Difference between revisions of "Applied Bioinformatics Main Page"

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<small>'''This is our main tool to coordinate information, activities and projects in University of Toronto's bioinformatics course BCH441'''. If you are not one of our students, you can still browse this site, however only users with a login account can edit or contribute or edit material. If you are here because you are interested in general aspects of bioinformatics or computational biology, you may want to review the [http://en.wikipedia.org/wiki/Bioinformatics Wikipedia article on bioinformatics], or visit [http://www.openwetware.org/wiki/Wikiomics Wikiomics]. Contact boris.steipe(at)utoronto.ca with any questions you may have.</small>
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<small>'''These wiki pages are provided to coordinate information, activities and projects in the applied bioinformatics courses taught by Boris Steipe at the University of Toronto'''. If you are not one of my students, you can still browse this site, however only users with a login account can edit or contribute or edit material. If you are here because you are interested in general aspects of bioinformatics or computational biology, you may want to review the [http://en.wikipedia.org/wiki/Bioinformatics Wikipedia article on bioinformatics], or visit [http://www.openwetware.org/wiki/Wikiomics Wikiomics]. Contact boris.steipe(at)utoronto.ca with any questions you may have.</small>
  
 
== The Course ==
 
== The Course ==
  
<div style="padding: 5px; background: #C3CBF7;  border:solid 1px #AAAAAA;">
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BCB410H1F is the undergraduate course code and JTB2020H1S is the course code for graduate students. However the delivery and scope of the courses is very different:
I am in the process of repairing the original course Wiki and many of the pages are still arbitrarily outdated. Please don't use pages other than those that are linked directly from here.
+
 
<br>
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* BCB410 is intended for students in the Bioinformatics and Computational Biology Specialist Program. Therefore I assume that all students are very familiar with a wide variety of computer science related topics and their practical application.
<span style="font-size:80%;">Contact Boris Steipe for all matters of urgency. November 11. 2011</span>
+
* JTB2020 is designed for students in the Collaborative PhD Program in Bioinformatics and Genome Biology. These students have a wide variety of backgrounds and prior experience. They participate in  the [[Computational_Systems_Biology_Main_Page|Computational Systems Biology Course]] and go through a number of targeted exercises in applied bioinformatics to add as much material to their knowledge- and skill set as can reasonably be acquired in a single term.
</div>
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===Organization===
 
===Organization===
 +
 +
 +
 
;Dates
 
;Dates
  
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</div>
 
</div>
  
== Temporary links for material ==
 
 
===Lecture slides===
 
*[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/01-Introduction.pdf 01 - Introduction to the course <small>(pdf, 6.1 MB)</small>]
 
*[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/02-SequenceData.pdf 02 - Sequence Data <small>(pdf, 4.6 MB)</small>]
 
*[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/03-StructureData.pdf  03 - Structure Data <small>(pdf, 13.6 MB)</small>]
 
*[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/04-SequenceAnalysis_I.pdf  04 - Sequence Analysis I <small>(pdf, 8.6 MB)</small>]
 
*[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/05-SequenceAnalysis_II.pdf  05 - Sequence Analysis II <small>(pdf, 3.1 MB)</small>]
 
*[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/06-InterpretingProteinStructure.pdf 06 - Interpreting Protein Structure <small>(pdf, 6.6 MB)</small>]
 
*[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/07-StructuralDomains.pdf 07 - Structural Domains <small>(pdf, 5.8 MB)</small>]
 
*[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/08-Genome_Sequencing_2011.pdf 08 - Genome Sequencing <small>(pdf, 1.4 MB)</small>]
 
*[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/09-GenomeAnnotation_2011.pdf 09 - Genome Annotation <small>(pdf, 4.2 MB)</small>]
 
*[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/10-Homology_I_Principles.pdf 10 - Homology I: Principles <small>(pdf, 2.6 MB)</small>]
 
*[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/11-Homology_II_Alignment.pdf 11 - Homology II: Optimal Sequence Alignment <small>(pdf, 2.6 MB)</small>]
 
*[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/12-Homology_III_BLAST.pdf 12 - Homology III: BLAST <small>(pdf, 2.6 MB)</small>]
 
