Difference between revisions of "Reference APSES domains (reference species)"
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__NOTOC__ | __NOTOC__ | ||
| − | |||
| − | + | <div class="alert"> | |
| + | The species used on this page are not the current set of [[Reference_species_for_fungi|reference species]]. Proceed with caution. | ||
| + | </div> | ||
| − | + | <section begin=contents_summary /> | |
| − | + | Sequences of APSES domains in the fungal reference species - domain definition, PSI-BLAST search, and header editing. | |
| − | + | <section end=contents_summary /> | |
| − | |||
| − | |||
| − | |||
| − | * see also: [[ | + | The APSES domain proteins were determined with a PSI-BLAST search in the refseq database, using 1BM8_A as the search sequence, and restricting the search to the [[Reference species for fungi]]. |
| + | |||
| + | |||
| + | |||
| + | |||
| + | * see also: [[Reference APSES proteins (reference species)]] | ||
| Line 58: | Line 61: | ||
A PSI-BLAST search was executed, searching in the '''refseq''' subset of the NCBI protein database and restricting the species to the six fungal reference species plus ''Escherichia coli''. The latter was chosen to retrieve the KilA-N domain sequence which we need as an outgroup for phylogenetic analysis. | A PSI-BLAST search was executed, searching in the '''refseq''' subset of the NCBI protein database and restricting the species to the six fungal reference species plus ''Escherichia coli''. The latter was chosen to retrieve the KilA-N domain sequence which we need as an outgroup for phylogenetic analysis. | ||
| − | The search converged after 5 iterations in which matches of less than 80% of the query length were manually removed, even if they had low E-values. Also, care was taken not to include false positives and thus to avoid profile corruption, and hits with E > 10<sup>-4</sup> were also removed. The check-boxes next to the alignments were used to select sequences with > 80% coverage to the query and only the highest-scoring KilA-N domain protein was kept. Clicking on '''Get selected sequences''' created a results page of 27 sequences. These were then displayed in a FASTA(text) format and their headers were slightly edited to create | + | The search converged after 5 iterations in which matches of less than 80% of the query length were manually removed, even if they had low E-values. Also, care was taken not to include false positives and thus to avoid profile corruption, and hits with E > 10<sup>-4</sup> were also removed. The check-boxes next to the alignments were used to select sequences with > 80% coverage to the query and only the highest-scoring KilA-N domain protein was kept. Clicking on '''Get selected sequences''' created a results page of 27 sequences. These were then displayed in a FASTA(text) format and their headers were slightly edited to create the dataset [[Reference APSES proteins (reference species)]]. |
===Constructing the multi-FASTA file=== | ===Constructing the multi-FASTA file=== | ||
| Line 192: | Line 195: | ||
MBP1_ASPNI -IGTDSVMRRRSDDWINATHILKVAGFDKPARTRILEREVQKGVHEKVQGGYGKYQGTWIPLQEGRQLAERNNI- | MBP1_ASPNI -IGTDSVMRRRSDDWINATHILKVAGFDKPARTRILEREVQKGVHEKVQGGYGKYQGTWIPLQEGRQLAERNNI- | ||
MBP1_SCHPO -IKGVSVMRRRRDSWLNATQILKVADFDKPQRTRVLERQVQIGAHEKVQGGYGKYQGTWVPFQRGVDLATKYKV- | MBP1_SCHPO -IKGVSVMRRRRDSWLNATQILKVADFDKPQRTRVLERQVQIGAHEKVQGGYGKYQGTWVPFQRGVDLATKYKV- | ||
| + | |||
| + | ===Sample Phylip format=== | ||
| + | Here is a sample set of the APSES domain sequences to illustrate the '''phylip''' format. Sequences were aligned with MAFFT and edited in JALVIEW to remove gapped regions and frayed termini. The FASTA sequences were converted with [http://www-bimas.cit.nih.gov/molbio/readseq/ the Readseq server]. | ||
| + | |||
| + | <pre> | ||
| + | 27 78 | ||
| + | KILA_ESCCO DGEIIHLRAK DGYINATSMC RT-A-GKLLS DYTRLKLSRD M-GIPIS-IQ | ||
| + | MBP1_SACCE STGSIMKRKK DDWVNATHIL KA-A-NFAKA KRTRI-LEKE V-LKETH--E | ||
| + | MBP1_USTMA NNVAVMRRRS DDWLNATQIL KV-V-GLDKP QRTRV-LERE I-QKGIH--E | ||
| + | MBP1_NEUCR ----VMRRRH DDWVNATHIL KA-A-GFDKP ARTRI-LERE V-QKDTH--E | ||
| + | MBP1_ASPNI GTDSVMRRRS DDWINATHIL KV-A-GFDKP ARTRI-LERE V-QKGVH--E | ||
| + | MBP1_SCHPO KGVSVMRRRR DSWLNATQIL KV-A-DFDKP QRTRV-LERQ V-QIGAH--E | ||
| + | MBP1_CANAL SEGPIMRRKK DSWINATHIL KI-A-KFPKA KRTRI-LEKD V-QTGIH--E | ||
| + | APS1_NEUCR NNVAVMRRQK DGWVNATQIL KV-A-NIDKG RRTKI-LEKE I-QIGEH--E | ||
| + | APS1_CANAL NESSIMRRCK DDWVNATQIL KC-C-NFPKA KRTKI-LEKG V-QQGLH--E | ||
| + | APS1_SCHPO NGFPLMKRCH DNWLNATQIL KI-A-ELDKP RRTRI-LEKF A-QKGLH--E | ||
| + | APS2_ASPNI NGVAVMKRRS DGWLNATQIL KV-A-GVVKA RRTKT-LEKE I-AAGEH--E | ||
| + | APS2_USTMA RGIAVMRRRG DGWLNATQIL KI-A-GIEKT RRTKI-LEKS I-LTGEH--E | ||
| + | SWI4_SACCE -TKIVMRRTK DDWINITQVF KI-A-QFSKT KRTKI-LEKE S-NDMQH--E | ||
| + | APS3_SCHPO GDNVALRRCP DSYFNISQIL RL-A-GTSSS ENAKE-LDDI I-ESGDY--E | ||
| + | APS3_CANAL NNVSVVRRAD NNMINGTKLL NV-A-QMTRG RRDGI-LKSE ----KVR--H | ||
| + | SOK2_SACCE NGISVVRRAD NDMVNGTKLL NV-T-KMTRG RRDGI-LKAE ----KIR--H | ||
| + | APS3_ASPNI -GVCVARRED NGMINGTKLL NV-A-GMTRG RRDGI-LKSE ----KVR--N | ||
| + | PHD1_SACCE NGISVVRRAD NNMINGTKLL NV-T-KMTRG RRDGI-LRSE ----KVR--E | ||
| + | APS4_CANAL NNHWVIWDYE TGWVHLTGIW KA-SLSHLKA DIVKL-LEST PKEYQQY-IK | ||
| + | APS3_NEUCR -GICVARRED NAMINGTKLL NV-A-GMTRG RRDGI-LKSE ----KVR--H | ||
| + | APS5_CANAL -NILVSRRED TNYINGTKLL NV-I-GMTRG KRDGI-LKTE ----KIK--N | ||
| + | APS4_ASPNI ---TVMWDYN IGLVRTTHLF KC-N-DYSKT TPAKM-LNQN PGLRDIC--H | ||
| + | APS3_USTMA RGHTMMIDVD TSFVRFTSIT QA-L-GKNKV NFGRL-VKTC P-ALDPH-IT | ||
| + | APS4_SCHPO --HFLMRMAK DSSISATSMF RS-A-FPKAT QEEED-LEMR WIRDNLN--- | ||
| + | APS6_CANAL GEIIVLRRVQ DSFVNVTQLF QILE-VLPTS QVDNY-FDNE I-LSNLKYLR | ||
| + | APS4_NEUCR ---FLMRRSQ DGYISATGMF KA-T-FPYAS QEEEE-AERK YIKSIPT--- | ||
| + | APS5_ASPNI -TYFLMRRSK DGYVSATGMF KI-A-FPWAK LEEER-SERE YLKTRPE--- | ||
| + | |||
| + | SFKGGRPENQ GTWVHPDIAI NLAQ---- | ||
| + | KVQGGFGKYQ GTWVPLNIAK QLAEKFSV | ||
| + | KVQGGYGKYQ GTWIPLDVAI ELAERYNI | ||
| + | KIQGGYGRYQ GTWIPLEQAE ALARRNNI | ||
| + | KVQGGYGKYQ GTWIPLQEGR QLAERNNI | ||
| + | KVQGGYGKYQ GTWVPFQRGV DLATKYKV | ||
| + | KVQGGYGKYQ GTYVPLDLGA AIARNFGV | ||
| + | KVQGGYGKYQ GTWIPFERGL EVCRQYGV | ||
| + | KVQGGFGRFQ GTWIPLEDAR KLAKTYGV | ||
| + | KIQGGCGKYQ GTWVPSERAV ELAHEYNV | ||
| + | KVQGGYGKYQ GTWVNYQRGV ELCREYHV | ||
| + | KIQGGYGKFQ GTWIPLQRAQ QVAAEYNV | ||
| + | KVQGGYGRFQ GTWIPLDSAK FLVNKYEI | ||
| + | NVDSKHPQID GVWVPYDRAI SIAKRYGV | ||
| + | VVKIGSMHLK GVWIPFERAL AMAQREQI | ||
| + | VVKIGSMHLK GVWIPFERAL AIAQREKI | ||
| + | VVKIGPMHLK GVWIPFDRAL EFANKEKI | ||
| + | VVKIGSMHLK GVWIPFERAY ILAQREQI | ||
| + | RIRGGFLKIQ GTWLPYKLCK ILARRFCY | ||
| + | VVKIGPMHLK GVWIPFERAL DFANKEKI | ||
| + | VVKVGSMNLK GVWIPFDRAY EIARNEGV | ||
| + | SITGGALAAQ GYWMPYEAAK AIAATFC- | ||
| + | KLKGGYLSIQ GTWLPFDLAK ELSRR--- | ||
| + | --PIEDKRVA GLWVPPADAL ALAKDYSM | ||
| + | KHQNIY--LQ GIWIPYDKAV NLALKFDI | ||
| + | --TSSEETAG NVWIPPEQAL ILAEEYQI | ||
| + | |||
| + | </pre> | ||
| + | |||
| + | |||
| + | <!-- | ||
| Line 205: | Line 273: | ||
* Paste the following organism restrictions into the '''Entrez query''' field. This includes all fungi we have worked with in the course, as well as ''Escherichia coli'' (for the KilA-N domain): | * Paste the following organism restrictions into the '''Entrez query''' field. This includes all fungi we have worked with in the course, as well as ''Escherichia coli'' (for the KilA-N domain): | ||
| − | < | + | <pre> |
Ajellomyces dermatitidis [ORGN] | Ajellomyces dermatitidis [ORGN] | ||
OR Arthroderma benhamiae [ORGN] | OR Arthroderma benhamiae [ORGN] | ||
| Line 249: | Line 317: | ||
OR Scheffersomyces stipitis [ORGN] | OR Scheffersomyces stipitis [ORGN] | ||
OR Schizosaccharomyces japonicus [ORGN] | OR Schizosaccharomyces japonicus [ORGN] | ||
| + | OR Schizosaccharomyces pombe [ORGN] | ||
OR Sclerotinia sclerotiorum [ORGN] | OR Sclerotinia sclerotiorum [ORGN] | ||
OR Sordaria macrospora [ORGN] | OR Sordaria macrospora [ORGN] | ||
| Line 260: | Line 329: | ||
OR Trichophyton verrucosum [ORGN] | OR Trichophyton verrucosum [ORGN] | ||
OR Uncinocarpus reesii [ORGN] | OR Uncinocarpus reesii [ORGN] | ||
| + | OR Ustilago maydis [ORGN] | ||
OR Vanderwaltozyma polyspora [ORGN] | OR Vanderwaltozyma polyspora [ORGN] | ||
OR Verticillium alfalfae [ORGN] | OR Verticillium alfalfae [ORGN] | ||
| Line 266: | Line 336: | ||
OR Zymoseptoria tritici [ORGN] | OR Zymoseptoria tritici [ORGN] | ||
OR Escherichia coli [ORGN] | OR Escherichia coli [ORGN] | ||
| − | </ | + | </pre> |
* Select '''PSI-BLAST''' as the algorithm. | * Select '''PSI-BLAST''' as the algorithm. | ||
* '''BLAST''' this. | * '''BLAST''' this. | ||
| Line 316: | Line 386: | ||
====Processing the PSI-BLAST results==== | ====Processing the PSI-BLAST results==== | ||
* We need to collapse the separate aligned sections, remove the profusion of gap characters, and replace the semantically meaningless GI numbers with something that we can use for interpreting alignments and trees. I could do this by hand for the ~300 sequences in about 2 hours. I chose to write some Perl code instead. It works on the copied alignments, the headers, and the RBM annotations. | * We need to collapse the separate aligned sections, remove the profusion of gap characters, and replace the semantically meaningless GI numbers with something that we can use for interpreting alignments and trees. I could do this by hand for the ~300 sequences in about 2 hours. I chose to write some Perl code instead. It works on the copied alignments, the headers, and the RBM annotations. | ||
| − | < | + | <pre> |
#!/usr/bin/perl | #!/usr/bin/perl | ||
# ProcessPSI-BLAST.pl | # ProcessPSI-BLAST.pl | ||
| Line 376: | Line 446: | ||
} | } | ||
close IN; | close IN; | ||
| + | |||
| + | # Many of the protein codes are now not unique and this will | ||
| + | # cause problems for alignment and phylogeny programs. We will | ||
| + | # retain all headers that have a Aaa1_ABCDE or AaaA_ABCDE format, | ||
| + | # and rename all others with Aps1_ABCDE, Aps2_ABCDE ... etc. | ||
| + | |||
| + | my %nonUnique; # hash to keep track of how often we have | ||
| + | # seen an entry | ||
| + | foreach my $key (keys(%headers)) { | ||
| + | # if the value doesn't match the requested pattern ... | ||
| + | if ($headers{$key} !~ m/^[A-Z][a-z][a-z][A-Z0-9]_([A-Z]{5})/) { | ||
| + | $headers{$key} =~ m/_([A-Z]{5})/; | ||
| + | my $x = $headers{$key}; | ||
| + | my $code = $1; | ||
| + | $nonUnique{$code}++; # increment count in this hash (or create | ||
| + | # entry if new) | ||
| + | my $h = "Aps" . $nonUnique{$code} . "_" . $code; # construct new string | ||
| + | $headers{$key} = $h; # replace old string | ||
| + | } | ||
| + | } | ||
# concatenate all sequence blocks for each accession number | # concatenate all sequence blocks for each accession number | ||
| Line 400: | Line 490: | ||
foreach my $key (keys(%headers)) { | foreach my $key (keys(%headers)) { | ||
print (">"); | print (">"); | ||
| − | print ("$headers{$key} | + | print ("$headers{$key} $key\n"); |
print ("$sequences{$key}\n"); | print ("$sequences{$key}\n"); | ||
} | } | ||
exit(); | exit(); | ||
| − | </ | + | |
| + | </pre> | ||
====Alignment==== | ====Alignment==== | ||
| − | * The alignment was done at the EBI using MAFFT and written using | + | * The alignment was done at the EBI using MAFFT and written using FASTA output format. |
| − | < | + | <pre> |
| − | >Aps1_ARTBE XP_003012641 | + | >Mbp1_USTMA XP_762343 |
| − | ----------------VMRRRVDDWVN--------------------------------- | + | --------IIN-NVA-VMRRRSDDWLN--------------------------------- |
| − | --ATHILKA-------------AGLDK--------PSRTRI---------LERDVQRG-- | + | --ATQILKV-------------VGLDK--------PQRTRV---------LEREIQKG-- |
| − | V-HE-----------KIQGG----------------YG---KYQ-------GTW------ | + | I-HE-----------KVQGG----------------YG---KYQ-------GTW------ |
| − | -------------IPLAEARALADKNNV- | + | -------------IPLDVAIELAERYNI- |
| + | >Aps2_MALGL XP_001730500 | ||
| + | --------IIK-DVA-VMRRRSDAWLN--------------------------------- | ||
| + | --ATQILKV-------------VGLDK--------SQRTRV---------LEKEVQKG-- | ||
| + | T-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
| + | -------------IPMDVAIALAEHYHI- | ||
| + | >Mbp1_SCHPO NP_593032 | ||
| + | ---------IK-GVS-VMRRRRDSWLN--------------------------------- | ||
| + | --ATQILKV-------------ADFDK--------PQRTRV---------LERQVQIG-- | ||
