BIO project GO-term table

GO term Table

 

Extracting Gene functions from GO and GOA

This table below of selected GO terms with human gene annotations in GOA is a starting point for function definition and gene selection.

Creation of the Function Table

The Function Table was created in the following steps:

1. I downloaded the file gene_association.goa_human from its GOA repository at the EBI. The file contains gene names and GO terms - here is an (abridged) example:

UniProtID  GeneName  GOtermID    Description                         taxID
A0A183     LCE6A     GO:0031424  Late cornified envelope protein 6A  taxon:9606		

2. I downloaded the GO Ontologies file go-basic.obo from its repository at GO -the Gene Ontology Consortium. It contains the actual ontology terms, they look like this.

[Term]
id: GO:0001776
name: leukocyte homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of cells of the
immune system such that the total number of cells of a particular cell type within a
whole or part of an organism is stable over time in the absence of an outside stimulus."
is_a: GO:0002376 ! immune system process
is_a: GO:0048872 ! homeostasis of number of cells

Note the two is_a relationships that indicate the parent node, of which this one is a specialization.

3. I reconstructed the DAG (Directed Acyclic Graph) by connecting each of the 40,402 nodes to its parent node.

4. I eliminated all nodes that don't have at least one human gene in GOA annotated to it or one of its descendants. These are genes that might be specific to fungi, prokaryotes, viruses or similar.

5. For each node, I counted its distance from the root node. This "depth" tells us a bit about how specific a term is.

6. For each node, I counted how many human genes have been specifically annotated to it. This helps us a bit to indetify categories that are overly broad.

7: I wrote this information to file for the biological process ontology. The result has 11,927 nodes, one per line, and looks like this:

01  GO:0002376  immune system process [ ADSS ... 17 genes ]
05      GO:0001776  leukocyte homeostasis [MEN1, FLT3, NKX2-3]
06        GO:0001780  neutrophil homeostasis [ MECOM ... 13 genes ]

Here, neutrophil homeostasis has 13 annotated genes, it is six steps removed from the root. Its parent is leukocyte homeostasis which itself is a specialization (a descendant) of an immune system process. The intermediate nodes are not shown because there are no genes directly annotated to these terms. Now consider what it means to find a gene at these levels: MECOM is involved in the homeostasis (keeping cell-numbers constant) of neutrophil white blood cells. MEN1 is also involved in white blood cell homeostasis, but it could either target several cell types, or it is not known which cell type it targets. Thus it is annotated to a higher node. ADSS seems to be a gene for which we know it is involved in the immune system, but we don't know what it does there. This illustrates how partial knowledge can be represented in this data structure, and you can easily imagine that, as we learn more about biology, we move annotations down to more precise locations, or create new nodes to represent new knowledge.

8. Next, I selected from this list. For this project we are looking for terms that give a good approximation of a cellular function, without being either too broad or too specialized. I selected nodes that have from 1 to 4 annotated genes at a depth between 2 and 5, and I excluded terms with keywords that indicate a role in a higher function of the organism such as "morphogenesis", "development" and "behavior". This yields 541 processes represented by 1,214 unique annotated genes.

9. To create the table you see below, I wrote the output in HTML table format to file, while adding links to the UniProt entry for the gene name. The gene names come from HGNC so I would expect all of the genes to be findable at UniProt.

How to use the table to adopt a function for the project

 

1 Browse the table and find a function that interests you. Its very diverse and will give you a good first sense of the complexity of functions in the cell and our state of knowledge about them.

2 Look at the function information available at UniProt. Most of these genes have more than one GO term annotated to them. For example I could choose (at random) SRPX, which plays a role in phagolysosome assembly. Here are the annotated processes in which this protein participates:

• autophagy
• cell adhesion
• negative regulation of cell proliferation involved in contact inhibition
• phagolysosome assembly
• positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
• response to endoplasmic reticulum stress

Complete GO annotation...

Just looking at these processes tells me a lot. The annotation is for one protein, but it is implied in several aspects of biology. Some of them are causal to others, and some of them are generalizations. Here, the phagolysosome needs to be assembled in order to function. Once it has been made, this enables stress response, and contact inhibition, likely via apoptotic pathways and autophagy. This phagolysosome assembly sounds like a good system to work on. But is the term too broad, or too narrow? Could I find a better name for it?

I follow the link to the phagolysosome assembly GOterm, I find tabs that contain ancestral nodes and child nodes:

Relationship to GO:0001845	Child Term	Child Term Name
Part of	GO:0090384	phagosome-lysosome docking
Part of	GO:0090385	phagosome-lysosome fusion
Is a	GO:0090387	phagolysosome assembly involved in apoptotic cell clearance

 

Exploring this a bit more, I see:

• There are 20 to 30 proteins annotated to this process;
• Most of them are not human, but from closely related species (e.g. baboon), that will probably allow inference from homology;
• The mechanism of this system will likely include proteins that are specific to this process, and others that are involved in membrane fusion in a general sense and are recruited to this specific task.

This actually looks like an ideal starting point to define the components of a system. For now, I would be oK with calling it the phagosome / lysosome fusion system.

 

What to submit for Part 1 of the project

• Head over to my 2015 project page on the student wiki.
• Copy the page content and create a subpage of your user space on the Student Wiki.
• Edit the page for your adopted system. Make sure the result contains all elements of the original.

 

The Function Table

 