*[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/13-Homology_IV_MSA.pdf 13 - Homology IV: Multiple Sequence Alignment <small>(pdf, 4.3 MB)</small>]
 
*[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/14-PredictingProteinStructure_I.pdf 14 - Predicting Protein Structure I: Homology Modeling <small>(pdf, 2.3 MB)</small>]
 
*[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/15-PhylogeneticAnalysis_I.pdf 15 - Phylogenetic Analysis I <small>(pdf, 3.3 MB)</small>]
 
*[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/16-PhylogeneticAnalysis_II.pdf 16 - Phylogenetic Analysis II <small>(pdf, 1.0 MB)</small>]
 
* 17 - ''Comparative Genomics ''
 
* 18 - ''Computational Systems Biology ''
 
*[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/19-StatisticsAndExploratoryDataAnalysis.pdf 19 - Statistics and Exploratory Data Analysis <small>(pdf, 3.4 MB)</small>]
 
* [http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/20-PredictingProteinStructure_II.pdf 20 - Structure Prediction II: ''ab initio'' Prediction  <small>(pdf, 10.0 MB)</small>]
 
* [http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/22-Outlook-ComputationalSystemsBiology.pdf 22 - Outlook: Computational Systems Biology <small>(pdf, 2.4 MB)</small>]
 
 
===Lecture recordings===
 
*Thursday, 15. September 2011: [http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/02-SequenceData_2011.mp4 Lecture 02 (Sequence data) <small>(mp4, 16.4 MB)</small>]
 
*Monday, 19. September 2011: [http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/03-Structure-Data_2011.mp4  Lecture 03 (Sequence data ''cont.''; Structure Data) <small>(mp4, 17.2 MB)</small>]
 
*Thursday, 22. September 2011: [http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/04-StructureData-SequenceAnalysis_I_2011.mp4  Lecture 04 (Structure data ''cont.''; Sequence Analysis I) <small>(mp4, 16.9 MB)</small>]
 
*Monday, 26. September 2011: [http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/05-SequenceAnalysis_I-II_2011.mp4  Lecture 05 Sequence Analysis I ''cont.'' & II <small>(mp4, 15.3 MB)</small>]
 
*Thursday, 29. September 2011: [http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/06-SequenceAnalysis_II-StructureAnalysis_2011.mp4  Lecture 06 Sequence Analysis II ''cont.'' & Analysis of structure <small>(mp4, 15.6 MB)</small>]
 
*Monday, 3. October 2011: [http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/2011-10-03_Topic-06b.mp4  Analysis of Structure (cont.) <small>(mp4, 18.3 MB)</small>]
 
*Thursday, 6. October 2011: [http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/2011-10-06_Topic-07.mp4  Lecture 07 Protein Structural Domains  <small>(mp4, 16.3 MB)</small>]
 
*Thursday, 13. October 2011: (Parkinson)
 
*Monday, 17. October 2011:  (Parkinson)
 
*Thursday, 20. October 2011: [http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/2011-10-20_Topic-10.mp4  Lecture 10 Homology I: Principles <small>(mp4, 19.4 MB)</small>]
 
 
*Monday, 24. October 2011: [http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/2011-10-24_Topic-11.mp4  Lecture 11 Homology II: Optimal Sequence Alignment <small>(mp4, 12.4 MB)</small>]
 
*Thursday, 27. October 2011: [http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/2011-10-27_Topic-12.mp4  Lecture 12 Homology III: BLAST <small>(mp4, 16.8 MB)</small>]
 
*Monday, 31. October 2011: [http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/2011-10-31_Topic-13.mp4  Lecture 13 Homology IV: Multiple Sequence Alignment <small>(mp4, 22.7 MB)</small>]
 
*Thursday, 3. November 2011: [http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/2011-11-04_Topic-14.mp4  Lecture 14 Predicting Protein Structure I: Homology Modeling <small>(mp4, 18.7 MB)</small>]
 
*Thursday, 10. November 2011: [http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/2011-11-10_Topic-15.mp4  Lecture 15 Phylogenetic Analysis I: Principles <small>(mp4, 16.7 MB)</small>]
 
*Monday, 14. November 2011: [http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/2011-11-14_Topic-16.mp4  Lecture 16 Phylogenetic Analysis II <small>(mp4, 18.5 MB)</small>]
 