| + | A-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
| + | -------------VPFQRGVDLATKYKV- | ||
| + | >Aps2_SCHJA XP_002172253 | ||
| + | --------LIK-GVS-VMRRRHDSWLN--------------------------------- | ||
| + | --ATQILKV-------------ADFDK--------PQRTRI---------LEKEVQKG-- | ||
| + | H-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
| + | -------------VPFKRGLELAVQFKV- | ||
| + | >Aps2_PUCGR XP_003327086 | ||
| + | ---------CE-GIA-VMRRRSDSWLN--------------------------------- | ||
| + | --ATQILKV-------------AGFDK--------PQRTRV---------LEREIQKG-- | ||
| + | T-HE-----------KIQGG----------------YG---KYQ-------GTW------ | ||
| + | -------------VPLDRGIDLAKQYGV- | ||
| + | >Aps2_YARLI XP_500257 | ||
| + | ---------CK-NVA-VMRRKSDGWVN--------------------------------- | ||
| + | --ATHILKV-------------AGFDK--------PQRTRI---------LEKEVQKG-- | ||
| + | V-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
| + | -------------VPLERAREIATLYDV- | ||
| + | >Aps1_ARTBE XP_003012641 | ||
| + | ----------------VMRRRVDDWVN--------------------------------- | ||
| + | --ATHILKA-------------AGLDK--------PSRTRI---------LERDVQRG-- | ||
| + | V-HE-----------KIQGG----------------YG---KYQ-------GTW------ | ||
| + | -------------IPLAEARALADKNNV- | ||
>Aps1_TRIVE XP_003024540 | >Aps1_TRIVE XP_003024540 | ||
----------------VMRRRVDDWVN--------------------------------- | ----------------VMRRRVDDWVN--------------------------------- | ||
| Line 431: | Line 552: | ||
-------------IPLAEARALADKNGV- | -------------IPLAEARALADKNGV- | ||
>Aps4_PYRTR XP_001940178 | >Aps4_PYRTR XP_001940178 | ||
| − | ----------- | + | ----------N-GNH-VMRRRADDWIN--------------------------------- |
--ATHILKV-------------ADYDK--------PARTRI---------LEREVQKG-- | --ATHILKV-------------ADYDK--------PARTRI---------LEREVQKG-- | ||
V-HE-----------KVQGG----------------YG---KYQ-------GTW------ | V-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------IPLEEGRHLAERNGV- | -------------IPLEEGRHLAERNGV- | ||
>Aps5_PYRTE XP_003297289 | >Aps5_PYRTE XP_003297289 | ||
| − | ----------- | + | ----------N-GNH-VMRRRADDWIN--------------------------------- |
--ATHILKV-------------ADYDK--------PARTRI---------LEREVQKG-- | --ATHILKV-------------ADYDK--------PARTRI---------LEREVQKG-- | ||
V-HE-----------KVQGG----------------YG---KYQ-------GTW------ | V-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------IPLEEGRHLAERNGV- | -------------IPLEEGRHLAERNGV- | ||
>Mbp1_ASPNI XP_660758 | >Mbp1_ASPNI XP_660758 | ||
| − | --------------- | + | --------------S-VMRRRSDDWIN--------------------------------- |
--ATHILKV-------------AGFDK--------PARTRI---------LEREVQKG-- | --ATHILKV-------------AGFDK--------PARTRI---------LEREVQKG-- | ||
V-HE-----------KVQGG----------------YG---KYQ-------GTW------ | V-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------IPLQEGRQLAERNNI- | -------------IPLQEGRQLAERNNI- | ||
>Mbp1_ASPTE XP_001213217 | >Mbp1_ASPTE XP_001213217 | ||
| − | --------------- | + | --------------S-VMRRRADDWIN--------------------------------- |
--ATHILKV-------------AGFDK--------PARTRI---------LEREVQKG-- | --ATHILKV-------------AGFDK--------PARTRI---------LEREVQKG-- | ||
V-HE-----------KVQGG----------------YG---KYQ-------GTW------ | V-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------IPLPEGRLLAERNNI- | -------------IPLPEGRLLAERNNI- | ||
>Aps6_ASPNI XP_001400103 | >Aps6_ASPNI XP_001400103 | ||
| − | --------------- | + | --------------S-VMRRRSDDWIN--------------------------------- |
--ATHILKV-------------AGFDK--------PARTRI---------LEREVQKG-- | --ATHILKV-------------AGFDK--------PARTRI---------LEREVQKG-- | ||
V-HE-----------KVQGG----------------YG---KYQ-------GTW------ | V-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------IPLPEGRMLAERNNI- | -------------IPLPEGRMLAERNNI- | ||
>Aps5_ASPCL XP_001271352 | >Aps5_ASPCL XP_001271352 | ||
| − | ------------- | + | ------------GES-VMRRRGDNWIN--------------------------------- |
--ATHILKV-------------AGFDK--------PARTRI---------LEREVQKG-- | --ATHILKV-------------AGFDK--------PARTRI---------LEREVQKG-- | ||
T-HE-----------KVQGG----------------YG---KYQ-------GTW------ | T-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------IPLPEGRLLAERNNI- | -------------IPLPEGRLLAERNNI- | ||
>Aps4_NEOFI XP_001263071 | >Aps4_NEOFI XP_001263071 | ||
| − | ------------- | + | ------------GES-VMRRRGDNWIN--------------------------------- |
--ATHILKV-------------AGFDK--------PARTRI---------LEREVQKG-- | --ATHILKV-------------AGFDK--------PARTRI---------LEREVQKG-- | ||
T-HE-----------KVQGG----------------YG---KYQ-------GTW------ | T-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
| Line 471: | Line 592: | ||
-------------IPLHEGRLLAERNNI- | -------------IPLHEGRLLAERNNI- | ||
>Aps3_TALST XP_002479844 | >Aps3_TALST XP_002479844 | ||
| − | ------------- | + | ------------GEC-LMRRRADDWIN--------------------------------- |
--ATHILKV-------------AGFDK--------PSRTRI---------LEREVQKG-- | --ATHILKV-------------AGFDK--------PSRTRI---------LEREVQKG-- | ||
V-HE-----------KVQGG----------------YG---KYQ-------GTW------ | V-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------IPLPEARLLAERNNI- | -------------IPLPEARLLAERNNI- | ||
>Aps4_TALMA XP_002143521 | >Aps4_TALMA XP_002143521 | ||
| − | ------------- | + | ------------GEC-LMRRRADDWIN--------------------------------- |
--ATHILKV-------------AGFDK--------PSRTRI---------LEREVQKG-- | --ATHILKV-------------AGFDK--------PSRTRI---------LEREVQKG-- | ||
V-HE-----------KVQGG----------------YG---KYQ-------GTW------ | V-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
| Line 491: | Line 612: | ||
-------------IPLPDGRLLAQKNSV- | -------------IPLPDGRLLAQKNSV- | ||
>Mbp1_UNCRE XP_002540670 | >Mbp1_UNCRE XP_002540670 | ||
| − | --------------- | + | --------------S-VMRRRHDDWIN--------------------------------- |
--ATHILKV-------------AGLDK--------PSRTRI---------LEREVQKG-- | --ATHILKV-------------AGLDK--------PSRTRI---------LEREVQKG-- | ||
T-HE-----------KIQGG----------------YG---KYQGTRHYTAGTW------ | T-HE-----------KIQGG----------------YG---KYQGTRHYTAGTW------ | ||
-------------VPLPDGRHLAERNNV- | -------------VPLPDGRHLAERNNV- | ||
>Mbp1_COCPO XP_003066829 | >Mbp1_COCPO XP_003066829 | ||
| − | --------------- | + | --------------S-VMRRRHDDWIN--------------------------------- |
--ATHILKV-------------AGLDK--------PSRTRI---------LEREVQKG-- | --ATHILKV-------------AGLDK--------PSRTRI---------LEREVQKG-- | ||
T-HE-----------KIQGG----------------YG---KYQ-------GTW------ | T-HE-----------KIQGG----------------YG---KYQ-------GTW------ | ||
-------------VPLADGRAVAERNKV- | -------------VPLADGRAVAERNKV- | ||
>Aps4_COCIM XP_001246304 | >Aps4_COCIM XP_001246304 | ||
| − | --------------- | + | --------------S-VMRRRHDDWIN--------------------------------- |
--ATHILKV-------------AGLDK--------PSRTRI---------LEREVQKG-- | --ATHILKV-------------AGLDK--------PSRTRI---------LEREVQKG-- | ||
T-HE-----------KIQGG----------------YG---KYQ-------GTW------ | T-HE-----------KIQGG----------------YG---KYQ-------GTW------ | ||
| Line 550: | Line 671: | ||
V-HE-----------KIQGG----------------YG---KYQ-------GTW------ | V-HE-----------KIQGG----------------YG---KYQ-------GTW------ | ||
-------------IPLESGQALAERHSV- | -------------IPLESGQALAERHSV- | ||
| − | > | + | >Aps2_USTMA XP_761485 |
| − | ---------- | + | ---------VR-GIA-VMRRRGDGWLN--------------------------------- |
| − | -- | + | --ATQILKI-------------AGIEK--------TRRTKI---------LEKSILTG-- |
| − | + | E-HE-----------KIQGG----------------YG---KFQ-------GTW------ | |
| − | ------------- | + | -------------IPLQRAQQVAAEYNV- |
| − | > | + | >Aps3_MALGL XP_001728900 |
| − | ---------- | + | ------------GIA-LMRRRSDGYLN--------------------------------- |
| − | -- | + | --ATQILKI-------------AGIEK--------ARRTRI---------LEKEILTG-- |
| − | + | E-HD-----------KVQGG----------------YG---TFQ-------GTW------ | |
| − | ------------- | + | -------------IPLQRAQELAISYNVY |
| − | > | + | >Aps3_PUCGR XP_003320997 |
| − | + | ------------GIG-VMRRRSDSYMN--------------------------------- | |
| − | + | --ATQILKV-------------AGLDK--------SKRTRI---------LEREIIQG-- | |
| − | + | E-HE-----------KIQGG----------------YG---RYQ-------GTW------ | |
| − | + | -------------VPFTRAQELATQLNV- | |
| − | |||
| − | |||
| − | --ATQILKV------------- | ||
| − | |||
| − | ------------- | ||
>Aps1_NEOFI XP_001261510 | >Aps1_NEOFI XP_001261510 | ||
| − | ----------- | + | ----------N-GVA-VMKRRSDSWLN--------------------------------- |
--ATQILKV-------------AGVVK--------ARRTKT---------LEKEIAAG-- | --ATQILKV-------------AGVVK--------ARRTKT---------LEKEIAAG-- | ||
E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------VNYQRGVELCREYHV- | -------------VNYQRGVELCREYHV- | ||
>Aps1_ASPFU XP_748947 | >Aps1_ASPFU XP_748947 | ||
| − | ----------- | + | ----------N-GVA-VMKRRSDSWLN--------------------------------- |
--ATQILKV-------------AGVVK--------ARRTKT---------LEKEIAAG-- | --ATQILKV-------------AGVVK--------ARRTKT---------LEKEIAAG-- | ||
E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------VNYQRGVELCREYHV- | -------------VNYQRGVELCREYHV- | ||
>Aps8_ASPNI XP_001391313 | >Aps8_ASPNI XP_001391313 | ||
| − | ----------- | + | ----------N-GVA-VMKRRSDSWLN--------------------------------- |
--ATQILKV-------------AGVVK--------ARRTKT---------LEKEIAAG-- | --ATQILKV-------------AGVVK--------ARRTKT---------LEKEIAAG-- | ||
E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------VNYQRGVELCREYHV- | -------------VNYQRGVELCREYHV- | ||
>Aps1_ASPCL XP_001273399 | >Aps1_ASPCL XP_001273399 | ||
| − | ----------- | + | ----------N-GVA-VMKRRSDSWLN--------------------------------- |
--ATQILKV-------------AGVVK--------ARRTKT---------LEKEIAAG-- | --ATQILKV-------------AGVVK--------ARRTKT---------LEKEIAAG-- | ||
E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------VNYQRGVDLCREYHV- | -------------VNYQRGVDLCREYHV- | ||
>Aps4_ASPTE XP_001215548 | >Aps4_ASPTE XP_001215548 | ||
| − | ----------- | + | ----------N-GVA-VMKRRSDSWLN--------------------------------- |
--ATQILKV-------------AGVVK--------ARRTKT---------LEKEIAAG-- | --ATQILKV-------------AGVVK--------ARRTKT---------LEKEIAAG-- | ||
E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------VNYQRGVDLCREYHV- | -------------VNYQRGVDLCREYHV- | ||
>Aps9_ASPNI XP_664319 | >Aps9_ASPNI XP_664319 | ||
| − | ----------- | + | ----------N-GVA-VMKRRSDGWLN--------------------------------- |
--ATQILKV-------------AGVVK--------ARRTKT---------LEKEIAAG-- | --ATQILKV-------------AGVVK--------ARRTKT---------LEKEIAAG-- | ||
E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------VNYQRGVELCREYHV- | -------------VNYQRGVELCREYHV- | ||
>Aps2_TALMA XP_002148693 | >Aps2_TALMA XP_002148693 | ||
| − | ----------- | + | ----------N-GIA-VMKRRSDSWLN--------------------------------- |
--ATQILKV-------------AGVVK--------AKRTKT---------LEKEIAAG-- | --ATQILKV-------------AGVVK--------AKRTKT---------LEKEIAAG-- | ||
E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------VSYQRGVELCREYQV- | -------------VSYQRGVELCREYQV- | ||
>Aps2_TALST XP_002485546 | >Aps2_TALST XP_002485546 | ||
| − | ----------- | + | ----------N-GIA-VMKRRSDSWLN--------------------------------- |
--ATQILKV-------------AGVVK--------AKRTKT---------LEKEIAAG-- | --ATQILKV-------------AGVVK--------AKRTKT---------LEKEIAAG-- | ||
E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------VSYQRGVELCREYQV- | -------------VSYQRGVELCREYQV- | ||
>Aps2_UNCRE XP_002583286 | >Aps2_UNCRE XP_002583286 | ||
| − | ----------- | + | ----------N-GVA-VMRRRSDSWLN--------------------------------- |
--ATQILKV-------------AGVVK--------ARRTKT---------LEKEVASG-- | --ATQILKV-------------AGVVK--------ARRTKT---------LEKEVASG-- | ||
E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------VSYQRGVELCRRYHV- | -------------VSYQRGVELCRRYHV- | ||
>Aps4_COCPO XP_003067661 | >Aps4_COCPO XP_003067661 | ||
| − | ----------- | + | ----------N-GVA-VMRRRSDSWLN--------------------------------- |
--ATQILKV-------------AGVVK--------ARRTKT---------LEKEVVSG-- | --ATQILKV-------------AGVVK--------ARRTKT---------LEKEVVSG-- | ||
E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------VSYQRGVELCRRYHV- | -------------VSYQRGVELCRRYHV- | ||
>Aps2_ARTGY XP_003175012 | >Aps2_ARTGY XP_003175012 | ||
| − | ----------- | + | ----------N-GVA-MMRRRSDSWLN--------------------------------- |
--ATQILKV-------------AGVAK--------ARRTKT---------LEKEVAAG-- | --ATQILKV-------------AGVAK--------ARRTKT---------LEKEVAAG-- | ||