Depth	GO Term	Text	Genes
5	GO:0001776	leukocyte homeostasis	MEN1, FLT3, NKX2-3
3	GO:0016445	somatic diversification of immunoglobulins	AICDA, CTNNBL1, RAG2
5	GO:0002366	leukocyte activation involved in immune response	SH2D1B, CLEC7A, SYK
5	GO:0019724	B cell mediated immunity	SLA2, MSH2, FAS
4	GO:0002679	respiratory burst involved in defense response	NCF1, MPO, PIK3CG, PIK3CD
5	GO:0045728	respiratory burst after phagocytosis	HCK, SELK
3	GO:0002352	B cell negative selection	BAX, BAK1
4	GO:0002367	cytokine production involved in immune response	MR1, NOD2
3	GO:0002377	immunoglobulin production	FAS, IL7R
4	GO:0002381	immunoglobulin production involved in immunoglobulin mediated immune response	HLA-DQB1, HLA-DRB1, NOD2
3	GO:0002513	tolerance induction to self antigen	LYN, FOXP3, TGFB1
4	GO:0002384	hepatic immune response	IL6, IL6R
4	GO:0002418	immune response to tumor cell	PRF1, MICA
3	GO:0042092	type 2 immune response	IL4, BCL6, IL18, IL10
4	GO:0002495	antigen processing and presentation of peptide antigen via MHC class II	MARCH1, MARCH8
2	GO:0045058	T cell selection	CD1D, CD4, CD74
3	GO:0043366	beta selection	ZAP70, SYK
3	GO:0043368	positive T cell selection	THEMIS, BCL11B
3	GO:0045061	thymic T cell selection	CARD11, JAG2, GATA3
5	GO:0050902	leukocyte adhesive activation	CX3CL1, SELPLG
5	GO:0018916	nitrobenzene metabolic process	GSTM1, GSTM2, GSTM3
5	GO:0006579	amino-acid betaine catabolic process	BHMT, DMGDH
5	GO:0033076	isoquinoline alkaloid metabolic process	CYP2D6, TH, DDC
5	GO:0000255	allantoin metabolic process	STAT5B, STAT5A, GHR
5	GO:0009822	alkaloid catabolic process	CYP2D6, CYP3A4, CYP3A5
5	GO:0070458	cellular detoxification of nitrogen compound	GSTM1, GSTM2, GSTM3
4	GO:0051410	detoxification of nitrogen compound	MARC1, MARC2
4	GO:0009820	alkaloid metabolic process	CYP2D6, CYP1A2
5	GO:0042412	taurine biosynthetic process	CDO1, CSAD
2	GO:0009056	catabolic process	TMEM150A, CES2, PTER
5	GO:0042447	hormone catabolic process	ECE1, ACE, IDE
5	GO:0044242	cellular lipid catabolic process	ACADL, MT3
4	GO:0046185	aldehyde catabolic process	ALDH3B1, GPI, AKR1A1
5	GO:0046294	formaldehyde catabolic process	ESD, ADH5
5	GO:0046952	ketone body catabolic process	BDH1, ACAT1, OXCT1, OXCT2
5	GO:0006706	steroid catabolic process	STS, CYP1A2, HSD17B14, CYP3A4
5	GO:0044240	multicellular organismal lipid catabolic process	PLA2G1B, APOA4
5	GO:0016139	glycoside catabolic process	GBA2, GBA3, NAGA, GLA
5	GO:0000272	polysaccharide catabolic process	CHIT1, CHIA
4	GO:0016052	carbohydrate catabolic process	PGM2, PGM2L1, NAGA, AMY2A
3	GO:0010025	wax biosynthetic process	FAR1, AWAT2
5	GO:0070814	hydrogen sulfide biosynthetic process	MPST, CBS, CTH
5	GO:0002378	immunoglobulin biosynthetic process	GALNT2, PTPRC
4	GO:0006082	organic acid metabolic process	CYP2C8, FMO2, FMO1
4	GO:0015980	energy derivation by oxidation of organic compounds	ACSM1, ACADVL
4	GO:0018894	dibenzo-p-dioxin metabolic process	CYP1A2, CYP17A1, STAR, CYP11A1
4	GO:0000103	sulfate assimilation	SULT2B1, PAPSS1, PAPSS2
4	GO:0019417	sulfur oxidation	MICAL1, MICAL2
5	GO:0030388	fructose 1,6-bisphosphate metabolic process	PFKL, ALDOA, ALDOC, ALDOB
5	GO:0017143	insecticide metabolic process	CYP1A1, STAR
5	GO:0052314	phytoalexin metabolic process	TH, DDC
4	GO:0016999	antibiotic metabolic process	TXN, DPEP1
4	GO:0042133	neurotransmitter metabolic process	GCHFR, CLN3, CACNA1A, AGTPBP1
4	GO:0042180	cellular ketone metabolic process	CYP2B6, DHRS4
5	GO:1901661	quinone metabolic process	CRYZL1, ADH4
5	GO:0006643	membrane lipid metabolic process	AGMO, B4GALT4
5	GO:0006720	isoprenoid metabolic process	PHYH, GGPS1
5	GO:0046485	ether lipid metabolic process	TMEM86B, AGMO, HRASLS
3	GO:0072592	oxygen metabolic process	NOX1, ME3, FMO2
4	GO:0042743	hydrogen peroxide metabolic process	NOX1, PARK7
4	GO:0005976	polysaccharide metabolic process	CHST1, CHST7, TYMS
5	GO:0070085	glycosylation	CLN5, COG6
5	GO:0042982	amyloid precursor protein metabolic process	KLK6, DLG1, LDLRAP1, ACHE
5	GO:1990000	amyloid fibril formation	RIPK1, RIPK3
3	GO:0044236	multicellular organismal metabolic process	GHR, TIPARP, MNAT1
4	GO:0044259	multicellular organismal macromolecule metabolic process	TUB, AKR1C3
5	GO:0002268	follicular dendritic cell differentiation	BCL3, NFKB2
4	GO:0014719	satellite cell activation	WNT7A, MEGF10
4	GO:0048143	astrocyte activation	AGT, ADORA2A
4	GO:0072537	fibroblast activation	RGCC, IL17A, IL17RA
4	GO:0016080	synaptic vesicle targeting	NLGN1, SCRIB, PSEN1, SEPT5
5	GO:0048203	vesicle targeting, trans-Golgi to endosome	AP1AR, WIPI1
5	GO:0030050	vesicle transport along actin filament	FNBP1L, WASL
5	GO:0031022	nuclear migration along microfilament	SYNE2, SUN2
5	GO:0070358	actin polymerization-dependent cell motility	JMY, NCKAP1L, EPS8
5	GO:0097491	sympathetic neuron projection guidance	NRP1, NRP2, SEMA3A, SEMA3F
3	GO:0006949	syncytium formation	ERCC1, CCNG1, ERVW-1
