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BCH441 - Bioinformatics
Welcome to the BCH441 Course Wiki.
This is our main tool to coordinate information, activities and projects in University of Toronto's bioinformatics course BCH441. If you are not one of our students, you can still browse this site, however only users with a login account can edit or contribute or edit material. If you are here because you are interested in general aspects of bioinformatics or computational biology, you may want to review the Wikipedia article on bioinformatics, or visit Wikiomics. Contact boris.steipe(at)utoronto.ca with any questions you may have.
The Course
Follow the link to read feedback from those who have taken this course before you..
I anticipate changes to the grading scheme, the schedule and the assignments. All changes will be posted here as they get decided on. Check back here in August.
The first session for the 2008 term will be held Monday, September 8., 12:00.
It is crucial that you make every effort to attend: we will be discussing access to the course Wiki, the mailing list and how groupwork will be organized.
Organization
Slowly gearing up for the 2008 Fall term ...
- Dates
- Monday and Thursday, 12:00 to 13:00
- Optional tutorial sessions will be offered as the need arises, most likely on Mondays, probably from 13:00 to 14:00.
- First class: Monday, September 8. 2008
- Location
- MSB 2173 (Medical Sciences Building)
See the Course Web page for general information.
Lecture Schedule
This is the current schedule for 2008, but changes may be still be made if required.
# | Date | Lecturer | Topic | Handout | Book |
0 | Mon. Sept 8 | Steipe | Organisation and Orientation | - | - |
The objects of bioinformatics | |||||
# | Date | Lecturer | Topic | Handout | Book |
1 | Thu. Sept 11 | Steipe | Sequence abstraction and sequence databases | - | Ch 3 |
2 | Mon. Sept 15 | Steipe | Protein Structure Databases | - | - |
3 | Thu. Sept 18 | Steipe | Bioinformatics methods | - | - |
Analysis based on properties | |||||
# | Date | Lecturer | Topic | Handout | Book |
4 | Mon. Sept 22 | Steipe | Sequence properties | - | Ch 4.9, 11, 12 |
5 | Thu. Sept 25 | Steipe | Sequence Analysis | - | - |
6 | Mon. Sept 29 | Steipe | Interpreting protein structure | - | Ch. 14 |
7 | Thu. Oct 2 | Parkinson | Genome sequencing, genome browsers | - | Ch. 9, 10 |
8 | Mon. Oct 6 | Parkinson | Genomes and genome structure | - | - |
Analysis based on homology | |||||
# | Date | Lecturer | Topic | Handout | Book |
9 | Thu. Oct 9. | Steipe | Homology I: the principles | - | - |
10 | Thu. Oct 16 | Steipe | Homology II: Sequence alignment | - | Ch. 4 |
11 | Mo. Oct 20 | Steipe | Homology III: Multiple sequence alignment | - | Ch. 5 |
12 | Mon. Oct 20 | Steipe | Homology IV: fast sequence database searches | - | Ch 6 |
13 | Thu. Oct 23 | Steipe | Structural domains | - | - |
14 | Mon. Oct 27 | Steipe | Homology modeling and structure prediction | - | Ch. 13 |
Analysis based on conservation | |||||
# | Date | Lecturer | Topic | Handout | Book |
15 | Thu. Oct 30 | Steipe | Essential concepts of probability and information theory | - | Appendix A |
16 | Mon. Nov 3 | Parkinson | Comparative genomics | - | Ch. 9.8, 10.8 |
17 | Thu. Nov 6 | NN | Human population genomics | - | - |
18 | Mon. Nov 10 | Steipe | Phylogenetic analysis I | - | Ch. 7, 8 |
19 | Thu. Nov 13 | Steipe | Phylogenetic analysis II | - | - |
20 | Mon. Nov 17 | Steipe | Protein structure motifs | - | - |
Analysis based on context | |||||
# | Date | Lecturer | Topic | Handout | Book |
21 | Thu. Nov 20 | Wodak | Gene regulation I | - | Ch. 15 |
22 | Mon. Nov 24 | Wodak | Gene regulation II | - | - |
23 | Thu. Nov 27 | Wodak | Functional annotation | - | Appendix A |
24 | Mon. Dec 1 | Wodak | Metabolic networks | - | Ch. 17.1 |
25 | Thu. Dec 4 | Parkinson | Computational systems biology | - | Ch. 17 |
Ongoing construction
Don't trust information below.
Assignments
First Assignment | Databases and Molecular Models | posted Sept. 13, due Oct. 1. |
Second Assignment | Search, Retrieve and Annotate | posted Sept. 24, due Oct. 9. |
Third Assignment | Multiple Sequence Alignment | posted Oct. 10, due Oct. 22. |
Fourth Assignment | Homology Modeling | posted Nov. 1, due Nov. 12. |
Fifth Assignment | Phylogenetic Analysis | posted Nov. 28, due Dec. 7. |
Sixth Assignment | Systems | posted Dec. 4, due Dec. 7 (last day of class) |
In depth...
Resources
- Course related
- The Course Web site.
- The Course Google Group.
- Netiquette for the Group mailing list
- Previous Exam_questions
- Contents related
- A Stereo Vision tutorial
- MetaDatabase
- NAR January-2007 Database issue
- NAR July-2007 Web server issue