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− | <div class="BIO_1"> | + | <div id="BIO> |
| + | <div class="b1"> |
| BCH441 - Bioinformatics | | BCH441 - Bioinformatics |
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− | <div class="BIO_2">
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− | </div>
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| == The Course == | | == The Course == |
| + | BCH441H1F is the undergraduate course code.<br> |
| + | BCH1441H1F is the cross-listed course code for graduate students. |
| | | |
− | BCH441H1F is the undergraduate course code and BCH1441H1F is the corresponding cross-listed course code for graduate students.
| |
| | | |
− | <div class="BIO_3">
| |
− | </div>
| |
| ===Organization=== | | ===Organization=== |
| ;Dates | | ;Dates |
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− | <div class="BIO_3">
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− | </div>
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| ===Grading and Activities=== | | ===Grading and Activities=== |
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− | <div class="BIO_2">
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− | </div>
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| == Assignments == | | == Assignments == |
| | | |
− | <div class="BIO_alert"> | + | <div class="alert"> |
| [[Assignment 5]] has been posted. | | [[Assignment 5]] has been posted. |
| <br> | | <br> |
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− | <div class="BIO_2">
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− | </div>
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| == Temporary links for material == | | == Temporary links for material == |
| | | |
| | | |
− | <div class="BIO_3">
| |
− | </div>
| |
| ===Lecture slides 2012=== | | ===Lecture slides 2012=== |
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− | <div class="BIO_3">
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− | </div>
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| ===Lecture slides 2011=== | | ===Lecture slides 2011=== |
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− | <div class="BIO_3">
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− | </div>
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| === Add this material === | | === Add this material === |
| * Quantitative evolution: signals of recent change and selective pressure | | * Quantitative evolution: signals of recent change and selective pressure |
| | | |
| | | |
− | <!-- | + | <!-- * [[Database Identifiers]] --> |
− | == Organization ==
| |
| | | |
− | ;Dates
| + | <!-- |
− | :''Lectures'': Monday and Thursday, 12:00 to 13:00
| |
− | :''Tutorial sessions'': Mondays, 13:00 to 14:00 <small> for in-class quizzes, quiz debriefings, exam preparation and other activities, as the need arises.</small>
| |
− | | |
− | ;Location
| |
− | :MSB 2173 (Medical Sciences Building)
| |
− | | |
− | See the [http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/ Course Web page] for general information.
| |
− | | |
− | We are recommending '''[http://www.garlandscience.com/textbooks/0815340249.asp Understanding Bioinformatics]''', Zvelebil & Baum, Garland 2008 as a background textbook for the course. <small>([http://www.amazon.ca/Understanding-Bioinformatics-Market-Zvelebil/dp/0815340249 amazon], [http://www.uoftbookstore.com/online/merchant.ihtml?pid=1051140&step=4 UofT Bookstore])</small>
| |
− | | |
− | == Grading and Activities ==
| |
− | | |
− | <table cellpadding="5">
| |
− | | |
− | <tr class="sh">
| |
− | <td>'''Activity'''</td>
| |
− | <td>'''Weight'''<br><small>(Undergraduates)</small></td>
| |
− | <td>'''Weight'''<br><small>(Graduates)</small></td>
| |
− | </tr>
| |
− | | |
− | <tr class="sp"><td colspan="3" style="height: 5px;"></td></tr>
| |
− | | |
− | <tr class="s0">
| |
− | <td>[[Assignments|'''5 Assignments''' (drop 1)]]</td>
| |
− | <td>16 marks <small>(4 x 4)</small></td>
| |
− | <td>12 marks <small>(4 x 3)</small></td>
| |
− | </tr>
| |
− | | |
− | | |
− | <tr class="s1">
| |
− | <td>[[Quizzes|'''5 In-class quizzes''' (drop 1)]]</td>
| |
− | <td>32 marks <small>(4 x 8)</small></td>
| |
− | <td>20 marks <small>(4 x 5)</small></td>
| |
− | </tr>
| |
− | | |
− | <tr class="s0">
| |
− | <td>'''[[Group project]]'''</td>
| |
− | <td>10 marks</td>
| |
− | <td>6 marks</td>
| |
− | </tr>
| |
− | | |
− | <tr class="s1">
| |
− | <td>'''[[Participation]]'''</td>
| |
− | <td>2 marks</td>
| |
− | <td>2 marks</td>
| |
− | </tr>
| |
− | | |
− | <tr class="s0">
| |
− | <td>'''[[Graduate project]]'''</td>
| |
− | <td> </td>
| |
− | <td>20 marks</td>
| |
− | </tr>
| |
− | | |
− | <tr class="s1">
| |
− | <td>[[Exam questions|'''Final exam''']]</td>
| |
− | <td>40 marks</td>
| |
− | <td>40 marks</td>
| |
− | </tr>
| |
− | | |
− | <tr class="sp"><td colspan="3" style="height: 5px;"></td></tr>
| |
− | | |
− | <tr class="s0">
| |
− | <td>'''Total'''</td>
| |
− | <td>100 marks</td>
| |
− | <td>100 marks</td>
| |
− | </tr>
| |
− | | |
− | </table>
| |
− | | |
− | I will not adjust marks towards a target average for the class ("Belling"). If your classmate gets a great mark because you helped him with a difficult concept, this will have no bearing whatsoever on your own mark. Collaborate as much as possible, it is a great way to learn. The only times I will consider adjusting marks is if we phrase questions ambiguously on quizzes or if I decide that the final exam was too long.