5	GO:0006999	nuclear pore organization	NUP98, SEH1L, NUP133, TPR
5	GO:0007000	nucleolus organization	NOLC1, RRN3, RPS19, PES1
5	GO:0007290	spermatid nucleus elongation	TNP1, H1FNT, KDM3A
5	GO:0030382	sperm mitochondrion organization	PVRL2, SEPT4
5	GO:0090161	Golgi ribbon formation	OPTN, TMED5, GCC2
5	GO:0090166	Golgi disassembly	PLK3, VRK1
4	GO:0007033	vacuole organization	MAN2A1, FIG4, NDP
5	GO:0006900	membrane budding	P2RX7, FNBP1L, WASL
5	GO:0030719	P granule organization	PLD6, TDRD5
4	GO:0031023	microtubule organizing center organization	PAFAH1B1, CLASP2, CLASP1, GCC2
5	GO:0000715	nucleotide-excision repair, DNA damage recognition	XPC, RAD23B
5	GO:0000819	sister chromatid segregation	TOP2B, TOP2A, LATS1
5	GO:0006344	maintenance of chromatin silencing	HDAC2, UBE2B, SIRT1
5	GO:0000022	mitotic spindle elongation	PRC1, KIF23
5	GO:0098535	de novo centriole assembly	CCDC78, PLK4, CEP152, CCDC67
3	GO:0007028	cytoplasm organization	TFCP2L1, RRN3, KIF5B
4	GO:0007296	vitellogenesis	ZMIZ1, FOSL1
5	GO:0007113	endomitotic cell cycle	UBA3, CIB1, PLK3
5	GO:0007060	male meiosis chromosome segregation	TEX11, MLH1
5	GO:0045143	homologous chromosome segregation	ESPL1, MSH4, MSH5
5	GO:0021937	cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation	LHX5, LHX1
5	GO:0035425	autocrine signaling	HILPDA, FZD1
5	GO:0038001	paracrine signaling	PDGFB, CD34
5	GO:0060638	mesenchymal-epithelial cell signaling	HOXA5, WNT5A, WNT2B
5	GO:0060684	epithelial-mesenchymal cell signaling	WNT6, SMO, BMP4, CDC42
4	GO:0007412	axon target recognition	UCHL1, BDNF, FOXB1, STXBP1
4	GO:0010643	cell communication by chemical coupling	DBN1, GJA1
4	GO:0010644	cell communication by electrical coupling	DBN1, GJA1
5	GO:0071460	cellular response to cell-matrix adhesion	SKP2, DSPP
4	GO:0035426	extracellular matrix-cell signaling	FZD4, FER, NDP
5	GO:0086067	AV node cell to bundle of His cell communication	CXADR, SCN10A, SCN5A, SCN4B
5	GO:0086070	SA node cell to atrial cardiac muscle cell communication	SCN3B, ANK2, SCN5A
5	GO:0006931	substrate-dependent cell migration, cell attachment to substrate	EPB41L5, TNFRSF12A, CUZD1
5	GO:0003365	establishment of cell polarity involved in ameboidal cell migration	AMOTL1, AMOT
5	GO:0045200	establishment of neuroblast polarity	DOCK7, FGF13, RAB10
4	GO:0030011	maintenance of cell polarity	DST, NCKAP1L, ATN1
5	GO:0001300	chronological cell aging	ENG, SERPINE1
5	GO:0001302	replicative cell aging	ERCC1, WRN, ROMO1
5	GO:0043654	recognition of apoptotic cell	JMJD6, PEAR1, SCARB1, MEGF10
5	GO:0016198	axon choice point recognition	GAP43, EFNB3
5	GO:0070593	dendrite self-avoidance	DSCAM, DSCAML1
4	GO:0009988	cell-cell recognition	CLEC4M, FUT3, CD209, ST6GALNAC6
5	GO:0001771	immunological synapse formation	DOCK2, CCL19, CCL21, DLG1
5	GO:0070269	pyroptosis	NLRC4, AIM2
5	GO:0001555	oocyte growth	KMT2D, GDF9
5	GO:0070050	neuron cellular homeostasis	CHRNA1, TYRO3, HAAO, FGGY
5	GO:0031577	spindle checkpoint	SPDL1, BIRC5, TAOK1
4	GO:0000320	re-entry into mitotic cell cycle	GSK3B, CCNF, CCND1
5	GO:0033206	meiotic cytokinesis	ACTR3, ACTR2
4	GO:0007127	meiosis I	PSMD13, CKS2
5	GO:0051322	anaphase	CUL3, USP44
5	GO:0007109	cytokinesis, completion of separation	SPAST, ANXA11
5	GO:0034088	maintenance of mitotic sister chromatid cohesion	NIPBL, DSCC1, RB1, MAU2
4	GO:0044770	cell cycle phase transition	TIPIN, TIMELESS, CDC7, PTPRC
4	GO:0045023	G0 to G1 transition	MDM4, CDK3
4	GO:0051304	chromosome separation	SMARCAD1, RECQL5
5	GO:0051306	mitotic sister chromatid separation	TEX14, DIS3L2
5	GO:0051653	spindle localization	ACTR3, ACTR2, WASL
4	GO:0070314	G1 to G0 transition	EZH2, CYP27B1, C2orf40
5	GO:0070315	G1 to G0 transition involved in cell differentiation	SLC39A5, CAPN3
4	GO:0048278	vesicle docking	EXOC5, CAV2, CCDC41
5	GO:0043241	protein complex disassembly	DDIT4, HDAC6
3	GO:0030029	actin filament-based process	ELMO1, SELE
5	GO:0006930	substrate-dependent cell migration, cell extension	OPHN1, SDCBP, MYH10, CD2AP
5	GO:0030035	microspike assembly	ACTN2, FGD4, MTSS1
4	GO:0032796	uropod organization	CORO1A, MYH9
5	GO:0044375	regulation of peroxisome size	PEX11G, PEX11A, PEX11B
4	GO:0043482	cellular pigment accumulation	SHROOM3, SHROOM2
5	GO:0002934	desmosome organization	DSP, PERP, PVRL1
3	GO:0035845	photoreceptor cell outer segment organization	AHI1, RP1, TOPORS, NPHP1
5	GO:0071711	basement membrane organization	FSHR, RIC8A, TFAP2A
4	GO:0097062	dendritic spine maintenance	PICK1, TANC1, MTMR2
5	GO:0007501	mesodermal cell fate specification	HOXA11, EYA2, PAX2, SIX2
5	GO:0048866	stem cell fate specification	SOX18, SOX17
5	GO:0007403	glial cell fate determination	NTF3, CTNNB1, SMARCA4
5	GO:0007493	endodermal cell fate determination	SOX17, GATA6
5	GO:0007500	mesodermal cell fate determination	KLF4, BMP4, TRIM15, TDGF1P3
5	GO:0007518	myoblast fate determination	IFRD1, MYOD1
5	GO:0007521	muscle cell fate determination	TBX2, MEF2C, MEF2A
