Difference between revisions of "De novo structure prediction"

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<div class="reference-box">[http://zhanglab.ccmb.med.umich.edu/ Zhang Lab (UMich)]</div>
 
<div class="reference-box">[http://zhanglab.ccmb.med.umich.edu/ Zhang Lab (UMich)]</div>
 
<div class="reference-box">[http://depts.washington.edu/bakerpg/drupal/ Baker Lab (UWash)]</div>
 
<div class="reference-box">[http://depts.washington.edu/bakerpg/drupal/ Baker Lab (UWash)]</div>
<div class="reference-box">{{RepoPDF|Zhang(2012)StructurePrediction.pdf|Y. Zhang (2012) Protein Structure Prediction. Encyclopedia of Life Sciences.}}</div>
 
  
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{{PDF
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|authors= Ambrish, R. & Zhang, Y.
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|year= 2012
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|title= Protein Structure Prediction
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|journal= Encyclopedia of Life Sciences
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|volume=
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|pages=
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|URL=
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|doi =
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|file= Zhang(2012)StructurePrediction.pdf
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|abstract= The goal of protein structure prediction is to estimate the spatial position of every atom of protein molecules from the amino acid sequence by computational methods. Depending on the availability of homologous templates in the PDB library, structure prediction approaches are categorised into template-based modelling (TBM) and free modelling (FM). While TBM is by far the only reliable method for high-resolution structure prediction, challenges in the field include constructing the correct folds without using template structures and refining the template models closer to the native state when templates are available. Nevertheless, the usefulness of various levels of protein structure predictions have been convincingly demonstrated in biological and medical applications.
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}}
 
{{#pmid: 22106262}}  
 
{{#pmid: 22106262}}  
 
{{#pmid: 22163331}}  
 
{{#pmid: 22163331}}  

Revision as of 18:45, 16 November 2012

ab initio Structure Prediction


This page is a placeholder, or under current development; it is here principally to establish the logical framework of the site. The material on this page is correct, but incomplete.


Protein structure prediction


Summary ...



 

Contents

   

Further reading and resources


Ambrish, R. & Zhang, Y. (2012) Protein Structure Prediction. Encyclopedia of Life Sciences 
(pmid: None)
Morcos et al. (2011) Direct-coupling analysis of residue coevolution captures native contacts across many protein families. Proc Natl Acad Sci U.S.A 108:E1293-301. (pmid: 22106262)

PubMed ] [ DOI ]

Marks et al. (2011) Protein 3D structure computed from evolutionary sequence variation. PLoS ONE 6:e28766. (pmid: 22163331)

PubMed ] [ DOI ]

Hopf et al. (2012) Three-dimensional structures of membrane proteins from genomic sequencing. Cell 149:1607-21. (pmid: 22579045)

PubMed ] [ DOI ]

Marks et al. (2012) Protein structure prediction from sequence variation. Nat Biotechnol 30:1072-80. (pmid: 23138306)

PubMed ] [ DOI ]