| |
− | | |
− | == Lecture Schedule ==
| |
− | <small>This section is currently under construction.</small>
| |
− | | |
− | | |
− | <table cellpadding="5">
| |
− | | |
− | <tr class="st">
| |
− | <td colspan="7">'''I n t r o d u c t i o n'''</td>
| |
− | </tr>
| |
− | | |
− | <tr class="sh">
| |
− | <td>'''#'''</td>
| |
− | <td>'''Date'''</td>
| |
− | <td>'''Lecturer'''</td>
| |
− | <td>'''Topic'''</td>
| |
− | <td>'''Handout'''</td>
| |
− | <td>'''Book'''</td>
| |
− | <td>'''Note'''</td>
| |
− | </tr>
| |
− | | |
− | <tr class="s1">
| |
− | <td>1</td>
| |
− | <td>Mon. Sept 8</td>
| |
− | <td>Steipe</td>
| |
− | <td>Organisation and Orientation</td>
| |
− | <td>[[Introduction]]</td>
| |
− | <td>Ch 1, 2</td>
| |
− | <td>-</td>
| |
− | </tr>
| |
− | | |
− | | |
− | | |
− | | |
− | --><!-- =================== TOPIC =================== --><!--
| |
− | <tr class="sp"><td colspan="7" style="height: 10px;"></td></tr>
| |
− | <tr class="st">
| |
− | <td colspan="7">'''A b s t r a c t i o n s'''</td>
| |
− | </tr>
| |
− | | |
− | <tr class="sh">
| |
− | <td>'''#'''</td>
| |
− | <td>'''Date'''</td>
| |
− | <td>'''Lecturer'''</td>
| |
− | <td>'''Topic'''</td>
| |
− | <td>'''Handout'''</td>
| |
− | <td>'''Book'''</td>
| |
− | <td>'''Note'''</td>
| |
− | </tr>
| |
− | | |
− | <tr class="sp"><td colspan="7" style="height: 5px;"></td></tr>
| |
− | | |
− | <tr class="s1">
| |
− | <td>2</td>
| |
− | <td>Thu. Sept 11</td>
| |
− | <td>Steipe</td>
| |
− | <td>Sequence abstraction and sequence databases</td>
| |
− | <td>[[Sequence data]]</td>
| |
− | <td>Ch 3</td>
| |
− | <td>[[Assignment 1|Assignment 1 to be handed out]]</td>
| |
− | </tr>
| |
− | | |
− | <tr class="s2">
| |
− | <td>3</td>
| |
− | <td>Mon. Sept 15</td>
| |
− | <td>Steipe</td>
| |
− | <td>Protein Structure Data</td>
| |
− | <td>[[Structure data]]</td>
| |
− | <td>-</td>
| |
− | <td>-</td>
| |
− | </tr>
| |
− | | |
− | --><!-- =================== TOPIC =================== --><!--
| |
− | <tr class="sp"><td colspan="7" style="height: 10px;"></td></tr>
| |
− | <tr class="st">
| |
− | <td colspan="7">'''A n a l y s i s'''</td>
| |
− | </tr>
| |
− | | |
− | <tr class="sh">
| |
− | <td>'''#'''</td>
| |
− | <td>'''Date'''</td>
| |
− | <td>'''Lecturer'''</td>
| |
− | <td>'''Topic'''</td>
| |
− | <td>'''Handout'''</td>
| |
− | <td>'''Book'''</td>
| |
− | <td>'''Note'''</td>
| |
− | </tr>
| |
− | | |
− | <tr class="sp"><td colspan="7" style="height: 5px;"></td></tr>
| |
− | | |
− | <tr class="s1">
| |
− | <td>3</td>
| |
− | <td>Thu. Sept 18</td>
| |
− | <td>Steipe</td>
| |
− | <td>Sequence properties</td>
| |
− | <td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/SequenceProperties.pdf Raw lecture PDF]</small></td>
| |
− | <td>Ch 4.9, 11, 12</td>
| |
− | <td>-</td>
| |
− | </tr>
| |
− | | |
− | <tr class="s2">
| |
− | <td>4</td>
| |
− | <td>Mon. Sept 22</td>
| |
− | <td>Steipe</td>
| |
− | <td> Sequence Analysis and Bioinformatics methods</td>
| |
− | <td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/SequenceAnalysis.pdf Raw lecture PDF]</small></td>
| |
− | <td>-</td>
| |
− | <td>-</td>
| |
− | </tr>
| |
− | | |
− | <tr class="s1">
| |
− | <td>5</td>
| |
− | <td>Thu. Sept 25.</td>
| |
− | <td>Steipe</td>
| |
− | <td>Interpreting protein structure</td>
| |
− | <td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/InterpretingProteinStructure.pdf Raw lecture PDF]</td>
| |
− | <td>-</td>
| |
− | <td>[[Assignment 1]] due<br>
| |
− | <hr>
| |
− | '''First quiz''' in class<br>
