Difference between revisions of "Gene Regulatory Circuits Project"
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The definition of molecular systems needs to take their functional components into account, as well as the components that create, assemble and disassemble these functional components. Among the latter, gene regulatory circuits play a particularly important role since they control when a particular system is constituted and becomes active. We can distinguish constitutive circuits (almost always '''on'''), developmental circuits ('''on''' only in certain cell-types), and regulated circuits ('''on''' in response to specific environmental signals or in ordered sequence of events such as the cell cycle). | The definition of molecular systems needs to take their functional components into account, as well as the components that create, assemble and disassemble these functional components. Among the latter, gene regulatory circuits play a particularly important role since they control when a particular system is constituted and becomes active. We can distinguish constitutive circuits (almost always '''on'''), developmental circuits ('''on''' only in certain cell-types), and regulated circuits ('''on''' in response to specific environmental signals or in ordered sequence of events such as the cell cycle). | ||
| − | In a [[BIO_systems_project|'''previous set of BCH441 projects''']], students have curated biological systems, essentially based on Gene Ontology Annotations. In | + | In a [[BIO_systems_project|'''previous set of BCH441 projects''']], students have curated biological systems, essentially based on Gene Ontology Annotations. In this special project the task is to define the gene regulatory circuits that operate on a select set of those systems, using four different information resources. |
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Revision as of 19:18, 1 March 2018
Gene Regulatory Circuits
This project concerns the application of various information sources to define gene-regulatory circuits in molecular systems.
Context
The definition of molecular systems needs to take their functional components into account, as well as the components that create, assemble and disassemble these functional components. Among the latter, gene regulatory circuits play a particularly important role since they control when a particular system is constituted and becomes active. We can distinguish constitutive circuits (almost always on), developmental circuits (on only in certain cell-types), and regulated circuits (on in response to specific environmental signals or in ordered sequence of events such as the cell cycle).
In a previous set of BCH441 projects, students have curated biological systems, essentially based on Gene Ontology Annotations. In this special project the task is to define the gene regulatory circuits that operate on a select set of those systems, using four different information resources.
Task
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Deliverables
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Evaluation
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Notes