D-HE-----------KVQGG----------------YG---KYQ-------GTW------ | D-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------VSYERGLELCRRYQV- | -------------VSYERGLELCRRYQV- | ||
>Aps2_TRIVE XP_003020882 | >Aps2_TRIVE XP_003020882 | ||
| − | ----------- | + | ----------N-GVA-MMRRRSDSWLN--------------------------------- |
--ATQILKV-------------AGVAK--------ARRTKT---------LEKEVAAG-- | --ATQILKV-------------AGVAK--------ARRTKT---------LEKEVAAG-- | ||
E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------VSYERGLELCRRYQV- | -------------VSYERGLELCRRYQV- | ||
>Aps3_TRIRU XP_003236744 | >Aps3_TRIRU XP_003236744 | ||
| − | ----------- | + | ----------N-GVA-MMRRRSDSWLN--------------------------------- |
--ATQILKV-------------AGVAK--------ARRTKT---------LEKEVAAG-- | --ATQILKV-------------AGVAK--------ARRTKT---------LEKEVAAG-- | ||
E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
| Line 641: | Line 757: | ||
-------------VSYERGLELCRRYQV- | -------------VSYERGLELCRRYQV- | ||
>Aps1_AJEDE XP_002624235 | >Aps1_AJEDE XP_002624235 | ||
| − | ----------- | + | ----------N-GVA-VMRRRSDSWLN--------------------------------- |
--ATQILKV-------------AGVMK--------ARRTKT---------LEKEVAAG-- | --ATQILKV-------------AGVMK--------ARRTKT---------LEKEVAAG-- | ||
E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------VNYERGVELCRHYHVF | -------------VNYERGVELCRHYHVF | ||
>Aps1_PYRTE XP_003298893 | >Aps1_PYRTE XP_003298893 | ||
| − | ----------- | + | ----------N-RVA-VMRRRSDGWLN--------------------------------- |
--ATQILKV-------------AGVDK--------GKRTKV---------LEKEILTG-- | --ATQILKV-------------AGVDK--------GKRTKV---------LEKEILTG-- | ||
E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------INYRRGREFCRQYGV- | -------------INYRRGREFCRQYGV- | ||
>Aps3_PYRTR XP_001935618 | >Aps3_PYRTR XP_001935618 | ||
| − | ----------- | + | ----------N-RVA-VMRRRSDGWLN--------------------------------- |
--ATQILKV-------------AGVDK--------GKRTKV---------LEKEILTG-- | --ATQILKV-------------AGVDK--------GKRTKV---------LEKEILTG-- | ||
E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------INYRRGREFCRQYGV- | -------------INYRRGREFCRQYGV- | ||
>Aps3_ZYMTR XP_003848849 | >Aps3_ZYMTR XP_003848849 | ||
| − | ---------- | + | ---------VH-NVA-VMRRRSDGWLN--------------------------------- |
--ATQILKV-------------AGVDK--------GKRTKV---------LEKEILPG-- | --ATQILKV-------------AGVDK--------GKRTKV---------LEKEILPG-- | ||
E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------ISYQRGREFCRQYGV- | -------------ISYQRGREFCRQYGV- | ||
>Aps4_SCLSC XP_001590455 | >Aps4_SCLSC XP_001590455 | ||
| − | ----------- | + | ----------N-RIA-VMRRRKDSWLN--------------------------------- |
--ATQILKV-------------AGIEK--------GKRTKV---------LEKEILIG-- | --ATQILKV-------------AGIEK--------GKRTKV---------LEKEILIG-- | ||
D-HE-----------KVQGG----------------YG---KYQ-------GTW------ | D-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------IRFERGVEFCKQYGV- | -------------IRFERGVEFCKQYGV- | ||
>Aps1_SORMA XP_003347917 | >Aps1_SORMA XP_003347917 | ||
| − | ----------- | + | ----------N-NVA-VMRRQKDGWVN--------------------------------- |
--ATQILKV-------------ANIDK--------GRRTKI---------LEKEIQIG-- | --ATQILKV-------------ANIDK--------GRRTKI---------LEKEIQIG-- | ||
E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------IPFERGLEVCRQYGV- | -------------IPFERGLEVCRQYGV- | ||
>Aps1_NEUCR XP_962967 | >Aps1_NEUCR XP_962967 | ||
| − | ----------- | + | ----------N-NVA-VMRRQKDGWVN--------------------------------- |
--ATQILKV-------------ANIDK--------GRRTKI---------LEKEIQIG-- | --ATQILKV-------------ANIDK--------GRRTKI---------LEKEIQIG-- | ||
E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------IPFERGLEVCRQYGV- | -------------IPFERGLEVCRQYGV- | ||
>Aps3_CHAGL XP_001224444 | >Aps3_CHAGL XP_001224444 | ||
| − | ----------- | + | ----------N-NVA-VMRRQTDGWLN--------------------------------- |
--ATQILKV-------------AGVDK--------GRRTKI---------LEKEIQTG-- | --ATQILKV-------------AGVDK--------GRRTKI---------LEKEIQTG-- | ||
E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------IPFERGFEVCRQYGV- | -------------IPFERGFEVCRQYGV- | ||
>Aps3_MYCTH XP_003663630 | >Aps3_MYCTH XP_003663630 | ||
| − | ----------- | + | ----------N-NVA-VMRRQADGWLN--------------------------------- |
--ATQILKV-------------AGVDK--------GRRTKI---------LEKEIQTG-- | --ATQILKV-------------AGVDK--------GRRTKI---------LEKEIQTG-- | ||
E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------IPFERGYEVCRQYGV- | -------------IPFERGYEVCRQYGV- | ||
>Aps1_THITE XP_003653705 | >Aps1_THITE XP_003653705 | ||
| − | ----------- | + | ----------N-NVA-VMRRQHDSWLN--------------------------------- |
--ATQILKV-------------AGVDK--------GRRTKI---------LEKEIQTG-- | --ATQILKV-------------AGVDK--------GRRTKI---------LEKEIQTG-- | ||
Q-HE-----------KVQGG----------------YG---KYQ-------GTW------ | Q-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------IPFERGVEVCRQYGV- | -------------IPFERGVEVCRQYGV- | ||
>Aps4_NECHA XP_003045061 | >Aps4_NECHA XP_003045061 | ||
| − | ----------- | + | ----------N-NIA-VMRRRNDSWLN--------------------------------- |
--ATQILKV-------------AGVDK--------GKRTKI---------LEKEIQTG-- | --ATQILKV-------------AGVDK--------GKRTKI---------LEKEIQTG-- | ||
E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------ITFDRGVQVCRQYGV- | -------------ITFDRGVQVCRQYGV- | ||
>Aps1_VERAL XP_003001507 | >Aps1_VERAL XP_003001507 | ||
| − | ------------- | + | ------------GVA-VMRRRNDSWLN--------------------------------- |
--ATQILKV-------------AGVEK--------GKRTKI---------LEKEIQTG-- | --ATQILKV-------------AGVEK--------GKRTKI---------LEKEIQTG-- | ||
E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------IKFERAVEVCRQYGV- | -------------IKFERAVEVCRQYGV- | ||
>Aps2_MAGOR XP_003720365 | >Aps2_MAGOR XP_003720365 | ||
| − | ----------- | + | ----------N-GVA-VMKRIGDSKLN--------------------------------- |
--ATQILKV-------------AGVEK--------GKRTKI---------LEKEIQTG-- | --ATQILKV-------------AGVEK--------GKRTKI---------LEKEIQTG-- | ||
E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | E-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------IKYERALEVCRQYGV- | -------------IKYERALEVCRQYGV- | ||
>Aps3_YARLI XP_501770 | >Aps3_YARLI XP_501770 | ||
| − | --------- | + | --------MAN-DVA-VMRRRTDSSLN--------------------------------- |
--ATQILKV-------------AGVEK--------SKRTKI---------LEKEILTG-- | --ATQILKV-------------AGVEK--------SKRTKI---------LEKEILTG-- | ||
A-HE-----------KVQGG----------------YG---KYQ-------GTW------ | A-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------IPYERGVDLCRQYSVY | -------------IPYERGVDLCRQYSVY | ||
| − | > | + | >Res1_SCHPO NP_595496 MBF transcription factor complex subunit Res1 |
| − | ----------- | + | ---------IN-GFP-LMKRCHDNWLN--------------------------------- |
| − | -- | + | --ATQILKI-------------AELDK--------PRRTRI---------LEKFAQKG-- |
| − | + | L-HE-----------KIQGG----------------CG---KYQ-------GTW------ | |
| − | + | -------------VPSERAVELAHEYNVF | |
| − | |||
| − | |||
| − | |||
| − | |||
| − | ------------- | ||
>Aps1_SCHJA XP_002171963 | >Aps1_SCHJA XP_002171963 | ||
| − | --------- | + | --------IVN-GVA-VMKRCRDGWLN--------------------------------- |
--ATQILKV-------------AELDK--------PKRTRV---------LEKFAQRG-- | --ATQILKV-------------AELDK--------PKRTRV---------LEKFAQRG-- | ||
I-HE-----------KVQGG----------------YG---KYQ-------GTW------ | I-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------VPLQRGVELAMEFQVH | -------------VPLQRGVELAMEFQVH | ||
>Mbp1_MILFA XP_004204377 | >Mbp1_MILFA XP_004204377 | ||
| − | --------- | + | --------VTS-EGP-IMRRKSDSWIN--------------------------------- |
--ATHILKI-------------AKFPK--------AKRTRI---------LEKDVQTG-- | --ATHILKI-------------AKFPK--------AKRTRI---------LEKDVQTG-- | ||
I-HE-----------KVQGG----------------YG---KYQ-------GTY------ | I-HE-----------KVQGG----------------YG---KYQ-------GTY------ | ||
-------------VPLDLGAEIARSFGIY | -------------VPLDLGAEIARSFGIY | ||
>Aps2_MILFA XP_004204934 | >Aps2_MILFA XP_004204934 | ||
| − | --------- | + | --------VTS-EGP-IMRRKSDSWIN--------------------------------- |
--ATHILKI-------------AKFPK--------AKRTRI---------LEKDVQTG-- | --ATHILKI-------------AKFPK--------AKRTRI---------LEKDVQTG-- | ||
I-HE-----------KVQGG----------------YG---KYQ-------GTY------ | I-HE-----------KVQGG----------------YG---KYQ-------GTY------ | ||
-------------VPLELGAEIARSFGIY | -------------VPLELGAEIARSFGIY | ||
>Aps6_CLALU XP_002615371 | >Aps6_CLALU XP_002615371 | ||
| − | --------- | + | --------VTK-EGP-IMRRKSDSWIN--------------------------------- |
--ATHILKI-------------AKFPK--------AKRTRI---------LEKDVQTG-- | --ATHILKI-------------AKFPK--------AKRTRI---------LEKDVQTG-- | ||
I-HE-----------KVQGG----------------YG---KYQ-------GTY------ | I-HE-----------KVQGG----------------YG---KYQ-------GTY------ | ||
-------------VPLDLGAEIAKSFGIF | -------------VPLDLGAEIAKSFGIF | ||
>Aps3_DEBHA XP_002770278 | >Aps3_DEBHA XP_002770278 | ||
| − | --------- | + | --------VTS-EGP-IMRRKSDSWIN--------------------------------- |
--ATHILKI-------------AKFPK--------AKRTRI---------LEKDVQTG-- | --ATHILKI-------------AKFPK--------AKRTRI---------LEKDVQTG-- | ||
V-HE-----------KVQGG----------------YG---KYQ-------GTY------ | V-HE-----------KVQGG----------------YG---KYQ-------GTY------ | ||
-------------VPLDLGADIAKNFGVF | -------------VPLDLGADIAKNFGVF | ||
>Aps3_SCHST XP_001386821 | >Aps3_SCHST XP_001386821 | ||
| − | --------- | + | --------VTS-EGP-IMRRKSDSWIN--------------------------------- |
--ATHILKI-------------AKFPK--------AKRTRI---------LEKDVQTG-- | --ATHILKI-------------AKFPK--------AKRTRI---------LEKDVQTG-- | ||
V-HE-----------KVQGG----------------YG---KYQ-------GTY------ | V-HE-----------KVQGG----------------YG---KYQ-------GTY------ | ||
-------------VPLELGRDIAKNFGVF | -------------VPLELGRDIAKNFGVF | ||
>Mbp1_CANAL XP_723071 | >Mbp1_CANAL XP_723071 | ||
| − | --------- | + | --------VTS-EGP-IMRRKKDSWIN--------------------------------- |
--ATHILKI-------------AKFPK--------AKRTRI---------LEKDVQTG-- | --ATHILKI-------------AKFPK--------AKRTRI---------LEKDVQTG-- | ||
I-HE-----------KVQGG----------------YG---KYQ-------GTY------ | I-HE-----------KVQGG----------------YG---KYQ-------GTY------ | ||
-------------VPLDLGAAIARNFGVY | -------------VPLDLGAAIARNFGVY | ||
>Aps3_CANDU XP_002419323 | >Aps3_CANDU XP_002419323 | ||
| − | --------- | + | --------VTS-EGP-IMRRKKDSWIN--------------------------------- |
--ATHILKI-------------AKFPK--------AKRTRI---------LEKDVQTG-- | --ATHILKI-------------AKFPK--------AKRTRI---------LEKDVQTG-- | ||
I-HE-----------KVQGG----------------YG---KYQ-------GTY------ | I-HE-----------KVQGG----------------YG---KYQ-------GTY------ | ||
-------------VPLDLGAAIAKNFGVY | -------------VPLDLGAAIAKNFGVY | ||
>Aps4_CANTR XP_002548345 | >Aps4_CANTR XP_002548345 | ||
| − | --------- | + | --------VTS-EGP-IMRRKSDSWIN--------------------------------- |
--ATHILKI-------------AKFPK--------ARRTRI---------LEKDVQTG-- | --ATHILKI-------------AKFPK--------ARRTRI---------LEKDVQTG-- | ||
V-HE-----------KVQGG----------------YG---KYQ-------GTY------ | V-HE-----------KVQGG----------------YG---KYQ-------GTY------ | ||
-------------VPLELGATIAKNFGVY | -------------VPLELGATIAKNFGVY | ||
>Mbp1_MEYGU XP_001484708 | >Mbp1_MEYGU XP_001484708 | ||
| − | --------- | + | --------VTS-EGP-IMRRKLDSWIN--------------------------------- |
--ATHILKI-------------ARFPK--------AKRTRI---------LEKDVQTG-- | --ATHILKI-------------ARFPK--------AKRTRI---------LEKDVQTG-- | ||
I-HE-----------KVQGG----------------YG---KYQ-------GTY------ | I-HE-----------KVQGG----------------YG---KYQ-------GTY------ | ||
-------------VPLNLGAEIAQSFGVY | -------------VPLNLGAEIAQSFGVY | ||
>Aps1_LODEL XP_001527262 | >Aps1_LODEL XP_001527262 | ||
| − | ------------- | + | ------------EGP-IMRRKLDSWIN--------------------------------- |
--ATHILKI-------------AKLPK--------AKRTRI---------LEKDVQTG-- | --ATHILKI-------------AKLPK--------AKRTRI---------LEKDVQTG-- | ||
I-HE-----------KVQGG----------------YG---KYQ-------GTY------ | I-HE-----------KVQGG----------------YG---KYQ-------GTY------ | ||
-------------VPLELGEIIARNYDVY | -------------VPLELGEIIARNYDVY | ||
>Mbp1_CANOR XP_003867545 | >Mbp1_CANOR XP_003867545 | ||
| − | --------- | + | --------VTS-EGP-IMRRKGDSWIN--------------------------------- |
--ATHILKI-------------AKLPK--------AKRTRI---------LEKDVQTG-- | --ATHILKI-------------AKLPK--------AKRTRI---------LEKDVQTG-- | ||