*Thursday, 17. November 2011: Lecture 17 Comparative Genomics (Parkinson)
 
*Monday, 21. November 2011: Lecture 18 Computational Systems Biology (Parkinson)
 
*Thursday, 24. November 2011: [http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/2011-11-24_Topic-19.mp4  Lecture 19 Exploratory Data Analysis <small>(mp4, 20.0 MB)</small>]
 
 
 
*Monday, 28. November 2011: [http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/2011-11-28_Topic-20a.mp4 Lecture 20 Protein structure prediction II: ''ab initio'' <small>(mp4, 15.5 MB)</small>]
 
*Thursday, 1. December 2011: [http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/2011-12-01_Topic-20b.mp4 Lecture 20 ''cont.'' <small>(mp4, 13.2 MB)</small>]
 
*Monday, 6. December 2011: Outlook: Computational Systems Biology
 
 
 
 
 
<!--
 
== Organization ==
 
 
;Dates
 
:''Lectures'': Monday and Thursday, 12:00 to 13:00
 
:''Tutorial sessions'': Mondays, 13:00 to 14:00 <small>&nbsp;&nbsp;for in-class quizzes, quiz debriefings, exam preparation and other activities, as the need arises.</small>
 
 
;Location
 
:MSB 2173 (Medical Sciences Building)
 
 
See the [http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/ Course Web page] for general information.
 
 
We are recommending '''[http://www.garlandscience.com/textbooks/0815340249.asp Understanding Bioinformatics]''', Zvelebil &amp; Baum, Garland 2008 as a background textbook for the course. <small>([http://www.amazon.ca/Understanding-Bioinformatics-Market-Zvelebil/dp/0815340249 amazon], [http://www.uoftbookstore.com/online/merchant.ihtml?pid=1051140&step=4 UofT Bookstore])</small>
 
 
== Grading and Activities ==
 
 
<table cellpadding="5">
 
 
<tr class="sh">
 
<td>'''Activity'''</td>
 
<td>'''Weight'''<br><small>(Undergraduates)</small></td>
 
<td>'''Weight'''<br><small>(Graduates)</small></td>
 
</tr>
 
 
<tr class="sp"><td colspan="3" style="height: 5px;"></td></tr>
 
 
<tr class="s0">
 
<td>[[Assignments|'''5 Assignments''' (drop 1)]]</td>
 
<td>16 marks <small>(4 x 4)</small></td>
 
<td>12 marks <small>(4 x 3)</small></td>
 
</tr>
 
 
 
<tr class="s1">
 
<td>[[Quizzes|'''5 In-class quizzes''' (drop 1)]]</td>
 
<td>32 marks <small>(4 x 8)</small></td>
 
<td>20 marks <small>(4 x 5)</small></td>
 
</tr>
 
 
<tr class="s0">
 
<td>'''[[Group project]]'''</td>
 
<td>10 marks</td>
 
<td>6 marks</td>
 
</tr>
 
 
<tr class="s1">
 
<td>'''[[Participation]]'''</td>
 
<td>2 marks</td>
 
<td>2 marks</td>
 
</tr>
 
 
<tr class="s0">
 
<td>'''[[Graduate project]]'''</td>
 
<td>&nbsp;</td>
 
<td>20 marks</td>
 
</tr>
 
 
<tr class="s1">
 
<td>[[Exam questions|'''Final exam''']]</td>
 
<td>40 marks</td>
 
<td>40 marks</td>
 
</tr>
 
 
<tr class="sp"><td colspan="3" style="height: 5px;"></td></tr>
 
 
<tr class="s0">
 
<td>'''Total'''</td>
 
<td>100 marks</td>
 
<td>100 marks</td>
 
</tr>
 
 
</table>
 
 
I will not adjust marks towards a target average for the class ("Belling"). If your classmate gets a great mark because you helped him with a difficult concept, this will have no bearing whatsoever on your own mark. Collaborate as much as possible, it is a great way to learn. The only times I will consider adjusting marks is if we phrase questions ambiguously on quizzes or if I decide that the final exam was too long.
 