5	GO:0048664	neuron fate determination	WNT1, LBX1, CDC42
5	GO:0060913	cardiac cell fate determination	MESP1, ISL1, POU5F1, SOX17
5	GO:0001826	inner cell mass cell differentiation	NLE1, TET1, HNF1B
5	GO:0009994	oocyte differentiation	KMT2B, NPM2
5	GO:0010668	ectodermal cell differentiation	ERF, VPS52
5	GO:0021533	cell differentiation in hindbrain	PHOX2B, NOG, FOXA2, GATA2
5	GO:0021979	hypothalamus cell differentiation	OTP, POU3F2, PROP1
5	GO:0035987	endodermal cell differentiation	NODAL, HMGA2, MIXL1
5	GO:0035990	tendon cell differentiation	TNMD, BMP4, MKX, SCXA
5	GO:0048333	mesodermal cell differentiation	HMGA2, KDM6A, INHBA
5	GO:0060126	somatotropin secreting cell differentiation	WNT4, PITX2, PROP1
5	GO:0060128	corticotropin hormone secreting cell differentiation	FGF8, FGF2, BMP2
5	GO:0060290	transdifferentiation	PDX1, SMAD3, CD34
5	GO:0060591	chondroblast differentiation	RARA, FGF4, FGF2, CYR61
5	GO:0060718	chorionic trophoblast cell differentiation	MAP3K4, DNMT3L, E2F7, E2F8
5	GO:0003329	pancreatic PP cell fate commitment	NEUROD1, NKX2-2
5	GO:0014034	neural crest cell fate commitment	SFRP1, WNT8A
5	GO:0021781	glial cell fate commitment	NRG1, HES5, SOX2
5	GO:0035854	eosinophil fate commitment	GATA2, GATA1
5	GO:0048625	myoblast fate commitment	PITX1, TCF7L2, EPAS1
5	GO:0072560	type B pancreatic cell maturation	NKX6-1, RFX3
5	GO:0051124	synaptic growth at neuromuscular junction	LRP4, APP
4	GO:0007529	establishment of synaptic specificity at neuromuscular junction	CHAT, GPHN, F2R
4	GO:0060074	synapse maturation	SHANK1, PALM, PTEN
4	GO:0008356	asymmetric cell division	PARD3, ACTR3, ACTR2
5	GO:0010070	zygote asymmetric cell division	RGS14, DICER1
4	GO:0021869	forebrain ventricular zone progenitor cell division	POU3F3, POU3F2, DIXDC1
5	GO:0032418	lysosome localization	HDAC6, LAMTOR1, VPS33B, VPS33A
5	GO:0051646	mitochondrion localization	MFN2, MUL1
5	GO:0051647	nucleus localization	DMD, CAV3
5	GO:0051648	vesicle localization	TPGS1, MYO1A
4	GO:0051668	localization within membrane	CDH13, RAC1, CNIH2
5	GO:0008298	intracellular mRNA localization	CASC3, STAU1, BICD1
5	GO:0006880	intracellular sequestering of iron ion	FTH1, SRI
5	GO:0023041	neuronal signal transduction	NLGN1, P2RY11, NRXN1
5	GO:0097527	necroptotic signaling pathway	RIPK1, TNF, TLR3, FASLG
5	GO:0070417	cellular response to cold	FOXO1, NFKBIA
5	GO:0071470	cellular response to osmotic stress	PKD2, TRPV4, DDX3X, SLC2A4
4	GO:0043503	skeletal muscle fiber adaptation	MYOD1, ACTA1
5	GO:0071453	cellular response to oxygen levels	MYOD1, LPAR1, UCK2
5	GO:0071467	cellular response to pH	KCNK18, GPLD1, HYAL1
5	GO:0071219	cellular response to molecule of bacterial origin	IRG1, FZD5
5	GO:0071226	cellular response to molecule of fungal origin	CLEC7A, SYK
3	GO:0060242	contact inhibition	PTPRJ, TSPO, YAP1
3	GO:0060352	cell adhesion molecule production	GCNT1, GOLPH3
3	GO:0072553	terminal button organization	NLGN2, NLGN1, SNAPIN
3	GO:0097061	dendritic spine organization	PICK1, ARF1
5	GO:0019043	establishment of viral latency	CREB3, IRF7
5	GO:0019046	release from viral latency	CREB3, HCFC1
5	GO:0019076	viral release from host cell	PPID, PPIA, IST1
5	GO:0046755	viral budding	TSG101, LRSAM1
4	GO:0043163	cell envelope organization	TGM1, TGM3
5	GO:0002176	male germ cell proliferation	DMRT1, EIF2S2, SPINK2
1	GO:0022414	reproductive process	ANTXR1, ANTXR2
4	GO:0001547	antral ovarian follicle growth	GPR149, FOXO3, ESR1
4	GO:0046661	male sex differentiation	DMRT1, FKBP4
3	GO:0022601	menstrual cycle phase	SFRP1, SFRP4, TGFB2, TGFB3
3	GO:0043084	penile erection	EDNRA, AVP, ACVR2A, AVPR1A
3	GO:0007320	insemination	P2RX1, TAC1, SEMG1, DDO
4	GO:0007620	copulation	ABAT, PI3
4	GO:0051856	adhesion to symbiont	ICAM1, SCARB1, PVRL2
1	GO:0023052	signaling	CCR5, CCL3
4	GO:0043932	ossification involved in bone remodeling	TGFB1, TGFB3, CTHRC1
4	GO:0010573	vascular endothelial growth factor production	GPR56, HIF1A
4	GO:0032602	chemokine production	S100A9, S100A8
5	GO:0071954	chemokine (C-C motif) ligand 11 production	CXCR3, TNFSF4
5	GO:0032608	interferon-beta production	TMEM173, TRIM56, IRF7
5	GO:0032611	interleukin-1 beta production	IL1B, MR1, PYCARD, CASP1
4	GO:0032623	interleukin-2 production	SLC11A1, STOML2
4	GO:0032633	interleukin-4 production	TXK, ITK
3	GO:0002532	production of molecular mediator involved in inflammatory response	IL4R, CHIA
4	GO:0002537	nitric oxide production involved in inflammatory response	SLC7A2, TLR4
5	GO:0002540	leukotriene production involved in inflammatory response	ALOX5AP, ALOX5
4	GO:0003012	muscle system process	TRIM72, SCO2
5	GO:0060073	micturition	KCNMA1, ADRA1A
5	GO:0070293	renal absorption	SLC9A3R1, HBB, AKR1C3
5	GO:0001976	neurological system process involved in regulation of systemic arterial blood pressure	DRD2, MECP2, CALCA
5	GO:0010159	specification of organ position	HOXA3, BMP4, FOXH1, TBX3
5	GO:0021532	neural tube patterning	PTCH1, RPGRIP1L, TMEM107
