BIN-PPI-Concepts

Protein-Protein Interaction (PPI) Concepts

(Detecting PPIs; the relationship abstraction; complexes, binary and n-ary interactions)

 

Abstract:

This unit introduces concepts and methods of protein-protein interaction networks.

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Objectives: This unit will ... ... introduce the graph abstraction for interaction-type data; ... explain methodologies for measuring protein-protein interactions.

Outcomes: After working through this unit you ... ... are familar with the terminology in the field; ... are aware of the distinction between pairwise interactions and interactions in complexes.

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Deliverables:

• Time management: Before you begin, estimate how long it will take you to complete this unit. Then, record in your course journal: the number of hours you estimated, the number of hours you worked on the unit, and the amount of time that passed between start and completion of this unit.
• Journal: Document your progress in your Course Journal. Some tasks may ask you to include specific items in your journal. Don't overlook these.
• Insights: If you find something particularly noteworthy about this unit, make a note in your insights! page.

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Prerequisites:
You need the following preparation before beginning this unit. If you are not familiar with this material from courses you took previously, you need to prepare yourself from other information sources:

• Biomolecules: The molecules of life; nucleic acids and amino acids; the genetic code; protein folding; post-translational modifications and protein biochemistry; membrane proteins; biological function.
• Metabolism: Enzymatic catalysis and control; reaction sequences and pathways; chemiosmotic coupling; catabolic- and anabolic pathways.
• Organelles: Compartmentalization, organelles and structures of the cell; the extracellular matrix.
• The Central Dogma: Regulation of transcription and translation; protein biosynthesis and degradation; quality control.

This unit builds on material covered in the following prerequisite units:

• BIN-SYS-Concepts (Systems Models)

 

 

 

Contents

Task:

• Read the introductory notes on the concepts behind the measurement and analysis of protein-protein interactions.

 

Self-evaluation

Notes

Further reading, links and resources

 

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If in doubt, ask! If anything about this learning unit is not clear to you, do not proceed blindly but ask for clarification. Post your question on the course mailing list: others are likely to have similar problems. Or send an email to your instructor.

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About ...
 
Author:

Boris Steipe <boris.steipe@utoronto.ca>

Created:

2017-08-05

Modified:

2017-11-09

Version:

1.0

Version history:

• 1.0 First live version
• 0.1 First stub

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