I-HE-----------KVQGG----------------YG---KYQ-------GTY------ | I-HE-----------KVQGG----------------YG---KYQ-------GTY------ | ||
-------------VPLKLGEVIARNYDVY | -------------VPLKLGEVIARNYDVY | ||
>Aps1_KAZAF XP_003958484 | >Aps1_KAZAF XP_003958484 | ||
| − | --------- | + | --------IHP-TGS-IMKRKKDGWVN--------------------------------- |
--ATHILKA-------------ANFAK--------AKRTRI---------LEKEVLPG-- | --ATHILKA-------------ANFAK--------AKRTRI---------LEKEVLPG-- | ||
T-HE-----------KVQGG----------------FG---KYQ-------GTW------ | T-HE-----------KVQGG----------------FG---KYQ-------GTW------ | ||
-------------IPLESAIALAEKFAVY | -------------IPLESAIALAEKFAVY | ||
>Mbp1_LACTH XP_002553316 | >Mbp1_LACTH XP_002553316 | ||
| − | --------- | + | --------IHP-TGS-IMKRKEDDWVN--------------------------------- |
--ATHILKA-------------AKFAK--------AKRTRI---------LEKEVIKD-- | --ATHILKA-------------AKFAK--------AKRTRI---------LEKEVIKD-- | ||
T-HE-----------KVQGG----------------FG---KYQ-------GTW------ | T-HE-----------KVQGG----------------FG---KYQ-------GTW------ | ||
-------------VPLDIARSLAAKFEV- | -------------VPLDIARSLAAKFEV- | ||
>Aps3_ERECY XP_003645298 | >Aps3_ERECY XP_003645298 | ||
| − | --------- | + | --------IHP-TGS-IMKRKADDWVN--------------------------------- |
--ATHILKA-------------AKFAK--------AKRTRI---------LEKEVIKD-- | --ATHILKA-------------AKFAK--------AKRTRI---------LEKEVIKD-- | ||
I-HE-----------KVQGG----------------FG---KYQ-------GTW------ | I-HE-----------KVQGG----------------FG---KYQ-------GTW------ | ||
-------------VPLDIARRLAEKFDV- | -------------VPLDIARRLAEKFDV- | ||
>Aps3_ASHGO NP_986147 | >Aps3_ASHGO NP_986147 | ||
| − | --------- | + | --------LHP-TGS-IMKRKADDWVN--------------------------------- |
--ATHILKA-------------AKFAK--------AKRTRI---------LEKEVIKD-- | --ATHILKA-------------AKFAK--------AKRTRI---------LEKEVIKD-- | ||
T-HE-----------KVQGG----------------FG---KYQ-------GTW------ | T-HE-----------KVQGG----------------FG---KYQ-------GTW------ | ||
-------------VPLDIARRLAQKFEV- | -------------VPLDIARRLAQKFEV- | ||
>Aps1_TORDE XP_003681593 | >Aps1_TORDE XP_003681593 | ||
| − | --------- | + | --------IHP-TGS-VMKRKTDDWVN--------------------------------- |
--ATHILKA-------------AKFAK--------AKRTRI---------LEKEVIKE-- | --ATHILKA-------------AKFAK--------AKRTRI---------LEKEVIKE-- | ||
V-HE-----------KVQGG----------------FG---KYQ-------GTW------ | V-HE-----------KVQGG----------------FG---KYQ-------GTW------ | ||
-------------VPLDIATRLANKFDVY | -------------VPLDIATRLANKFDVY | ||
>Aps3_KLULA XP_454189 | >Aps3_KLULA XP_454189 | ||
| − | --------- | + | --------IHP-TGS-IMKRKADNWVN--------------------------------- |
--ATHILKA-------------AKFPK--------AKRTRI---------LEKEVITD-- | --ATHILKA-------------AKFPK--------AKRTRI---------LEKEVITD-- | ||
T-HE-----------KVQGG----------------FG---KYQ-------GTW------ | T-HE-----------KVQGG----------------FG---KYQ-------GTW------ | ||
-------------IPLELASKLAEKFEV- | -------------IPLELASKLAEKFEV- | ||
>Mbp1_CANGA XP_445458 | >Mbp1_CANGA XP_445458 | ||
| − | --------- | + | --------IHP-TGS-IMKRKNDGWVN--------------------------------- |
--ATHILKA-------------ANFAK--------AKRTRI---------LEKEVLKE-- | --ATHILKA-------------ANFAK--------AKRTRI---------LEKEVLKE-- | ||
M-HE-----------KVQGG----------------FG---KYQ-------GTW------ | M-HE-----------KVQGG----------------FG---KYQ-------GTW------ | ||
-------------VPLNIAINLAEKFDVY | -------------VPLNIAINLAEKFDVY | ||
>Mbp1_SACCE NP_010227 | >Mbp1_SACCE NP_010227 | ||
| − | --------- | + | --------IHS-TGS-IMKRKKDDWVN--------------------------------- |
--ATHILKA-------------ANFAK--------AKRTRI---------LEKEVLKE-- | --ATHILKA-------------ANFAK--------AKRTRI---------LEKEVLKE-- | ||
T-HE-----------KVQGG----------------FG---KYQ-------GTW------ | T-HE-----------KVQGG----------------FG---KYQ-------GTW------ | ||
-------------VPLNIAKQLAEKFSVY | -------------VPLNIAKQLAEKFSVY | ||
>Aps4_NAUDA XP_003670000 | >Aps4_NAUDA XP_003670000 | ||
| − | --------- | + | --------VHP-TGS-VMKRKSDDWVN--------------------------------- |
--ATHILKV-------------ANFSK--------AKRTRI---------LEKEVLKE-- | --ATHILKV-------------ANFSK--------AKRTRI---------LEKEVLKE-- | ||
T-HE-----------KVQGG----------------FG---KYQ-------GTW------ | T-HE-----------KVQGG----------------FG---KYQ-------GTW------ | ||
-------------VPMNIALNLAEKYGVY | -------------VPMNIALNLAEKYGVY | ||
>Mbp1_ZYGRO XP_002495259 | >Mbp1_ZYGRO XP_002495259 | ||
| − | --------- | + | --------IHP-TGS-VMKRRDDDWVN--------------------------------- |
--ATHILKA-------------ARFAK--------AKRTRI---------LEKEVIKE-- | --ATHILKA-------------ARFAK--------AKRTRI---------LEKEVIKE-- | ||
V-HE-----------KVQGG----------------FG---KYQ-------GTW------ | V-HE-----------KVQGG----------------FG---KYQ-------GTW------ | ||
-------------VPMDVARTLATKFGVH | -------------VPMDVARTLATKFGVH | ||
>Aps4_VANPO XP_001643445 | >Aps4_VANPO XP_001643445 | ||
| − | --------- | + | --------IHP-TGS-VMKRKLDNWVN--------------------------------- |
--ATHILKA-------------ANFAK--------AKRTRI---------LEKEVIKE-- | --ATHILKA-------------ANFAK--------AKRTRI---------LEKEVIKE-- | ||
T-HE-----------KVQGG----------------FG---KYQ-------GTW------ | T-HE-----------KVQGG----------------FG---KYQ-------GTW------ | ||
-------------VPLDIARKLAEKFGVH | -------------VPLDIARKLAEKFGVH | ||
>Mbp1_TETPH XP_003684194 | >Mbp1_TETPH XP_003684194 | ||
| − | --------- | + | --------LHS-TGS-VMKRKKDGWVN--------------------------------- |
--ATHILKT-------------ANFAK--------AKRTRI---------LEKEVIQE-- | --ATHILKT-------------ANFAK--------AKRTRI---------LEKEVIQE-- | ||
T-HE-----------KVQGG----------------FG---KYQ-------GTW------ | T-HE-----------KVQGG----------------FG---KYQ-------GTW------ | ||
-------------VPLSVAISLAQKFEVY | -------------VPLSVAISLAQKFEVY | ||
>Aps5_NAUCA XP_003673193 | >Aps5_NAUCA XP_003673193 | ||
| − | --------- | + | --------IHP-TGS-VMKRKKDDWVN--------------------------------- |
--ATHILKA-------------ANFAK--------AKRTRI---------LDKEVMGR-- | --ATHILKA-------------ANFAK--------AKRTRI---------LDKEVMGR-- | ||
K-HE-----------KVQGG----------------FG---KYQ-------GTW------ | K-HE-----------KVQGG----------------FG---KYQ-------GTW------ | ||
-------------VPLEIATELAMKFDVY | -------------VPLEIATELAMKFDVY | ||
>Mbp1_TETRE XP_004182459 | >Mbp1_TETRE XP_004182459 | ||
| − | --------- | + | --------IHP-TGS-IMKRKIDGWVN--------------------------------- |
--ATHILKA-------------AKFPK--------AKRTRI---------LEKEVIHE-- | --ATHILKA-------------AKFPK--------AKRTRI---------LEKEVIHE-- | ||
I-HE-----------KVQGG----------------FG---KYQ-------GTW------ | I-HE-----------KVQGG----------------FG---KYQ-------GTW------ | ||
-------------VPTDIATRLSKKFGVF | -------------VPTDIATRLSKKFGVF | ||
>Aps1_TETBL XP_004178121 | >Aps1_TETBL XP_004178121 | ||
| − | --------- | + | --------LHP-TGS-IMKRKTDNWVN--------------------------------- |
--ATHILKA-------------AHLPK--------AKRTRI---------LERQILNN-- | --ATHILKA-------------AHLPK--------AKRTRI---------LERQILNN-- | ||
NHHE-----------KVQGG----------------FG---KYQ-------GTW------ | NHHE-----------KVQGG----------------FG---KYQ-------GTW------ | ||
-------------IPLEDAVALAREFGVY | -------------IPLEDAVALAREFGVY | ||
>Aps2_KOMPA XP_002491420 | >Aps2_KOMPA XP_002491420 | ||
| − | --------- | + | --------VTP-LTS-VMRRKSDDWIN--------------------------------- |
--ATHILKV-------------ADFPK--------AKRTRI---------LERDIQVG-- | --ATHILKV-------------ADFPK--------AKRTRI---------LERDIQVG-- | ||
T-HE-----------KVQGG----------------YG---KYQ-------GTW------ | T-HE-----------KVQGG----------------YG---KYQ-------GTW------ | ||
-------------VPLESAVKIAETFDV- | -------------VPLESAVKIAETFDV- | ||
>Aps2_CANTR XP_002550287 | >Aps2_CANTR XP_002550287 | ||
| − | ----------- | + | ----------N-DSP-IMRRCKDDWVN--------------------------------- |
--ATQILKC-------------CNFPK--------AKRTKI---------LEKGVQQG-- | --ATQILKC-------------CNFPK--------AKRTKI---------LEKGVQQG-- | ||
L-HE-----------KVQGG----------------FG---RFQ-------GTW------ | L-HE-----------KVQGG----------------FG---RFQ-------GTW------ | ||
-------------IPLEDARRLAETYGV- | -------------IPLEDARRLAETYGV- | ||
>Swi4_CANOR XP_003868155 | >Swi4_CANOR XP_003868155 | ||
| − | ----------- | + | ----------N-DSP-IMRRCKDDWVN--------------------------------- |
--ATQILKC-------------CNFPK--------AKRTKI---------LEKGVQQG-- | --ATQILKC-------------CNFPK--------AKRTKI---------LEKGVQQG-- | ||
L-HE-----------KVQGG----------------FG---RFQ-------GTW------ | L-HE-----------KVQGG----------------FG---RFQ-------GTW------ | ||
-------------IPLEDARRLACTYGV- | -------------IPLEDARRLACTYGV- | ||
>Aps3_LODEL XP_001526754 | >Aps3_LODEL XP_001526754 | ||
| − | ----------- | + | ----------N-DSP-IMRRCKDDWVN--------------------------------- |
--ATQILKC-------------CNFPK--------AKRTKI---------LEKGVQQG-- | --ATQILKC-------------CNFPK--------AKRTKI---------LEKGVQQG-- | ||
V-HE-----------KIQGG----------------FG---RFQ-------GTW------ | V-HE-----------KIQGG----------------FG---RFQ-------GTW------ | ||
-------------IPLEDARRLAATYGV- | -------------IPLEDARRLAATYGV- | ||
>Aps5_SCHST XP_001383745 | >Aps5_SCHST XP_001383745 | ||
| − | ----------- | + | ----------N-DSP-IMRRCKDDWVN--------------------------------- |
--ATQILKC-------------CNFPK--------AKRTKI---------LEKGVQQG-- | --ATQILKC-------------CNFPK--------AKRTKI---------LEKGVQQG-- | ||
L-HE-----------KVQGG----------------FG---RFQ-------GTW------ | L-HE-----------KVQGG----------------FG---RFQ-------GTW------ | ||
-------------IPLPDAQRLATMYGV- | -------------IPLPDAQRLATMYGV- | ||
>Aps1_DEBHA XP_457246 | >Aps1_DEBHA XP_457246 | ||
| − | ----------- | + | ----------N-NSP-IMRRCKDDWVN--------------------------------- |
--ATQILKC-------------CNFPK--------AKRTKI---------LEKGVQQG-- | --ATQILKC-------------CNFPK--------AKRTKI---------LEKGVQQG-- | ||
L-HE-----------KIQGG----------------YG---RFQ-------GTW------ | L-HE-----------KIQGG----------------YG---RFQ-------GTW------ | ||
-------------IPLADAQRLAASYGV- | -------------IPLADAQRLAASYGV- | ||
>Aps7_MILFA XP_004194775 | >Aps7_MILFA XP_004194775 | ||
| − | ----------- | + | ----------N-NSP-IMRRCKDDWVN--------------------------------- |
--ATQILKC-------------CNFPK--------AKRTKI---------LEKGVQQG-- | --ATQILKC-------------CNFPK--------AKRTKI---------LEKGVQQG-- | ||
L-HE-----------KIQGG----------------YG---RFQ-------GTW------ | L-HE-----------KIQGG----------------YG---RFQ-------GTW------ | ||
-------------IPLANAQKLAASYGV- | -------------IPLANAQKLAASYGV- | ||
>Aps9_MILFA XP_004195866 | >Aps9_MILFA XP_004195866 | ||
| − | ----------- | + | ----------N-NSP-IMRRCKDDWVN--------------------------------- |
--ATQILKC-------------CNFPK--------AKRTKI---------LEKGVQQG-- | --ATQILKC-------------CNFPK--------AKRTKI---------LEKGVQQG-- | ||
L-HE-----------KIQGG----------------YG---RFQ-------GTW------ | L-HE-----------KIQGG----------------YG---RFQ-------GTW------ | ||
-------------IPLANAQKLAASYGV- | -------------IPLANAQKLAASYGV- | ||
>Aps1_CANDU XP_002416839 | >Aps1_CANDU XP_002416839 | ||
| − | --------- | + | --------IMN-DYS-IMRRCKDDWVN--------------------------------- |
--ATQILKC-------------CNFPK--------AKRTKI---------LEKGVQQG-- | --ATQILKC-------------CNFPK--------AKRTKI---------LEKGVQQG-- | ||
L-HE-----------KVQGG----------------FG---RFQ-------GTW------ | L-HE-----------KVQGG----------------FG---RFQ-------GTW------ | ||
-------------IPLEDARRLAESYGV- | -------------IPLEDARRLAESYGV- | ||
>Aps2_CANAL XP_712970 | >Aps2_CANAL XP_712970 | ||
| − | --------- | + | --------MMN-ESS-IMRRCKDDWVN--------------------------------- |
--ATQILKC-------------CNFPK--------AKRTKI---------LEKGVQQG-- | --ATQILKC-------------CNFPK--------AKRTKI---------LEKGVQQG-- | ||
L-HE-----------KVQGG----------------FG---RFQ-------GTW------ | L-HE-----------KVQGG----------------FG---RFQ-------GTW------ | ||
-------------IPLEDARKLAKTYGV- | -------------IPLEDARKLAKTYGV- | ||
>Aps6_CANAL XP_712876 | >Aps6_CANAL XP_712876 | ||
| − | --------- | + | --------MMN-ESS-IMRRCKDDWVN--------------------------------- |
--ATQILKC-------------CNFPK--------AKRTKI---------LEKGVQQG-- | --ATQILKC-------------CNFPK--------AKRTKI---------LEKGVQQG-- | ||
L-HE-----------KVQGG----------------FG---RFQ-------GTW------ | L-HE-----------KVQGG----------------FG---RFQ-------GTW------ | ||
| Line 921: | Line 1,032: | ||
-------------IPLEDAQQLAANYGL- | -------------IPLEDAQQLAANYGL- | ||
>Aps3_KAZAF XP_003955178 | >Aps3_KAZAF XP_003955178 | ||
