Lecture 01

Update Warning! This page has not been revised yet for the 2007 Fall term. Some of the slides may be reused, but please consider the page as a whole out of date as long as this warning appears here.

 

 

(Next lecture)

Organisation and Orientation

Add/expand:

• Mission: Analysis must be followed by interpretation, course is hands-on, interactive and goal oriented.
• Technology: Google group, Wiki, supporting material on the Web
• Contact information
• Technical details of course organisation

Lecture Slides

Slide 001

Lecture 01, Slide 001
Bioinformatics is not only required to master the quantitative aspects of the post-genomic era in molecular biology, it is a qualitative change in our approach to biology as well.

Slide 002

Lecture 01, Slide 002
Bioinformatics can be viewed as the science that develops between the two poles of data management and computational modeling of life.

Slide 003

Lecture 01, Slide 003
From its beginning, it was recognized that molecular biology is an information science, just as much as a molecular science. The abstractions and models that focus on the essence of this information, rather than on the details of its representation, have proven to be remarkably powerful in explaining the basic features of life, such as inheritance, self-organization and the process of evolution.

Slide 004

Lecture 01, Slide 004
The promises of genome analysis include harnessing the power of self assembly towards a bio-nanotechnologic revolution: growth, rather than manufacturing. This includes the vision of regenerative molecular medicine, essentially relegating disease to the dark past ages of ignorance. But while the information for a complete specification of life is undoubtedly present in the genome, life realizes itself in complex interactions between context-dependent components. This makes life essentially unpredictable, at least to our current approaches. The sheer volume of data is a comparatively minor obstacle.

Slide 005

Lecture 01, Slide 005
The current emphasis on -omic sciences creates novel challenges both in the quantity as well as the quality of scientific enquiry. The scale has become larger; molecular components are analyzed not in isolation but in their associations;comparison between genes within and across species is a major source of new insight and the absence of particular components and features is just as informative as their presence. However the availability technology should not lead to a purely methods-driven agenda.

Slide 006

Lecture 01, Slide 006
The US National Center of Biotechnology Information is one of the world's major centres for molecular data.

Slide 007

Lecture 01, Slide 007
The PDB (Protein structure DataBase) is the world's central repository for 3D structural data of proteins and nucleic acids.

Slide 008

Lecture 01, Slide 008

Slide 009

Lecture 01, Slide 009

Slide 010

Lecture 01, Slide 010

Slide 011

Lecture 01, Slide 011

Slide 012

Lecture 01, Slide 012

Slide 013

Lecture 01, Slide 013

Slide 014

Lecture 01, Slide 014

Slide 015

Lecture 01, Slide 015

Slide 016

Lecture 01, Slide 016

Slide 017

Lecture 01, Slide 017

Slide 018

Lecture 01, Slide 018

Slide 019

Lecture 01, Slide 019

Slide 020

Lecture 01, Slide 020

Slide 021

Lecture 01, Slide 021

Slide 022

Lecture 01, Slide 022

Slide 023

Lecture 01, Slide 023

Slide 024

Lecture 01, Slide 024

Slide 025

Lecture 01, Slide 025

Slide 026

Lecture 01, Slide 026

Slide 027

Lecture 01, Slide 027

Slide 028

Lecture 01, Slide 028

Slide 029

Lecture 01, Slide 029

Slide 030

Lecture 01, Slide 030

Slide 031

Lecture 01, Slide 031

Slide 032

Lecture 01, Slide 032

Slide 033

Lecture 01, Slide 033

Slide 034

Lecture 01, Slide 034

Slide 035

Lecture 01, Slide 035

Slide 036

Lecture 01, Slide 036

Slide 037

Lecture 01, Slide 037

Slide 038

Lecture 01, Slide 038

Slide 039

Lecture 01, Slide 039

Slide 040

Lecture 01, Slide 040

Slide 041

Lecture 01, Slide 041