 
== Lecture Schedule ==
 
<small>This section is currently under construction.</small>
 
 
 
<table cellpadding="5">
 
 
<tr class="st">
 
<td colspan="7">'''I n t r o d u c t i o n'''</td>
 
</tr>
 
 
<tr class="sh">
 
<td>'''#'''</td>
 
<td>'''Date'''</td>
 
<td>'''Lecturer'''</td>
 
<td>'''Topic'''</td>
 
<td>'''Handout'''</td>
 
<td>'''Book'''</td>
 
<td>'''Note'''</td>
 
</tr>
 
 
<tr class="s1">
 
<td>1</td>
 
<td>Mon. Sept 8</td>
 
<td>Steipe</td>
 
<td>Organisation and Orientation</td>
 
<td>[[Introduction]]</td>
 
<td>Ch 1, 2</td>
 
<td>-</td>
 
</tr>
 
 
 
 
 
--><!--  ===================    TOPIC    ===================  --><!--
 
<tr class="sp"><td colspan="7" style="height: 10px;"></td></tr>
 
<tr class="st">
 
<td colspan="7">'''A b s t r a c t i o n s'''</td>
 
</tr>
 
 
<tr class="sh">
 
<td>'''#'''</td>
 
<td>'''Date'''</td>
 
<td>'''Lecturer'''</td>
 
<td>'''Topic'''</td>
 
<td>'''Handout'''</td>
 
<td>'''Book'''</td>
 
<td>'''Note'''</td>
 
</tr>
 
 
<tr class="sp"><td colspan="7" style="height: 5px;"></td></tr>
 
 
<tr class="s1">
 
<td>2</td>
 
<td>Thu. Sept 11</td>
 
<td>Steipe</td>
 
<td>Sequence abstraction and sequence databases</td>
 
<td>[[Sequence data]]</td>
 
<td>Ch 3</td>
 
<td>[[Assignment 1|Assignment 1 to be handed out]]</td>
 
</tr>
 
 
<tr class="s2">
 
<td>3</td>
 
<td>Mon. Sept 15</td>
 
<td>Steipe</td>
 
<td>Protein Structure Data</td>
 
<td>[[Structure data]]</td>
 
<td>-</td>
 
<td>-</td>
 
</tr>
 
 
--><!--  ===================    TOPIC    ===================  --><!--
 
<tr class="sp"><td colspan="7" style="height: 10px;"></td></tr>
 
<tr class="st">
 
<td colspan="7">'''A n a l y s i s'''</td>
 
</tr>
 
 
<tr class="sh">
 
<td>'''#'''</td>
 
<td>'''Date'''</td>
 
<td>'''Lecturer'''</td>
 
<td>'''Topic'''</td>
 
<td>'''Handout'''</td>
 
<td>'''Book'''</td>
 
<td>'''Note'''</td>
 
</tr>
 
 
<tr class="sp"><td colspan="7" style="height: 5px;"></td></tr>
 
 
<tr class="s1">
 
<td>3</td>
 
<td>Thu. Sept 18</td>
 
<td>Steipe</td>
 
<td>Sequence properties</td>
 
<td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/SequenceProperties.pdf Raw lecture PDF]</small></td>
 
<td>Ch 4.9, 11, 12</td>
 
<td>-</td>
 
</tr>
 
 
<tr class="s2">
 
<td>4</td>
 
<td>Mon. Sept 22</td>
 
<td>Steipe</td>
 
<td> Sequence Analysis and Bioinformatics methods</td>
 
<td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/SequenceAnalysis.pdf Raw lecture PDF]</small></td>
 
<td>-</td>
 
<td>-</td>
 
</tr>
 
 
<tr class="s1">
 
<td>5</td>
 
<td>Thu. Sept 25.</td>
 
<td>Steipe</td>
 
<td>Interpreting protein structure</td>
 
<td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/InterpretingProteinStructure.pdf Raw lecture PDF]</td>
 
<td>-</td>
 
<td>[[Assignment 1]] due<br>
 
<hr>
 
'''First quiz''' in class<br>
 
<hr>
 
[[Assignment 2]] to be posted
 
</td>
 
</tr>
 
 
<tr class="s1">
 
<td>12</td>
 
<td>Thu. Oct 23.</td>
 
<td>Steipe</td>
 
<td>Structural domains</td>
 
<td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/StructuralDomains.pdf Raw lecture PDF]</small></td>
 
