Difference between revisions of "Reference alignment for Mbp1 orthologues (T-COFFEE)"

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Superseded by http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/T-coffee_scores.html .
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For a score-colored alignment, see:  http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/T-coffee_scores.html .
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 +
 
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Result of T-COFFEE alignment of all Mbp1 protein orthologues. Default parameters. Output order of rows kept same as input order, i.e. according to sequence similarity of adjacent rows as represented in the CLUSTAL guide tree. Click [http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/T-coffee_scores.html '''here'''] to view the score-colored version of this alignment.
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 +
 
 +
Annotation Keys:
 +
 
 +
* *  Proposed binding region
 +
* +  positively charged residues, oriented for possible DNA binding interactions
 +
* -  negatively charged residues, oriented for possible DNA binding interactions
 +
* E  beta strand
 +
* H  alpha helix
 +
* t  beta turn
 +
* x  Low complexity region
 +
* C  Coiled coil regions predicted by Coils2 program
 +
 
 +
 
 +
 
 +
 
 +
CLUSTAL FORMAT for T-COFFEE Version_5.05 http://www.tcoffee.org, CPU=144.32 sec, SCORE=41, Nseq=18, Len=1485
 +
 +
Mbp1_ASPFU      ------------------------------------------------------------
 +
Mbp1_ASPNI      ---------------------MAA------------------------------------
 +
Mbp1_ASPTE      ---------------------MAG------------------------------------
 +
Mbp1_CRYNE      --MEPPSNPIQPPVTPSHHSLLSAISPALSEQTPAPIHTLPPHLRPSIPQPHIAPPRPSS
 +
Mbp1_GIBZE      ------------------------------------------------------------
 +
Mbp1_MAGGR      MASTVAGNSFVSQQHPGNLHSANLQSQSQGFRRQNSTSSVPSTASFDPPNGSIANTGSQK
 +
Mbp1_NEUCR      -------------MQPPQLGGASQQSQ---------------------------------
 +
Mbp1_CANAL      ------------------------------------------------------------
 +
Mbp1_DEBHA      -----------------------M------------------------------------
 +
Mbp1_PICST      ------------------------------------------------------------
 +
Mbp1_CANGL      ------------------------------------------------------------
 +
Mbp1_SACCE      ------------------------------------------------------------
 +
Mbp1_EREGO      ------------------MSAGSA------------------------------------
 +
Mbp1_KLULA      ------------------------------------------------------------
 +
Mbp1_YARLI      ------------------------------------------------------------
 +
Mbp1_COPCI      ------------------------------------------------------------
 +
Mbp1_USTMA      -----------------------M------------------------------------
 +
Mbp1_SCHPO      ----------------------MA------------------------------------
 +
                                                                           
 +
 +
Mbp1_ASPFU      ------------------------------------------------------------
 +
Mbp1_ASPNI      ---------------------------------------------------VDFS-NVYS
 +
Mbp1_ASPTE      ---------------------------------------------------VDFS-KIYS
 +
Mbp1_CRYNE      VQPTMEEQQRMHHIQQH-QQQQHFQQQQNDENVFGSVMGAPGHVPGHEAPMSTQP-KVYA
 +
Mbp1_GIBZE      ----MSQQSQS---------------------GMGNS--FRGGYN--GD--PDNS-GIYS
 +
Mbp1_MAGGR      HHPMSSQQSQPPASQQSFSMSQTGSQPQPSQSSFRSY--SDQNVP--QQP-QEAS-PIYT
 +
Mbp1_NEUCR      -----------PSSQQSFSMSQS------SQSVYRQY--TDPPNR--LHN-DHAVPTIYS
 +
Mbp1_CANAL      ---------------------------------------------------MSDS-QIYS
 +
Mbp1_DEBHA      ---------------------------------------------------ADNT-QIYS
 +
Mbp1_PICST      ---------------------------------------------------MTST-QIYS
 +
Mbp1_CANGL      ----------------------------------------------------MSN-QIYS
 +
Mbp1_SACCE      ----------------------------------------------------MSN-QIYS
 +
Mbp1_EREGO      ---------------------------------------------------VSAT-QIYS
 +
Mbp1_KLULA      ---------------------------------------------------MSSN-QIYS
 +
Mbp1_YARLI      ------------------------------------------------------M-SIYK
 +
Mbp1_COPCI      ---------------------------------------------------MPEA-QIFK
 +
Mbp1_USTMA      ---------------------------------------------------SGDK-TIFK
 +
Mbp1_SCHPO      ---------------------------------------------------PRSS-AVHV
 +
'''1MB1  3D                                                            ----EEE'''
 +
                                                                           
 +
 +
Mbp1_ASPFU      ------------------MRRRGDDWINATHILKVAGFDKPARTRILEREVQKGTHEKVQ
 +
Mbp1_ASPNI      ATYSSVPVYEFKIGTDSVMRRRSDDWINATHILKVAGFDKPARTRILEREVQKGVHEKVQ
 +
Mbp1_ASPTE      ATYSSVPVYEFKIEGDSVMRRRADDWINATHILKVAGFDKPARTRILEREVQKGVHEKVQ
 +
Mbp1_CRYNE      SVYSGVPVFEAMIRGISVMRRASDSWVNATQILKVAGVHKSARTKILEKEVLNGIHEKIQ
 +
Mbp1_GIBZE      ASYSGVDVYEMEVNNIAVMRRRNDSWLNATQILKVAGVDKGKRTKILEKEIQTGEHEKVQ
 +
Mbp1_MAGGR      AVYSNVEVYEFEVNGVAVMKRIGDSKLNATQILKVAGVEKGKRTKILEKEIQTGEHEKVQ
 +
Mbp1_NEUCR      ATYSGVGVYEMEVNNVAVMRRQKDGWVNATQILKVANIDKGRRTKILEKEIQIGEHEKVQ
 +
Mbp1_CANAL      ATYSNVPAFEFVTSEGPIMRRKKDSWINATHILKIAKFPKAKRTRILEKDVQTGIHEKVQ
 +
Mbp1_DEBHA      ATYSNVPVFEFVTLEGPIMRRKLDSWINATHILKIAKFPKAKRTRILEKDVQTGVHEKVQ
 +
Mbp1_PICST      ATYSNVPVFEYVTSEGPIMRRKSDSWINATHILKIAKFPKAKRTRILEKDVQTGVHEKVQ
 +
Mbp1_CANGL      AKYSGVDVYEFIHPTGSIMKRKNDGWVNATHILKAANFAKAKRTRILEKEVLKEMHEKVQ
 +
Mbp1_SACCE      ARYSGVDVYEFIHSTGSIMKRKKDDWVNATHILKAANFAKAKRTRILEKEVLKETHEKVQ
 +
Mbp1_EREGO      AKYSGVEVYEFLHPTGSIMKRKADDWVNATHILKAAKFAKAKRTRILEKEVIKDTHEKVQ
 +
Mbp1_KLULA      AKYSGVDVYEFIHPTGSIMKRKADNWVNATHILKAAKFPKAKRTRILEKEVITDTHEKVQ
 +
Mbp1_YARLI      ATYSGVPVYEFQCKNVAVMRRKSDGWVNATHILKVAGFDKPQRTRILEKEVQKGVHEKVQ
 +
Mbp1_COPCI      ATYSGIPVYEMMCKGVAVMRRRSDSWLNATQILKVAGFDKPQRTRVLEREVQKGEHEKVQ
 +
Mbp1_USTMA      ATYSGVPVYECIINNVAVMRRRSDDWLNATQILKVVGLDKPQRTRVLEREIQKGIHEKVQ
 +
Mbp1_SCHPO      AVYSGVEVYECFIKGVSVMRRRRDSWLNATQILKVADFDKPQRTRVLERQVQIGAHEKVQ
 +
                                  *:*  *. :***:*** . . *  **::**:::    ***:*
 +
'''1MB1  3D        EEtt-EEEEEEEEt-EEEEEEtt---EEHHHHHHH----HHHHHHHHhhhHHH---EEE-'''
 +
'''Annotation                                                **+**-+******+*+**'''
 +
 +
Mbp1_ASPFU      GGYGKYQGTWIPLHEGRLLAERNNIIDKLRPIFDY--VAG-DH---TPPPAPKHTSAASS
 +
Mbp1_ASPNI      GGYGKYQGTWIPLQEGRQLAERNNILDKLLPIFDY--VAG-DR---SPPPAPKHTSAASK
 +
Mbp1_ASPTE      GGYGKYQGTWIPLPEGRLLAERNNIIDKLRPIFDY--VAG-DR---SPPPAPKHTSAASK
 +
Mbp1_CRYNE      GGYGKYQGTWVPLDRGRDLAEQYGVGSYLSSVFDFVPS---AS---VIAALPVIRTGTPD
 +
Mbp1_GIBZE      GGYGKYQGTWIKFERGLQVCRQYGVEELLRPLLTYDMGQDGGVAGRGDLNTPTKEQAMAA
 +
Mbp1_MAGGR      GGYGKYQGTWIKYERALEVCRQYGVEELLRPLLEYNRNPDGSVS-QANLNTPTKEQAMAA
 +
Mbp1_NEUCR      GGYGKYQGTWIPFERGLEVCRQYGVEELLSKLLTHNRGQEGET---GNVDTPTKEQAMAA
 +
Mbp1_CANAL      GGYGKYQGTYVPLDLGAAIARNFGVYDVLKPIFEFQYIEGQTE---VPPPAPKHNHASAL
 +
Mbp1_DEBHA      GGYGKYQGTYVPLDLGADIAKNFGVFDSLRPIFEFTYVEGKSE---TPPPAPKHSHASAS
 +
Mbp1_PICST      GGYGKYQGTYVPLELGRDIAKNFGVFDILKPIFDFKYIEGKSE---TPPPAPKHNHASAL
 +
Mbp1_CANGL      GGFGKYQGTWVPLNIAINLAEKFDVYQDLKPLFDFSEENG-DA---APPPAPKHHHASKA
 +
Mbp1_SACCE      GGFGKYQGTWVPLNIAKQLAEKFSVYDQLKPLFDFTQTDG-SA---SPPPAPKHHHASKV
 +
Mbp1_EREGO      GGFGKYQGTWVPLDIARRLAQKFEVLEELRPLFDFTRRDG-SE---SPPQAPKHHHASRA
 +
Mbp1_KLULA      GGFGKYQGTWIPLELASKLAEKFEVLDELKPLFDFTQQEG-SA---SPPQAPKHHHASRS
 +
Mbp1_YARLI      GGYGKYQGTWVPLERAREIATLYDVDSHLAPIFNYDDEDG------SPPPAPKHRPNLER
 +
Mbp1_COPCI      GGYGKYQGTWIPLERGMQLAKQYNCEHLLRPIIEFT--PA-AK---SPPLAPKHLVATAG
 +
Mbp1_USTMA      GGYGKYQGTWIPLDVAIELAERYNIQGLLQPITSYVP-SA-AD---SPPPAPKHTISTSN
 +
Mbp1_SCHPO      GGYGKYQGTWVPFQRGVDLATKYKVDGIMSPILSLDIDEGKAIA-------PKKKQTKQK
 +
                **:******::    .  :.        :  :                  *       
 +
'''1MB1  3D        ---tt--EEEE-HHHHHHHHHH---HHHHtt-        '''
 +
'''Annotation      *******                                  xx---xxxxxxxxxxxx'''
 +
 +
Mbp1_ASPFU      RPRASK----KKAVN----------------------EQ-----VFSAA-----------
 +
Mbp1_ASPNI      P-RAPKI--NKRVVK----------------------ED-----VFSAV-----------
 +
Mbp1_ASPTE      P-RVSKAAANRRVAN----------------------EE-----VFSAV-----------
 +
Mbp1_CRYNE      R-SGQQTPSGLPGHPNQRVISPFA---------------NHGQTT-PHMPPPQ-FIHQ--
 +
Mbp1_GIBZE      Q-R---KRLYNQSA-DGRANGVSGTFFKNISTTASHAVAAISKARFDSPGPRSSRNGASR
 +
Mbp1_MAGGR      Q-R---KKMYNSGA-DSRNNNGGGTFFKNISQTAHSAMTAISKARFDSPGPRG-RNGPTR
 +
Mbp1_NEUCR      Q-R---KRMYNASSQENRGIGSTGTFFKNISSTASTAVAAISKARFDSPAPRN-RSGPSR
 +
Mbp1_CANAL      N-VAKRQASLLKKQK-EKQVQPTLSDTS-----FGSSTS-----VPPTTVPKK-RGRPKR
 +
Mbp1_DEBHA      N-VAKRQSSVNNSSG-DANSLNKTSHAR-----KTKSMT-----SLSGEPPKK-RGRPKR
 +
Mbp1_PICST      N-IAKRSAVPQQAKK-SRTASATL----------------------TGEPPKK-RGRPKR
 +
Mbp1_CANGL      S-SAKAKKAGRSVSSPAMNDSKTRASTRKANTPSSNDITSDSGAVVNPVVTRR-RGRPPN
 +
Mbp1_SACCE      D-R---KKAIRSASTSAIMETKRNNKKAEENQFQSSKILGNPTA-----APRK-RGRPVG
 +
Mbp1_EREGO      D-SAR-KRTTKSPPLPHGQL----------------------DA-----LPKR-RGRPPR
 +
Mbp1_KLULA      D-STR-KKATKSASVPSGKVSEKASSQQ--QQPVSQQQQQQPGS-----APKR-RGRPPR
 +
Mbp1_YARLI      -KKRTKV----TGSPLVRQPSRMETLTQSTGSTMG--------------------GTPQH
 +
Mbp1_COPCI      N-R----P----VADGVGEESDHDTHSLRGSED------------------------GSM
 +
Mbp1_USTMA      R-SKKIIP----ADPGALGRSRRATSIETESEV-------------IGAAPNN-VSEGSM
 +
Mbp1_SCHPO      KPSVRGR-----------------------------------------------RGRKPS
 +
                                                                           