| |
− | <hr>
| |
− | [[Assignment 2]] to be posted
| |
− | </td>
| |
− | </tr>
| |
− | | |
− | <tr class="s1">
| |
− | <td>12</td>
| |
− | <td>Thu. Oct 23.</td>
| |
− | <td>Steipe</td>
| |
− | <td>Structural domains</td>
| |
− | <td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/StructuralDomains.pdf Raw lecture PDF]</small></td>
| |
− | <td>-</td>
| |
− | <td>[[Assignment 3]] due</td>
| |
− | </tr>
| |
− | | |
− | <tr class="s1">
| |
− | <td>6</td>
| |
− | <td>Mon. Sept 29</td>
| |
− | <td>Steipe</td>
| |
− | <td>Homology I: the principles</td>
| |
− | <td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/Homology_I_Principles.pdf Raw lecture PDF]</small></td>
| |
− | <td>Ch. 14</td>
| |
− | <td>-</td>
| |
− | </tr>
| |
− | | |
− | <tr class="s1">
| |
− | <td>7</td>
| |
− | <td>Thu. Oct 2</td>
| |
− | <td>Parkinson</td>
| |
− | <td>Genome sequencing, genome browsers</td>
| |
− | <td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/Genome_sequencing.pdf Lecture slide PDFs (1.8 MB)]</small></td>
| |
− | <td>Ch. 9, 10</td>
| |
− | <td>-</td>
| |
− | </tr>
| |
− | | |
− | <tr class="s2">
| |
− | <td>8</td>
| |
− | <td>Mon. Oct 6</td>
| |
− | <td>Parkinson</td>
| |
− | <td>Genomes and genome structure</td>
| |
− | <td>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/Genomes.pdf Lecture slide PDFs (2.4 MB)]</td>
| |
− | <td>-</td>
| |
− | <td>-</td>
| |
− | </tr>
| |
− | | |
− | --><!-- =================== TOPIC =================== --><!--
| |
− | <tr class="sp"><td colspan="7" style="height: 10px;"></td></tr>
| |
− | <tr class="st">
| |
− | <td colspan="7">'''H o m o l o g y'''</td>
| |
− | </tr>
| |
− | | |
− | <tr class="sh">
| |
− | <td>'''#'''</td>
| |
− | <td>'''Date'''</td>
| |
− | <td>'''Lecturer'''</td>
| |
− | <td>'''Topic'''</td>
| |
− | <td>'''Handout'''</td>
| |
− | <td>'''Book'''</td>
| |
− | <td>'''Note'''</td>
| |
− | </tr>
| |
− | | |
− | <tr class="sp"><td colspan="7" style="height: 5px;"></td></tr>
| |
− | | |
− | <tr class="s1">
| |
− | <td>9</td>
| |
− | <td>Thu. Oct 9.</td>
| |
− | <td>Steipe</td>
| |
− | <td>Lecture: Homology II: Sequence alignment</td>
| |
− | <td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/Homology_II_Alignment.pdf Raw lecture PDF]</small></td>
| |
− | <td></td>
| |
− | <td>[[Assignment 2]] due<br>
| |
− | <hr>
| |
− | [[Assignment 3]] to be posted
| |
− | <hr>
| |
− | </td>
| |
− | </tr>
| |
− | | |
− | | |
− | <tr class="s2">
| |
− | <td>10</td>
| |
− | <td>'''Thu. Oct 16'''</td>
| |
− | <td>Steipe</td>
| |
− | <td>Lecture: Homology III: Fast sequence database searches</td>
| |
− | <td>[[BLAST]]</td>
| |
− | <td>Ch. 5</td>
| |
− | <td>-</td>
| |
− | </tr>
| |
− | | |
− | <tr class="s1">
| |
− | <td>11</td>
| |
− | <td>Mo. Oct 20</td>
| |
− | <td>Steipe</td>
| |
− | <td>Homology IV: Multiple sequence alignment</td>
| |
− | <td>[[Multiple Sequence Alignment]]</td>
| |
− | <td>Ch. 6</td>
| |
− | <td>'''Second quiz''' in class (13:00 tutorial time slot)</td>
| |
− | </tr>
| |
− | | |
− | <tr class="s2">
| |
− | <td>18</td>
| |
− | <td>Thu. Nov 13</td>
| |
− | <td>Steipe</td>
| |
− | <td>Homology modeling and structure prediction (Part 1)</td>
| |
− | <td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/PredictingProteinStructure_I.pdf Raw lecture PDF]</small></td>
| |
− | <td>-</td>
| |
− | <td>-</td>
| |
− | </tr>
| |
− | | |
− | <tr class="s1">
| |
− | <td>19</td>
| |
− | <td>Mon. Nov 17</td>
| |
− | <td>Steipe</td>
| |