5	GO:0021796	cerebral cortex regionalization	EMX2, EMX1, PAX6
5	GO:0021871	forebrain regionalization	WNT7B, LHX1, PGAP1, WNT2B
5	GO:0021978	telencephalon regionalization	LHX2, BMP4, BMP2, SHH
4	GO:0009798	axis specification	WNT6, APC
5	GO:0009855	determination of bilateral symmetry	ALDH1A2, RALDH2
4	GO:0065001	specification of axis polarity	AHI1, BCOR
5	GO:0010085	polarity specification of proximal/distal axis	NODAL, WNT8A
4	GO:0044241	lipid digestion	PNLIP, CEL, CLPS, PNLIPRP2
5	GO:0042637	catagen	TGFB2, BARX2
5	GO:0048820	hair follicle maturation	ERCC2, RBPJ
4	GO:0032902	nerve growth factor production	PCSK6, FURIN
4	GO:0042596	fear response	ADRA2A, DRD4, DBH, ADRB1
3	GO:0034381	plasma lipoprotein particle clearance	MSR1, CD36
4	GO:0034447	very-low-density lipoprotein particle clearance	APOC1, APOE, VLDLR
4	GO:0060437	lung growth	RSPO2, SPRY2
4	GO:0042633	hair cycle	PTCH2, PPP1R13L, MPZL3, SNRPE
4	GO:0002248	connective tissue replacement involved in inflammatory response wound healing	TGFB1, HIF1A, F2R
4	GO:0003294	atrial ventricular junction remodeling	GJA1, GJA5
4	GO:0048871	multicellular organismal homeostasis	PPP1R13L, TENC1, NDN
3	GO:0050878	regulation of body fluid levels	PDSS2, HEG1, EPHB2
5	GO:0050882	voluntary musculoskeletal movement	HIPK2, ITPR1
5	GO:0050883	musculoskeletal movement, spinal reflex action	DRD3, CACNA1A
4	GO:0007509	mesoderm migration involved in gastrulation	EPB41L5, T
5	GO:0042249	establishment of planar polarity of embryonic epithelium	FOXF2, CELSR1
4	GO:0060197	cloacal septation	TP63, BMP4, WNT11
3	GO:0035922	foramen ovale closure	TBX20, GJA5
2	GO:0009838	abscission	SPG20, IST1
5	GO:0061042	vascular wound healing	MCAM, CD34, HPSE
4	GO:0001705	ectoderm formation	LHX1, FOXA2
5	GO:0048320	axial mesoderm formation	EPHA2, AXIN1
5	GO:0048341	paraxial mesoderm formation	HTT, LEF1, HNF1A, FOXC1
3	GO:0003188	heart valve formation	SOX9, SCXA
4	GO:0003190	atrioventricular valve formation	SMAD4, HEY1
4	GO:0003192	mitral valve formation	NOTCH1, ZFPM1
4	GO:0003193	pulmonary valve formation	TBX20, GJA5
4	GO:0003195	tricuspid valve formation	ZFPM1, HEY2
3	GO:0003207	cardiac chamber formation	NOTCH1, TBX20
5	GO:0003218	cardiac left ventricle formation	HAND1, TBX5
5	GO:0003219	cardiac right ventricle formation	NOTCH1, HAND1, HAND2, SMARCD3
3	GO:0003272	endocardial cushion formation	TBX20, BMPR1A
4	GO:0010260	organ senescence	PDX1, CTGF
5	GO:0032289	central nervous system myelin formation	ERCC2, TENM4
5	GO:0032290	peripheral nervous system myelin formation	DICER1, NCMAP
3	GO:0014028	notochord formation	EPHA2, T, EFNA1
3	GO:0021508	floor plate formation	SMO, FOXH1, GLI2
4	GO:0021623	oculomotor nerve formation	PHOX2A, TFAP2A
5	GO:0021722	superior olivary nucleus maturation	CDK5R1, CDK5R2
5	GO:0070977	bone maturation	GH1, FGFR3
5	GO:0034505	tooth mineralization	COL1A1, AMELX
5	GO:0001838	embryonic epithelial tube formation	WNT4, SHANK3, RET
3	GO:0035802	adrenal cortex formation	CITED2, WT1
4	GO:0048069	eye pigmentation	LEF1, HPS1
4	GO:0021589	cerebellum structural organization	DAB1, HSPA5
5	GO:0021612	facial nerve structural organization	HOXA1, EGR2, HOXB2, HOXB1
5	GO:0021633	optic nerve structural organization	KCNA2, PAX2
4	GO:0001832	blastocyst growth	ZNF830, UBTF, NBN, SMARCA4
4	GO:0048630	skeletal muscle tissue growth	CHRNA1, IGFBP5, CHRND
5	GO:0072092	ureteric bud invasion	SALL1, KIF26B
4	GO:0060440	trachea formation	BMP4, TGFBR2, CTNNB1
4	GO:0060914	heart formation	SOX17, BMPR1A
3	GO:0048859	formation of anatomical boundary	NODAL, SMAD4, SHH, GDF3
3	GO:0060033	anatomical structure regression	WNT7B, CD248, LEF1, SPI1
4	GO:0060032	notochord regression	GLI2, GLI1
3	GO:0060061	Spemann organizer formation	WNT1, FZD5
3	GO:0060214	endocardium formation	OVOL2, SOX18, SOX17, PROX1
3	GO:0060661	submandibular salivary gland formation	FGF10, CDC42
5	GO:0046619	optic placode formation involved in camera-type eye formation	FRS2, PROX1
4	GO:0030910	olfactory placode formation	AXIN1, SOX2, POU2F1, PROX1
4	GO:0060596	mammary placode formation	LRP6, TBX2, NRG3, TBX3
3	GO:0060900	embryonic camera-type eye formation	STRA6, TWIST1
3	GO:0072033	renal vesicle formation	WNT4, CTNNB1
3	GO:0072104	glomerular capillary formation	NOTCH3, BMP4
4	GO:0072277	metanephric glomerular capillary formation	TCF21, PDGFRB, PDGFRA
3	GO:0072179	nephric duct formation	PAX2, GATA3
4	GO:0044117	growth of symbiont in host	PGLYRP3, PGLYRP2, PGLYRP1, PGLYRP4
2	GO:0033058	directional locomotion	GRIN2C, GRIN2A, ARPIN
3	GO:0003419	growth plate cartilage chondrocyte proliferation	CER1, NPPC
3	GO:0014009	glial cell proliferation	LGI4, SOX11, SOX4, PTK2B
4	GO:0014010	Schwann cell proliferation	CTNNB1, NF2
4	GO:0048659	smooth muscle cell proliferation	EDNRA, AGT, NAA35
3	GO:0033687	osteoblast proliferation	LRRC17, OSR2, JUNB, FIGNL1
3	GO:0035726	common myeloid progenitor cell proliferation	UNCX, GSTP1, FLT3
3	GO:0048144	fibroblast proliferation	WNT7B, EDNRA, SP2, AGT