 +
 +
Mbp1_ASPFU      ---------------------------------------KPIRN-MGPPSF--------P
 +
Mbp1_ASPNI      ---------------------------------------NHHRS-MGPPSF--------H
 +
Mbp1_ASPTE      ---------------------------------------KPHRP-MGPPSF--------T
 +
Mbp1_CRYNE      -----GNEQMMNLPPHPSSLAYPTQPKPYFSMPLQH----TVGPQYDERHEGMTMTPTMS
 +
Mbp1_GIBZE      TA-------SFSRQASMQNGD-------------------DFPS-NSQQS----------
 +
Mbp1_MAGGR      AP-------SFQRQLSTQSID-------------------DFHGGNSQAS----------
 +
Mbp1_NEUCR      AP-------SFNRQSSMQDVA-------------------DFP--NSQQS----------
 +
Mbp1_CANAL      ATLS---AT-PSLQRSDTTPINKSLIDFNANDHSAKSSF----I-GVVPSF--------A
 +
Mbp1_DEBHA      VPMQN--NIEPSLQHTDTTPITTIPES-----GPSIGTFNNKKS-LGHPTL--------T
 +
Mbp1_PICST      VPMT---AAEPVLKHSDTTPINGPMNS---INGPLEGSF-------THPAL--------S
 +
Mbp1_CANGL      STLTNKRKLGTGLQRSQSEMAFLKPEIPND---LNSNDIANIQQ-----VNSGDL----L
 +
Mbp1_SACCE      STRGSRRKLGVNLQRSQSDMGFPRPAIPNS--SISTTQLPSIRSTMGPQSPTLGILEE-E
 +
Mbp1_EREGO      ARKLSDVANVAGQTQVYSD--FPRPSIPVS--SISSNQLPSLQSTLHRSISI---EHNR-
 +
Mbp1_KLULA      NKATVTLQR-SQSEMV-----FPKPSIPSS--SIQSTKLPSLQPQFGRSATSLSPIMDV-
 +
Mbp1_YARLI      SRQSSLSQLAQ-------------------------------------------------
 +
Mbp1_COPCI      -----------------------------------------------------------T
 +
Mbp1_USTMA      -----------------------------------------------------------S
 +
Mbp1_SCHPO      SLSSSTL-------------HSVNEKQPNS--SISPTIESSMNKVN--------------
 +
                                                                           
 +
 +
Mbp1_ASPFU      HEQFEI--NPGYDDNESIEQA--TLES--SSMAADEEMMSMSQ-----HGAY-SRKRKRE
 +
Mbp1_ASPNI      HEHYDV--NTGLDEDESIEQA--TLES--SSMIADEDMISMSQ-----NGPYSSRKRKRG
 +
Mbp1_ASPTE      HEQYEM--HSGFDEDESIEQA--TLES--SSMVADEDMMTMSQ-----SGAY-SRKRKRG
 +
Mbp1_CRYNE      MDGLAPPA-DIARMGFPYNPS--DIYI--DQYGQPHATYQAS-PYGKESGHPSKRQRSDA
 +
Mbp1_GIBZE      -------------FASDYG-Q--QVDS--AYSTQQAN------NSVQMTEPDPPRKRQRV
 +
Mbp1_MAGGR      ------------NFAENFPPQ--DVNM--AFSAGSEP------QPGGLNGTEPPRKRQRM
 +
Mbp1_NEUCR      ------------LVSTEYATQ--TQNADSGFGSQTTQ------PLAGDGLEQPPRKRQRV
 +
Mbp1_CANAL      RNDTEQDALQIMTNNMNLRQE--DLAS--VETDDDEEYHNGSRGDGLQNDSFTTKRRKYP
 +
Mbp1_DEBHA      RQDTEQDALQIMASNMSANQE--DLEL--ADKSSDEDMGNRTPIDTQDE-----------
 +
Mbp1_PICST      RHDTEQDALQVMAGNMNIKNE--DLEL--VDSDDDDDVVKKRR-----------------
 +
Mbp1_CANGL      R------N-EKIQKNIQLKEI--DLDD--GLSSDVEVQ--------ETD-----------
 +
Mbp1_SACCE      RHDSRQQQ-PQQNNSAQFKEI--DLED--GLSSDVEPSQQLQQVFNQNT-----------
 +
Mbp1_EREGO      -------NKAPPQPNHKYEEL--DIED--GLSSDIETSICTNMVYAGHS-----------
 +
Mbp1_KLULA      -------KSPLDQASPQFKEL--DIED--GLSSDVEPN---SIMGTKHE-----------
 +
Mbp1_YARLI      --------SYGLDDSDHVTPSPPTVADDSSDFMSDEEVDR--------------------
 +
Mbp1_COPCI      PSPSEA--SSSSRTPSPIHSP--GTYH--SNGL-DGP-----------------------
 +
Mbp1_USTMA      PSPSDI--SSSSRTPSPLPAD---------------------------------------
 +
Mbp1_SCHPO      ------------------------------------------------------------
 +
'''Annotation          xxx-xxx'''
 +
                                                                           
 +
 +
Mbp1_ASPFU      MNE---------------------------------------------------------
 +
Mbp1_ASPNI      INE---------------------------------------------------------
 +
Mbp1_ASPTE      -ND---------------------------------------------------------
 +
Mbp1_CRYNE      EGSYIE-----------------------SGAAVQQHVEQD------EEADDGLDN----
 +
Mbp1_GIBZE      T-MTPAESFNGYGQNVD------M------------YAAAYPGSPTEPNESFMYTQSAIH
 +
Mbp1_MAGGR      D-MTPANSFGAYANNSQ------MQ----------AYADAFPGSPTEPNDSFIYTQHAAA
 +
Mbp1_NEUCR      --LTPARSFGGQTPGHQPLDPFNAG----------NIANGDSGSPTEPSNSFNYDQVTAN
 +
Mbp1_CANAL      GGMTNGNGL--ESQADL-LTSKELF------GVSRTSFEKR------AN-----------
 +
Mbp1_DEBHA      -------NIHHEDNDEL-MTGRELF------GTPRNSFERI------VQSHNQSHN----
 +
Mbp1_PICST      NGVNVALSLDSQVGDDL-LGSKELF------GASRGSFERV------IHNHNSNNN----
 +
Mbp1_CANGL      -------TFQPNHQSSL-LGAEGHELRNNDSPLSPSSSSSLPTSPANLNDSNPFDQ----
 +
Mbp1_SACCE      -------GFVPQQQSSL-IQTQQTE----SMATSVSSSPSLPTSPGDFADSNPFEE----
 +
Mbp1_EREGO      -------NARLPMNTSL--------LPDKEEP---GLSSSLPSSPSEFSAPMVFDTQ---
 +
Mbp1_KLULA      -------D-----NTHL--------MNTKDEP--VSSSSSLPSSPSEFSQSVAFGSRSNM
 +
Mbp1_YARLI      ------------------------------------------------------------
 +
Mbp1_COPCI      ------------------------------------------------------------
 +
Mbp1_USTMA      ------------------------------------------------------------
 +
Mbp1_SCHPO      -------------------------LPGAEEQ---VSATPLPASPNALLSPN--------
 +
'''Annotation                xxxxxx-xxxxxxx----xxxxxxxxxxxxxxxx'''
 +
                                                                           
