYSSRKRKRGINEV------
XP_955821.1 ----------------------RYDHSHFS-TGHRKRKRD--EL------
NP_010227.1 -----------------------------TSDINDKVNKYLSKLVDYFIS
NP_593032.1 -----------------------------LGMLEAPLDKYEESLLDFFLH
XP_001837394.2 --------------------------AS-RHNGMGDPRSYGDQILEYFIS
XP_003327086.2 YSD---------------GADDQ---YINGNPSNAASAKYAKLILDYFVS
XP_006957051.1 --------------------------TI-PSSAIDGSISYEDIILDYFIS
XP_007682304.1 -----------------------------MSLLDQQHQIWADQLLDYFML
XP_007734318.1 ---------------------------I-ATASDLEHTMYGDELLDYFVT
XP_011392621.1 --------------------------------DANNHARYADIILDYFVT
XP_569090.1 QFGQLRSIRGNSAVHTPHGTPRHLGIGM-P-PEPIGPEQYTDIILNYFVS
XP_660758.1 --------------------------AA-MSLSEQEHILYGDQLLDYFMT
XP_955821.1 ---------------------------I-EDMTEQQHAVYGDELLDYFLL
: . ::::*:
NP_010227.1 -NEMKSNKSLPQV---LLHPPPHSAPYIDAPIDPELHTAFHWACSMGNLP
NP_593032.1 PEE----GRIPSF---LYSPPPDFQ--VNSVIDDDGHTSLHWACSMGHIE
XP_001837394.2 -DT----NQIPPI---LITPPPDFD--PNMAIDDDGHTSLHWACAMGRIR
XP_003327086.2 -ES----SQIPNF---LNDPPSDFD--PNVVIDDDGHTALHWACAMGRIK
XP_006957051.1 -ES----TQIPAL---LIHPPSDFN--PNMSIDDEGHTAMHWACAMGKVR
XP_007682304.1 -LD----HEAAVS---WPEPPPSIN--LDRPIDEKGHAAMHWAAAMGDVG
XP_007734318.1 -AG----DDPAASNILPPQPPAQFD--VDRPIDNLGNNALHWACAMGDVR
XP_011392621.1 -EN----TTVPSL---LINPPPDFN--PDMSIDDDEHTALHWACAMGRIR
XP_569090.1 -ET----SQIPSI---LVSPPHDFD--PNAPIDDDGHTALHWACAMGRVR
XP_660758.1 -VG----DAPEATRIPPPQPPANFQ--VDRPIDDSGNTALHWACAMGDLE
XP_955821.1 -SR----NEQPAV---RPDPPPNFK--PDWPIDNERHTCLHWASAMGDVD
** : ** : .:***.:** :
- What to include in the alignment?
- Defining domain ranges: how?
- How to prepare sequences?
- Be aware of marking rubrics