− | <td>Homology modeling and structure prediction (Part 2)</td>
| |
− | <td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/PredictingProteinStructure_II.pdf Raw lecture PDF]</small></td>
| |
− | <td>-</td>
| |
− | <td>[[Assignment 4]] due.
| |
− | <hr>
| |
− | '''Fourth quiz''' in class: 13:00 in tutorial time slot.
| |
− | <hr>
| |
− | [[Assignment 5]] to be posted.</td>
| |
− | </tr>
| |
− | | |
− | | |
− | | |
− | --><!-- =================== TOPIC =================== --><!--
| |
− | <tr class="sp"><td colspan="7" style="height: 10px;"></td></tr>
| |
− | <tr class="st">
| |
− | <td colspan="7">'''P h y l o g e n y'''</td>
| |
− | </tr>
| |
− | | |
− | <tr class="sh">
| |
− | <td>'''#'''</td>
| |
− | <td>'''Date'''</td>
| |
− | <td>'''Lecturer'''</td>
| |
− | <td>'''Topic'''</td>
| |
− | <td>'''Handout'''</td>
| |
− | <td>'''Book'''</td>
| |
− | <td>'''Note'''</td>
| |
− | </tr>
| |
− | | |
− | <tr class="sp"><td colspan="7" style="height: 5px;"></td></tr>
| |
− | | |
− | <tr class="s1">
| |
− | <td>13</td>
| |
− | <td>Mon. Oct 27</td>
| |
− | <td>Steipe</td>
| |
− | <td>Phylogenetic analysis I</td>
| |
− | <td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/PhylogeneticAnalysis_I.pdf Raw lecture PDF]</small></td>
| |
− | <td>Ch. 7,8</td>
| |
− | <td>'''Third quiz''' in class, 13:00 in tutorial time-slot</td>
| |
− | </tr>
| |
− | | |
− | <tr class="s2">
| |
− | <td>14</td>
| |
− | <td>Thu. Oct 30</td>
| |
− | <td>Steipe</td>
| |
− | <td>Phylogenetic analysis II</td>
| |
− | <td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/PhylogeneticAnalysis_II.pdf Raw lecture PDF]</small></td>
| |
− | <td>Ch. 7,8</td>
| |
− | <td>-</td>
| |
− | </tr>
| |
− | | |
− | <tr class="s1">
| |
− | <td>15</td>
| |
− | <td>Mon. Nov 3</td>
| |
− | <td>Parkinson</td>
| |
− | <td>Comparative genomics</td>
| |
− | <td>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/ComparativeGenomics.pdf Lecture slide PDFs (1.6 MB)]</td>
| |
− | <td>Ch. 9.8, 10.8</td>
| |
− | <td>-</td>
| |
− | </tr>
| |
− | | |
− | <tr class="s2">
| |
− | <td>17</td>
| |
− | <td>Mon. Nov 10</td>
| |
− | <td>Steipe</td>
| |
− | <td>Human population genomics</td>
| |
− | <td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/HumanPopulationGenomics.pdf Raw lecture PDF]</small></td>
| |
− | <td>-</td>
| |
− | <td>[[Assignment 4]] to be posted</td>
| |
− | </tr>
| |
− | | |
− | --><!-- =================== TOPIC =================== --><!--
| |
− | <tr class="sp"><td colspan="7" style="height: 10px;"></td></tr>
| |
− | <tr class="st">
| |
− | <td colspan="7">'''I n t e r a c t i o n s'''</td>
| |
− | </tr>
| |
− | | |
− | <tr class="sh">
| |
− | <td>'''#'''</td>
| |
− | <td>'''Date'''</td>
| |
− | <td>'''Lecturer'''</td>
| |
− | <td>'''Topic'''</td>
| |
− | <td>'''Handout'''</td>
| |
− | <td>'''Book'''</td>
| |
− | <td>'''Note'''</td>
| |
− | </tr>
| |
− | | |
− | <tr class="sp"><td colspan="7" style="height: 5px;"></td></tr>
| |
− | | |
− | <tr class="s1">
| |
− | <td>20</td>
| |
− | <td>Thu. Nov 20</td>
| |
− | <td> Wodak </td>
| |
− | <td>Gene regulation (Part 1)</td>
| |
− | <td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/GeneRegulation.pdf Lecture slide PDFs (2.1 MB)]</small></td>
| |
− | <td>Ch. 15</td>
| |
− | <td>-</td>
| |
− | </tr>
| |
− | | |
− | <tr class="s2">
| |
− | <td>21</td>
| |
− | <td>Mon. Nov 24</td>
| |
− | <td>Wodak</td>
| |
− | <td>Gene regulation (Part 2)</td>
| |
− | <td>-</td>
| |
− | <td>-</td>
| |
− | <td>-</td>
| |
− | </tr>