 +
 +
Mbp1_ASPFU      -------------------------VTAMSI---SEQEHILYGDQLLDYFMTVGD----A
 +
Mbp1_ASPNI      -------------------------VAAMSL---SEQEHILYGDQLLDYFMTVGD----A
 +
Mbp1_ASPTE      -------------------------VPTMSI---GEQEHILYGDQLLDYFMTVGD----A
 +
Mbp1_CRYNE      -DSTASDDARDPPPLPSSMLLPHKP-----IRPKATPANGRIKSRLVQIFNVEG-----Q
 +
Mbp1_GIBZE      DR----------------SPIEEGNGPLEPLPYEMSPDVENKRNVLMGLFLETT-----G
 +
Mbp1_MAGGR      NDT-------------LLQQQHDQQTPLQPLPYEQSVEAENKRSMLMSIFMNDG-----M
 +
Mbp1_NEUCR      D-----------------GDASYALGPLRPLPYENNADAEAKRGMLMGLFMDAN-----G
 +
Mbp1_CANAL      ----Q-------QHNHYS-PLQPYHQPSISLSQE-NQIYSDYFQSLLSYFLDDNN-----
 +
Mbp1_DEBHA      --HLN-----GSIHDPYG-LLQYHHHTSHTHSMRDDAIYADYFTNLLNYFLEDGNNKVRS
 +
Mbp1_PICST      -GHLQ-------SHDPYS-F-SQYHQPSVSSQNETDVVYSDYFSSLLTYFLDDSK-----
 +
Mbp1_CANGL      --RLG-----GGGTSPIISLIPRYSVQSRPQVTDINEKVNDYLTKLVDYFISNE-----M
 +
Mbp1_SACCE      --RFP-----GGGTSPIISMIPRYPVTSRPQTSDINDKVNKYLSKLVDYFISNE-----M
 +
Mbp1_EREGO      ---RM-----GSATSPLGSMLPRYMAPSRPRTSELDQKANEYLSKLVDYFINCE-----V
 +
Mbp1_KLULA      QTPLQ-----LNGTTSMNMILPKFS-SSQNGPSDSNQRANEYLSKLVNYFISND-----T
 +
Mbp1_YARLI      ----------QMGNYP-------RPMMAKPKPIQVRDPKDLYTNDLLNYFVSAD------
 +
Mbp1_COPCI      ----S-----SGGRNRYRQSNDRYDEDDDASRHNGMGDPRSYGDQILEYFISD-------
 +
Mbp1_USTMA      ------------RAHPLHANHALAGYNGRDA-----NNHARYADIILDYFVTE-------
 +
Mbp1_SCHPO      ----------------------DNTIKPVEELGMLEAPLDKYEESLLDFFLHPE------
 +
                                                              ::  *         
 +
 +
Mbp1_ASPFU      PEATRIP-----PPQPPANFQVDRPIDDSGNTALHWACAMGDLEIVKDLLRRGA---NIK
 +
Mbp1_ASPNI      PEATRIP-----PPQPPANFQVDRPIDDSGNTALHWACAMGDLEIVKDLLRRGA---DMK
 +
Mbp1_ASPTE      PEATRVP-----PPEPPVNFQVDRPIDDSGNTALHWACAMGDLEIVRDLLRRGA---DVK
 +
Mbp1_CRYNE      VNLRSV---FGLAPDQLPNFDIDMVIDDQGHSALHWACALARLSIVQQLIELGA---DIH
 +
Mbp1_GIBZE      TDPTKNDTLRG-----FTPLELDMPIDLQSHTALHWAATLARMPLLRALIAAGA---SPA
 +
Mbp1_MAGGR      SEQARVDTLRQ-----IHPRDLDMPIDSQCHTALHWAATLSRMTILRRLIEAGA---SPF
 +
Mbp1_NEUCR      PEEAIQAALCN-----VSPQELDSPIDTQSHTALHWAATLSRMPLLRALIHAGA---NPW
 +
Mbp1_CANAL      KIRSPIPDSLLSPPLPLSKIHIYQTIDSDGNTIFHWACSMGNLNMVEFLLKTFTHSLNPD
 +
Mbp1_DEBHA      TQESNIPDKILNPPQPLSKINITQPVDNEGNTIFHWACSMANNGMIEFLLATFESFLNSD
 +
Mbp1_PICST      IRSNNIPEKLLNPPQPISKIQINQPIDNEGNTIFHWACSMANISSIEFLLVTF--QISPD
 +
Mbp1_CANGL      KSNKTVPQELLHPPTQSAP-FIDAPIDPELHTAFHWACSMGNLPIVEALYETGT---NIR
 +
Mbp1_SACCE      KSNKSLPQVLLHPPPHSAP-YIDAPIDPELHTAFHWACSMGNLPIAEALYEAGT---SIR
 +
Mbp1_EREGO      QNNGAVPMELLNPP-HSSP-CIDSWIDSEHHTAFHWACAMGTLPIVEALLQAGA---SPR
 +
Mbp1_KLULA      QNESEIPMELLNPPLHCSP-FIDTWIDPEHHTAFHWACAMGTLPIVEALLKAGS---SIR
 +
Mbp1_YARLI      --DEKIPAFLENPP---AEFDVHRPIDEEGHTALHWACAMGHLRVIELLLKAGS---DVR
 +
Mbp1_COPCI      --TNQIPPILITPP---PDFDPNMAIDDDGHTSLHWACAMGRIRIVKLLLSAGA---DIF
 +
Mbp1_USTMA      --NTTVPSLLINPP---PDFNPDMSIDDDEHTALHWACAMGRIRVVKLLLSAGA---DIF
 +
Mbp1_SCHPO      --EGRIPSFLYSPP---PDFQVNSVIDDDGHTSLHWACSMGHIEMIKLLLRANA---DIG
 +
                                          :* . :: :***.::.    . *        . 
 +
'''Ankyrin 3D                            --t----HHHHHHH---HHHHHt-t--t-t-----t-'''
 +
 +
Mbp1_ASPFU      ALSVHEETPLVRAVLFTNNYEKRTFPALLDLLLDTVSFRDWFGATIFHHISETT------
 +
Mbp1_ASPNI      ALSIHEETPLVRAVLFTNNYEKRTFPALLDLLLDTISFRDWFGATLFHHIAQTT------
 +
Mbp1_ASPTE      ALSVHEETPLVRAVLFTNNYEKRTFPALLELLLDTVSFRDWFGATLFHHIAETT------
 +
Mbp1_CRYNE      RGNYAGETPLIRAVLTSNHAEAGSFTDLLHLLSPSIRTLDHAYRTVLHHIALVA------
 +
Mbp1_GIBZE      RVNGSGETALMRACLVTNSQDHNSFPDLLEVLGGTIEARDHKGRTVLHHIAVTS------
 +
Mbp1_MAGGR      RVNTSGETPLMRACIVTNSHDNDSMPAILDILGNTMEVRDSKERTVLHHIALTS------
 +
Mbp1_NEUCR      RVNACGETALMRACTVTNSMENNTFPELLDLLGCTLDVTDDKGRTVLHHIAVTS------
 +
Mbp1_CANAL      VRNNNGETPLMFMVKFNNSFQLRNFPLILDLLKESVLLVDSNGKTVLHHIVDTD------
 +
Mbp1_DEBHA      LKNNRGETPLMFLVKFSNSYQLKNFPTLLDLLFDSILSIDNYGRTVLHHIALAANNLTSE
 +
Mbp1_PICST      IRNNKGETPLMFLVKFVNSFQLRNFPSILQMLLESILLVDKSGKTVLHHIALID------
 +
Mbp1_CANGL      AANANGQTPLMRSAMFHNSYTRRSFPRIFELLSETVFDIDSMGQTVLHHIV---------
 +
Mbp1_SACCE      STNSQGQTPLMRSSLFHNSYTRRTFPRIFQLLHETVFDIDSQSQTVIHHIV---------
 +
Mbp1_EREGO      ALNQAGETPLMRASLVHNSYTKRTYPRIFQLLQDTVFDVDSRSQTVVHHIV---------
 +
Mbp1_KLULA      SLNNVGETPLIRSSIFHNCYTKRTYPQIFEILKDTVFDLDAKSRNVIHRIV---------
 +
Mbp1_YARLI      ATNMFGQTPLTRAIMFTNNYDRRTFPKVVDILQDTLFQVDGQGRTVLHHIAQHVS-----
 +
Mbp1_COPCI      KVNKAGQTALMRSVMFANNYDVRKFPELYELLHRSTLNIDNSNRTVFHHVVDVA------
 +
Mbp1_USTMA      RVNSNQQTALMRATIFPNSLSSFTDPSL---------NIDRNDRTVFHHVVDLA------
 +
Mbp1_SCHPO      VCNRLSQTPLMRSVIFTNNYDCQTFGQVLELLQSTIYAVDTNGQSIFHHIVQST------
 +
                  .  :*.*      *    .  :          *    .:.*::         
 +
'''Ankyrin 3D      ---t----HHHHHHHH---------HHHHHHHHH-ttHHH-----HHHHHH---------'''
 +
 +
Mbp1_ASPFU      -----------RSKGKWKSSRYYCEVLLDKLHNT--------------------------
 +
Mbp1_ASPNI      -----------KSKGKWKSSRYYCEVALEKLRTT--------------------------
 +
Mbp1_ASPTE      -----------RSKGKWKSSRYYCEVLLEKLRAT--------------------------
 +
Mbp1_CRYNE      -----------GVKGRVPAARTYMASVLEWVAREQQANNTHS----------ITNPPNPA
 +
Mbp1_GIBZE      -----------AVKGRNAASRYYLESLLEWVVRQGSAPNSQ-NTQTNGNGPSNSQAASP-
 +
Mbp1_MAGGR      -----------AVSGRSAASRYYLQCLLGWVVRQGAANGGQLNSQTFNGG-ATVSQSQNA
 +
Mbp1_NEUCR      -----------AVKGRHYASRYYLESLLEWVVRQGSAPSSQE----NGIGDRK------G
 +
Mbp1_CANAL      -----------SKHKREKFAQYYLESLLEKIVDERQEQGDSN----------GHAME-DD
 +
Mbp1_DEBHA      GSINANTDIHTFKKNKERFARYYMECLFAKIIEFQEIRDLQE----------IENKKLSL
 +
Mbp1_PICST      -----------S-EKKFRFARYYMETLFDKIIESLEDEED-------------FAKD-PD
 +
Mbp1_CANGL      -----------KRKSSTPSAIYYVNVLLSKIKDI--------------------------
 +
Mbp1_SACCE      -----------KRKSTTPSAVYYLDVVLSKIKDF--------------------------
 +
Mbp1_EREGO      -----------KRKSNTPSALYYLDVLLSKLKDF--------------------------
 +
Mbp1_KLULA      -----------SRKSHTPSAVYYLDVVLSKIKDF--------------------------
 +
Mbp1_YARLI      --------------KSQSAAKYYVTILLSKISEN--------------------------
 +
Mbp1_COPCI      -----------MSKGKTHAARYYMETILTRLADY--------------------------
 +
Mbp1_USTMA      -----------LSRGKPHAARYYMETMINRLADY--------------------------
 +
Mbp1_SCHPO      -----------STPSKVAAAKYYLDCILEKLISI--------------------------
 +
                                    :  *    :  :                           
 +
'''Ankyrin 3D      -----------H--tH--HHHHHHHHH---------------------------------'''
 +
 +
Mbp1_ASPFU      ----CSQDEIDLLLSCQDSNGDTAALVAARNGAFRLVNLLLGHCPRA-GDLVNKKGETAT
 +
Mbp1_ASPNI      ----FSPEEVDLLLSCQDSVGDTAVLVAARNGVFRLVDLLLSRCPRA-GDLVNKRGETAS
 +
Mbp1_ASPTE      ----CSAEEIDLLLSCQDSNGDTAALVAARNGAFRLVDILLTHCSRA-GDLVNKKGETAI
 +
Mbp1_CRYNE      DRNELAPINLRTLVDVQDVHGDTALNVAARVGNKGLVGLLLDAGADK--TRANKLGLRPE
 +
Mbp1_GIBZE      -KM-GIARFMTEIVNAQDSVGDTALNIAARIGNRSIISQLLEVGADP--NIANRVGLRPL
 +
Mbp1_MAGGR      TRL-DLGRFMSEMLNAQDSAGDTALNIAARIGNRSIISQLLEVCASP--HIANRSGLRPT
 +
Mbp1_NEUCR      RRM-GIARFMSEIVNAQDNSGDTALNVAARVGNRSIISQLLEVGADP--TIPNRANLKPL
 +
Mbp1_CANAL      ---LTKDELVTKFINHQDSDGNTAFHIAAHNLNKKCIKVFINYHRFINFGLRNLVSCTVE
 +
Mbp1_DEBHA      ---SDKKELIAKFINHQDIDGNTAFHIVAYNLNKKCIKVFISYHKYINFHLKNLVSYTVE
 +
Mbp1_PICST      ----NKKDLIAKFINHQDSDGNTAFHICSHNLNKRCIKVFISYHKYIDFGLRNLVGYTVE
 +
Mbp1_CANGL      ----SPKYRIELLLNTKDANGDTALHIAARNNDREFFDILIKNGSLS--TISNNDGQTPT
 +
Mbp1_SACCE      ----SPQYRIELLLNTQDKNGDTALHIASKNGDVVFFNTLVKMGALT--TISNKEGLTAN
 +
Mbp1_EREGO      ----SPQYRIETLINAQDCKGSTPLHIAAMNRDKKFFQTLVGNGALS--TIKNHDGVTAD
 +
Mbp1_KLULA      ----TPQYRIDVLINQQDNDGNSPLHYAATNKDDQFYQLLLQNGALT--TVQNNSGMTPN
 +
Mbp1_YARLI      ----HSLGVLSQFMDTQNNEGDTALHILARSGAKKVSRALMDFNVKT--DIVNADGRTAL
 +
Mbp1_COPCI      ------PKELADVINFQDEDGETALTMAARCRSKRLVKLLIDHGADP--KINNHDGKNAE
 +
Mbp1_USTMA      ------GDQLADILNFQDDEGETPLTMAARARSKRLVRLLLEHGADP--KIRNKEGKNAE
 +
Mbp1_SCHPO      ----QPFENVVRLVNLQDSNGDTSLLIAARNGAMDCVNSLLSYNANP--SIPNRQRRTAS
 +
                          :  .:. ::  *.:.    :          ::          *     
 +
'''Ankyrin 3D      -------------t----tt---HHHHHHH---HHHHHHHH--t-tt------t----HH'''
 +
 +
Mbp1_ASPFU      SITQRAHLPEQNIPP-PPSSITMGIDHTEGDL----------------------TVLETP
 +
Mbp1_ASPNI      SIMQRAHLAERDIPP-PPSSITMGNDHIDGEV----------------------GAPTSL
 +
Mbp1_ASPTE      SITQRAHPSERDVPP-PPSSVTMGNDHIDGEV----------------------NTSTNP
 +
Mbp1_CRYNE      NFGLEIE-ALKISNGEAVMA-----------NLKSEVSKP--------------------
 +
Mbp1_GIBZE      DFGIGSEN---AENKTNGEA-------------------------------------NVE
 +
Mbp1_MAGGR      DFGIGVDSDGAMKTKGDSGG-------------------------------------DVE
 +
Mbp1_NEUCR      DFGIGIAD---AETNDDPAQ-------------------------------------EKT
 +
Mbp1_CANAL      DYLASHNYVLRLDPVEHDQSNNSDGDE----DIMED---------------------YTN
 +
Mbp1_DEBHA      EYLASHNHVLRLDTSNDDSKEIQDIQEEAYKYLNPQFQGNN-------------LTIRNN
 +
Mbp1_PICST      DYLASHNYVLRLDQT-GEEGEQEETED----LLYSQ---------------------EAV
 +
Mbp1_CANGL      EIMNQHYQDLHLQAQTNIAGSNTSAYTDSFSSFGGKVKGSKLHSISELDDDKNTQNPENT
 +
Mbp1_SACCE      EIMNQQYEQMMIQNGTNQHVNSSNTD------LNIHVNTNNIET-------KNDVNSMVI
 +
Mbp1_EREGO      ELINNRFVKTIQPTQRGNYHENRAS-------------HSPLNS-------ASAAGGMVP
 +
Mbp1_KLULA      GIISGRYSMDE--ITKG----------------------QRLDD-------PYEF-----
 +
Mbp1_YARLI      DLLEGDRQMQQH-PPPAMALHHQ-------------------------------------
 +
Mbp1_COPCI      DYILEDERFRSSPAPSSRVAAMSYRNAQVA------YPPPG------------APSTYSF
 +
Mbp1_USTMA      DYIIEDERFRSSPSRTGPAGIELGADGLPV------LPT---------------------
 +
Mbp1_SCHPO      EYLLEADKKPHSLLQSNSNASHSA-FSFSGIS----------------------------
 +
'''Ankyrin 3D      HHHHHH--HHHHH-t--HHH-t----------HHHHHHH--tHH-------HHHHHHHH-'''
 +
                                                                           
 +
 +
Mbp1_ASPFU      D-QTD--ALPAEASLATSALLAKISAIMAETNKKLAACYGHTKSNEPVSDDVANPEALYE
 +
Mbp1_ASPNI      EPQSV--TLHHESSPATAQLLSQIGAIMAEASRKLTSSYGAAKPSQKDSDDVANPEALYE
 +
Mbp1_ASPTE      DNQSV--AITPDTSSVTATLLSKIGVIIAEANKKLAVSYGSSKPGQQGSDDIANPEALYD
 +
Mbp1_CRYNE      -----------------ERKSRDVQKNIATIFESISSTFSSEM--LAKQTKLNATEASVR
 +
Mbp1_GIBZE      NGVVG-------TNQRSRESSDEIVASISHLLSETGSTFQSEM--KAKQASLDTLHSTLR
 +
Mbp1_MAGGR      NGDVGG------SSQKSNESSNEIVTSITHLLTETSANFQEEI--KNKQKNIDSLHATLR
 +
Mbp1_NEUCR      GATTG-------SGHKSRETSDEVVRSITHLIGESASIFQNEL--KKKQESIDTLHSQLR
 +
Mbp1_CANAL      ENQSF--ETQLHNSKMAINLQNTTANLLTEKMTQLAYAIDSEL--SEKDEVILTYFKVLS
 +
Mbp1_DEBHA      STQSF--ESQMYFSKMAVNLQNTTANLITEKLTELAYIVDKEL--SEKDEKLLMYFKLLK
 +
Mbp1_PICST      STQSF--ESQLYYSKVAVNLQNTTSNLITERLTELAYTIDKEL--SEKDETILTFFKILK
 +
Mbp1_CANGL      VTNIVSN--LHFSSNAAINLVKNIPAF-TDSMKHLAEKFDGSY--KNHEESCRSTEKMLG
 +
Mbp1_SACCE      MSPVSPSDYITYPSQIATNISRNIPNV-VNSMKQMASIYNDLH--EQHDNEIKSLQKTLK
 +
Mbp1_EREGO      ASLIHTG--DMYPSQSATSVSRAIPEV-INLMKDMADSYQFLY--EDRNQEVQDLVKMLK
 +
Mbp1_KLULA      ------N--KMYPSQAATRTNRIIPEV-INMMKEMANSYQNAY--QKRQNEVLQMERTVK
 +
Mbp1_YARLI      -----PPYQMLHESETAIAAHN-LAGTVVHNLQVLAHAFDAEL--KEKDADVQQVRQMAT
 +
Mbp1_COPCI      APAN-HDRPPLHYSAAAQKASTRCVNDMASMLDSLAASFDQEL--RDKERDMAQAQALLT
 +
Mbp1_USTMA      --------SSLHTSEAGQRTAGRAVTLMSNLLHSLADSYDSEI--NTAEKKLTQAHGLLK
 +
Mbp1_SCHPO      --------PAIISPSCSSHAFVKAIPSISSKFSQLAEEYESQL--REKEEDLIRANRLKQ
 +
                                                                .         
 +
'''Ankyrin 3D      --t---tt----HHHHHHH---HHHHH-HHH'''
 +
'''Annotation                                        CCCCCCC--CCCCCCCCCCCCCCCC'''
 +
 +
Mbp1_ASPFU      QLEVDRQKIQEQTAALEAKETEGEPVEAQ----LERYERLRSTY--E-------------
 +
Mbp1_ASPNI      QLEQDRQKIRRQYDALAAKEAAEESSDAQ----LGRYEQMRDNY--E-------------
 +
Mbp1_ASPTE      QLELDRQKIKQQTAALSAKEAEEEPVDTQ----LARYEQLRASY--E-------------
 +
Mbp1_CRYNE      HATRALADKRQHLHRAQEKLATMQLFEQRSENVRRIMDAIAAGTLLTPAEFTGRTQTMHE
 +
Mbp1_GIBZE      TTSTQLGEARRSLEHLSATLKKQQLA-------KQKVANLSHA-----------------
 +
Mbp1_MAGGR      LTTTDVNDLRRKLDEAQARVKAQQLA-------RQKVTNLQRA-----------------
 +
Mbp1_NEUCR      VTSSQVGDARRTLESLQEKLKAQQLA-------KQKIVNFNRA-----------------
 +
Mbp1_CANAL      QINQIKLESQRKILSFFKLDHLIEELEQNKDDSQQQQQQVTDDD--DPTSVHGNDLHLDF
 +
Mbp1_DEBHA      AIGHEKLLSQRAVLQFFKLEYLIDDIMADYDQN------------------NSDNLIIDT
 +
Mbp1_PICST      SINTEKLVSQKAILSFFKLEYLIEDLERVNKE------------------TNPQELSLDF
 +
Mbp1_CANGL      SIKRTVHSTDNRIREILET---------D--------------------------ADADI
 +
Mbp1_SACCE      SISKTKIQVSLKTLEVLKESSKDENGEAQ--------------------------TNDDF
 +
'''Annotation      C'''
 +
 
 +
Mbp1_EREGO      SMSATVTSLDMKVLEILEVK-----------------------------------DMNNI
 +
Mbp1_KLULA      SMKKTITSVEMKLLEALNLK-----------------------------------ETDNV
 +
Mbp1_YARLI      KMEEDIAATNEAIREYEAKHGTAEELEK--------------------------------
 +
Mbp1_COPCI      NIQAEILESQRTVLQLR---QQAEGLSQA----KQRLADLENA----LQDKMGRRYRLGF
 +
Mbp1_USTMA      QIQTEIEDSAKVAEALH---HEAQGVDEE----RKRVDSLQLA----LKHAINKRARDDL
 +
Mbp1_SCHPO      DTLNEISRTYQELTFLQ---KNNPTY-------SQSMENLIRE-AQETYQQLSKRLLIWL
 +
                                                                           