5	GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation	TFAP2C, WNT5A, MED1, ESR1
3	GO:0051450	myoblast proliferation	IGF1, MET, HGF, GPX1
4	GO:0033278	cell proliferation in midbrain	FZD3, FZD6
4	GO:0002158	osteoclast proliferation	NPR3, CSF1, TNFSF11
4	GO:0032943	mononuclear cell proliferation	ACE, TGFB1
4	GO:0010463	mesenchymal cell proliferation	HAND2, FGF7, FGF4
2	GO:0016265	death	SLC18A2, TCF15, NR4A2
3	GO:0001543	ovarian follicle rupture	NRIP1, AGT
3	GO:0001546	preantral ovarian follicle growth	GPR149, AMH
3	GO:0001550	ovarian cumulus expansion	EREG, BMPR1B
3	GO:0001554	luteolysis	MMP19, CASP2
3	GO:0060112	generation of ovulation cycle rhythm	KISS1, NPY5R
5	GO:0045475	locomotor rhythm	KCNMA1, NPAS2, NAGLU, PTEN
5	GO:0015993	molecular hydrogen transport	SLC23A2, ADHFE1
5	GO:0043490	malate-aspartate shuttle	SLC25A13, SLC25A12
5	GO:0015918	sterol transport	ABCG5, ABCG8, NPC1L1
5	GO:0015920	lipopolysaccharide transport	LBP, SCARB1
4	GO:0015697	quaternary ammonium group transport	SLC22A5, SLC22A3, SLC22A4
4	GO:0015837	amine transport	AQP9, SLC22A16, RHCG
4	GO:0015851	nucleobase transport	SLC23A2, SLC23A1
5	GO:0048227	plasma membrane to endosome transport	SORT1, RAB11A
5	GO:1990126	retrograde transport, endosome to plasma membrane	MICALL1, RAB11B, SNX27
4	GO:0030185	nitric oxide transport	AQP1, EDN1, HBB
5	GO:0032066	nucleolus to nucleoplasm transport	NOC2L, WRN, TBRG1
4	GO:0035526	retrograde transport, plasma membrane to Golgi	USP6NL, RAB43
5	GO:0042045	epithelial fluid transport	EDN1, EDNRB, SLC26A6, CSF2
5	GO:0046717	acid secretion	DRD2, DRD3, SLC22A16
5	GO:0046967	cytosol to ER transport	TAP1, TAP2
5	GO:0015889	cobalamin transport	GIF, TCN1, TCN2, CUBN
4	GO:0070633	transepithelial transport	CXADR, SLC26A6, GPLD1
4	GO:0071985	multivesicular body sorting pathway	RAB27A, RAB27B, SYTL4, EXPH5
5	GO:0034436	glycoprotein transport	ABCG1, VLDLR
5	GO:0001941	postsynaptic membrane organization	CHRNB1, GDNF
5	GO:0010256	endomembrane system organization	ARFGEF1, ARFGEF2
5	GO:0031579	membrane raft organization	PPT1, CAV3, DLG1
5	GO:0033292	T-tubule organization	CAV3, ANK2
5	GO:0045161	neuronal ion channel clustering	MTCH1, PICK1
5	GO:0048499	synaptic vesicle membrane organization	AP3D1, SYP
5	GO:0071709	membrane assembly	SPTBN1, ANK3
5	GO:0071763	nuclear membrane organization	TOR1A, TOR1B, TOR1AIP1
5	GO:0097035	regulation of membrane lipid distribution	TRIAP1, PRELID1
5	GO:0042745	circadian sleep/wake cycle	TH, NPAS2
4	GO:0002357	defense response to tumor cell	PRF1, PLK5
5	GO:0002215	defense response to nematode	EPX, TNFSF4
5	GO:0010193	response to ozone	SCGB1A1, CYP2E1, NGF, TACR1
5	GO:0071731	response to nitric oxide	CCL19, EGLN1, CCR7
4	GO:0001306	age-dependent response to oxidative stress	SOD2, CLN8, COQ7
5	GO:0006982	response to lipid hydroperoxide	APOA4, GPX3
3	GO:0006991	response to sterol depletion	LYN, INSIG1
5	GO:0009414	response to water deprivation	TH, CD9
5	GO:0002246	wound healing involved in inflammatory response	HMOX1, CD44
5	GO:0034059	response to anoxia	OXTR, CTGF
3	GO:0035902	response to immobilization stress	CRHR1, TPH1, CRH, UCN3
5	GO:0051788	response to misfolded protein	F12, HDAC6, CLU
3	GO:0051409	response to nitrosative stress	ADH5, GCLM, GCLC, DUSP6
5	GO:0051599	response to hydrostatic pressure	KRT8, NTRK1
5	GO:0002023	reduction of food intake in response to dietary excess	NMUR2, PRLH
5	GO:0009583	detection of light stimulus	PDE6B, OPN3
4	GO:0009590	detection of gravity	OTOP1, NOX3
4	GO:0016048	detection of temperature stimulus	NGFR, DRGX
5	GO:0035995	detection of muscle stretch	TCAP, CSRP3, TTN
5	GO:0050974	detection of mechanical stimulus involved in sensory perception	SERPINE2, ASIC2
4	GO:0010996	response to auditory stimulus	NTRK2, CXCL10, TACR1
4	GO:0035994	response to muscle stretch	TCAP, ANKRD1
3	GO:0009991	response to extracellular stimulus	RASGRP4, RPS19, ACTA1
4	GO:0060005	vestibular reflex	NR4A3, TMC1, TMC2
4	GO:0097195	pilomotor reflex	HPN, ADRA1A, NPNT
4	GO:0002238	response to molecule of fungal origin	MYD88, TLR2
3	GO:0009595	detection of biotic stimulus	NLRP3, NOD1, NOD2
4	GO:0001562	response to protozoan	VTCN1, SPN, IER3
5	GO:0009609	response to symbiotic bacterium	GPX1, GPX2
5	GO:0009597	detection of virus	IFIH1, DDX58, TLR3
5	GO:0001878	response to yeast	NCF1, MPO, ELANE, PTX3
4	GO:0009624	response to nematode	IL25, CYP1A1, ITLN1
4	GO:0071502	cellular response to temperature stimulus	HTR1B, HTR2B
4	GO:0010447	response to acidity	GPR65, SLC9A1
5	GO:0009642	response to light intensity	SLC24A1, GNAT1, GNAT2
5	GO:0009648	photoperiodism	NMU, CLOCK
3	GO:0009582	detection of abiotic stimulus	NPFFR2, TAC1, TIMELESS, TACR1
4	GO:0014878	response to electrical stimulus involved in regulation of muscle adaptation	RPS6KB1, TRIM63, MYOG
4	GO:0003032	detection of oxygen	SOD2, CYB5R4, SLC11A2
5	GO:0044321	response to leptin	NR1D1, STAR
5	GO:0097066	response to thyroid hormone	HPN, AK2