<td>-</td>
 
<td>[[Assignment 3]] due</td>
 
</tr>
 
 
<tr class="s1">
 
<td>6</td>
 
<td>Mon. Sept 29</td>
 
<td>Steipe</td>
 
<td>Homology I: the principles</td>
 
<td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/Homology_I_Principles.pdf Raw lecture PDF]</small></td>
 
<td>Ch. 14</td>
 
<td>-</td>
 
</tr>
 
 
<tr class="s1">
 
<td>7</td>
 
<td>Thu. Oct 2</td>
 
<td>Parkinson</td>
 
<td>Genome sequencing, genome browsers</td>
 
<td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/Genome_sequencing.pdf Lecture slide PDFs (1.8 MB)]</small></td>
 
<td>Ch. 9, 10</td>
 
<td>-</td>
 
</tr>
 
 
<tr class="s2">
 
<td>8</td>
 
<td>Mon. Oct 6</td>
 
<td>Parkinson</td>
 
<td>Genomes and genome structure</td>
 
<td>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/Genomes.pdf Lecture slide PDFs (2.4 MB)]</td>
 
<td>-</td>
 
<td>-</td>
 
</tr>
 
 
--><!--  ===================    TOPIC    ===================  --><!--
 
<tr class="sp"><td colspan="7" style="height: 10px;"></td></tr>
 
<tr class="st">
 
<td colspan="7">'''H o m o l o g y'''</td>
 
</tr>
 
  
<tr class="sh">
 
<td>'''#'''</td>
 
<td>'''Date'''</td>
 
<td>'''Lecturer'''</td>
 
<td>'''Topic'''</td>
 
<td>'''Handout'''</td>
 
<td>'''Book'''</td>
 
<td>'''Note'''</td>
 
</tr>
 
  
<tr class="sp"><td colspan="7" style="height: 5px;"></td></tr>
 
  
<tr class="s1">
+
=== Add this material ===
<td>9</td>
+
* GPU and Cloud computing
<td>Thu. Oct 9.</td>
 
<td>Steipe</td>
 
<td>Lecture: Homology II: Sequence alignment</td>
 
<td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/Homology_II_Alignment.pdf Raw lecture PDF]</small></td>
 
<td></td>
 
<td>[[Assignment 2]] due<br>
 
<hr>
 
[[Assignment 3]] to be posted
 
<hr>
 
</td>
 
</tr>
 
  
  
<tr class="s2">
 
<td>10</td>
 
<td>'''Thu. Oct 16'''</td>
 
<td>Steipe</td>
 
<td>Lecture: Homology III: Fast sequence database searches</td>
 
<td>[[BLAST]]</td>
 
<td>Ch. 5</td>
 
<td>-</td>
 
</tr>
 
  
<tr class="s1">
 
<td>11</td>
 
<td>Mo. Oct 20</td>
 
<td>Steipe</td>
 
<td>Homology IV: Multiple sequence alignment</td>
 
<td>[[Multiple Sequence Alignment]]</td>
 
<td>Ch. 6</td>
 
<td>'''Second quiz''' in class (13:00 tutorial time slot)</td>
 
</tr>
 
 
<tr class="s2">
 
<td>18</td>
 
<td>Thu. Nov 13</td>
 
<td>Steipe</td>
 
<td>Homology modeling and structure prediction (Part 1)</td>
 
<td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/PredictingProteinStructure_I.pdf Raw lecture PDF]</small></td>
 
<td>-</td>
 
<td>-</td>
 
</tr>
 
 
<tr class="s1">
 
<td>19</td>
 
<td>Mon. Nov 17</td>
 
<td>Steipe</td>
 
<td>Homology modeling and structure prediction (Part 2)</td>
 
<td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/PredictingProteinStructure_II.pdf Raw lecture PDF]</small></td>
 
<td>-</td>
 
<td>[[Assignment 4]] due.
 
<hr>
 
'''Fourth quiz''' in class: 13:00 in tutorial time slot.
 