 +
 +
Mbp1_ASPFU      ------------------------------------SLLEQIQQVRLKERLTSMPPPAKE
 +
Mbp1_ASPNI      ------------------------------------SLLEQIQRARLKERLASTPVPTQT
 +
Mbp1_ASPTE      ------------------------------------SLLEHIQQARLKERVASMPIPTKE
 +
Mbp1_CRYNE      KSTGQLPPLAFRHVPG--------------------LALDASSQSQLNGAPPSTPLSVED
 +
Mbp1_GIBZE      ---REAEQVRLMQEQ------SRASQPNPSSS------WETELSAMLEAADDTSDG----
 +
Mbp1_MAGGR      ---EERERYRLTQLE------QTTGRRDIASAN----GWEAESNTLLATINATTNG----
 +
Mbp1_NEUCR      ---CEEEEQILIELE------QRHGRLDVASAN----AWEMELESALEIVKTQSPKGL--
 +
Mbp1_CANAL      KRDHILQEEIYRLMNDLTYQELHQQDELDKVEHSYRMTKERLH-EKVLDASSF----VID
 +
Mbp1_DEBHA      EKDRIIQDEINRLISDLSFQFLQRKDQLDQVFMKYKAISSAIQNTKVAELAST----LSQ
 +
Mbp1_PICST      KRDQIIQDEIHRLINDLTYQFLQKKEDLYQLHQKYILVNEKVQ-----------------
 +
Mbp1_CANGL      SSAILAQEKDITELK------IEAENHL--------RKLKNQFEYLQKQRLLKLTEYHN-
 +
Mbp1_SACCE      EILSRLQEQNTKKLR------KRLIRYK--------RLIKQKLEYRQTVLLNKLIEDETQ
 +
Mbp1_EREGO      TYEMDSLKENIAGLK------QKLSEKQ--------KVLVSLLEKSQRVTLRKCVEEEKK
 +
Mbp1_KLULA      DIVLNDRKEKIDELQ------RRIATDK--------RVLINRLEEGQVKLIRKFVDEETK
 +
Mbp1_YARLI      ---------LASEAE------ERVTTRV--------NQLRKVFERSQAKGLAMLVAEEER
 +
Mbp1_COPCI      EKWIKDE-----------------------------ETREKVIRDAANGDLVLTPATTSY
 +
Mbp1_USTMA      ER--RWS-----------------------------EGKQAIKRARLQAGLEPGALSTSN
 +
Mbp1_SCHPO      EA---------RQIFDLERSLKPHTSLSISFPSDF-------------------------
 +
'''Annotation                xxxx------xxxxxxx--------xxxxxxx'''
 +
                                                                           
 +
 +
Mbp1_ASPFU      NMMPS--------------------------------------SSDQNQL-LITYQLARQ
 +
Mbp1_ASPNI      AVIGS-------------------------------------SSPEQDRL-LTTFQLSRA
 +
Mbp1_ASPTE      Q--AE-------------------------------------SSKDTSQL-TTVFQLAQK
 +
Mbp1_CRYNE      QEDI------------------------------ALPERDDP----------ECLVKLRR
 +
Mbp1_GIBZE      ------------------------------------------EFGGEGLLP-SAAVLEAR
 +
Mbp1_MAGGR      ------------------------------------------EPDADAKLP-SSALLRAR
 +
Mbp1_NEUCR      ------------------------------------------DPDSRPSLP-SAAVLRAR
 +
Mbp1_CANAL      QTHQQ-------------------------------------GNVH------EQLELAKQ
 +
Mbp1_DEBHA      HESNS-------------------------------------SSTEDETP-SEQVRLSIE
 +
Mbp1_PICST      ------------------------------------------------------------
 +
Mbp1_CANGL      ---GE-------------------------------------HNDTDNTL-DNKIEICKQ
 +
Mbp1_SACCE      ATTNN-------------------------------------TVEKDNNT-LERLELAQE
 +
Mbp1_EREGO      AIESVI--------------------------------AAPADDATHSSKE-TLADDLRE
 +
Mbp1_KLULA      NV---------------------------------------EGKTTDGEESEDIEALLKE
 +
Mbp1_YARLI      EI-------------------------------------------SREQT-KGEFKTAKE
 +
Mbp1_COPCI      TV--DEDGDSDSGSNGDKNKGKRKAQVQQEEVSDLVELYSNIPTDPEELR-KQCEALREE
 +
Mbp1_USTMA      ATNAPATGDQKSKDDA-------------KSLIEALPAGTNVKTAIA--------ELRKQ
 +
Mbp1_SCHPO      -------------------LKKEDGLSLNNDF--KKPACNN-----VTNS-DEYEQLINK
 +
                                                                           
 +
 +
Mbp1_ASPFU      LCSLQKARRAAVRDLAQQTADAGV------------------------------------
 +
Mbp1_ASPNI      LCSEQKIRRAAVKELAQQRADAGV------------------------------------
 +
Mbp1_ASPTE      LCAAQKARRAAVKELAQQTADAGV------------------------------------
 +
Mbp1_CRYNE      MALWEDRIAEVLEDKIRAMEGEGV------------------------------------
 +
Mbp1_GIBZE      VRAVKK-RCESTRK------------------------------------------MVSA
 +
Mbp1_MAGGR      IEAVKK-QTESTRQ------------------------------------------SVVA
 +
Mbp1_NEUCR      IKALRA-RSSKTRQ------------------------------------------AVAA
 +
Mbp1_CANAL      LQVEIIKRKKLVDEISKLTKNVPLPE------------------------NPNAKTIIDT
 +
Mbp1_DEBHA      LQTQIVKYKQMLHKLHQQHLQVPLSSLNDNTDTKENKENIKEESQTNDTAEPAPHSVIAK
 +
Mbp1_PICST      LTEEIIKCKKLSQQLYKQQMVVPIPQ-----------TSIDKENNSTPT-GSSSNSIVAK
 +
Mbp1_CANGL      ISVLQIERKRKISE------------------------------------------LISH
 +
Mbp1_SACCE      LTMLQLQRKNKLSS------------------------------------------LVKK
 +
Mbp1_EREGO      LTVLQLRRKHKINR------------------------------------------LIEL
 +
Mbp1_KLULA      LVLIQLKRKRKLNQ------------------------------------------IIDV
 +
Mbp1_YARLI      LTDLQHGRKDLVDDVVELFANAGV------------------------------------
 +
Mbp1_COPCI      VSQSRKRRKAMFDELVTFQAEAGT------------------------------------
 +
Mbp1_USTMA      LSQVQANKTELVDKFVARAREQGT------------------------------------
 +
Mbp1_SCHPO      LTSLQASRKKDTLYIRKLYEELGI------------------------------------
 +
                :                                                         
 +
 +
Mbp1_ASPFU      ----S-TKFDVHRRLVALAT-GLKEEELD-PMAAELAETLEFDRMNGR-GPGGESPE---
 +
Mbp1_ASPNI      ----S-TKFDVHRKLVALAT-GLKEEELD-PMAAELAETLEFDRMNGK-GVGPESPE---
 +
Mbp1_ASPTE      ----S-TKFDVHRKLVALAT-GLKEEELD-PMAAELAEALEFDRMNGK-GNGAESPD---
 +
Mbp1_CRYNE      ------DRAVKYRKLVSVCA-KVPVDKVD-SMLDGLVAAVESEGQG--------------
 +
Mbp1_GIBZE      LKGRSRDTEVKYRRVVALCT-GVQEDEVD-AVIDGLLKAVESEQEE--------------
 +
Mbp1_MAGGR      LKGRSREVEGRYRHLVALAT-KCRDEDVD-STMEGLLKAVESEKGE--------------
 +
Mbp1_NEUCR      LQAQSKEKELKYRRLVSLCT-RRPEIEVE-ALLDTLTRAVESEKPE--------------
 +
Mbp1_CANAL      YPS-T-DKLYKYCKLISLSC-GIPMDEIE-TSIDAMEESLVKK-----------------
 +
Mbp1_DEBHA      YPK-D-DKLHKYCKLIALCC-GMNFNDVE-NSIDLIEQSLSKSAPNM-------------
 +
Mbp1_PICST      YPH-D-NLLSKYCHLIAQCC-GMDFDDVE-GSIDEIEQSLLKSN--V-------------
 +
Mbp1_CANGL      YED-S-RKIHKYRRMISEGT-EMKTEEVD-GCLDIILQTLINNSS---------------
 +
Mbp1_SACCE      FED-N-AKIHKYRRIIREGT-EMNIEEVD-SSLDVILQTLIANNNK---NKGAEQII---
 +
Mbp1_EREGO      LCG-N-SKIHKFRKMISQGT-DMDISEVD-NFLDVIFQQLNEDEENTN-NGG--------
 +
Mbp1_KLULA      ITD-N-SKVYKYRKMISQGT-DIDVSDVD-ECLDVIYQTLSKEG----------------
 +
Mbp1_YARLI      ----G-EKMNEYRRLVAMSC-GVKVEDID-GLLDGIEKALLEGER---------------
 +
Mbp1_COPCI      ----S-GRMSDYRRLIAAGCGGLEPLEID-SVLGMLLETLEAE-----------------
 +
Mbp1_USTMA      ----G-RTMAAYRRLIAAGCGGIAPDEVD-AVVGVLCELLQESHTGARAGAGGERDDRAR
 +
Mbp1_SCHPO      ----D-DTVNSYRRLIAMSC-GINPEDLSLEILDAVEEALTREK----------------
 +
                            . :::          .:.      :  :                   
 +
 +
Mbp1_ASPFU      ---------PVQKR----------------------------------------------
 +
Mbp1_ASPNI      ---------A--------------------------------------------------
 +
Mbp1_ASPTE      ---------L--------------------------------------------------
 +
Mbp1_CRYNE      ------------------------------------------------------------
 +
Mbp1_GIBZE      ------------------------------------------------------------
 +
Mbp1_MAGGR      ------------------------------------------------------------
 +
Mbp1_NEUCR      ------------------------------------------------------------
 +
Mbp1_CANAL      ------------------------------------------------------------
 +
Mbp1_DEBHA      ------------------------------------------------------------
 +
Mbp1_PICST      ------------------------------------------------------------
 +
Mbp1_CANGL      ------------------------------------------------------------
 +
Mbp1_SACCE      ---------TISNA----------------------------------------------
 +
Mbp1_EREGO      ------------------------------------------------------------
 +
Mbp1_KLULA      ------------------------------------------------------------
 +
Mbp1_YARLI      ------------------------------------------------------------
 +
Mbp1_COPCI      ------------------------------------------------------------
 +
Mbp1_USTMA      DVAMMLKAFPVYSRCIVMNRQLAVTRYPCCRLLFYSLPCRTNMISGLWMQSDSVAAVLAR
 +
Mbp1_SCHPO      ------------------------------------------------------------
 +
                                                                           
 +
 +
Mbp1_ASPFU      ------------------------------------------------------------
 +
Mbp1_ASPNI      ------------------------------------------------------------
 +
Mbp1_ASPTE      ------------------------------------------------------------
 +
Mbp1_CRYNE      ------------------------------------------------------------
 +
Mbp1_GIBZE      ------------------------------------------------------------
 +
Mbp1_MAGGR      ------------------------------------------------------------
 +
Mbp1_NEUCR      ------------------------------------------------------------
 +
Mbp1_CANAL      ------------------------------------------------------------
 +
Mbp1_DEBHA      ------------------------------------------------------------
 +
Mbp1_PICST      ------------------------------------------------------------
 +
Mbp1_CANGL      ------------------------------------------------------------
 +
Mbp1_SACCE      ------------------------------------------------------------
 +
Mbp1_EREGO      ------------------------------------------------------------
 +
Mbp1_KLULA      ------------------------------------------------------------
 +
Mbp1_YARLI      ------------------------------------------------------------
 +
Mbp1_COPCI      ------------------------------------------------------------
 +
Mbp1_USTMA      SNAVLRISPCPKCARMSKLQAHLYEASAARLCGGKMLRRTLALFSEAARSSSSSSASAAA
 +
Mbp1_SCHPO      ------------------------------------------------------------
 +
                                                                           
 +
 +
Mbp1_ASPFU      ----------LPS-----------------------------------------------
 +
Mbp1_ASPNI      ------------D-----------------------------------------------
 +
Mbp1_ASPTE      ------------E-----------------------------------------------
 +
Mbp1_CRYNE      ------------------------------------------------------------
 +
Mbp1_GIBZE      ------------------------------------------------------------
 +
Mbp1_MAGGR      ------------------------------------------------------------
 +
Mbp1_NEUCR      ------------------------------------------------------------
 +
Mbp1_CANAL      ------------------------------------------------------------
 +
Mbp1_DEBHA      ------------------------------------------------------------
 +
Mbp1_PICST      ------------------------------------------------------------
 +
Mbp1_CANGL      ------------------------------------------------------------
 +
Mbp1_SACCE      ----------N-------------------------------------------------
 +
Mbp1_EREGO      ------------------------------------------------------------
 +
Mbp1_KLULA      ------------------------------------------------------------
 +
Mbp1_YARLI      ------------------------------------------------------------
 +
Mbp1_COPCI      ------------------------------------------------------------
 +
Mbp1_USTMA      SSSASILTSHLSKAHLPPSLARSAKPHKNLYQMLSTLPKDGVGARVRQRRWAAKGLDVSH
 +
Mbp1_SCHPO      ------------------------------------------------------------
 +
                                                                           
