Gene Regulatory Circuits Project

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Gene Regulatory Circuits

A BCB420 Special Project


 


This project concerns the application of various information sources to define gene-regulatory circuits in molecular systems.



 




 


Context

 

The definition of molecular systems needs to take their functional components into account, as well as the components that create, assemble and disassemble these functional components. Among the latter, gene regulatory circuits play a particularly important role since they control when a particular system is constituted and becomes active. We can distinguish constitutive circuits (almost always on), developmental circuits (on only in certain cell-types), and regulated circuits (on in response to specific environmental signals or in ordered sequence of events such as the cell cycle).

In a previous set of BCH441 projects, students have curated biological systems, essentially based on Gene Ontology Annotations. In this special project the task is to define the gene regulatory circuits that operate on a select set of those systems, using four different information resources.


 

Task

 

Select the following annotated systems:


 

Deliverables

 

Text...


 

Evaluation

 

Text...


 

Notes



 

Further reading and resources