<hr>
 
[[Assignment 5]] to be posted.</td>
 
</tr>
 
 
 
 
--><!--  ===================    TOPIC    ===================  --><!--
 
<tr class="sp"><td colspan="7" style="height: 10px;"></td></tr>
 
<tr class="st">
 
<td colspan="7">'''P h y l o g e n y'''</td>
 
</tr>
 
 
<tr class="sh">
 
<td>'''#'''</td>
 
<td>'''Date'''</td>
 
<td>'''Lecturer'''</td>
 
<td>'''Topic'''</td>
 
<td>'''Handout'''</td>
 
<td>'''Book'''</td>
 
<td>'''Note'''</td>
 
</tr>
 
 
<tr class="sp"><td colspan="7" style="height: 5px;"></td></tr>
 
 
<tr class="s1">
 
<td>13</td>
 
<td>Mon. Oct 27</td>
 
<td>Steipe</td>
 
<td>Phylogenetic analysis I</td>
 
<td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/PhylogeneticAnalysis_I.pdf Raw lecture PDF]</small></td>
 
<td>Ch. 7,8</td>
 
<td>'''Third quiz''' in class, 13:00 in tutorial time-slot</td>
 
</tr>
 
 
<tr class="s2">
 
<td>14</td>
 
<td>Thu. Oct 30</td>
 
<td>Steipe</td>
 
<td>Phylogenetic analysis II</td>
 
<td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/PhylogeneticAnalysis_II.pdf Raw lecture PDF]</small></td>
 
<td>Ch. 7,8</td>
 
<td>-</td>
 
</tr>
 
 
<tr class="s1">
 
<td>15</td>
 
<td>Mon. Nov 3</td>
 
<td>Parkinson</td>
 
<td>Comparative genomics</td>
 
<td>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/ComparativeGenomics.pdf Lecture slide PDFs (1.6 MB)]</td>
 
<td>Ch. 9.8, 10.8</td>
 
<td>-</td>
 
</tr>
 
 
<tr class="s2">
 
<td>17</td>
 
<td>Mon. Nov 10</td>
 
<td>Steipe</td>
 
<td>Human population genomics</td>
 
<td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/HumanPopulationGenomics.pdf Raw lecture PDF]</small></td>
 
<td>-</td>
 
<td>[[Assignment 4]] to be posted</td>
 
</tr>
 
 
--><!--  ===================    TOPIC    ===================  --><!--
 
<tr class="sp"><td colspan="7" style="height: 10px;"></td></tr>
 
<tr class="st">
 
<td colspan="7">'''I n t e r a c t i o n s'''</td>
 
</tr>
 
 
<tr class="sh">
 
<td>'''#'''</td>
 
<td>'''Date'''</td>
 
<td>'''Lecturer'''</td>
 
<td>'''Topic'''</td>
 
<td>'''Handout'''</td>
 
<td>'''Book'''</td>
 
<td>'''Note'''</td>
 
</tr>
 
 
<tr class="sp"><td colspan="7" style="height: 5px;"></td></tr>
 
 
<tr class="s1">
 
<td>20</td>
 
<td>Thu. Nov 20</td>
 
<td> Wodak </td>
 
<td>Gene regulation (Part 1)</td>
 
<td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/GeneRegulation.pdf Lecture slide PDFs (2.1 MB)]</small></td>
 
<td>Ch. 15</td>
 
<td>-</td>
 
</tr>
 
 
<tr class="s2">
 
<td>21</td>
 
<td>Mon. Nov 24</td>
 
<td>Wodak</td>
 
<td>Gene regulation (Part 2)</td>
 
<td>-</td>
 
<td>-</td>
 
<td>-</td>
 
</tr>
 
 
<tr class="s1">
 
<td>22</td>
 
<td>Thu. Nov 27</td>
 
<td>Wodak</td>
 
<td>Functional annotation</td>
 
<td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/FunctionalAnnotations.pdf Lecture slide PDFs ('''10.6 MB''')]</small></td>
 
<td>Appendix A</td>
 
<td>-</td>
 
</tr>
 
 
 
<tr class="s2">
 
<td>23</td>
 
<td>Mon. Dec 1</td>
 
<td>Wodak</td>
 
<td>Metabolic networks</td>
 
<td><small>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/PathwaysAndNetworks.pdf Lecture slide PDFs (3.1 MB)]</small></td>
 
