Lecture 18

(Previous lecture) ... (Next lecture)

Clinical Genomics

Clinical Genomics is the application of genome information to our understanding of human disease. (Do not confuse with Clinical Genetics - i.e. genetic counseling).

...

Add:

• Summary points
• Exercises
• Further reading

Lecture Slides

Slide 001

Lecture 18, Slide 001

Slide 002

Lecture 18, Slide 002

Slide 003

Lecture 18, Slide 003
(*) see Redon et al. (2006) Nature 444:444-454

Slide 004

Lecture 18, Slide 004

Slide 005

Lecture 18, Slide 005

Slide 006

Lecture 18, Slide 006

Slide 007

Lecture 18, Slide 007

Slide 008

Lecture 18, Slide 008

Slide 009

Lecture 18, Slide 009

Slide 010

Lecture 18, Slide 010

Slide 011

Lecture 18, Slide 011

Slide 012

Lecture 18, Slide 012

Slide 013

Lecture 18, Slide 013

Slide 014

Lecture 18, Slide 014

Slide 015

Lecture 18, Slide 015

Slide 016

Lecture 18, Slide 016
All integrated bioinformatics resources cross reference SNP information. It is often quite a challenge to wade through the large amounts of information that are being offered. Example: BRCA-2 gene

Slide 017

Lecture 18, Slide 017
Example: BRCA-2 gene in ensembl (note: SNPs only displayed for <50 kb long regions)

Slide 018

Lecture 18, Slide 018
Example: BRCA-2 gene - SNP from search results for NP_000050 in dbSNP

Slide 019

Lecture 18, Slide 019

Slide 020

Lecture 18, Slide 020

Slide 021

Lecture 18, Slide 021

Slide 022

Lecture 18, Slide 022

Slide 023

Lecture 18, Slide 023

Slide 024

Lecture 18, Slide 024

Slide 025

Lecture 18, Slide 025

Slide 026

Lecture 18, Slide 026

Slide 027

Lecture 18, Slide 027

Slide 028

Lecture 18, Slide 028
As in so many examples we have looked at: the future lies in the intelligent integration of evidence.