Difference between revisions of "Lecture 25"
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<small>[[Lecture_24|(Previous lecture)]] ... [[Lecture_26|(Next lecture)]]</small> | <small>[[Lecture_24|(Previous lecture)]] ... [[Lecture_26|(Next lecture)]]</small> |
Revision as of 15:31, 1 September 2007
Update Warning! This page has not been revised yet for the 2007 Fall term. Some of the slides may be reused, but please consider the page as a whole out of date as long as this warning appears here.
(Previous lecture) ... (Next lecture)
Pathways and Networks
- A general reference for this section is the book chapter
- Intermolecular Interactions and Biological Pathways
- Gary D. Bader, Anton J. Enright
- in Bioinformatics 3E Eds. Andreas D. Baxevanis and B.F.Francis Ouellette. John Wiley and Sons, New Jersey
Lecture Slides
Slide 001
Slide 002
Slide 003
Slide 004

Lecture 25, Slide 004
Ref: Pathway information for systems biology
Cary MP, Bader GD, Sander C, FEBS Lett. 2005 Mar 21;579(8):1815-20
Available from http://baderlab.org/Publications
Ref: Pathway information for systems biology
Cary MP, Bader GD, Sander C, FEBS Lett. 2005 Mar 21;579(8):1815-20
Available from http://baderlab.org/Publications
Slide 005

Lecture 25, Slide 005
Text book versions of pathways are often not cell specific - they lack context in time and space because experimental method generally don’t have the power to map pathways at this level of resolution or we are not organized enough as a community to map one pathway in one cell. Genomic and proteomic approaches will help us map whole pathways with single experimental methods in individual cell types in the future.
Text book versions of pathways are often not cell specific - they lack context in time and space because experimental method generally don’t have the power to map pathways at this level of resolution or we are not organized enough as a community to map one pathway in one cell. Genomic and proteomic approaches will help us map whole pathways with single experimental methods in individual cell types in the future.
Slide 006
Slide 007
Slide 008
Slide 009

Lecture 25, Slide 009
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry
Ho Y et al. Nature 2002 Jan 10;415(6868): 180-183
Available from http://baderlab.org/Publications
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry
Ho Y et al. Nature 2002 Jan 10;415(6868): 180-183
Available from http://baderlab.org/Publications
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Slide 028

Lecture 25, Slide 028
Active modules reference:
Ideker T, Ozier O, Schwikowski B, Siegel AF. Discovering regulatory and signalling circuits in molecular interaction networks. Bioinformatics. 2002;18 Suppl 1:S233-40.
http://www.pathblast.org/
http://www.agilent.com/labs/research/mtl/projects/sysbio/sysinformatics/litsearch.html
Active modules reference:
Ideker T, Ozier O, Schwikowski B, Siegel AF. Discovering regulatory and signalling circuits in molecular interaction networks. Bioinformatics. 2002;18 Suppl 1:S233-40.
http://www.pathblast.org/
http://www.agilent.com/labs/research/mtl/projects/sysbio/sysinformatics/litsearch.html
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Slide 060

Lecture 25, Slide 060
Movie can be downloaded from http://www.studiodaily.com/main/searchlist/6850.html
or download from http://baderlab.org/Home?action=AttachFile&do=get&target=InnerCellLife.mov
Movie can be downloaded from http://www.studiodaily.com/main/searchlist/6850.html
or download from http://baderlab.org/Home?action=AttachFile&do=get&target=InnerCellLife.mov