| − | --------- | + | --------LHPVAGS-IMKRRIDNWVN--------------------------------- |
--ATHVLKI-------------ANFNK--------SKRLRL---------LEKEVIKAGK | --ATHVLKI-------------ANFNK--------SKRLRL---------LEKEVIKAGK | ||
A-YE-----------KIQGG----------------SG---KYQ-------GTW------ | A-YE-----------KIQGG----------------SG---KYQ-------GTW------ | ||
-------------VPLEVAKELAVKFEV- | -------------VPLEVAKELAVKFEV- | ||
>Aps3_KOMPA XP_002489438 | >Aps3_KOMPA XP_002489438 | ||
| − | --------- | + | --------ICN-TFP-LMRRCSDDWVN--------------------------------- |
--VTQILKI-------------AQFPK--------AQRTKI---------LEKEVHDK-- | --VTQILKI-------------AQFPK--------AQRTKI---------LEKEVHDK-- | ||
T-HQ-----------RIQGG----------------YG---RFQ-------GTW------ | T-HQ-----------RIQGG----------------YG---RFQ-------GTW------ | ||
| Line 936: | Line 1,047: | ||
-------------IPWESTKYLVEKYNI- | -------------IPWESTKYLVEKYNI- | ||
>Aps2_KAZAF XP_003959931 | >Aps2_KAZAF XP_003959931 | ||
| − | ------------- | + | ------------SHI-VMRRTRDDWIN--------------------------------- |
--ITQVFKV-------------AKFSK--------NHRTKV---------LERESSNL-- | --ITQVFKV-------------AKFSK--------NHRTKV---------LERESSNL-- | ||
R-HE-----------KVQGG----------------YG---RFQ-------GTW------ | R-HE-----------KVQGG----------------YG---RFQ-------GTW------ | ||
-------------IPLVDAKRLIAEYNI- | -------------IPLVDAKRLIAEYNI- | ||
>Aps1_ASHGO NP_986370 | >Aps1_ASHGO NP_986370 | ||
| − | --------------- | + | --------------I-VMRRLHDDWVN--------------------------------- |
--ITQVFKV-------------ATFSK--------TQRTKI---------LEKESADI-- | --ITQVFKV-------------ATFSK--------TQRTKI---------LEKESADI-- | ||
S-HE-----------KIQGG----------------YG---RFQ-------GTW------ | S-HE-----------KIQGG----------------YG---RFQ-------GTW------ | ||
-------------IPLDSAKGLVAKYEI- | -------------IPLDSAKGLVAKYEI- | ||
>Aps4_ERECY XP_003647811 | >Aps4_ERECY XP_003647811 | ||
| − | --------------- | + | --------------I-VMRRLHDDWVN--------------------------------- |
--ITQVFKV-------------ASFTK--------TQRTKV---------LEKESTDI-- | --ITQVFKV-------------ASFTK--------TQRTKV---------LEKESTDI-- | ||
N-HE-----------KIQGG----------------YG---RFQ-------GTW------ | N-HE-----------KIQGG----------------YG---RFQ-------GTW------ | ||
-------------IPLLSAQNLVAKYCI- | -------------IPLLSAQNLVAKYCI- | ||
>Aps2_ZYGRO XP_002495118 | >Aps2_ZYGRO XP_002495118 | ||
| − | --------------- | + | --------------I-VMRRTQDDWVN--------------------------------- |
--ITQVFKI-------------AQFSK--------TQRTKV---------LEKESNDM-- | --ITQVFKI-------------AQFSK--------TQRTKV---------LEKESNDM-- | ||
R-HE-----------KVQGG----------------YG---RFQ-------GTW------ | R-HE-----------KVQGG----------------YG---RFQ-------GTW------ | ||
-------------IPLEDAKYMVTKYNI- | -------------IPLEDAKYMVTKYNI- | ||
>Aps3_TORDE XP_003680369 | >Aps3_TORDE XP_003680369 | ||
| − | --------------- | + | --------------I-VMRRTADDWVN--------------------------------- |
--ITQVFKI-------------AQFSK--------TQRTKV---------LEKESTDM-- | --ITQVFKI-------------AQFSK--------TQRTKV---------LEKESTDM-- | ||
R-HE-----------KVQGG----------------YG---RFQ-------GTW------ | R-HE-----------KVQGG----------------YG---RFQ-------GTW------ | ||
-------------IPLENAKYMVSKYNI- | -------------IPLENAKYMVSKYNI- | ||
>Aps4_CANGL XP_444966 | >Aps4_CANGL XP_444966 | ||
| − | --------------- | + | --------------I-VMRRTMDDWVN--------------------------------- |
--VTQVFKI-------------AQFSK--------TQRTKI---------LEKESTNM-- | --VTQVFKI-------------AQFSK--------TQRTKI---------LEKESTNM-- | ||
K-HE-----------KVQGG----------------YG---RFQ-------GTW------ | K-HE-----------KVQGG----------------YG---RFQ-------GTW------ | ||
-------------VPLEAAKFMTTKYNI- | -------------VPLEAAKFMTTKYNI- | ||
>Swi4_SACCE NP_011036 | >Swi4_SACCE NP_011036 | ||
| − | ------------- | + | ------------TKI-VMRRTKDDWIN--------------------------------- |
--ITQVFKI-------------AQFSK--------TKRTKI---------LEKESNDM-- | --ITQVFKI-------------AQFSK--------TKRTKI---------LEKESNDM-- | ||
Q-HE-----------KVQGG----------------YG---RFQ-------GTW------ | Q-HE-----------KVQGG----------------YG---RFQ-------GTW------ | ||
-------------IPLDSAKFLVNKYEI- | -------------IPLDSAKFLVNKYEI- | ||
>Aps8_KAZAF XP_003959682 | >Aps8_KAZAF XP_003959682 | ||
| − | --------------- | + | --------------V-VMRRTRDDWVN--------------------------------- |
--ITQVFKI-------------AQFSK--------TQRTKL---------LEKESMNI-- | --ITQVFKI-------------AQFSK--------TQRTKL---------LEKESMNI-- | ||
Q-HE-----------KVQGG----------------YG---RFQ-------GTW------ | Q-HE-----------KVQGG----------------YG---RFQ-------GTW------ | ||
-------------VPLDAARDIAAKYSI- | -------------VPLDAARDIAAKYSI- | ||
>Aps3_VANPO XP_001647430 | >Aps3_VANPO XP_001647430 | ||
| − | --------------- | + | --------------I-VMRRTSNDWIN--------------------------------- |
--ITQIFKL-------------ASFTK--------TKRTKV---------LEIESNNI-- | --ITQIFKL-------------ASFTK--------TKRTKV---------LEIESNNI-- | ||
Q-HE-----------KVQGG----------------YG---RFQ-------GTW------ | Q-HE-----------KVQGG----------------YG---RFQ-------GTW------ | ||
-------------IPLNDAKNLVQKYNI- | -------------IPLNDAKNLVQKYNI- | ||
>Aps3_TETBL XP_004180077 | >Aps3_TETBL XP_004180077 | ||
| − | --------------- | + | --------------I-VMRRTKNDWIN--------------------------------- |
--ITQVFKL-------------ASFSK--------TKRTKI---------LEKESIDI-- | --ITQVFKL-------------ASFSK--------TKRTKI---------LEKESIDI-- | ||
E-HE-----------KVQGG----------------YG---RFQ-------GTW------ | E-HE-----------KVQGG----------------YG---RFQ-------GTW------ | ||
-------------IPLHYAKLLVNKYNI- | -------------IPLHYAKLLVNKYNI- | ||
>Aps5_TETPH XP_003685604 | >Aps5_TETPH XP_003685604 | ||
| − | --------------- | + | --------------I-VMRRKNNDWVN--------------------------------- |
--ITQVLKL-------------ASFSK--------TKRTKI---------IEKESMNM-- | --ITQVLKL-------------ASFSK--------TKRTKI---------IEKESMNM-- | ||
E-HE-----------KVQGG----------------YG---RFQ-------GTW------ | E-HE-----------KVQGG----------------YG---RFQ-------GTW------ | ||
-------------IPLSSTKELIEKYNI- | -------------IPLSSTKELIEKYNI- | ||
>Aps6_NAUCA XP_003674387 | >Aps6_NAUCA XP_003674387 | ||
| − | --------------- | + | --------------I-VMRRTKDDWIN--------------------------------- |
--VTQVFKI-------------ADFSK--------AHRTKV---------LEKESSDM-- | --VTQVFKI-------------ADFSK--------AHRTKV---------LEKESSDM-- | ||
M-HE-----------KVQGG----------------YG---RFQ-------GTW------ | M-HE-----------KVQGG----------------YG---RFQ-------GTW------ | ||
-------------IPLESALMLVQKYKI- | -------------IPLESALMLVQKYKI- | ||
>Aps2_LACTH XP_002552498 | >Aps2_LACTH XP_002552498 | ||
| − | --------------- | + | --------------I-VMRRCMDNWVN--------------------------------- |
--ITQVFKI-------------ASFSK--------TQRTKI---------LEKESNMV-- | --ITQVFKI-------------ASFSK--------TQRTKI---------LEKESNMV-- | ||
K-HE-----------KIQGG----------------YG---RFQ-------GTW------ | K-HE-----------KIQGG----------------YG---RFQ-------GTW------ | ||
-------------IPLENAHYLVQKYSV- | -------------IPLENAHYLVQKYSV- | ||
>Aps5_VANPO XP_001645902 | >Aps5_VANPO XP_001645902 | ||
| − | --------------- | + | --------------T-VMRRTLDDWIN--------------------------------- |
--ITQVFKL-------------ASFSK--------TKRTKI---------LEKETKSI-- | --ITQVFKL-------------ASFSK--------TKRTKI---------LEKETKSI-- | ||
D-HE-----------KIQGG----------------YG---RFQ-------GTW------ | D-HE-----------KIQGG----------------YG---RFQ-------GTW------ | ||
-------------IPLICAKTIVIKYNI- | -------------IPLICAKTIVIKYNI- | ||
>Aps3_NAUDA XP_003667554 | >Aps3_NAUDA XP_003667554 | ||
| − | -------------- | + | -------------KV-VMRRTRDDWIN--------------------------------- |
--ITQVFKI-------------GKFSK--------AQRTKV---------LELEANEM-- | --ITQVFKI-------------GKFSK--------AQRTKV---------LELEANEM-- | ||
K-HE-----------KVQGG----------------YG---RFQ-------GTW------ | K-HE-----------KVQGG----------------YG---RFQ-------GTW------ | ||
-------------IPLESAMFLAKKYTI- | -------------IPLESAMFLAKKYTI- | ||
>Aps4_TETPH XP_003687643 | >Aps4_TETPH XP_003687643 | ||
| − | ------------- | + | ------------TKT-VMRKVSNDWVN--------------------------------- |
--ATQIFKI-------------ANFTK--------NKRTRI---------LEREAKLI-- | --ATQIFKI-------------ANFTK--------NKRTRI---------LEREAKLI-- | ||
K-HE-----------KIQGG----------------YG---RFQ-------GTW------ | K-HE-----------KIQGG----------------YG---RFQ-------GTW------ | ||
-------------IPLDDAKMLVNKYEI- | -------------IPLDDAKMLVNKYEI- | ||
>Aps1_SCHST XP_001385235 | >Aps1_SCHST XP_001385235 | ||
| − | ------------- | + | ------------GVL-VSRREDTNFVN--------------------------------- |
| − | --GTKLLNV-------------IGMTR--------GKRDGI--------- | + | --GTKLLNV-------------IGMTR--------GKRDGI---------LKTEK----- |
| − | + | T-RN-----------VVKVG----------------SM---NLK-------GVW------ | |
-------------IPFDRAFEIARNEGV- | -------------IPFDRAFEIARNEGV- | ||
>Aps3_CANAL XP_711513 | >Aps3_CANAL XP_711513 | ||
| − | ------------- | + | ------------NIL-VSRREDTNYIN--------------------------------- |
| − | --GTKLLNV-------------IGMTR--------GKRDGI--------- | + | --GTKLLNV-------------IGMTR--------GKRDGI---------LKTEK----- |
| − | + | I-KN-----------VVKVG----------------SM---NLK-------GVW------ | |
-------------IPFDRAYEIARNEGV- | -------------IPFDRAYEIARNEGV- | ||
>Aps4_CANDU XP_002418552 | >Aps4_CANDU XP_002418552 | ||
| − | ------------- | + | ------------NIL-VSRREDTNYIN--------------------------------- |
| − | --GTKLLNV-------------IGMTR--------GKRDGI--------- | + | --GTKLLNV-------------IGMTR--------GKRDGI---------LKTEK----- |
| − | + | I-KN-----------VVKVG----------------SM---NLK-------GVW------ | |
-------------IPFDRAYEIARNEGV- | -------------IPFDRAYEIARNEGV- | ||
>Aps5_CANTR XP_002547473 | >Aps5_CANTR XP_002547473 | ||
| − | ------------- | + | ------------NIL-VSRREDSNYIN--------------------------------- |
| − | --GTKLLNV-------------IGMTR--------GKRDGI--------- | + | --GTKLLNV-------------IGMTR--------GKRDGI---------LKTEK----- |
| − | + | V-KN-----------VVKVG----------------SM---NLK-------GVW------ | |
-------------IPFDRAYEIARNEGV- | -------------IPFDRAYEIARNEGV- | ||
>Aps4_LODEL XP_001527061 | >Aps4_LODEL XP_001527061 | ||
| − | ------------- | + | ------------NIL-VSRREDTNYIN--------------------------------- |
| − | --CTKLLNV-------------VGMTR--------GKRDGI--------- | + | --CTKLLNV-------------VGMTR--------GKRDGI---------LKTEK----- |
| − | + | V-KQ-----------VVKVG----------------SM---NLK-------GVW------ | |
-------------IPFDRAYEIARNEGV- | -------------IPFDRAYEIARNEGV- | ||
>Aps3_MILFA XP_004203535 | >Aps3_MILFA XP_004203535 | ||
| − | ------------- | + | ------------GIL-VSRREDTNFVN--------------------------------- |
| − | --GTKLLNV-------------AGMTR--------GKRDGI--------- | + | --GTKLLNV-------------AGMTR--------GKRDGI---------LKTEK----- |
| − | + | T-KS-----------VIKVG----------------TM---NLK-------GVW------ | |
-------------IPFERAAEIARNEGI- | -------------IPFERAAEIARNEGI- | ||
>Aps4_DEBHA XP_460447 | >Aps4_DEBHA XP_460447 | ||
| − | ------------- | + | ------------GIL-VSRREDTNYVN--------------------------------- |
| − | --GTKLLNV-------------AGMTR--------GKRDGI--------- | + | --GTKLLNV-------------AGMTR--------GKRDGI---------LKTEK----- |
| − | + | T-KS-----------VVKVG----------------AM---NLK-------GVW------ | |
-------------IPFERASEIARNEGI- | -------------IPFERASEIARNEGI- | ||
>Efh1_CANOR XP_003867732 | >Efh1_CANOR XP_003867732 | ||
| − | ----------- | + | ----------N-EIL-VSRREDNNYIN--------------------------------- |
| − | --CTKLLNV-------------TGMSR--------GKRDGI--------- | + | --CTKLLNV-------------TGMSR--------GKRDGI---------LKTEK----- |
| − | + | V-KD-----------VVKVG----------------TM---NLK-------GVW------ | |
-------------VPFDRAYEIARNEGV- | -------------VPFDRAYEIARNEGV- | ||
>Aps2_MEYGU XP_001486611 | >Aps2_MEYGU XP_001486611 | ||
| − | ------------- | + | ------------GVL-VSRREDTNYIN--------------------------------- |
| − | --GTKLLNV-------------AGMSR--------GKRDGI--------- | + | --GTKLLNV-------------AGMSR--------GKRDGI---------LKTEK----- |
| − | + | D-RY-----------VVRAG----------------AM---SLK-------GVW------ | |
-------------IPYERAKEIARNEGV- | -------------IPYERAKEIARNEGV- | ||
>Aps4_CLALU XP_002618164 | >Aps4_CLALU XP_002618164 | ||
| − | -------------- | + | -------------VV-VSRREKDDYVN--------------------------------- |
| − | --GTKLLNV-------------TGMSR--------GKRDGL--------- | + | --GTKLLNV-------------TGMSR--------GKRDGL---------LKTEK----- |
| − | + | G-RI-----------VVRNG----------------PM---NLK-------GVW------ | |