4	GO:0003127	detection of nodal flow	PKD2, PKD1L1
5	GO:0034776	response to histamine	DRD4, DRD2, DRD3
5	GO:0046898	response to cycloheximide	BCL2L1, GHR
5	GO:0097338	response to clozapine	PRKAR2B, PRKACB
5	GO:0055098	response to low-density lipoprotein particle	ABCA1, SREBF2, PPARG
5	GO:0055099	response to high density lipoprotein particle	ADAM17, ABCG1
4	GO:0014873	response to muscle activity involved in regulation of muscle adaptation	AGT, MYOG
2	GO:0014854	response to inactivity	DRD2, IL10
3	GO:0009593	detection of chemical stimulus	DRGX, UGT2A1
5	GO:0050968	detection of chemical stimulus involved in sensory perception of pain	ASIC3, TRPA1
5	GO:0046684	response to pyrethroid	SCN1B, TH, SCN2B, DDC
4	GO:0060992	response to fungicide	GRIN1, CYP17A1, STAR, CYP11A1
5	GO:0043331	response to dsRNA	PMAIP1, PELI1
5	GO:0070669	response to interleukin-2	CITED1, STAT5B, JAK3
5	GO:0070671	response to interleukin-12	RIPK2, JAK2
5	GO:0070672	response to interleukin-15	STAT5B, JAK3, ACSL4
5	GO:0070741	response to interleukin-6	CITED1, CHI3L1, SFTPC, FOXA2
5	GO:0071104	response to interleukin-9	CITED1, JAK3
4	GO:0034465	response to carbon monoxide	EGR1, KCNMA1, IL10
4	GO:0046683	response to organophosphorus	TYMS, RFC3, AKR1C1, TRIM16
5	GO:0010044	response to aluminum ion	MAOB, QDPR, LONP1
5	GO:0032025	response to cobalt ion	D2HGDH, CASP8
4	GO:0010157	response to chlorate	PTCH1, PDX1
4	GO:0034021	response to silicon dioxide	SOD2, SCGB1A1
3	GO:0050906	detection of stimulus involved in sensory perception	PPEF2, PPEF1
4	GO:0008105	asymmetric protein localization	SCRIB, WNT7A, COLQ, DYNC2H1
5	GO:0045175	basal protein localization	NCKAP1, ERBB2IP
4	GO:0031503	protein complex localization	KIF17, BIRC5, DNMT3B, FKBP4
5	GO:0071896	protein localization to adherens junction	SCRIB, DSP, MPP7
3	GO:1901998	toxin transport	SLC17A3, LRP6, ABCG1, SLC7A8
5	GO:0071169	establishment of protein localization to chromatin	CCDC101, LRWD1
3	GO:0051303	establishment of chromosome localization	NDE1, BIRC5
4	GO:0051310	metaphase plate congression	CENPF, SPICE1
5	GO:0032401	establishment of melanosome localization	RAB17, SHROOM2
5	GO:0051877	pigment granule aggregation in cell center	MKKS, BBS4, BBS7
3	GO:0051654	establishment of mitochondrion localization	PVRL2, FEZ1
3	GO:0051683	establishment of Golgi localization	ARHGAP21, COPG1, CDC42
2	GO:0009405	pathogenesis	TMEM181, MECP2, CARM1
3	GO:0051702	interaction with symbiont	GPX1, GPX2
5	GO:0002920	regulation of humoral immune response	CD37, SPNS2, CXCL13
3	GO:0006808	regulation of nitrogen utilization	BCL2, BAX
5	GO:0009890	negative regulation of biosynthetic process	GCHFR, GSTP1
5	GO:0060267	positive regulation of respiratory burst	INSR, CAMK1D, INS
4	GO:0032350	regulation of hormone metabolic process	FSHR, TCF7L2
4	GO:0060263	regulation of respiratory burst	RAC2, RAC1, NOXO1, NOXA1
5	GO:0051712	positive regulation of killing of cells of other organism	NOS2, IFNG, FCER2
5	GO:0031652	positive regulation of heat generation	SLC27A1, APLN
5	GO:2000189	positive regulation of cholesterol homeostasis	NR1D1, ACOX1, NR1H3, HNF4A
5	GO:2000507	positive regulation of energy homeostasis	SGIP1, PPARGC1A
5	GO:0003254	regulation of membrane depolarization	FHL1, NEDD4L, RANGRF
5	GO:0061088	regulation of sequestering of zinc ion	SLC30A8, SLC30A4, SLC30A3, AP3D1
4	GO:2000188	regulation of cholesterol homeostasis	NR1D1, SREBF2, FGFR4
5	GO:0060178	regulation of exocyst localization	RALB, RALGAPA2, RALGAPB
5	GO:0060632	regulation of microtubule-based movement	IGBP1, MAPT, HDAC6
5	GO:0001560	regulation of cell growth by extracellular stimulus	KIF26A, PPP1R9B, MYOCD
4	GO:0040009	regulation of growth rate	PARP1, WRN, BNIPL
5	GO:0060420	regulation of heart growth	DUSP6, MYH6
4	GO:0042753	positive regulation of circadian rhythm	BTRC, FBXW11
5	GO:0060406	positive regulation of penile erection	EDNRB, OXT, OXTR, P2RY1
5	GO:0033623	regulation of integrin activation	FBLIM1, FARP2, SELP
5	GO:0060491	regulation of cell projection assembly	CCL19, FAM110C
4	GO:0090083	regulation of inclusion body assembly	SNCAIP, BAG5
5	GO:0090084	negative regulation of inclusion body assembly	SACS, HSPA1A, DNAJB2
5	GO:1900106	positive regulation of hyaluranon cable assembly	HAS3, BMP7, HYAL1
4	GO:1901888	regulation of cell junction assembly	RAPGEF1, RAPGEF2, RAP1B, RAP1A
5	GO:0043243	positive regulation of protein complex disassembly	TNF, MGEA5, BNIP3
5	GO:0050867	positive regulation of cell activation	JAK2, CTGF
5	GO:0090343	positive regulation of cell aging	LMNA, TP53
5	GO:0060760	positive regulation of response to cytokine stimulus	TAF9, WNT5A
5	GO:0010902	positive regulation of very-low-density lipoprotein particle remodeling	APOC2, APOA5
5	GO:0060279	positive regulation of ovulation	PLAT, INHBA, INHBB
5	GO:0010716	negative regulation of extracellular matrix disassembly	CST3, FAP, DPP4