 +
 +
Mbp1_ASPFU      -----------------------------QREPSSLPFSGPPVSVDA-------------
 +
Mbp1_ASPNI      -----------------------------HKDSASLPFPGPVVSVDA-------------
 +
Mbp1_ASPTE      -----------------------------HKDSASFPFPEPTISVDA-------------
 +
Mbp1_CRYNE      ----------------------------LDFSRASNFVNRIKATK-S-------------
 +
Mbp1_GIBZE      ----------------------------LEINRVRRFLGGVEGV--Q-------------
 +
Mbp1_MAGGR      ----------------------------LEIGRVRRFLGGVEGVI-G-------------
 +
Mbp1_NEUCR      ----------------------------LEIARVRRFLGGVEGVV-H-------------
 +
Mbp1_CANAL      ------------------------------------------------------------
 +
Mbp1_DEBHA      ----------------------------------------------Q-------------
 +
Mbp1_PICST      ----------------------------------------------K-------------
 +
Mbp1_CANGL      ------------------------------------------------------------
 +
Mbp1_SACCE      --------------------------------------------SHA-------------
 +
Mbp1_EREGO      ---------------------------------HTNYNG---------------------
 +
Mbp1_KLULA      ------------------------------------------------------------
 +
Mbp1_YARLI      ------------------------------------------------------------
 +
Mbp1_COPCI      -----------------------------DPSSTSATWSGSKGQQTG-------------
 +
Mbp1_USTMA      DVDLKAHLAKLHHTGATKTNKDEGHLCYWEITKVRLKDGGNHGKAWGRFVWRERNAGVVK
 +
Mbp1_SCHPO      ------------------------------------------------------------
 +
                                                                           
 +
 +
Mbp1_ASPFU      ---------------------------------------------
 +
Mbp1_ASPNI      ---------------------------------------------
 +
Mbp1_ASPTE      ---------------------------------------------
 +
Mbp1_CRYNE      ---------------------------------------------
 +
Mbp1_GIBZE      ---------------------------------------------
 +
Mbp1_MAGGR      ---------------------------------------------
 +
Mbp1_NEUCR      ---------------------------------------------
 +
Mbp1_CANAL      ---------------------------------------------
 +
Mbp1_DEBHA      ---------------------------------------------
 +
Mbp1_PICST      ---------------------------------------------
 +
Mbp1_CANGL      ---------------------------------------------
 +
Mbp1_SACCE      ---------------------------------------------
 +
Mbp1_EREGO      ------HVSCAILDTVEGYGIENIENKRGT-------SQNDGPAK
 +
Mbp1_KLULA      ---------------------------------------------
 +
Mbp1_YARLI      ---------------------------------------------
 +
Mbp1_COPCI      ---------------------------------------------
 +
Mbp1_USTMA      QGQAQAKLTKVCLSMVVAHPGKPITKAESGERIPGALKYCWDLAH
 +
Mbp1_SCHPO      ---------------------------------------------

Revision as of 17:19, 1 December 2014

For a score-colored alignment, see: http://biochemistry.utoronto.ca/undergraduates/courses/BCH441H/resources/T-coffee_scores.html .


Result of T-COFFEE alignment of all Mbp1 protein orthologues. Default parameters. Output order of rows kept same as input order, i.e. according to sequence similarity of adjacent rows as represented in the CLUSTAL guide tree. Click here to view the score-colored version of this alignment.


Annotation Keys:

  • * Proposed binding region
  • + positively charged residues, oriented for possible DNA binding interactions
  • - negatively charged residues, oriented for possible DNA binding interactions
  • E beta strand
  • H alpha helix
  • t beta turn
  • x Low complexity region
  • C Coiled coil regions predicted by Coils2 program



CLUSTAL FORMAT for T-COFFEE Version_5.05 http://www.tcoffee.org, CPU=144.32 sec, SCORE=41, Nseq=18, Len=1485 

Mbp1_ASPFU      ------------------------------------------------------------
Mbp1_ASPNI      ---------------------MAA------------------------------------
Mbp1_ASPTE      ---------------------MAG------------------------------------
Mbp1_CRYNE      --MEPPSNPIQPPVTPSHHSLLSAISPALSEQTPAPIHTLPPHLRPSIPQPHIAPPRPSS
Mbp1_GIBZE      ------------------------------------------------------------
Mbp1_MAGGR      MASTVAGNSFVSQQHPGNLHSANLQSQSQGFRRQNSTSSVPSTASFDPPNGSIANTGSQK
Mbp1_NEUCR      -------------MQPPQLGGASQQSQ---------------------------------
Mbp1_CANAL      ------------------------------------------------------------
Mbp1_DEBHA      -----------------------M------------------------------------
Mbp1_PICST      ------------------------------------------------------------
Mbp1_CANGL      ------------------------------------------------------------
Mbp1_SACCE      ------------------------------------------------------------
Mbp1_EREGO      ------------------MSAGSA------------------------------------
Mbp1_KLULA      ------------------------------------------------------------
Mbp1_YARLI      ------------------------------------------------------------
Mbp1_COPCI      ------------------------------------------------------------
Mbp1_USTMA      -----------------------M------------------------------------
Mbp1_SCHPO      ----------------------MA------------------------------------
                                                                            

Mbp1_ASPFU      ------------------------------------------------------------
Mbp1_ASPNI      ---------------------------------------------------VDFS-NVYS
Mbp1_ASPTE      ---------------------------------------------------VDFS-KIYS
Mbp1_CRYNE      VQPTMEEQQRMHHIQQH-QQQQHFQQQQNDENVFGSVMGAPGHVPGHEAPMSTQP-KVYA
Mbp1_GIBZE      ----MSQQSQS---------------------GMGNS--FRGGYN--GD--PDNS-GIYS
Mbp1_MAGGR      HHPMSSQQSQPPASQQSFSMSQTGSQPQPSQSSFRSY--SDQNVP--QQP-QEAS-PIYT
Mbp1_NEUCR      -----------PSSQQSFSMSQS------SQSVYRQY--TDPPNR--LHN-DHAVPTIYS
Mbp1_CANAL      ---------------------------------------------------MSDS-QIYS
Mbp1_DEBHA      ---------------------------------------------------ADNT-QIYS
Mbp1_PICST      ---------------------------------------------------MTST-QIYS
Mbp1_CANGL      ----------------------------------------------------MSN-QIYS
Mbp1_SACCE      ----------------------------------------------------MSN-QIYS
Mbp1_EREGO      ---------------------------------------------------VSAT-QIYS
Mbp1_KLULA      ---------------------------------------------------MSSN-QIYS
Mbp1_YARLI      ------------------------------------------------------M-SIYK
Mbp1_COPCI      ---------------------------------------------------MPEA-QIFK
Mbp1_USTMA      ---------------------------------------------------SGDK-TIFK
Mbp1_SCHPO      ---------------------------------------------------PRSS-AVHV
1MB1  3D                                                             ----EEE
                                                                            

Mbp1_ASPFU      ------------------MRRRGDDWINATHILKVAGFDKPARTRILEREVQKGTHEKVQ
Mbp1_ASPNI      ATYSSVPVYEFKIGTDSVMRRRSDDWINATHILKVAGFDKPARTRILEREVQKGVHEKVQ
Mbp1_ASPTE      ATYSSVPVYEFKIEGDSVMRRRADDWINATHILKVAGFDKPARTRILEREVQKGVHEKVQ
Mbp1_CRYNE      SVYSGVPVFEAMIRGISVMRRASDSWVNATQILKVAGVHKSARTKILEKEVLNGIHEKIQ
Mbp1_GIBZE      ASYSGVDVYEMEVNNIAVMRRRNDSWLNATQILKVAGVDKGKRTKILEKEIQTGEHEKVQ
Mbp1_MAGGR      AVYSNVEVYEFEVNGVAVMKRIGDSKLNATQILKVAGVEKGKRTKILEKEIQTGEHEKVQ
Mbp1_NEUCR      ATYSGVGVYEMEVNNVAVMRRQKDGWVNATQILKVANIDKGRRTKILEKEIQIGEHEKVQ
Mbp1_CANAL      ATYSNVPAFEFVTSEGPIMRRKKDSWINATHILKIAKFPKAKRTRILEKDVQTGIHEKVQ
Mbp1_DEBHA      ATYSNVPVFEFVTLEGPIMRRKLDSWINATHILKIAKFPKAKRTRILEKDVQTGVHEKVQ
Mbp1_PICST      ATYSNVPVFEYVTSEGPIMRRKSDSWINATHILKIAKFPKAKRTRILEKDVQTGVHEKVQ
Mbp1_CANGL      AKYSGVDVYEFIHPTGSIMKRKNDGWVNATHILKAANFAKAKRTRILEKEVLKEMHEKVQ
Mbp1_SACCE      ARYSGVDVYEFIHSTGSIMKRKKDDWVNATHILKAANFAKAKRTRILEKEVLKETHEKVQ
Mbp1_EREGO      AKYSGVEVYEFLHPTGSIMKRKADDWVNATHILKAAKFAKAKRTRILEKEVIKDTHEKVQ
Mbp1_KLULA      AKYSGVDVYEFIHPTGSIMKRKADNWVNATHILKAAKFPKAKRTRILEKEVITDTHEKVQ
Mbp1_YARLI      ATYSGVPVYEFQCKNVAVMRRKSDGWVNATHILKVAGFDKPQRTRILEKEVQKGVHEKVQ
Mbp1_COPCI      ATYSGIPVYEMMCKGVAVMRRRSDSWLNATQILKVAGFDKPQRTRVLEREVQKGEHEKVQ
Mbp1_USTMA      ATYSGVPVYECIINNVAVMRRRSDDWLNATQILKVVGLDKPQRTRVLEREIQKGIHEKVQ
Mbp1_SCHPO      AVYSGVEVYECFIKGVSVMRRRRDSWLNATQILKVADFDKPQRTRVLERQVQIGAHEKVQ
                                  *:*  *. :***:*** . . *  **::**:::    ***:*
1MB1  3D        EEtt-EEEEEEEEt-EEEEEEtt---EEHHHHHHH----HHHHHHHHhhhHHH---EEE-
Annotation                                                **+**-+******+*+**

Mbp1_ASPFU      GGYGKYQGTWIPLHEGRLLAERNNIIDKLRPIFDY--VAG-DH---TPPPAPKHTSAASS
Mbp1_ASPNI      GGYGKYQGTWIPLQEGRQLAERNNILDKLLPIFDY--VAG-DR---SPPPAPKHTSAASK
Mbp1_ASPTE      GGYGKYQGTWIPLPEGRLLAERNNIIDKLRPIFDY--VAG-DR---SPPPAPKHTSAASK
Mbp1_CRYNE      GGYGKYQGTWVPLDRGRDLAEQYGVGSYLSSVFDFVPS---AS---VIAALPVIRTGTPD
Mbp1_GIBZE      GGYGKYQGTWIKFERGLQVCRQYGVEELLRPLLTYDMGQDGGVAGRGDLNTPTKEQAMAA
Mbp1_MAGGR      GGYGKYQGTWIKYERALEVCRQYGVEELLRPLLEYNRNPDGSVS-QANLNTPTKEQAMAA
Mbp1_NEUCR      GGYGKYQGTWIPFERGLEVCRQYGVEELLSKLLTHNRGQEGET---GNVDTPTKEQAMAA
Mbp1_CANAL      GGYGKYQGTYVPLDLGAAIARNFGVYDVLKPIFEFQYIEGQTE---VPPPAPKHNHASAL
Mbp1_DEBHA      GGYGKYQGTYVPLDLGADIAKNFGVFDSLRPIFEFTYVEGKSE---TPPPAPKHSHASAS
Mbp1_PICST      GGYGKYQGTYVPLELGRDIAKNFGVFDILKPIFDFKYIEGKSE---TPPPAPKHNHASAL
Mbp1_CANGL      GGFGKYQGTWVPLNIAINLAEKFDVYQDLKPLFDFSEENG-DA---APPPAPKHHHASKA
Mbp1_SACCE      GGFGKYQGTWVPLNIAKQLAEKFSVYDQLKPLFDFTQTDG-SA---SPPPAPKHHHASKV
Mbp1_EREGO      GGFGKYQGTWVPLDIARRLAQKFEVLEELRPLFDFTRRDG-SE---SPPQAPKHHHASRA
Mbp1_KLULA      GGFGKYQGTWIPLELASKLAEKFEVLDELKPLFDFTQQEG-SA---SPPQAPKHHHASRS
Mbp1_YARLI      GGYGKYQGTWVPLERAREIATLYDVDSHLAPIFNYDDEDG------SPPPAPKHRPNLER
Mbp1_COPCI      GGYGKYQGTWIPLERGMQLAKQYNCEHLLRPIIEFT--PA-AK---SPPLAPKHLVATAG
Mbp1_USTMA      GGYGKYQGTWIPLDVAIELAERYNIQGLLQPITSYVP-SA-AD---SPPPAPKHTISTSN
Mbp1_SCHPO      GGYGKYQGTWVPFQRGVDLATKYKVDGIMSPILSLDIDEGKAIA-------PKKKQTKQK
                **:******::    .  :.        :  :                   *        
1MB1  3D        ---tt--EEEE-HHHHHHHHHH---HHHHtt-        
Annotation      *******                                  xx---xxxxxxxxxxxx

Mbp1_ASPFU      RPRASK----KKAVN----------------------EQ-----VFSAA-----------
Mbp1_ASPNI      P-RAPKI--NKRVVK----------------------ED-----VFSAV-----------
Mbp1_ASPTE      P-RVSKAAANRRVAN----------------------EE-----VFSAV-----------
Mbp1_CRYNE      R-SGQQTPSGLPGHPNQRVISPFA---------------NHGQTT-PHMPPPQ-FIHQ--
Mbp1_GIBZE      Q-R---KRLYNQSA-DGRANGVSGTFFKNISTTASHAVAAISKARFDSPGPRSSRNGASR
Mbp1_MAGGR      Q-R---KKMYNSGA-DSRNNNGGGTFFKNISQTAHSAMTAISKARFDSPGPRG-RNGPTR
Mbp1_NEUCR      Q-R---KRMYNASSQENRGIGSTGTFFKNISSTASTAVAAISKARFDSPAPRN-RSGPSR
Mbp1_CANAL      N-VAKRQASLLKKQK-EKQVQPTLSDTS-----FGSSTS-----VPPTTVPKK-RGRPKR
Mbp1_DEBHA      N-VAKRQSSVNNSSG-DANSLNKTSHAR-----KTKSMT-----SLSGEPPKK-RGRPKR
Mbp1_PICST      N-IAKRSAVPQQAKK-SRTASATL----------------------TGEPPKK-RGRPKR
Mbp1_CANGL      S-SAKAKKAGRSVSSPAMNDSKTRASTRKANTPSSNDITSDSGAVVNPVVTRR-RGRPPN
Mbp1_SACCE      D-R---KKAIRSASTSAIMETKRNNKKAEENQFQSSKILGNPTA-----APRK-RGRPVG
Mbp1_EREGO      D-SAR-KRTTKSPPLPHGQL----------------------DA-----LPKR-RGRPPR
Mbp1_KLULA      D-STR-KKATKSASVPSGKVSEKASSQQ--QQPVSQQQQQQPGS-----APKR-RGRPPR
Mbp1_YARLI      -KKRTKV----TGSPLVRQPSRMETLTQSTGSTMG--------------------GTPQH
Mbp1_COPCI      N-R----P----VADGVGEESDHDTHSLRGSED------------------------GSM
Mbp1_USTMA      R-SKKIIP----ADPGALGRSRRATSIETESEV-------------IGAAPNN-VSEGSM
Mbp1_SCHPO      KPSVRGR-----------------------------------------------RGRKPS
                                                                            