| |
− | | |
− | <tr class="s1">
| |
− | <td>22</td>
| |
− | <td>Thu. Nov 27</td>
| |
− | <td>Wodak</td>
| |
− | <td>Functional annotation</td>
| |
− | <td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/FunctionalAnnotations.pdf Lecture slide PDFs ('''10.6 MB''')]</small></td>
| |
− | <td>Appendix A</td>
| |
− | <td>-</td>
| |
− | </tr>
| |
− | | |
− | | |
− | <tr class="s2">
| |
− | <td>23</td>
| |
− | <td>Mon. Dec 1</td>
| |
− | <td>Wodak</td>
| |
− | <td>Metabolic networks</td>
| |
− | <td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/PathwaysAndNetworks.pdf Lecture slide PDFs (3.1 MB)]</small></td>
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− | <td>Ch. 17.1</td>
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− | <td>[[Assignment 5]] due<br>
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− | <hr>
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− | '''Fifth quiz''' in class: 13:00 in tutorial time slot
| |
− | </td>
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− | </tr>
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− | | |
− | <tr class="s1">
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− | <td>24</td>
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− | <td>Thu. Dec 4</td>
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− | <td>Parkinson</td>
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− | <td>Computational systems biology</td>
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− | <td>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/ComputationalSystemsBiology.pdf Lecture slide PDFs (3.4 MB)]</td>
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− | <td>Ch. 17</td>
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− | <td>-</td>
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− | </tr>
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− | | |
− | </table>
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− | | |
− | <div class="BIO_2">
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− | </div>
| |
− | ==In depth...==
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− | | |
− | * [[Glossary]]
| |
− | * [[Mutation Data Matrices]]
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− | * [http://en.wikipedia.org/wiki/List_of_standard_amino_acids Amino acids]
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− | | |
− | --><!-- * [[Database Identifiers]] --><!--
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− |
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− | <!--
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− | ;Course Wiki
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− | *[[Help:Introduction|Introduction:]] Concept and contents of the Course Wiki
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− | *[[Soapbox]]: A page to commmunicate. Do you want to leave a message? Alert the course members? Voice an opinion? Praise or flame? Use this page.
| |
− | *[[Help:Editing| Editing:]] Editing principles and Wiki markup syntax for the Course Wiki pages
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− | *[[Sandbox]]: A page for your editing experiments. Content added to this page will not stay permanently.
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− | *[[Feedback]]: Share your views on the course, suggest improvements.
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| [[Category:Bioinformatics]] | | [[Category:Bioinformatics]] |
| + | </div> |