5	GO:0043242	negative regulation of protein complex disassembly	SLN, TNF, HDAC6, IRAK3
5	GO:0051782	negative regulation of cell division	PTCH1, TXNIP, BLM, MYC
5	GO:0090288	negative regulation of cellular response to growth factor stimulus	CASK, SLIT2
5	GO:2000360	negative regulation of binding of sperm to zona pellucida	ASTL, ZP3, ZP4
5	GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling	APOC3, APOA1, APOA2
5	GO:0050819	negative regulation of coagulation	PROCR, HS3ST5, ANXA5, ANXA4
5	GO:1900222	negative regulation of beta-amyloid clearance	LRPAP1, SRF, MYOCD
5	GO:0047484	regulation of response to osmotic stress	MLC1, TRPV4, GYPA
5	GO:0061041	regulation of wound healing	PLAU, VIL1
4	GO:2001023	regulation of response to drug	ADIRF, GABRA4
5	GO:2001038	regulation of cellular response to drug	NCOA1, HMGA2
5	GO:0010453	regulation of cell fate commitment	FGFR2, PAX7
5	GO:0051147	regulation of muscle cell differentiation	SUPT6H, CAMK1, MEGF10
5	GO:0010649	regulation of cell communication by electrical coupling	CASQ2, TRDN, ASPH, SRI
5	GO:1901214	regulation of neuron death	RILPL1, SARM1, DHCR24
4	GO:0032878	regulation of establishment or maintenance of cell polarity	IGF1, LLGL2, TEK
4	GO:0032970	regulation of actin filament-based process	PARD3, CNN2, FRMD6
5	GO:0090170	regulation of Golgi inheritance	MAPK3, MAPK1, MAP2K2, MAP2K1
5	GO:1900063	regulation of peroxisome organization	MAVS, DNM1L, MFF
5	GO:0014842	regulation of satellite cell proliferation	PAXBP1, CFLAR, ANGPT1, MYOG
5	GO:0033688	regulation of osteoblast proliferation	RHOA, NPR3, FGFR2
5	GO:0072091	regulation of stem cell proliferation	AGO3, SOX18, SOX17, YAP1
5	GO:2000254	regulation of male germ cell proliferation	RHBDD1, RSPO1
5	GO:0051823	regulation of synapse structural plasticity	CAMK2B, CTNNA2, NCAN, DMPK
5	GO:0009786	regulation of asymmetric cell division	POU5F1, WNT9B
5	GO:2000035	regulation of stem cell division	SFRP2, SOX17
4	GO:0060968	regulation of gene silencing	HIST1H3A, CDK2
5	GO:2000327	positive regulation of ligand-dependent nuclear receptor transcription coactivator activity	RQCD1, CNOT6
5	GO:0032649	regulation of interferon-gamma production	RIPK3, ISG15, CCR7
5	GO:0032675	regulation of interleukin-6 production	MAPKAPK2, HLA-B, AFAP1L2
5	GO:0032680	regulation of tumor necrosis factor production	MAPKAPK2, TBC1D23, ZFP36, LTF
5	GO:0034344	regulation of type III interferon production	IFIH1, DDX58
5	GO:0010988	regulation of low-density lipoprotein particle clearance	HNRNPK, CNPY2, FGF21
4	GO:0034103	regulation of tissue remodeling	CST3, TP53, THBS4
5	GO:0046850	regulation of bone remodeling	INPP4B, SUCO, GJA1
4	GO:0042634	regulation of hair cycle	NIPBL, FA2H
5	GO:0044065	regulation of respiratory system process	MTG2, MTG1, FTO
3	GO:0051917	regulation of fibrinolysis	APOH, FAP
3	GO:0097006	regulation of plasma lipoprotein particle levels	LPCAT3, DGAT2
3	GO:1900271	regulation of long-term synaptic potentiation	NLGN3, SHANK3
4	GO:0080154	regulation of fertilization	RNASE10, ASUN, PLCB1
3	GO:0001505	regulation of neurotransmitter levels	ZNF219, GABRA2, PDE1B, DVL1
4	GO:0014916	regulation of lung blood pressure	GCH1, BMPR2
5	GO:0003085	negative regulation of systemic arterial blood pressure	NEDD4L, IER3, BBS4, BMPR2
3	GO:0010817	regulation of hormone levels	BCAT2, FOXA3, FOXA2, SOX8
5	GO:0045759	negative regulation of action potential	CNR1, CNR2, CHRNB2
5	GO:0086001	regulation of cardiac muscle cell action potential	DMD, PKP2
5	GO:0010917	negative regulation of mitochondrial membrane potential	PMAIP1, PRELID1
4	GO:0045838	positive regulation of membrane potential	PIAS3, ANK3, GIMAP5
5	GO:0010918	positive regulation of mitochondrial membrane potential	STOML2, BAD
5	GO:0086010	membrane depolarization involved in regulation of action potential	YWHAH, SCN3B, KCNH2, SCN5A
4	GO:0060075	regulation of resting membrane potential	KCNJ10, PSEN1, KCNJ2
4	GO:0086036	regulation of cardiac muscle cell membrane potential	ATP2A2, TRDN, EHD3, PLN
5	GO:0030104	water homeostasis	IGF1, AQP9, NEDD4L, GHRHR
5	GO:0050801	ion homeostasis	WNK4, KLHL3, AMELX, CRH
3	GO:0050803	regulation of synapse structure and activity	PPT1, APP, SYNGAP1
5	GO:0030730	sequestering of triglyceride	IL1B, TNF, ENPP1
5	GO:0032119	sequestering of zinc ion	S100A9, S100A8, SLC30A8, SLC30A7
5	GO:0051208	sequestering of calcium ion	ATP7B, CALR, CASQ2, HSP90B1
5	GO:0035565	regulation of pronephros size	HNF1B, HNF1A
5	GO:0035566	regulation of metanephros size	PAX2, AGTR2
3	GO:0040030	regulation of molecular function, epigenetic	ASIP, CTCF
4	GO:0051100	negative regulation of binding	CYP2D6, YBX2, P2RY1
5	GO:0035562	negative regulation of chromatin binding	TDG, WAPAL, MEPCE, SENP2
5	GO:1901877	negative regulation of calcium ion binding	SLN, PLN
5	GO:0001845	phagolysosome assembly	P2RX7, SRPX, CORO1A, MYO7A
4	GO:0010324	membrane invagination	FCHO2, FNBP1L
4	GO:0016557	peroxisome membrane biogenesis	PEX11A, PEX19, PEX16, PEX3