Mbp1_ASPFU      ---------------------------------------KPIRN-MGPPSF--------P
Mbp1_ASPNI      ---------------------------------------NHHRS-MGPPSF--------H
Mbp1_ASPTE      ---------------------------------------KPHRP-MGPPSF--------T
Mbp1_CRYNE      -----GNEQMMNLPPHPSSLAYPTQPKPYFSMPLQH----TVGPQYDERHEGMTMTPTMS
Mbp1_GIBZE      TA-------SFSRQASMQNGD-------------------DFPS-NSQQS----------
Mbp1_MAGGR      AP-------SFQRQLSTQSID-------------------DFHGGNSQAS----------
Mbp1_NEUCR      AP-------SFNRQSSMQDVA-------------------DFP--NSQQS----------
Mbp1_CANAL      ATLS---AT-PSLQRSDTTPINKSLIDFNANDHSAKSSF----I-GVVPSF--------A
Mbp1_DEBHA      VPMQN--NIEPSLQHTDTTPITTIPES-----GPSIGTFNNKKS-LGHPTL--------T
Mbp1_PICST      VPMT---AAEPVLKHSDTTPINGPMNS---INGPLEGSF-------THPAL--------S
Mbp1_CANGL      STLTNKRKLGTGLQRSQSEMAFLKPEIPND---LNSNDIANIQQ-----VNSGDL----L
Mbp1_SACCE      STRGSRRKLGVNLQRSQSDMGFPRPAIPNS--SISTTQLPSIRSTMGPQSPTLGILEE-E
Mbp1_EREGO      ARKLSDVANVAGQTQVYSD--FPRPSIPVS--SISSNQLPSLQSTLHRSISI---EHNR-
Mbp1_KLULA      NKATVTLQR-SQSEMV-----FPKPSIPSS--SIQSTKLPSLQPQFGRSATSLSPIMDV-
Mbp1_YARLI      SRQSSLSQLAQ-------------------------------------------------
Mbp1_COPCI      -----------------------------------------------------------T
Mbp1_USTMA      -----------------------------------------------------------S
Mbp1_SCHPO      SLSSSTL-------------HSVNEKQPNS--SISPTIESSMNKVN--------------
                                                                            

Mbp1_ASPFU      HEQFEI--NPGYDDNESIEQA--TLES--SSMAADEEMMSMSQ-----HGAY-SRKRKRE
Mbp1_ASPNI      HEHYDV--NTGLDEDESIEQA--TLES--SSMIADEDMISMSQ-----NGPYSSRKRKRG
Mbp1_ASPTE      HEQYEM--HSGFDEDESIEQA--TLES--SSMVADEDMMTMSQ-----SGAY-SRKRKRG
Mbp1_CRYNE      MDGLAPPA-DIARMGFPYNPS--DIYI--DQYGQPHATYQAS-PYGKESGHPSKRQRSDA
Mbp1_GIBZE      -------------FASDYG-Q--QVDS--AYSTQQAN------NSVQMTEPDPPRKRQRV
Mbp1_MAGGR      ------------NFAENFPPQ--DVNM--AFSAGSEP------QPGGLNGTEPPRKRQRM
Mbp1_NEUCR      ------------LVSTEYATQ--TQNADSGFGSQTTQ------PLAGDGLEQPPRKRQRV
Mbp1_CANAL      RNDTEQDALQIMTNNMNLRQE--DLAS--VETDDDEEYHNGSRGDGLQNDSFTTKRRKYP
Mbp1_DEBHA      RQDTEQDALQIMASNMSANQE--DLEL--ADKSSDEDMGNRTPIDTQDE-----------
Mbp1_PICST      RHDTEQDALQVMAGNMNIKNE--DLEL--VDSDDDDDVVKKRR-----------------
Mbp1_CANGL      R------N-EKIQKNIQLKEI--DLDD--GLSSDVEVQ--------ETD-----------
Mbp1_SACCE      RHDSRQQQ-PQQNNSAQFKEI--DLED--GLSSDVEPSQQLQQVFNQNT-----------
Mbp1_EREGO      -------NKAPPQPNHKYEEL--DIED--GLSSDIETSICTNMVYAGHS-----------
Mbp1_KLULA      -------KSPLDQASPQFKEL--DIED--GLSSDVEPN---SIMGTKHE-----------
Mbp1_YARLI      --------SYGLDDSDHVTPSPPTVADDSSDFMSDEEVDR--------------------
Mbp1_COPCI      PSPSEA--SSSSRTPSPIHSP--GTYH--SNGL-DGP-----------------------
Mbp1_USTMA      PSPSDI--SSSSRTPSPLPAD---------------------------------------
Mbp1_SCHPO      ------------------------------------------------------------
Annotation           xxx-xxx
                                                                            

Mbp1_ASPFU      MNE---------------------------------------------------------
Mbp1_ASPNI      INE---------------------------------------------------------
Mbp1_ASPTE      -ND---------------------------------------------------------
Mbp1_CRYNE      EGSYIE-----------------------SGAAVQQHVEQD------EEADDGLDN----
Mbp1_GIBZE      T-MTPAESFNGYGQNVD------M------------YAAAYPGSPTEPNESFMYTQSAIH
Mbp1_MAGGR      D-MTPANSFGAYANNSQ------MQ----------AYADAFPGSPTEPNDSFIYTQHAAA
Mbp1_NEUCR      --LTPARSFGGQTPGHQPLDPFNAG----------NIANGDSGSPTEPSNSFNYDQVTAN
Mbp1_CANAL      GGMTNGNGL--ESQADL-LTSKELF------GVSRTSFEKR------AN-----------
Mbp1_DEBHA      -------NIHHEDNDEL-MTGRELF------GTPRNSFERI------VQSHNQSHN----
Mbp1_PICST      NGVNVALSLDSQVGDDL-LGSKELF------GASRGSFERV------IHNHNSNNN----
Mbp1_CANGL      -------TFQPNHQSSL-LGAEGHELRNNDSPLSPSSSSSLPTSPANLNDSNPFDQ----
Mbp1_SACCE      -------GFVPQQQSSL-IQTQQTE----SMATSVSSSPSLPTSPGDFADSNPFEE----
Mbp1_EREGO      -------NARLPMNTSL--------LPDKEEP---GLSSSLPSSPSEFSAPMVFDTQ---
Mbp1_KLULA      -------D-----NTHL--------MNTKDEP--VSSSSSLPSSPSEFSQSVAFGSRSNM
Mbp1_YARLI      ------------------------------------------------------------
Mbp1_COPCI      ------------------------------------------------------------
Mbp1_USTMA      ------------------------------------------------------------
Mbp1_SCHPO      -------------------------LPGAEEQ---VSATPLPASPNALLSPN--------
Annotation                 xxxxxx-xxxxxxx----xxxxxxxxxxxxxxxx
                                                                            

Mbp1_ASPFU      -------------------------VTAMSI---SEQEHILYGDQLLDYFMTVGD----A
Mbp1_ASPNI      -------------------------VAAMSL---SEQEHILYGDQLLDYFMTVGD----A
Mbp1_ASPTE      -------------------------VPTMSI---GEQEHILYGDQLLDYFMTVGD----A
Mbp1_CRYNE      -DSTASDDARDPPPLPSSMLLPHKP-----IRPKATPANGRIKSRLVQIFNVEG-----Q
Mbp1_GIBZE      DR----------------SPIEEGNGPLEPLPYEMSPDVENKRNVLMGLFLETT-----G
Mbp1_MAGGR      NDT-------------LLQQQHDQQTPLQPLPYEQSVEAENKRSMLMSIFMNDG-----M
Mbp1_NEUCR      D-----------------GDASYALGPLRPLPYENNADAEAKRGMLMGLFMDAN-----G
Mbp1_CANAL      ----Q-------QHNHYS-PLQPYHQPSISLSQE-NQIYSDYFQSLLSYFLDDNN-----
Mbp1_DEBHA      --HLN-----GSIHDPYG-LLQYHHHTSHTHSMRDDAIYADYFTNLLNYFLEDGNNKVRS
Mbp1_PICST      -GHLQ-------SHDPYS-F-SQYHQPSVSSQNETDVVYSDYFSSLLTYFLDDSK-----
Mbp1_CANGL      --RLG-----GGGTSPIISLIPRYSVQSRPQVTDINEKVNDYLTKLVDYFISNE-----M
Mbp1_SACCE      --RFP-----GGGTSPIISMIPRYPVTSRPQTSDINDKVNKYLSKLVDYFISNE-----M
Mbp1_EREGO      ---RM-----GSATSPLGSMLPRYMAPSRPRTSELDQKANEYLSKLVDYFINCE-----V
Mbp1_KLULA      QTPLQ-----LNGTTSMNMILPKFS-SSQNGPSDSNQRANEYLSKLVNYFISND-----T
Mbp1_YARLI      ----------QMGNYP-------RPMMAKPKPIQVRDPKDLYTNDLLNYFVSAD------
Mbp1_COPCI      ----S-----SGGRNRYRQSNDRYDEDDDASRHNGMGDPRSYGDQILEYFISD-------
Mbp1_USTMA      ------------RAHPLHANHALAGYNGRDA-----NNHARYADIILDYFVTE-------
Mbp1_SCHPO      ----------------------DNTIKPVEELGMLEAPLDKYEESLLDFFLHPE------
                                                             ::  *          

Mbp1_ASPFU      PEATRIP-----PPQPPANFQVDRPIDDSGNTALHWACAMGDLEIVKDLLRRGA---NIK
Mbp1_ASPNI      PEATRIP-----PPQPPANFQVDRPIDDSGNTALHWACAMGDLEIVKDLLRRGA---DMK
Mbp1_ASPTE      PEATRVP-----PPEPPVNFQVDRPIDDSGNTALHWACAMGDLEIVRDLLRRGA---DVK
Mbp1_CRYNE      VNLRSV---FGLAPDQLPNFDIDMVIDDQGHSALHWACALARLSIVQQLIELGA---DIH
Mbp1_GIBZE      TDPTKNDTLRG-----FTPLELDMPIDLQSHTALHWAATLARMPLLRALIAAGA---SPA
Mbp1_MAGGR      SEQARVDTLRQ-----IHPRDLDMPIDSQCHTALHWAATLSRMTILRRLIEAGA---SPF
Mbp1_NEUCR      PEEAIQAALCN-----VSPQELDSPIDTQSHTALHWAATLSRMPLLRALIHAGA---NPW
Mbp1_CANAL      KIRSPIPDSLLSPPLPLSKIHIYQTIDSDGNTIFHWACSMGNLNMVEFLLKTFTHSLNPD
Mbp1_DEBHA      TQESNIPDKILNPPQPLSKINITQPVDNEGNTIFHWACSMANNGMIEFLLATFESFLNSD
Mbp1_PICST      IRSNNIPEKLLNPPQPISKIQINQPIDNEGNTIFHWACSMANISSIEFLLVTF--QISPD
Mbp1_CANGL      KSNKTVPQELLHPPTQSAP-FIDAPIDPELHTAFHWACSMGNLPIVEALYETGT---NIR
Mbp1_SACCE      KSNKSLPQVLLHPPPHSAP-YIDAPIDPELHTAFHWACSMGNLPIAEALYEAGT---SIR
Mbp1_EREGO      QNNGAVPMELLNPP-HSSP-CIDSWIDSEHHTAFHWACAMGTLPIVEALLQAGA---SPR
Mbp1_KLULA      QNESEIPMELLNPPLHCSP-FIDTWIDPEHHTAFHWACAMGTLPIVEALLKAGS---SIR
Mbp1_YARLI      --DEKIPAFLENPP---AEFDVHRPIDEEGHTALHWACAMGHLRVIELLLKAGS---DVR
Mbp1_COPCI      --TNQIPPILITPP---PDFDPNMAIDDDGHTSLHWACAMGRIRIVKLLLSAGA---DIF
Mbp1_USTMA      --NTTVPSLLINPP---PDFNPDMSIDDDEHTALHWACAMGRIRVVKLLLSAGA---DIF
Mbp1_SCHPO      --EGRIPSFLYSPP---PDFQVNSVIDDDGHTSLHWACSMGHIEMIKLLLRANA---DIG
                                         :* . :: :***.::.     . *        .  
Ankyrin 3D                             --t----HHHHHHH---HHHHHt-t--t-t-----t-

Mbp1_ASPFU      ALSVHEETPLVRAVLFTNNYEKRTFPALLDLLLDTVSFRDWFGATIFHHISETT------
Mbp1_ASPNI      ALSIHEETPLVRAVLFTNNYEKRTFPALLDLLLDTISFRDWFGATLFHHIAQTT------
Mbp1_ASPTE      ALSVHEETPLVRAVLFTNNYEKRTFPALLELLLDTVSFRDWFGATLFHHIAETT------
Mbp1_CRYNE      RGNYAGETPLIRAVLTSNHAEAGSFTDLLHLLSPSIRTLDHAYRTVLHHIALVA------
Mbp1_GIBZE      RVNGSGETALMRACLVTNSQDHNSFPDLLEVLGGTIEARDHKGRTVLHHIAVTS------
Mbp1_MAGGR      RVNTSGETPLMRACIVTNSHDNDSMPAILDILGNTMEVRDSKERTVLHHIALTS------
Mbp1_NEUCR      RVNACGETALMRACTVTNSMENNTFPELLDLLGCTLDVTDDKGRTVLHHIAVTS------
Mbp1_CANAL      VRNNNGETPLMFMVKFNNSFQLRNFPLILDLLKESVLLVDSNGKTVLHHIVDTD------
Mbp1_DEBHA      LKNNRGETPLMFLVKFSNSYQLKNFPTLLDLLFDSILSIDNYGRTVLHHIALAANNLTSE
Mbp1_PICST      IRNNKGETPLMFLVKFVNSFQLRNFPSILQMLLESILLVDKSGKTVLHHIALID------
Mbp1_CANGL      AANANGQTPLMRSAMFHNSYTRRSFPRIFELLSETVFDIDSMGQTVLHHIV---------
Mbp1_SACCE      STNSQGQTPLMRSSLFHNSYTRRTFPRIFQLLHETVFDIDSQSQTVIHHIV---------
Mbp1_EREGO      ALNQAGETPLMRASLVHNSYTKRTYPRIFQLLQDTVFDVDSRSQTVVHHIV---------
Mbp1_KLULA      SLNNVGETPLIRSSIFHNCYTKRTYPQIFEILKDTVFDLDAKSRNVIHRIV---------
Mbp1_YARLI      ATNMFGQTPLTRAIMFTNNYDRRTFPKVVDILQDTLFQVDGQGRTVLHHIAQHVS-----
Mbp1_COPCI      KVNKAGQTALMRSVMFANNYDVRKFPELYELLHRSTLNIDNSNRTVFHHVVDVA------
Mbp1_USTMA      RVNSNQQTALMRATIFPNSLSSFTDPSL---------NIDRNDRTVFHHVVDLA------
Mbp1_SCHPO      VCNRLSQTPLMRSVIFTNNYDCQTFGQVLELLQSTIYAVDTNGQSIFHHIVQST------
                  .   :*.*       *     .   :           *    .:.*::          
Ankyrin 3D      ---t----HHHHHHHH---------HHHHHHHHH-ttHHH-----HHHHHH---------