-------------IPFHRASEIARNEGV- | -------------IPFHRASEIARNEGV- | ||
>Aps1_ASPNI XP_663440 | >Aps1_ASPNI XP_663440 | ||
| − | ----------- | + | ----------K-GVC-VARREDNGMIN--------------------------------- |
| − | --GTKLLNV-------------AGMTR--------GRRDGI--------- | + | --GTKLLNV-------------AGMTR--------GRRDGI---------LKSEK----- |
| − | + | V-RN-----------VVKIG----------------PM---HLK-------GVW------ | |
-------------IPFDRALEFANKEKI- | -------------IPFDRALEFANKEKI- | ||
>Aps1_SCLSC XP_001590416 | >Aps1_SCLSC XP_001590416 | ||
| − | ----------- | + | ----------K-GVC-VARREDNHMIN--------------------------------- |
| − | --GTKLLNV-------------AGMTR--------GRRDGI--------- | + | --GTKLLNV-------------AGMTR--------GRRDGI---------LKSEK----- |
| − | + | M-RH-----------VVKIG----------------PM---HLK-------GVW------ | |
-------------IPFERALDFANKEKI- | -------------IPFERALDFANKEKI- | ||
>Aps2_ARTBE XP_003013983 | >Aps2_ARTBE XP_003013983 | ||
| − | ----------- | + | ----------K-GVC-VARREDNHMIN--------------------------------- |
| − | --GTKLLNV-------------AGMTR--------GRRDGI--------- | + | --GTKLLNV-------------AGMTR--------GRRDGI---------LKSEK----- |
| − | + | I-RH-----------VVKIG----------------PM---HLK-------GVW------ | |
-------------IPFERALDFANKEKI- | -------------IPFERALDFANKEKI- | ||
>Aps5_TRIRU XP_003238727 | >Aps5_TRIRU XP_003238727 | ||
| − | ----------- | + | ----------K-GVC-VARREDNHMIN--------------------------------- |
| − | --GTKLLNV-------------AGMTR--------GRRDGI--------- | + | --GTKLLNV-------------AGMTR--------GRRDGI---------LKSEK----- |
| − | + | I-RH-----------VVKIG----------------PM---HLK-------GVW------ | |
-------------IPFERALDFANKEKI- | -------------IPFERALDFANKEKI- | ||
>Aps5_ARTGY XP_003176766 | >Aps5_ARTGY XP_003176766 | ||
| − | ----------- | + | ----------K-GVC-VARREDNHMIN--------------------------------- |
| − | --GTKLLNV-------------AGMTR--------GRRDGI--------- | + | --GTKLLNV-------------AGMTR--------GRRDGI---------LKSEK----- |
| − | + | I-RH-----------VVKIG----------------PM---HLK-------GVW------ | |
-------------IPFERALDFANKEKI- | -------------IPFERALDFANKEKI- | ||
>Aps5_TALMA XP_002146488 | >Aps5_TALMA XP_002146488 | ||
| − | ----------- | + | ----------K-GVC-VARREDNHMIN--------------------------------- |
| − | --GTKLLNV-------------AGMTR--------GRRDGI--------- | + | --GTKLLNV-------------AGMTR--------GRRDGI---------LKSEK----- |
| − | + | V-RH-----------VVKIG----------------PM---HLK-------GVW------ | |
-------------IPYERALDFANKEKI- | -------------IPYERALDFANKEKI- | ||
>Aps5_TALST XP_002478786 | >Aps5_TALST XP_002478786 | ||
| − | ----------- | + | ----------K-GVC-VARREDNHMIN--------------------------------- |
| − | --GTKLLNV-------------AGMTR--------GRRDGI--------- | + | --GTKLLNV-------------AGMTR--------GRRDGI---------LKSEK----- |
| − | + | V-RH-----------VVKIG----------------PM---HLK-------GVW------ | |
-------------IPYERALDFANKEKI- | -------------IPYERALDFANKEKI- | ||
>Aps1_COCIM XP_001247133 | >Aps1_COCIM XP_001247133 | ||
| − | ----------- | + | ----------K-GVC-VARREDNHMIN--------------------------------- |
| − | --GTKLLNV-------------AGMTR--------GRRDGI--------- | + | --GTKLLNV-------------AGMTR--------GRRDGI---------LKSEK----- |
| − | + | V-RH-----------VVKIG----------------PM---HLK-------GVW------ | |
-------------IPFERALEFANKEKI- | -------------IPFERALEFANKEKI- | ||
>Aps3_ASPNI XP_001390623 | >Aps3_ASPNI XP_001390623 | ||
| − | ----------- | + | ----------K-GVC-VARREDNHMIN--------------------------------- |
| − | --GTKLLNV-------------AGMTR--------GRRDGI--------- | + | --GTKLLNV-------------AGMTR--------GRRDGI---------LKSEK----- |
| − | + | V-RH-----------VVKIG----------------PM---HLK-------GVW------ | |
-------------IPFERALEFANKEKI- | -------------IPFERALEFANKEKI- | ||
>Aps1_COCPO XP_003066203 | >Aps1_COCPO XP_003066203 | ||
| − | ----------- | + | ----------K-GVC-VARREDNHMIN--------------------------------- |
| − | --GTKLLNV-------------AGMTR--------GRRDGI--------- | + | --GTKLLNV-------------AGMTR--------GRRDGI---------LKSEK----- |
| − | + | V-RH-----------VVKIG----------------PM---HLK-------GVW------ | |
-------------IPFERALEFANKEKI- | -------------IPFERALEFANKEKI- | ||
>Aps3_ASPCL XP_001267726 | >Aps3_ASPCL XP_001267726 | ||
| − | ----------- | + | ----------K-GVC-VARREDNHMIN--------------------------------- |
| − | --GTKLLNV-------------AGMTR--------GRRDGI--------- | + | --GTKLLNV-------------AGMTR--------GRRDGI---------LKSEK----- |
| − | + | V-RH-----------VVKIG----------------PM---HLK-------GVW------ | |
-------------IPFERALEFANKEKI- | -------------IPFERALEFANKEKI- | ||
>Aps3_NEOFI XP_001260304 | >Aps3_NEOFI XP_001260304 | ||
| − | ----------- | + | ----------K-GVC-VARREDNHMIN--------------------------------- |
| − | --GTKLLNV-------------AGMTR--------GRRDGI--------- | + | --GTKLLNV-------------AGMTR--------GRRDGI---------LKSEK----- |
| − | + | V-RH-----------VVKIG----------------PM---HLK-------GVW------ | |
-------------IPFERALEFANKEKI- | -------------IPFERALEFANKEKI- | ||
>Aps4_ASPFU XP_755125 | >Aps4_ASPFU XP_755125 | ||
| − | ----------- | + | ----------K-GVC-VARREDNHMIN--------------------------------- |
| − | --GTKLLNV-------------AGMTR--------GRRDGI--------- | + | --GTKLLNV-------------AGMTR--------GRRDGI---------LKSEK----- |
| − | + | V-RH-----------VVKIG----------------PM---HLK-------GVW------ | |
-------------IPFERALEFANKEKI- | -------------IPFERALEFANKEKI- | ||
>Aps3_UNCRE XP_002541343 | >Aps3_UNCRE XP_002541343 | ||
| − | ----------- | + | ----------K-GVC-VARREDNHMVN--------------------------------- |
| − | --GTKLLNV-------------AGMTR--------GRRDGI--------- | + | --GTKLLNV-------------AGMTR--------GRRDGI---------LKSEK----- |
| − | + | I-RH-----------VVKIG----------------PM---HLK-------GVW------ | |
-------------IPFERALEFANKEKI- | -------------IPFERALEFANKEKI- | ||
>Aps2_PYRTR XP_001932216 | >Aps2_PYRTR XP_001932216 | ||
| − | ----------- | + | ----------K-GVC-VARREDNHMIN--------------------------------- |
| − | --GTKLLNV-------------AGMTR--------GRRDGI--------- | + | --GTKLLNV-------------AGMTR--------GRRDGI---------LKSEK----- |
| − | + | T-RH-----------VVKIG----------------PM---HLK-------GVW------ | |
-------------IPFERALEFANKEKI- | -------------IPFERALEFANKEKI- | ||
>Aps3_PYRTE XP_003306747 | >Aps3_PYRTE XP_003306747 | ||
| − | ----------- | + | ----------K-GVC-VARREDNHMIN--------------------------------- |
| − | --GTKLLNV-------------AGMTR--------GRRDGI--------- | + | --GTKLLNV-------------AGMTR--------GRRDGI---------LKSEK----- |
| − | + | T-RH-----------VVKIG----------------PM---HLK-------GVW------ | |
-------------IPFERALEFANKEKI- | -------------IPFERALEFANKEKI- | ||
>Aps2_AJEDE XP_002621560 | >Aps2_AJEDE XP_002621560 | ||
| − | ----------- | + | ----------K-GVC-VARREDNHMIN--------------------------------- |
| − | --GTKLLNV-------------AGMTR--------GRRDGI--------- | + | --GTKLLNV-------------AGMTR--------GRRDGI---------LKSEK----- |
| − | + | V-RN-----------VVKIG----------------PM---HLK-------GVW------ | |
-------------IPFERALEFANKEKI- | -------------IPFERALEFANKEKI- | ||
>Aps1_ASPTE XP_001218256 | >Aps1_ASPTE XP_001218256 | ||
| − | ----------- | + | ----------K-GVC-VARREDNSMIN--------------------------------- |
| − | --GTKLLNV-------------AGMTR--------GRRDGI--------- | + | --GTKLLNV-------------AGMTR--------GRRDGI---------LKSEK----- |
| − | + | I-RH-----------VVKIG----------------PM---HLK-------GVW------ | |
-------------IPFERALEFANKEKI- | -------------IPFERALEFANKEKI- | ||
>Aps2_ZYMTR XP_003851453 | >Aps2_ZYMTR XP_003851453 | ||
| − | ----------- | + | ----------N-GVC-VARREDNHMIN--------------------------------- |
| − | --GTKLLNV-------------AGMTR--------GRRDGI--------- | + | --GTKLLNV-------------AGMTR--------GRRDGI---------LKSEK----- |
| − | + | T-RH-----------VVKIG----------------PM---HLK-------GVW------ | |
-------------IPFDRALDFANKEKI- | -------------IPFDRALDFANKEKI- | ||
>Aps1_MYCTH XP_003661163 | >Aps1_MYCTH XP_003661163 | ||
| − | ------------- | + | ------------GIC-VARREDNSMIN--------------------------------- |
| − | --GTKLLNV-------------AGMTR--------GRRDGI--------- | + | --GTKLLNV-------------AGMTR--------GRRDGI---------LKSEK----- |
| − | + | V-RH-----------VVKIG----------------PM---HLK-------GVW------ | |
-------------IPFERALDFANKEKI- | -------------IPFERALDFANKEKI- | ||
>Aps2_NEUCR XP_960837 | >Aps2_NEUCR XP_960837 | ||
| − | ------------- | + | ------------GIC-VARREDNAMIN--------------------------------- |
| − | --GTKLLNV-------------AGMTR--------GRRDGI--------- | + | --GTKLLNV-------------AGMTR--------GRRDGI---------LKSEK----- |
| − | + | V-RH-----------VVKIG----------------PM---HLK-------GVW------ | |
-------------IPFERALDFANKEKI- | -------------IPFERALDFANKEKI- | ||
>Aps3_SORMA XP_003343963 | >Aps3_SORMA XP_003343963 | ||
| − | ------------- | + | ------------GIC-VARREDNAMIN--------------------------------- |
| − | --GTKLLNV-------------AGMTR--------GRRDGI--------- | + | --GTKLLNV-------------AGMTR--------GRRDGI---------LKSEK----- |
| − | + | V-RH-----------VVKIG----------------PM---HLK-------GVW------ | |
-------------IPFERALDFANKEKI- | -------------IPFERALDFANKEKI- | ||
>Aps1_MAGOR XP_003718315 | >Aps1_MAGOR XP_003718315 | ||
| − | ------------- | + | ------------GVC-VARREDNHMIN--------------------------------- |
| − | --GTKLLNV-------------AGMTR--------GRRDGI--------- | + | --GTKLLNV-------------AGMTR--------GRRDGI---------LKSEK----- |
| − | + | M-RH-----------VVKIG----------------PM---HLK-------GVW------ | |
-------------IPFERALDFANKEKI- | -------------IPFERALDFANKEKI- | ||
>Aps4_VERAL XP_003008681 | >Aps4_VERAL XP_003008681 | ||
| − | ------------- | + | ------------GIC-VARREDNHMIN--------------------------------- |
| − | --GTKLLNV-------------AGMTR--------GRRDGI--------- | + | --GTKLLNV-------------AGMTR--------GRRDGI---------LKSEK----- |
| − | + | L-RH-----------VVKIG----------------PM---HLK-------GVW------ | |
-------------IPFERALDFANKEKI- | -------------IPFERALDFANKEKI- | ||
>Aps3_THITE XP_003648650 | >Aps3_THITE XP_003648650 | ||
| − | ------------- | + | ------------GIC-VARREDNHMIN--------------------------------- |
| − | --GTKLLNV-------------AGMTR--------GRRDGI--------- | + | --GTKLLNV-------------AGMTR--------GRRDGI---------LKSEK----- |
| − | + | I-RH-----------VVKIG----------------PM---HLK-------GVW------ | |
-------------IPFERALDFANKEKI- | -------------IPFERALDFANKEKI- | ||
>Aps4_CHAGL XP_001219797 | >Aps4_CHAGL XP_001219797 | ||
| − | ------------- | + | ------------GIC-VARREDNAMIN--------------------------------- |
| − | --GTKLLNV-------------AGMTR--------GRRDGI--------- | + | --GTKLLNV-------------AGMTR--------GRRDGI---------LKSEK----- |
| − | + | V-RH-----------VVKIG----------------PM---HLK-------GVW------ | |
-------------IPYDRALDFANKEKI- | -------------IPYDRALDFANKEKI- | ||
>Aps3_NECHA XP_003051234 | >Aps3_NECHA XP_003051234 | ||
| − | ------------- | + | ------------GIC-VARREDNHMIN--------------------------------- |
| − | --GTKLLNV-------------AGMTR--------GRRDGI--------- | + | --GTKLLNV-------------AGMTR--------GRRDGI---------LKSEK----- |
| − | + | V-RH-----------VVKIG----------------PM---HLK-------GVW------ | |
-------------IPYDRALDFANKEKI- | -------------IPYDRALDFANKEKI- | ||
>Aps3_TRIVE XP_003018714 | >Aps3_TRIVE XP_003018714 | ||
| − | ----------- | + | ----------K-GVC-VARREDNHMIN--------------------------------- |
| − | --GTKLLNV-------------AGMTR--------GRRDGI--------- | + | --GTKLLNV-------------AGMTR--------GRRDGI---------LKSEK----- |
| − | + | I-RH-----------VVKIG----------------PM---HLK-------GVWYVESLL | |
FLTQKYPELTSRRIPFERALDFANKEKI- | FLTQKYPELTSRRIPFERALDFANKEKI- | ||
>Aps5_YARLI XP_502292 | >Aps5_YARLI XP_502292 | ||
| − | ------------- | + | ------------GIC-VARREDNDMIN--------------------------------- |
| − | --GTKLLNV-------------AGMTR--------GRRDGI--------- | + | --GTKLLNV-------------AGMTR--------GRRDGI---------LKGEK----- |
| − | + | L-RH-----------VVKAG----------------AM---HLK-------GVW------ | |
-------------IPYDRALEFANKEKI- | -------------IPYDRALEFANKEKI- | ||
>Aps4_YARLI XP_501102 | >Aps4_YARLI XP_501102 | ||
| − | ------------- | + | ------------GVC-VARREDNNMIN--------------------------------- |
| − | --GTKLLNV-------------VGMTR--------GRRDGI--------- | + | --GTKLLNV-------------VGMTR--------GRRDGI---------LKTEK----- |
| − | + | I-RH-----------VVKIG----------------AM---HLK-------GVW------ | |
-------------IPYERALAFAQRERI- | -------------IPYERALAFAQRERI- | ||