<td>Ch. 17.1</td>
 
<td>[[Assignment 5]] due<br>
 
<hr>
 
'''Fifth quiz''' in class: 13:00 in tutorial time slot
 
</td>
 
</tr>
 
 
<tr class="s1">
 
<td>24</td>
 
<td>Thu. Dec 4</td>
 
<td>Parkinson</td>
 
<td>Computational systems biology</td>
 
<td>[http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/ComputationalSystemsBiology.pdf Lecture slide PDFs (3.4 MB)]</td>
 
<td>Ch. 17</td>
 
<td>-</td>
 
</tr>
 
 
 
</table>
 
  
 
==In depth...==
 
==In depth...==
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* [[Mutation Data Matrices]]
 
* [[Mutation Data Matrices]]
 
* [http://en.wikipedia.org/wiki/List_of_standard_amino_acids Amino acids]
 
* [http://en.wikipedia.org/wiki/List_of_standard_amino_acids Amino acids]
 
+
* [[Database Identifiers]]
--><!-- * [[Database Identifiers]] --><!--
 
  
 
&nbsp;
 
&nbsp;
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&nbsp;<br>
 
&nbsp;<br>
  
 
 
-->
 
  
  
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Revision as of 19:40, 29 December 2011

Applied Bioinformatics

Welcome to the Applied Bioinformatics Course Wiki.

These wiki pages are provided to coordinate information, activities and projects in the applied bioinformatics courses taught by Boris Steipe at the University of Toronto. If you are not one of my students, you can still browse this site, however only users with a login account can edit or contribute or edit material. If you are here because you are interested in general aspects of bioinformatics or computational biology, you may want to review the Wikipedia article on bioinformatics, or visit Wikiomics. Contact boris.steipe(at)utoronto.ca with any questions you may have.

The Course

BCB410H1F is the undergraduate course code and JTB2020H1S is the course code for graduate students. However the delivery and scope of the courses is very different:

  • BCB410 is intended for students in the Bioinformatics and Computational Biology Specialist Program. Therefore I assume that all students are very familiar with a wide variety of computer science related topics and their practical application.
  • JTB2020 is designed for students in the Collaborative PhD Program in Bioinformatics and Genome Biology. These students have a wide variety of backgrounds and prior experience. They participate in the Computational Systems Biology Course and go through a number of targeted exercises in applied bioinformatics to add as much material to their knowledge- and skill set as can reasonably be acquired in a single term.


Organization

Dates
Lectures: Monday, 13:00 to 14:00 and Thursday, 12:00 to 13:00
Tutorial sessions: Mondays, 12:00 to 13:00 for in-class quizzes, quiz debriefings, exam preparation and other activities, as the need arises.
Location
MSB 2173 (Medical Sciences Building)
General

See the Course Web page for general information.

We are recommending Understanding Bioinformatics, Zvelebil & Baum, Garland 2008 as a background textbook for the course. (buy used at AbeBooks)

This is an electronic submission only course; but if you must print material, you might consider printing double-sided. Learn how, at the Print-Double-Sided Student Initiative.


Grading and Activities

Activity Weight
(Undergraduates)
Weight
(Graduates)
5 Assignments 15 marks (5 x 3) 10 marks (5 x 2)
5 In-class quizzes 35 marks (5 x 7) 25 marks (5 x 5)
Open project 7 marks 5 marks
"Classroom" participation 3 marks 3 marks
Graduate project   17 marks
Final exam 40 marks 40 marks
Total 100 marks 100 marks


A note on marking

It is not my policy to adjust marks towards a target mean and variance (i.e. there will be no "belling" of grades). I feel strongly that such "normalization" detracts from a collaborative and mutually supportive learning environment. If your classmate gets a great mark because you helped him with a difficult concept, this should never have the effect that it brings down your mark through class average adjustments. Collaborate as much as possible, it is a great way to learn. However I may adjust marks is if we phrase questions ambiguously on quizzes or if I decide that the final exam was too long.

Assignments

Assignment 5 has been posted.
Due Monday, Dec. 5.



Add this material

  • GPU and Cloud computing



In depth...

 

Resources

Course related


 

Contents related

 




 

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