Mbp1_ASPFU      -----------RSKGKWKSSRYYCEVLLDKLHNT--------------------------
Mbp1_ASPNI      -----------KSKGKWKSSRYYCEVALEKLRTT--------------------------
Mbp1_ASPTE      -----------RSKGKWKSSRYYCEVLLEKLRAT--------------------------
Mbp1_CRYNE      -----------GVKGRVPAARTYMASVLEWVAREQQANNTHS----------ITNPPNPA
Mbp1_GIBZE      -----------AVKGRNAASRYYLESLLEWVVRQGSAPNSQ-NTQTNGNGPSNSQAASP-
Mbp1_MAGGR      -----------AVSGRSAASRYYLQCLLGWVVRQGAANGGQLNSQTFNGG-ATVSQSQNA
Mbp1_NEUCR      -----------AVKGRHYASRYYLESLLEWVVRQGSAPSSQE----NGIGDRK------G
Mbp1_CANAL      -----------SKHKREKFAQYYLESLLEKIVDERQEQGDSN----------GHAME-DD
Mbp1_DEBHA      GSINANTDIHTFKKNKERFARYYMECLFAKIIEFQEIRDLQE----------IENKKLSL
Mbp1_PICST      -----------S-EKKFRFARYYMETLFDKIIESLEDEED-------------FAKD-PD
Mbp1_CANGL      -----------KRKSSTPSAIYYVNVLLSKIKDI--------------------------
Mbp1_SACCE      -----------KRKSTTPSAVYYLDVVLSKIKDF--------------------------
Mbp1_EREGO      -----------KRKSNTPSALYYLDVLLSKLKDF--------------------------
Mbp1_KLULA      -----------SRKSHTPSAVYYLDVVLSKIKDF--------------------------
Mbp1_YARLI      --------------KSQSAAKYYVTILLSKISEN--------------------------
Mbp1_COPCI      -----------MSKGKTHAARYYMETILTRLADY--------------------------
Mbp1_USTMA      -----------LSRGKPHAARYYMETMINRLADY--------------------------
Mbp1_SCHPO      -----------STPSKVAAAKYYLDCILEKLISI--------------------------
                                   :  *    :  :                             
Ankyrin 3D      -----------H--tH--HHHHHHHHH---------------------------------

Mbp1_ASPFU      ----CSQDEIDLLLSCQDSNGDTAALVAARNGAFRLVNLLLGHCPRA-GDLVNKKGETAT
Mbp1_ASPNI      ----FSPEEVDLLLSCQDSVGDTAVLVAARNGVFRLVDLLLSRCPRA-GDLVNKRGETAS
Mbp1_ASPTE      ----CSAEEIDLLLSCQDSNGDTAALVAARNGAFRLVDILLTHCSRA-GDLVNKKGETAI
Mbp1_CRYNE      DRNELAPINLRTLVDVQDVHGDTALNVAARVGNKGLVGLLLDAGADK--TRANKLGLRPE
Mbp1_GIBZE      -KM-GIARFMTEIVNAQDSVGDTALNIAARIGNRSIISQLLEVGADP--NIANRVGLRPL
Mbp1_MAGGR      TRL-DLGRFMSEMLNAQDSAGDTALNIAARIGNRSIISQLLEVCASP--HIANRSGLRPT
Mbp1_NEUCR      RRM-GIARFMSEIVNAQDNSGDTALNVAARVGNRSIISQLLEVGADP--TIPNRANLKPL
Mbp1_CANAL      ---LTKDELVTKFINHQDSDGNTAFHIAAHNLNKKCIKVFINYHRFINFGLRNLVSCTVE
Mbp1_DEBHA      ---SDKKELIAKFINHQDIDGNTAFHIVAYNLNKKCIKVFISYHKYINFHLKNLVSYTVE
Mbp1_PICST      ----NKKDLIAKFINHQDSDGNTAFHICSHNLNKRCIKVFISYHKYIDFGLRNLVGYTVE
Mbp1_CANGL      ----SPKYRIELLLNTKDANGDTALHIAARNNDREFFDILIKNGSLS--TISNNDGQTPT
Mbp1_SACCE      ----SPQYRIELLLNTQDKNGDTALHIASKNGDVVFFNTLVKMGALT--TISNKEGLTAN
Mbp1_EREGO      ----SPQYRIETLINAQDCKGSTPLHIAAMNRDKKFFQTLVGNGALS--TIKNHDGVTAD
Mbp1_KLULA      ----TPQYRIDVLINQQDNDGNSPLHYAATNKDDQFYQLLLQNGALT--TVQNNSGMTPN
Mbp1_YARLI      ----HSLGVLSQFMDTQNNEGDTALHILARSGAKKVSRALMDFNVKT--DIVNADGRTAL
Mbp1_COPCI      ------PKELADVINFQDEDGETALTMAARCRSKRLVKLLIDHGADP--KINNHDGKNAE
Mbp1_USTMA      ------GDQLADILNFQDDEGETPLTMAARARSKRLVRLLLEHGADP--KIRNKEGKNAE
Mbp1_SCHPO      ----QPFENVVRLVNLQDSNGDTSLLIAARNGAMDCVNSLLSYNANP--SIPNRQRRTAS
                         :  .:. ::  *.:.    :          ::           *       
Ankyrin 3D      -------------t----tt---HHHHHHH---HHHHHHHH--t-tt------t----HH

Mbp1_ASPFU      SITQRAHLPEQNIPP-PPSSITMGIDHTEGDL----------------------TVLETP
Mbp1_ASPNI      SIMQRAHLAERDIPP-PPSSITMGNDHIDGEV----------------------GAPTSL
Mbp1_ASPTE      SITQRAHPSERDVPP-PPSSVTMGNDHIDGEV----------------------NTSTNP
Mbp1_CRYNE      NFGLEIE-ALKISNGEAVMA-----------NLKSEVSKP--------------------
Mbp1_GIBZE      DFGIGSEN---AENKTNGEA-------------------------------------NVE
Mbp1_MAGGR      DFGIGVDSDGAMKTKGDSGG-------------------------------------DVE
Mbp1_NEUCR      DFGIGIAD---AETNDDPAQ-------------------------------------EKT
Mbp1_CANAL      DYLASHNYVLRLDPVEHDQSNNSDGDE----DIMED---------------------YTN
Mbp1_DEBHA      EYLASHNHVLRLDTSNDDSKEIQDIQEEAYKYLNPQFQGNN-------------LTIRNN
Mbp1_PICST      DYLASHNYVLRLDQT-GEEGEQEETED----LLYSQ---------------------EAV
Mbp1_CANGL      EIMNQHYQDLHLQAQTNIAGSNTSAYTDSFSSFGGKVKGSKLHSISELDDDKNTQNPENT
Mbp1_SACCE      EIMNQQYEQMMIQNGTNQHVNSSNTD------LNIHVNTNNIET-------KNDVNSMVI
Mbp1_EREGO      ELINNRFVKTIQPTQRGNYHENRAS-------------HSPLNS-------ASAAGGMVP
Mbp1_KLULA      GIISGRYSMDE--ITKG----------------------QRLDD-------PYEF-----
Mbp1_YARLI      DLLEGDRQMQQH-PPPAMALHHQ-------------------------------------
Mbp1_COPCI      DYILEDERFRSSPAPSSRVAAMSYRNAQVA------YPPPG------------APSTYSF
Mbp1_USTMA      DYIIEDERFRSSPSRTGPAGIELGADGLPV------LPT---------------------
Mbp1_SCHPO      EYLLEADKKPHSLLQSNSNASHSA-FSFSGIS----------------------------
Ankyrin 3D      HHHHHH--HHHHH-t--HHH-t----------HHHHHHH--tHH-------HHHHHHHH-
                                                                            

Mbp1_ASPFU      D-QTD--ALPAEASLATSALLAKISAIMAETNKKLAACYGHTKSNEPVSDDVANPEALYE
Mbp1_ASPNI      EPQSV--TLHHESSPATAQLLSQIGAIMAEASRKLTSSYGAAKPSQKDSDDVANPEALYE
Mbp1_ASPTE      DNQSV--AITPDTSSVTATLLSKIGVIIAEANKKLAVSYGSSKPGQQGSDDIANPEALYD
Mbp1_CRYNE      -----------------ERKSRDVQKNIATIFESISSTFSSEM--LAKQTKLNATEASVR
Mbp1_GIBZE      NGVVG-------TNQRSRESSDEIVASISHLLSETGSTFQSEM--KAKQASLDTLHSTLR
Mbp1_MAGGR      NGDVGG------SSQKSNESSNEIVTSITHLLTETSANFQEEI--KNKQKNIDSLHATLR
Mbp1_NEUCR      GATTG-------SGHKSRETSDEVVRSITHLIGESASIFQNEL--KKKQESIDTLHSQLR
Mbp1_CANAL      ENQSF--ETQLHNSKMAINLQNTTANLLTEKMTQLAYAIDSEL--SEKDEVILTYFKVLS
Mbp1_DEBHA      STQSF--ESQMYFSKMAVNLQNTTANLITEKLTELAYIVDKEL--SEKDEKLLMYFKLLK
Mbp1_PICST      STQSF--ESQLYYSKVAVNLQNTTSNLITERLTELAYTIDKEL--SEKDETILTFFKILK
Mbp1_CANGL      VTNIVSN--LHFSSNAAINLVKNIPAF-TDSMKHLAEKFDGSY--KNHEESCRSTEKMLG
Mbp1_SACCE      MSPVSPSDYITYPSQIATNISRNIPNV-VNSMKQMASIYNDLH--EQHDNEIKSLQKTLK
Mbp1_EREGO      ASLIHTG--DMYPSQSATSVSRAIPEV-INLMKDMADSYQFLY--EDRNQEVQDLVKMLK
Mbp1_KLULA      ------N--KMYPSQAATRTNRIIPEV-INMMKEMANSYQNAY--QKRQNEVLQMERTVK
Mbp1_YARLI      -----PPYQMLHESETAIAAHN-LAGTVVHNLQVLAHAFDAEL--KEKDADVQQVRQMAT
Mbp1_COPCI      APAN-HDRPPLHYSAAAQKASTRCVNDMASMLDSLAASFDQEL--RDKERDMAQAQALLT
Mbp1_USTMA      --------SSLHTSEAGQRTAGRAVTLMSNLLHSLADSYDSEI--NTAEKKLTQAHGLLK
Mbp1_SCHPO      --------PAIISPSCSSHAFVKAIPSISSKFSQLAEEYESQL--REKEEDLIRANRLKQ
                                                                .           
Ankyrin 3D      --t---tt----HHHHHHH---HHHHH-HHH
Annotation                                         CCCCCCC--CCCCCCCCCCCCCCCC

Mbp1_ASPFU      QLEVDRQKIQEQTAALEAKETEGEPVEAQ----LERYERLRSTY--E-------------
Mbp1_ASPNI      QLEQDRQKIRRQYDALAAKEAAEESSDAQ----LGRYEQMRDNY--E-------------
Mbp1_ASPTE      QLELDRQKIKQQTAALSAKEAEEEPVDTQ----LARYEQLRASY--E-------------
Mbp1_CRYNE      HATRALADKRQHLHRAQEKLATMQLFEQRSENVRRIMDAIAAGTLLTPAEFTGRTQTMHE
Mbp1_GIBZE      TTSTQLGEARRSLEHLSATLKKQQLA-------KQKVANLSHA-----------------
Mbp1_MAGGR      LTTTDVNDLRRKLDEAQARVKAQQLA-------RQKVTNLQRA-----------------
Mbp1_NEUCR      VTSSQVGDARRTLESLQEKLKAQQLA-------KQKIVNFNRA-----------------
Mbp1_CANAL      QINQIKLESQRKILSFFKLDHLIEELEQNKDDSQQQQQQVTDDD--DPTSVHGNDLHLDF
Mbp1_DEBHA      AIGHEKLLSQRAVLQFFKLEYLIDDIMADYDQN------------------NSDNLIIDT
Mbp1_PICST      SINTEKLVSQKAILSFFKLEYLIEDLERVNKE------------------TNPQELSLDF
Mbp1_CANGL      SIKRTVHSTDNRIREILET---------D--------------------------ADADI
Mbp1_SACCE      SISKTKIQVSLKTLEVLKESSKDENGEAQ--------------------------TNDDF
Annotation      C

Mbp1_EREGO      SMSATVTSLDMKVLEILEVK-----------------------------------DMNNI
Mbp1_KLULA      SMKKTITSVEMKLLEALNLK-----------------------------------ETDNV
Mbp1_YARLI      KMEEDIAATNEAIREYEAKHGTAEELEK--------------------------------
Mbp1_COPCI      NIQAEILESQRTVLQLR---QQAEGLSQA----KQRLADLENA----LQDKMGRRYRLGF
Mbp1_USTMA      QIQTEIEDSAKVAEALH---HEAQGVDEE----RKRVDSLQLA----LKHAINKRARDDL
Mbp1_SCHPO      DTLNEISRTYQELTFLQ---KNNPTY-------SQSMENLIRE-AQETYQQLSKRLLIWL
                                                                            