>Aps1_NAUDA XP_003668432 | >Aps1_NAUDA XP_003668432 | ||
| − | ----------- | + | ----------N-GVS-VVRRADNDMIN--------------------------------- |
| − | --GTKLLNV-------------SKMTR--------GRRDGI--------- | + | --GTKLLNV-------------SKMTR--------GRRDGI---------LKAEK----- |
| − | + | I-RH-----------VVKIG----------------SM---HLK-------GVW------ | |
-------------IPFERARIMAEKEKI- | -------------IPFERARIMAEKEKI- | ||
>Aps4_KAZAF XP_003954785 | >Aps4_KAZAF XP_003954785 | ||
| − | ----------- | + | ----------N-GVS-VVRRADNDMIN--------------------------------- |
| − | --GTKLLNV-------------TKMTR--------GRRDGI--------- | + | --GTKLLNV-------------TKMTR--------GRRDGI---------LKAEK----- |
| − | + | I-RH-----------VVKIG----------------SM---HLK-------GVW------ | |
-------------IPFERARYMAEKEKI- | -------------IPFERARYMAEKEKI- | ||
>Aps1_ZYGRO XP_002499194 | >Aps1_ZYGRO XP_002499194 | ||
| − | ----------- | + | ----------N-GVS-VVRRADNDMIN--------------------------------- |
| − | --GTKLLNV-------------AKITR--------GRRDGI--------- | + | --GTKLLNV-------------AKITR--------GRRDGI---------LKAER----- |
| − | + | I-RH-----------VVKIG----------------SM---HLK-------GVW------ | |
-------------IPFERAQVMAEREKI- | -------------IPFERAQVMAEREKI- | ||
>Aps2_TORDE XP_003679993 | >Aps2_TORDE XP_003679993 | ||
| − | ----------- | + | ----------N-GVS-VVRRADNDMIN--------------------------------- |
| − | --GTKLLNV-------------AKITR--------GRRDGI--------- | + | --GTKLLNV-------------AKITR--------GRRDGI---------LKAER----- |
| − | + | I-RH-----------VVKIG----------------SM---HLK-------GVW------ | |
-------------IPFERAHAMAQREKI- | -------------IPFERAHAMAQREKI- | ||
>Aps1_LACTH XP_002553055 | >Aps1_LACTH XP_002553055 | ||
| − | ----------- | + | ----------N-GVS-VVRRADNDMIN--------------------------------- |
| − | --GTKLLNV-------------AKMTR--------GRRDGI--------- | + | --GTKLLNV-------------AKMTR--------GRRDGI---------LKAEK----- |
| − | + | I-RH-----------VVKVG----------------SM---HLK-------GVW------ | |
-------------IPFDRALAMAQREKI- | -------------IPFDRALAMAQREKI- | ||
>Aps2_ASHGO NP_983001 | >Aps2_ASHGO NP_983001 | ||
| − | ----------- | + | ----------N-GVS-VVRRADNDMIN--------------------------------- |
| − | --GTKLLNV-------------AKMTR--------GRRDGI--------- | + | --GTKLLNV-------------AKMTR--------GRRDGI---------LKAEK----- |
| − | + | V-RH-----------VVKIG----------------SM---HLK-------GVW------ | |
-------------IPFERALALAQREKI- | -------------IPFERALALAQREKI- | ||
>Aps2_ERECY XP_003646434 | >Aps2_ERECY XP_003646434 | ||
| − | ----------- | + | ----------N-SVS-VVRRADNDMIN--------------------------------- |
| − | --GTKLLNV-------------AKMTR--------GRRDGI--------- | + | --GTKLLNV-------------AKMTR--------GRRDGI---------LKAEK----- |
| − | + | V-RH-----------VVKIG----------------SM---HLK-------GVW------ | |
-------------IPFERALALAQREKI- | -------------IPFERALALAQREKI- | ||
>Sok2_SACCE NP_013729 | >Sok2_SACCE NP_013729 | ||
| − | ----------- | + | ----------N-GIS-VVRRADNDMVN--------------------------------- |
| − | --GTKLLNV-------------TKMTR--------GRRDGI--------- | + | --GTKLLNV-------------TKMTR--------GRRDGI---------LKAEK----- |
| − | + | I-RH-----------VVKIG----------------SM---HLK-------GVW------ | |
-------------IPFERALAIAQREKI- | -------------IPFERALAIAQREKI- | ||
>Aps2_KLULA XP_455299 | >Aps2_KLULA XP_455299 | ||
| − | ----------- | + | ----------N-GVS-VVRRADNDMIN--------------------------------- |
| − | --GTKLLNV-------------TRMTR--------GRRDGI--------- | + | --GTKLLNV-------------TRMTR--------GRRDGI---------LKAEK----- |
| − | + | I-RH-----------VVKIG----------------SM---HLK-------GVW------ | |
-------------IPFERALVMAQREKI- | -------------IPFERALVMAQREKI- | ||
>Aps1_VANPO XP_001643248 | >Aps1_VANPO XP_001643248 | ||
| − | ----------- | + | ----------N-GVS-VVRRADNDMIN--------------------------------- |
| − | --GTKLLNV-------------TKMTR--------GRRDGI--------- | + | --GTKLLNV-------------TKMTR--------GRRDGI---------LKAEK----- |
| − | + | I-RH-----------VVKVG----------------SM---NLK-------GVW------ | |
-------------IPFERALLMAKKEKI- | -------------IPFERALLMAKKEKI- | ||
>Aps4_KOMPA XP_002490663 | >Aps4_KOMPA XP_002490663 | ||
| − | ----------- | + | ----------N-GVS-VVRRADNNMIN--------------------------------- |
| − | --GTKLLNV-------------AKMTR--------GRRDGM--------- | + | --GTKLLNV-------------AKMTR--------GRRDGM---------LKSEK----- |
| − | + | I-RH-----------VVKIG----------------SM---HLK-------GVW------ | |
-------------IPFDRALAMAQKEHI- | -------------IPFDRALAMAQKEHI- | ||
>Aps1_CANAL XP_714197 | >Aps1_CANAL XP_714197 | ||
| − | ----------- | + | ----------N-NVS-VVRRADNNMIN--------------------------------- |
| − | --GTKLLNV-------------AQMTR--------GRRDGI--------- | + | --GTKLLNV-------------AQMTR--------GRRDGI---------LKSEK----- |
| − | + | V-RH-----------VVKIG----------------SM---HLK-------GVW------ | |
-------------IPFERALAMAQREQI- | -------------IPFERALAMAQREQI- | ||
>Aps5_CANAL XP_714237 | >Aps5_CANAL XP_714237 | ||
| − | ----------- | + | ----------N-NVS-VVRRADNNMIN--------------------------------- |
| − | --GTKLLNV-------------AQMTR--------GRRDGI--------- | + | --GTKLLNV-------------AQMTR--------GRRDGI---------LKSEK----- |
| − | + | V-RH-----------VVKIG----------------SM---HLK-------GVW------ | |
-------------IPFERALAMAQREQI- | -------------IPFERALAMAQREQI- | ||
>Aps1_MEYGU XP_001484270 | >Aps1_MEYGU XP_001484270 | ||
| − | ----------- | + | ----------N-NVS-VVRRADNNMIN--------------------------------- |
| − | --GTKLLNV-------------AQMTR--------GRRDGI--------- | + | --GTKLLNV-------------AQMTR--------GRRDGI---------LKSEK----- |
| − | + | V-RH-----------VVKIG----------------SM---HLK-------GVW------ | |
-------------IPFDRALAMAQREGI- | -------------IPFDRALAMAQREGI- | ||
>Aps2_CLALU XP_002618588 | >Aps2_CLALU XP_002618588 | ||
| − | ----------- | + | ----------N-NVS-VVRRADNNMIN--------------------------------- |
| − | --GTKLLNV-------------AQMTR--------GRRDGI--------- | + | --GTKLLNV-------------AQMTR--------GRRDGI---------LKSEK----- |
| − | + | I-RH-----------VVKIG----------------SM---HLK-------GVW------ | |
-------------IPFERALAMAQREGI- | -------------IPFERALAMAQREGI- | ||
>Aps5_MILFA XP_004202992 | >Aps5_MILFA XP_004202992 | ||
| − | ----------- | + | ----------N-NVS-VVRRADNNMIN--------------------------------- |
| − | --GTKLLNV-------------AQMTR--------GRRDGI--------- | + | --GTKLLNV-------------AQMTR--------GRRDGI---------LKSEK----- |
| − | + | V-RH-----------VVKIG----------------SM---HLK-------GVW------ | |
-------------IPFERALAMAQREGI- | -------------IPFERALAMAQREGI- | ||
>Aps2_SCHST XP_001383609 | >Aps2_SCHST XP_001383609 | ||
| − | ----------- | + | ----------N-NVS-VVRRADNNMIN--------------------------------- |
| − | --GTKLLNV-------------AQMTR--------GRRDGI--------- | + | --GTKLLNV-------------AQMTR--------GRRDGI---------LKSEK----- |
| − | + | V-RH-----------VVKIG----------------SM---HLK-------GVW------ | |
-------------IPFERALAMAQREGI- | -------------IPFERALAMAQREGI- | ||
>Aps8_MILFA XP_004202373 | >Aps8_MILFA XP_004202373 | ||
| − | ----------- | + | ----------N-NVS-VVRRADNNMIN--------------------------------- |
| − | --GTKLLNV-------------AQMTR--------GRRDGI--------- | + | --GTKLLNV-------------AQMTR--------GRRDGI---------LKSEK----- |
| − | + | V-RH-----------VVKIG----------------SM---HLK-------GVW------ | |
-------------IPFERALAMAQREGI- | -------------IPFERALAMAQREGI- | ||
>Aps5_DEBHA XP_459785 | >Aps5_DEBHA XP_459785 | ||
| − | ----------- | + | ----------N-NVS-VVRRADNNMIN--------------------------------- |
| − | --GTKLLNV-------------AQMTR--------GRRDGI--------- | + | --GTKLLNV-------------AQMTR--------GRRDGI---------LKSEK----- |
| − | + | V-RH-----------VVKIG----------------SM---HLK-------GVW------ | |
-------------IPFERALAMAQREGI- | -------------IPFERALAMAQREGI- | ||
>Aps6_CANDU XP_002422294 | >Aps6_CANDU XP_002422294 | ||
| − | ----------- | + | ----------N-NVS-VVRRADNNMIN--------------------------------- |
| − | --GTKLLNV-------------AQMTR--------GRRDGI--------- | + | --GTKLLNV-------------AQMTR--------GRRDGI---------LKSEK----- |
| − | + | V-RH-----------VVKIG----------------SM---HLK-------GVW------ | |
-------------IPFERALVMAQREGI- | -------------IPFERALVMAQREGI- | ||
>Efg1_CANOR XP_003870987 | >Efg1_CANOR XP_003870987 | ||
| − | ----------- | + | ----------N-NVS-VVRRADNNMIN--------------------------------- |
| − | --GTKLLNV-------------AQMTR--------GRRDGI--------- | + | --GTKLLNV-------------AQMTR--------GRRDGI---------LKSEK----- |
| − | + | V-RH-----------VVKIG----------------SM---HLK-------GVW------ | |
-------------IPFERALSMAQRENI- | -------------IPFERALSMAQRENI- | ||
>Aps2_LODEL XP_001523544 | >Aps2_LODEL XP_001523544 | ||
| − | ----------- | + | ----------N-NVS-VVRRADNNMIN--------------------------------- |
| − | --GTKLLNV-------------AQMTR--------GRRDGI--------- | + | --GTKLLNV-------------AQMTR--------GRRDGI---------LKLEK----- |
| − | + | V-RH-----------VVKIG----------------SM---HLK-------GVW------ | |
-------------IPFERALTMAQRENI- | -------------IPFERALTMAQRENI- | ||
>Aps2_NAUCA XP_003674209 | >Aps2_NAUCA XP_003674209 | ||
| − | ----------- | + | ----------N-GVS-VVRRADNDMIN--------------------------------- |
| − | --GTKLLNV-------------TKMTR--------GRRDGI--------- | + | --GTKLLNV-------------TKMTR--------GRRDGI---------LKSEK----- |
| − | + | I-RH-----------VVKIG----------------SM---HLK-------GVW------ | |
-------------VPFERARLMAGREHI- | -------------VPFERARLMAGREHI- | ||
>Phd1_SACCE NP_012881 | >Phd1_SACCE NP_012881 | ||
| − | ----------- | + | ----------N-GIS-VVRRADNNMIN--------------------------------- |
| − | --GTKLLNV-------------TKMTR--------GRRDGI--------- | + | --GTKLLNV-------------TKMTR--------GRRDGI---------LRSEK----- |
| − | + | V-RE-----------VVKIG----------------SM---HLK-------GVW------ | |
-------------IPFERAYILAQREQI- | -------------IPFERAYILAQREQI- | ||
>Aps6_KAZAF XP_003955575 | >Aps6_KAZAF XP_003955575 | ||
| − | ----------- | + | ----------N-GVS-VVRRADNDMIN--------------------------------- |
| − | --GTKLLNV-------------TKMTR--------GRRDGI--------- | + | --GTKLLNV-------------TKMTR--------GRRDGI---------LRGEK----- |
| − | + | V-RN-----------VVKIG----------------SM---HLK-------GVW------ | |
-------------IPFERAYLIAQREKI- | -------------IPFERAYLIAQREKI- | ||
>Aps3_CANGL XP_448847 | >Aps3_CANGL XP_448847 | ||
| − | ----------- | + | ----------N-GVS-VVRRADNDMIN--------------------------------- |
| − | --GTKLLNV-------------TKMTR--------GKRDGI--------- | + | --GTKLLNV-------------TKMTR--------GKRDGI---------LRSEK----- |
| − | + | Y-RK-----------VVKIG----------------SM---HLK-------GVW------ | |
-------------IPFERALFIAKREKI- | -------------IPFERALFIAKREKI- | ||
>Aps5_NAUDA XP_003672610 | >Aps5_NAUDA XP_003672610 | ||
| − | ----------- | + | ----------N-SVS-VIRRADNDMIN--------------------------------- |
| − | --GTKLLNV-------------TKMTR--------GRRDGI--------- | + | --GTKLLNV-------------TKMTR--------GRRDGI---------LRTEK----- |
| − | + | I-RK-----------VVKIG----------------SM---HLK-------GVW------ | |
-------------IPFDRAYEIARREKI- | -------------IPFDRAYEIARREKI- | ||
>Aps2_TETPH XP_003688350 | >Aps2_TETPH XP_003688350 | ||
| − | ----------- | + | ----------N-GIS-VVRRADNDMIN--------------------------------- |
| − | --GTKLLNV-------------TKMTR--------GRRDGI--------- | + | --GTKLLNV-------------TKMTR--------GRRDGI---------LKAEK----- |
| − | + | T-RK-----------VVKMG----------------TL---NLK-------GVW------ | |
-------------IPFDRAYCIARREKI- | -------------IPFDRAYCIARREKI- | ||
>Aps1_NAUCA XP_003673416 | >Aps1_NAUCA XP_003673416 | ||
| − | ---------- | + | ---------CN-GVA-VVRRADNDMIN--------------------------------- |
| − | --GTKLLNV-------------TKMTR--------GRRDGI--------- | + | --GTKLLNV-------------TKMTR--------GRRDGI---------LRAEK----- |
| − | + | V-RS-----------VIKIG----------------SM---HLK-------GVW------ | |
-------------IPFDRALMMAKREKI- | -------------IPFDRALMMAKREKI- | ||
>Aps2_VANPO XP_001644666 | >Aps2_VANPO XP_001644666 | ||
| − | --------- | + | --------VVN-GIT-VLRRDDNNMIN--------------------------------- |
| − | --GTKLLNV-------------TKMTR--------GRRDRI--------- | + | --GTKLLNV-------------TKMTR--------GRRDRI---------LRAEK----- |
| − | + | I-RH-----------VVKIG----------------SM---HLK-------GVW------ | |
-------------IPLERAKRMAQMENIY | -------------IPLERAKRMAQMENIY | ||
>Aps1_TETPH XP_003687180 | >Aps1_TETPH XP_003687180 | ||
| − | --------- | + | --------IAN-GVV-VLRRADNHMVN--------------------------------- |
