Difference between revisions of "BIN-EXPR-Multiple testing"
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Time management: Before you begin, estimate how long it will take you to complete this unit. Then, record in your course journal: the number of hours you estimated, the number of hours you worked on the unit, and the amount of time that passed between start and completion of this unit.
Journal: Document your progress in your Course Journal. Some tasks may ask you to include specific items in your journal. Don't overlook these.
Insights: If you find something particularly noteworthy about this unit, make a note in your insights! page.
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Multiple Testing and Significance | Multiple Testing and Significance | ||
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(Multiple testing problem. Concepts, Bonferroni correction and FDR) | (Multiple testing problem. Concepts, Bonferroni correction and FDR) | ||
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| − | + | <li><b>Time management</b>: Before you begin, estimate how long it will take you to complete this unit. Then, record in your course journal: the number of hours you estimated, the number of hours you worked on the unit, and the amount of time that passed between start and completion of this unit.</li> | |
<!-- included from "./data/ABC-unit_components.txt", section: "deliverables-journal" --> | <!-- included from "./data/ABC-unit_components.txt", section: "deliverables-journal" --> | ||
| − | + | <li><b>Journal</b>: Document your progress in your [[FND-Journal|Course Journal]]. Some tasks may ask you to include specific items in your journal. Don't overlook these.</li> | |
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| − | + | <li><b>Insights</b>: If you find something particularly noteworthy about this unit, make a note in your [[ABC-Insights|'''insights!''' page]].</li> | |
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| − | This unit builds on material covered in the following prerequisite units: | + | This unit builds on material covered in the following prerequisite units:<br /> |
*[[BIN-EXPR-DE|BIN-EXPR-DE (Discovering Differentially Expressed Genes)]] | *[[BIN-EXPR-DE|BIN-EXPR-DE (Discovering Differentially Expressed Genes)]] | ||
*[[FND-STA-Significance|FND-STA-Significance (Significance)]] | *[[FND-STA-Significance|FND-STA-Significance (Significance)]] | ||
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Revision as of 12:38, 16 September 2020
Multiple Testing and Significance
(Multiple testing problem. Concepts, Bonferroni correction and FDR)
Abstract:
Searching for significant effects in high-throughput experiments changes the statistical odds of finding highly unusual outcomes. This needs to be properly corrected, especially in situations like expression analysis where we observe tens of thousands of measurements simultaneously and need to determine which ones should be followed up on.
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Objectives:
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Outcomes:
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Deliverables:
Prerequisites:
This unit builds on material covered in the following prerequisite units:
This page is tagged for revision; expect changes and proceed with caution.
Contents
Task:
- Read the introductory notes on multiple testing.
Self-evaluation
Notes
Further reading, links and resources
If in doubt, ask! If anything about this learning unit is not clear to you, do not proceed blindly but ask for clarification. Post your question on the course mailing list: others are likely to have similar problems. Or send an email to your instructor.
About ...
Author:
- Boris Steipe <boris.steipe@utoronto.ca>
Created:
- 2017-08-05
Modified:
- 2017-11-10
Version:
- 1.0
Version history:
- 1.0 First live version
- 0.1 First stub
This copyrighted material is licensed under a Creative Commons Attribution 4.0 International License. Follow the link to learn more.