Mbp1_ASPFU      ------------------------------------SLLEQIQQVRLKERLTSMPPPAKE
Mbp1_ASPNI      ------------------------------------SLLEQIQRARLKERLASTPVPTQT
Mbp1_ASPTE      ------------------------------------SLLEHIQQARLKERVASMPIPTKE
Mbp1_CRYNE      KSTGQLPPLAFRHVPG--------------------LALDASSQSQLNGAPPSTPLSVED
Mbp1_GIBZE      ---REAEQVRLMQEQ------SRASQPNPSSS------WETELSAMLEAADDTSDG----
Mbp1_MAGGR      ---EERERYRLTQLE------QTTGRRDIASAN----GWEAESNTLLATINATTNG----
Mbp1_NEUCR      ---CEEEEQILIELE------QRHGRLDVASAN----AWEMELESALEIVKTQSPKGL--
Mbp1_CANAL      KRDHILQEEIYRLMNDLTYQELHQQDELDKVEHSYRMTKERLH-EKVLDASSF----VID
Mbp1_DEBHA      EKDRIIQDEINRLISDLSFQFLQRKDQLDQVFMKYKAISSAIQNTKVAELAST----LSQ
Mbp1_PICST      KRDQIIQDEIHRLINDLTYQFLQKKEDLYQLHQKYILVNEKVQ-----------------
Mbp1_CANGL      SSAILAQEKDITELK------IEAENHL--------RKLKNQFEYLQKQRLLKLTEYHN-
Mbp1_SACCE      EILSRLQEQNTKKLR------KRLIRYK--------RLIKQKLEYRQTVLLNKLIEDETQ
Mbp1_EREGO      TYEMDSLKENIAGLK------QKLSEKQ--------KVLVSLLEKSQRVTLRKCVEEEKK
Mbp1_KLULA      DIVLNDRKEKIDELQ------RRIATDK--------RVLINRLEEGQVKLIRKFVDEETK
Mbp1_YARLI      ---------LASEAE------ERVTTRV--------NQLRKVFERSQAKGLAMLVAEEER
Mbp1_COPCI      EKWIKDE-----------------------------ETREKVIRDAANGDLVLTPATTSY
Mbp1_USTMA      ER--RWS-----------------------------EGKQAIKRARLQAGLEPGALSTSN
Mbp1_SCHPO      EA---------RQIFDLERSLKPHTSLSISFPSDF-------------------------
Annotation                 xxxx------xxxxxxx--------xxxxxxx
                                                                            

Mbp1_ASPFU      NMMPS--------------------------------------SSDQNQL-LITYQLARQ
Mbp1_ASPNI      AVIGS-------------------------------------SSPEQDRL-LTTFQLSRA
Mbp1_ASPTE      Q--AE-------------------------------------SSKDTSQL-TTVFQLAQK
Mbp1_CRYNE      QEDI------------------------------ALPERDDP----------ECLVKLRR
Mbp1_GIBZE      ------------------------------------------EFGGEGLLP-SAAVLEAR
Mbp1_MAGGR      ------------------------------------------EPDADAKLP-SSALLRAR
Mbp1_NEUCR      ------------------------------------------DPDSRPSLP-SAAVLRAR
Mbp1_CANAL      QTHQQ-------------------------------------GNVH------EQLELAKQ
Mbp1_DEBHA      HESNS-------------------------------------SSTEDETP-SEQVRLSIE
Mbp1_PICST      ------------------------------------------------------------
Mbp1_CANGL      ---GE-------------------------------------HNDTDNTL-DNKIEICKQ
Mbp1_SACCE      ATTNN-------------------------------------TVEKDNNT-LERLELAQE
Mbp1_EREGO      AIESVI--------------------------------AAPADDATHSSKE-TLADDLRE
Mbp1_KLULA      NV---------------------------------------EGKTTDGEESEDIEALLKE
Mbp1_YARLI      EI-------------------------------------------SREQT-KGEFKTAKE
Mbp1_COPCI      TV--DEDGDSDSGSNGDKNKGKRKAQVQQEEVSDLVELYSNIPTDPEELR-KQCEALREE
Mbp1_USTMA      ATNAPATGDQKSKDDA-------------KSLIEALPAGTNVKTAIA--------ELRKQ
Mbp1_SCHPO      -------------------LKKEDGLSLNNDF--KKPACNN-----VTNS-DEYEQLINK
                                                                            

Mbp1_ASPFU      LCSLQKARRAAVRDLAQQTADAGV------------------------------------
Mbp1_ASPNI      LCSEQKIRRAAVKELAQQRADAGV------------------------------------
Mbp1_ASPTE      LCAAQKARRAAVKELAQQTADAGV------------------------------------
Mbp1_CRYNE      MALWEDRIAEVLEDKIRAMEGEGV------------------------------------
Mbp1_GIBZE      VRAVKK-RCESTRK------------------------------------------MVSA
Mbp1_MAGGR      IEAVKK-QTESTRQ------------------------------------------SVVA
Mbp1_NEUCR      IKALRA-RSSKTRQ------------------------------------------AVAA
Mbp1_CANAL      LQVEIIKRKKLVDEISKLTKNVPLPE------------------------NPNAKTIIDT
Mbp1_DEBHA      LQTQIVKYKQMLHKLHQQHLQVPLSSLNDNTDTKENKENIKEESQTNDTAEPAPHSVIAK
Mbp1_PICST      LTEEIIKCKKLSQQLYKQQMVVPIPQ-----------TSIDKENNSTPT-GSSSNSIVAK
Mbp1_CANGL      ISVLQIERKRKISE------------------------------------------LISH
Mbp1_SACCE      LTMLQLQRKNKLSS------------------------------------------LVKK
Mbp1_EREGO      LTVLQLRRKHKINR------------------------------------------LIEL
Mbp1_KLULA      LVLIQLKRKRKLNQ------------------------------------------IIDV
Mbp1_YARLI      LTDLQHGRKDLVDDVVELFANAGV------------------------------------
Mbp1_COPCI      VSQSRKRRKAMFDELVTFQAEAGT------------------------------------
Mbp1_USTMA      LSQVQANKTELVDKFVARAREQGT------------------------------------
Mbp1_SCHPO      LTSLQASRKKDTLYIRKLYEELGI------------------------------------
                :                                                           

Mbp1_ASPFU      ----S-TKFDVHRRLVALAT-GLKEEELD-PMAAELAETLEFDRMNGR-GPGGESPE---
Mbp1_ASPNI      ----S-TKFDVHRKLVALAT-GLKEEELD-PMAAELAETLEFDRMNGK-GVGPESPE---
Mbp1_ASPTE      ----S-TKFDVHRKLVALAT-GLKEEELD-PMAAELAEALEFDRMNGK-GNGAESPD---
Mbp1_CRYNE      ------DRAVKYRKLVSVCA-KVPVDKVD-SMLDGLVAAVESEGQG--------------
Mbp1_GIBZE      LKGRSRDTEVKYRRVVALCT-GVQEDEVD-AVIDGLLKAVESEQEE--------------
Mbp1_MAGGR      LKGRSREVEGRYRHLVALAT-KCRDEDVD-STMEGLLKAVESEKGE--------------
Mbp1_NEUCR      LQAQSKEKELKYRRLVSLCT-RRPEIEVE-ALLDTLTRAVESEKPE--------------
Mbp1_CANAL      YPS-T-DKLYKYCKLISLSC-GIPMDEIE-TSIDAMEESLVKK-----------------
Mbp1_DEBHA      YPK-D-DKLHKYCKLIALCC-GMNFNDVE-NSIDLIEQSLSKSAPNM-------------
Mbp1_PICST      YPH-D-NLLSKYCHLIAQCC-GMDFDDVE-GSIDEIEQSLLKSN--V-------------
Mbp1_CANGL      YED-S-RKIHKYRRMISEGT-EMKTEEVD-GCLDIILQTLINNSS---------------
Mbp1_SACCE      FED-N-AKIHKYRRIIREGT-EMNIEEVD-SSLDVILQTLIANNNK---NKGAEQII---
Mbp1_EREGO      LCG-N-SKIHKFRKMISQGT-DMDISEVD-NFLDVIFQQLNEDEENTN-NGG--------
Mbp1_KLULA      ITD-N-SKVYKYRKMISQGT-DIDVSDVD-ECLDVIYQTLSKEG----------------
Mbp1_YARLI      ----G-EKMNEYRRLVAMSC-GVKVEDID-GLLDGIEKALLEGER---------------
Mbp1_COPCI      ----S-GRMSDYRRLIAAGCGGLEPLEID-SVLGMLLETLEAE-----------------
Mbp1_USTMA      ----G-RTMAAYRRLIAAGCGGIAPDEVD-AVVGVLCELLQESHTGARAGAGGERDDRAR
Mbp1_SCHPO      ----D-DTVNSYRRLIAMSC-GINPEDLSLEILDAVEEALTREK----------------
                           . :::          .:.      :   :                    

Mbp1_ASPFU      ---------PVQKR----------------------------------------------
Mbp1_ASPNI      ---------A--------------------------------------------------
Mbp1_ASPTE      ---------L--------------------------------------------------
Mbp1_CRYNE      ------------------------------------------------------------
Mbp1_GIBZE      ------------------------------------------------------------
Mbp1_MAGGR      ------------------------------------------------------------
Mbp1_NEUCR      ------------------------------------------------------------
Mbp1_CANAL      ------------------------------------------------------------
Mbp1_DEBHA      ------------------------------------------------------------
Mbp1_PICST      ------------------------------------------------------------
Mbp1_CANGL      ------------------------------------------------------------
Mbp1_SACCE      ---------TISNA----------------------------------------------
Mbp1_EREGO      ------------------------------------------------------------
Mbp1_KLULA      ------------------------------------------------------------
Mbp1_YARLI      ------------------------------------------------------------
Mbp1_COPCI      ------------------------------------------------------------
Mbp1_USTMA      DVAMMLKAFPVYSRCIVMNRQLAVTRYPCCRLLFYSLPCRTNMISGLWMQSDSVAAVLAR
Mbp1_SCHPO      ------------------------------------------------------------
                                                                            

Mbp1_ASPFU      ------------------------------------------------------------
Mbp1_ASPNI      ------------------------------------------------------------
Mbp1_ASPTE      ------------------------------------------------------------
Mbp1_CRYNE      ------------------------------------------------------------
Mbp1_GIBZE      ------------------------------------------------------------
Mbp1_MAGGR      ------------------------------------------------------------
Mbp1_NEUCR      ------------------------------------------------------------
Mbp1_CANAL      ------------------------------------------------------------
Mbp1_DEBHA      ------------------------------------------------------------
Mbp1_PICST      ------------------------------------------------------------
Mbp1_CANGL      ------------------------------------------------------------
Mbp1_SACCE      ------------------------------------------------------------
Mbp1_EREGO      ------------------------------------------------------------
Mbp1_KLULA      ------------------------------------------------------------
Mbp1_YARLI      ------------------------------------------------------------
Mbp1_COPCI      ------------------------------------------------------------
Mbp1_USTMA      SNAVLRISPCPKCARMSKLQAHLYEASAARLCGGKMLRRTLALFSEAARSSSSSSASAAA
Mbp1_SCHPO      ------------------------------------------------------------
                                                                            

Mbp1_ASPFU      ----------LPS-----------------------------------------------
Mbp1_ASPNI      ------------D-----------------------------------------------
Mbp1_ASPTE      ------------E-----------------------------------------------
Mbp1_CRYNE      ------------------------------------------------------------
Mbp1_GIBZE      ------------------------------------------------------------
Mbp1_MAGGR      ------------------------------------------------------------
Mbp1_NEUCR      ------------------------------------------------------------
Mbp1_CANAL      ------------------------------------------------------------
Mbp1_DEBHA      ------------------------------------------------------------
Mbp1_PICST      ------------------------------------------------------------
Mbp1_CANGL      ------------------------------------------------------------
Mbp1_SACCE      ----------N-------------------------------------------------
Mbp1_EREGO      ------------------------------------------------------------
Mbp1_KLULA      ------------------------------------------------------------
Mbp1_YARLI      ------------------------------------------------------------
Mbp1_COPCI      ------------------------------------------------------------
Mbp1_USTMA      SSSASILTSHLSKAHLPPSLARSAKPHKNLYQMLSTLPKDGVGARVRQRRWAAKGLDVSH
Mbp1_SCHPO      ------------------------------------------------------------
                                                                            

Mbp1_ASPFU      -----------------------------QREPSSLPFSGPPVSVDA-------------
Mbp1_ASPNI      -----------------------------HKDSASLPFPGPVVSVDA-------------
Mbp1_ASPTE      -----------------------------HKDSASFPFPEPTISVDA-------------
Mbp1_CRYNE      ----------------------------LDFSRASNFVNRIKATK-S-------------
Mbp1_GIBZE      ----------------------------LEINRVRRFLGGVEGV--Q-------------
Mbp1_MAGGR      ----------------------------LEIGRVRRFLGGVEGVI-G-------------
Mbp1_NEUCR      ----------------------------LEIARVRRFLGGVEGVV-H-------------
Mbp1_CANAL      ------------------------------------------------------------
Mbp1_DEBHA      ----------------------------------------------Q-------------
Mbp1_PICST      ----------------------------------------------K-------------
Mbp1_CANGL      ------------------------------------------------------------
Mbp1_SACCE      --------------------------------------------SHA-------------
Mbp1_EREGO      ---------------------------------HTNYNG---------------------
Mbp1_KLULA      ------------------------------------------------------------
Mbp1_YARLI      ------------------------------------------------------------
Mbp1_COPCI      -----------------------------DPSSTSATWSGSKGQQTG-------------
Mbp1_USTMA      DVDLKAHLAKLHHTGATKTNKDEGHLCYWEITKVRLKDGGNHGKAWGRFVWRERNAGVVK
Mbp1_SCHPO      ------------------------------------------------------------
                                                                            

Mbp1_ASPFU      ---------------------------------------------
Mbp1_ASPNI      ---------------------------------------------
Mbp1_ASPTE      ---------------------------------------------
Mbp1_CRYNE      ---------------------------------------------
Mbp1_GIBZE      ---------------------------------------------
Mbp1_MAGGR      ---------------------------------------------
Mbp1_NEUCR      ---------------------------------------------
Mbp1_CANAL      ---------------------------------------------
Mbp1_DEBHA      ---------------------------------------------
Mbp1_PICST      ---------------------------------------------
Mbp1_CANGL      ---------------------------------------------
Mbp1_SACCE      ---------------------------------------------
Mbp1_EREGO      ------HVSCAILDTVEGYGIENIENKRGT-------SQNDGPAK
Mbp1_KLULA      ---------------------------------------------
Mbp1_YARLI      ---------------------------------------------
Mbp1_COPCI      ---------------------------------------------
Mbp1_USTMA      QGQAQAKLTKVCLSMVVAHPGKPITKAESGERIPGALKYCWDLAH
Mbp1_SCHPO      ---------------------------------------------
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