| − | --GTKLLNV-------------TGMTR--------GRRDRM--------- | + | --GTKLLNV-------------TGMTR--------GRRDRM---------LRSEK----- |
| − | + | E-RH-----------VVKVG----------------LM---HSK-------GVW------ | |
-------------IPLERARYLAEKTNI- | -------------IPLERARYLAEKTNI- | ||
>Aps2_CANGL XP_449680 | >Aps2_CANGL XP_449680 | ||
| − | ---------- | + | ---------HN-GVT-VVRRADNDMVN--------------------------------- |
| − | --GTKLLNV-------------TGMTR--------GRRDGI--------- | + | --GTKLLNV-------------TGMTR--------GRRDGI---------LKNEP----- |
| − | + | V-RD-----------VVKGG----------------PM---TLK-------GVW------ | |
-------------IPIDRARAIARQEGI- | -------------IPIDRARAIARQEGI- | ||
>Aps1_MALGL XP_001732538 | >Aps1_MALGL XP_001732538 | ||
| − | ----------- | + | ----------K-GVC-VARRHDNNMVN--------------------------------- |
| − | --GTKLLNV-------------CGMSR--------GKRDGI--------- | + | --GTKLLNV-------------CGMSR--------GKRDGI---------LKNEK----- |
| − | + | E-RI-----------VVKVG----------------AM---HLK-------GVW------ | |
-------------IAFSRGKQLAEQHGI- | -------------IAFSRGKQLAEQHGI- | ||
>Aps4_PUCGR XP_003321545 | >Aps4_PUCGR XP_003321545 | ||
| − | ---------- | + | ---------HK-GVT-VGRLKGSGLVN--------------------------------- |
| − | --GTKLLNL-------------AGISR--------GKRDGI--------- | + | --GTKLLNL-------------AGISR--------GKRDGI---------LKNEK----- |
| − | + | I-RK-----------VVKHG----------------TM---HLK-------GVW------ | |
-------------IAFDRAVFLAEQHSI- | -------------IAFDRAVFLAEQHSI- | ||
>Aps1_KOMPA XP_002493748 | >Aps1_KOMPA XP_002493748 | ||
| − | --------- | + | --------VVQ-KIP-LSRRADNDYVN--------------------------------- |
| − | --ATKLLNL-------------TGMRR--------GRRDGI--------- | + | --ATKLLNL-------------TGMRR--------GRRDGI---------LKLEK----- |
| − | + | Q-RQ-----------VVKTG----------------TI---DLK-------GVW------ | |
-------------VPLKRAIKLAKAEQVF | -------------VPLKRAIKLAKAEQVF | ||
| + | >CdcA_SCHPO NP_596132 | ||
| + | ------------GDNVALRRCPDSYFN--------------------------------- | ||
| + | --ISQILRL-------------AGTSS--------SENAKE---------LDDIIESG-- | ||
| + | D-YE-----------NVDSK----------------HP---QID-------GVW------ | ||
| + | -------------VPYDRAISIAKRYGVY | ||
>Aps3_SCHJA XP_002174002 | >Aps3_SCHJA XP_002174002 | ||
| − | ------------- | + | ------------GKR-VLRRCSDSYVN--------------------------------- |
--LSHVLQL-------------IGSSP--------MQIARE---------LDPIIAAG-- | --LSHVLQL-------------IGSSP--------MQIARE---------LDPIIAAG-- | ||
D-FE-----------NVDGR----------------DA---ELN-------GVW------ | D-FE-----------NVDGR----------------DA---ELN-------GVW------ | ||
-------------VPLSRIGNICEKHGL- | -------------VPLSRIGNICEKHGL- | ||
>Aps1_MILFA XP_004195060 | >Aps1_MILFA XP_004195060 | ||
| − | -------------- | + | -------------VI-ILRRVQDSYVN--------------------------------- |
--ISQLLSIL---------VKMGHFNQ--------TRLNNF---------LNNEIITN-- | --ISQLLSIL---------VKMGHFNQ--------TRLNNF---------LNNEIITN-- | ||
P-QY-----------S--AE--EKGINVYVDWVDHEVR---QLR-------GLW------ | P-QY-----------S--AE--EKGINVYVDWVDHEVR---QLR-------GLW------ | ||
-------------IPYDKAVSLALKFDIY | -------------IPYDKAVSLALKFDIY | ||
>Aps10_MILFA XP_004196154 | >Aps10_MILFA XP_004196154 | ||
| − | -------------- | + | -------------VI-ILRRVQDSYVN--------------------------------- |
--ISQLLSIL---------VKMGHFNQ--------TRLNNF---------LNNEIITN-- | --ISQLLSIL---------VKMGHFNQ--------TRLNNF---------LNNEIITN-- | ||
P-QY-----------S--AD--EKGINVYVDWVDHEVK---QLR-------GLW------ | P-QY-----------S--AD--EKGINVYVDWVDHEVK---QLR-------GLW------ | ||
-------------ISYDKAVSLALKFDIY | -------------ISYDKAVSLALKFDIY | ||
>Aps4_SCHST XP_001387125 | >Aps4_SCHST XP_001387125 | ||
| − | --------- | + | --------LDN-TVV-ILRRVQDSYVN--------------------------------- |
--VTQLFGIL---------LKLGHFNE--------TQLNNF---------FNNEIVTN-- | --VTQLFGIL---------LKLGHFNE--------TQLNNF---------FNNEIVTN-- | ||
I-QL-----------Q--GA--GTKNNHFLDLRKHENT---QLR-------GLW------ | I-QL-----------Q--GA--GTKNNHFLDLRKHENT---QLR-------GLW------ | ||
-------------ISYDRAVALALQFDIY | -------------ISYDRAVALALQFDIY | ||
>Aps6_DEBHA XP_002770480 | >Aps6_DEBHA XP_002770480 | ||
| − | ---------- | + | ---------DD-PIV-ILRRVQDSYIN--------------------------------- |
--ISQLFSIL---------LKIGHLSE--------AQLTNF---------LNNEILTN-- | --ISQLFSIL---------LKIGHLSE--------AQLTNF---------LNNEILTN-- | ||
T-QY-----------L--SS--GGSNPQFNDLRNHEVR---DLR-------GLW------ | T-QY-----------L--SS--GGSNPQFNDLRNHEVR---DLR-------GLW------ | ||
-------------IPYDRAVSLALKFDIY | -------------IPYDRAVSLALKFDIY | ||
>Aps3_CANTR XP_002548922 | >Aps3_CANTR XP_002548922 | ||
| − | ---------- | + | ---------DE-ELI-ILRRVQDSFIN--------------------------------- |
--VTQLFEIL---------VKLDLLTL--------SQLNNF---------FDNEILSN-- | --VTQLFEIL---------VKLDLLTL--------SQLNNF---------FDNEILSN-- | ||
L-KY-----------F--GS--STKNPQYLDLRSHENT---YIK-------GIW------ | L-KY-----------F--GS--STKNPQYLDLRSHENT---YIK-------GIW------ | ||
| − | -------------IPYDKAVELALKFDIY | + | -------------IPYDKAVELALKFDIY |
| − | >Aps5_CANDU XP_002417464 | + | >Aps5_CANDU XP_002417464 |
| − | ---------- | + | ---------HN-EII-VLRRVQDSFVN--------------------------------- |
| − | --ITQLFQIL---------IKLDLLSA--------SQVNNY---------FDNEILSN-- | + | --ITQLFQIL---------IKLDLLSA--------SQVNNY---------FDNEILSN-- |
| − | L-EY-----------F--GS--SSNTPQYLDLRKHQNT---FLQ-------GIW------ | + | L-EY-----------F--GS--SSNTPQYLDLRKHQNT---FLQ-------GIW------ |
| − | -------------IPYDRAVNLALKFDVY | + | -------------IPYDRAVNLALKFDVY |
| − | >Aps7_CANAL XP_723412 | + | >Aps7_CANAL XP_723412 |
| − | ---------- | + | ---------HG-EII-VLRRVQDSFVN--------------------------------- |
| − | --VTQLFQIL---------IKLEVLPT--------SQVDNY---------FDNEILSN-- | + | --VTQLFQIL---------IKLEVLPT--------SQVDNY---------FDNEILSN-- |
| − | L-KY-----------F--GS--SSNTPQYLDLRKHQNI---YLQ-------GIW------ | + | L-KY-----------F--GS--SSNTPQYLDLRKHQNI---YLQ-------GIW------ |
| − | -------------IPYDKAVNLALKFDIY | + | -------------IPYDKAVNLALKFDIY |
| − | >Aps1_CLALU XP_002617825 | + | >Aps1_CLALU XP_002617825 |
| − | ---------- | + | ---------DK-PIL-VLRRVQDSYVN--------------------------------- |
| − | --VSQMLEIL---------VLTGHFSK--------DQVSGF---------LRNEILHS-- | + | --VSQMLEIL---------VLTGHFSK--------DQVSGF---------LRNEILHS-- |
| − | T-QY-----------LPRGN--PTHLASFNDFRTHAVE---QIR-------GLW------ | + | T-QY-----------LPRGN--PTHLASFNDFRTHAVE---QIR-------GLW------ |
| − | -------------IPYDKAVSIAVRFDLY | + | -------------IPYDKAVSIAVRFDLY |
| − | >Swi6_CANOR XP_003866226 | + | >Swi6_CANOR XP_003866226 |
| − | ------------- | + | ------------EII-VLRRVQDSFIN--------------------------------- |
| − | --ASQLLKIL---------VRLHIVTP--------IQVKNY---------LNNEVLSN-- | + | --ASQLLKIL---------VRLHIVTP--------IQVKNY---------LNNEVLSN-- |
| − | L-EY-----------F--GNPVSKDNLQVLDYSKHENK---SLR-------GIW------ | + | L-EY-----------F--GNPVSKDNLQVLDYSKHENK---SLR-------GIW------ |
| − | -------------VPYNKGVKIALDFDVY | + | -------------VPYNKGVKIALDFDVY |
| − | >Aps5_MEYGU XP_001483939 | + | >Aps5_MEYGU XP_001483939 |
| − | ------------- | + | ------------SLV-ILRRVQDSFVN--------------------------------- |
| − | --VSQLFSIL---------VRLGHSNP--------DQISSF---------LSNEILSS-- | + | --VSQLFSIL---------VRLGHSNP--------DQISSF---------LSNEILSS-- |
| − | S-HY-----------T--GS--IEGSVFYNDFRSHENP---MLQ-------GLW------ | + | S-HY-----------T--GS--IEGSVFYNDFRSHENP---MLQ-------GLW------ |
| − | -------------VSYDRAVALALRFDIY | + | -------------VSYDRAVALALRFDIY |
| + | >Aps4_SCHPO NP_596166 | ||
| + | --------------HFLMRMAKDSSIS--------------------------------- | ||
| + | --ATSMFRSA---------FPKATQEE--------EDLEMR---------WIRDNLNP-- | ||
| + | I-ED-----------KRVA--------------------------------GLW------ | ||
| + | -------------VPPADALALAKDYSM- | ||
| + | >Aps4_SCHJA XP_002172515 | ||
| + | ------------NPHFLMRMAKNSHIS--------------------------------- | ||
| + | --ATSMFRSA---------FPKATPEE--------EEAEMS---------WIQQHLHP-- | ||
| + | V-EE-----------KQVS--------------------------------GLW------ | ||
| + | -------------VSPEDALALAKDYHM- | ||
>Aps2_ASPNI XP_657766 | >Aps2_ASPNI XP_657766 | ||
-------------TYFLMRRSKDGYVS--------------------------------- | -------------TYFLMRRSKDGYVS--------------------------------- | ||
| Line 1,570: | Line 1,696: | ||
G-AE-----------EVAG--------------------------------SVW------ | G-AE-----------EVAG--------------------------------SVW------ | ||
-------------IAPEEALALSEEYGM- | -------------IAPEEALALSEEYGM- | ||
| − | > | + | >Aps4_USTMA XP_760925 |
| − | ----------- | + | -----------VRGHTMMIDVDTSFVR--------------------------------- |
| − | -- | + | --FTSITQAL-------------GKNK--------VNFGRL---------VKTCP-ALDP |
| − | + | H-IT-----------KLKGG----------------YL---SIQ-------GTW------ | |
| − | ------------- | + | -------------LPFDLAKELSRR---- |
>Aps1_CANTR XP_002547216 | >Aps1_CANTR XP_002547216 | ||
------------NNHWVIWDYETGWVH--------------------------------- | ------------NNHWVIWDYETGWVH--------------------------------- | ||
| Line 1,795: | Line 1,921: | ||
ELIQ-----------SFKGG----------------RP---ENQ-------GTW------ | ELIQ-----------SFKGG----------------RP---ENQ-------GTW------ | ||
-------------VHPDIAINLAQ----- | -------------VHPDIAINLAQ----- | ||
| − | </ | + | </pre> |
| + | --> | ||
[[Category:Bioinformatics]] | [[Category:Bioinformatics]] | ||
</div> | </div> | ||
Latest revision as of 06:51, 26 September 2020
Reference APSES domains
The species used on this page are not the current set of reference species. Proceed with caution.
Sequences of APSES domains in the fungal reference species - domain definition, PSI-BLAST search, and header editing.
The APSES domain proteins were determined with a PSI-BLAST search in the refseq database, using 1BM8_A as the search sequence, and restricting the search to the Reference species for fungi.
Executing the PSI-BLAST search
Defining the APSES Domain sequence
- The APSES domain "proper"
- Navigate to the NCBI BLAST page, accessed protein BLAST;
- Follow the link to protein BLAST and enter the yeast Mbp1 refseq ID NP_010227 into the input form;
- Select the PHI-BLAST algorithm to search for domains in the sequence and Run BLAST;
- Click on the graphical summary of the result to access the CDD conserved domains report for the sequence;
- Click on the (+) sign next to the link to KilA-N(pfam 04383) domain to display the query/profile alignment. This is what it looks like:
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320147 19 IHSTGSIMKRKKDDWVNATHILKAANFAKAKRTRILEKEVLKETHEKVQ---------------GGFGKYQGTWVPLNIA 83
Cdd:pfam04383 3 YNDFEIIIRRDKDGYINATKLCKAAGAKGKRFRNWLRLESTKELIEELSkennpdkliiienrkGKGGRLQGTYVHPDLA 82
90
....*....|....
gi 6320147 84 KQLA----EKFSVY 93
Cdd:pfam04383 83 LAIAswisPEFALK 96
|
This gives us the following APSES domain sequence:
>Yeast Mbp1 APSES domain (AA 19..93 of NP_010227) IHSTGSIMKRKKDDWVNATHILKAANFAKAKRTRILEKEVLKETHEKVQG GFGKYQGTWVPLNIAKQLAEKFSVY
Searching for APSES domains
A PSI-BLAST search was executed, searching in the refseq subset of the NCBI protein database and restricting the species to the six fungal reference species plus Escherichia coli. The latter was chosen to retrieve the KilA-N domain sequence which we need as an outgroup for phylogenetic analysis.
The search converged after 5 iterations in which matches of less than 80% of the query length were manually removed, even if they had low E-values. Also, care was taken not to include false positives and thus to avoid profile corruption, and hits with E > 10-4 were also removed. The check-boxes next to the alignments were used to select sequences with > 80% coverage to the query and only the highest-scoring KilA-N domain protein was kept. Clicking on Get selected sequences created a results page of 27 sequences. These were then displayed in a FASTA(text) format and their headers were slightly edited to create the dataset Reference APSES proteins (reference species).
Constructing the multi-FASTA file
A multi-FASTA file is the default input format for many MSA programs, it is simply a file that contains more than one FASTA formatted sequence. To generate the multi-FASTA file of APSES domains, we could have simply edited the full length proteins manually. But there is a simpler way to achieve this. The PSI-BLAST search has already defined the sequences from each source protein that are similar to the APSES search profile. We only need to extract them in a convenient way from the search results. NCBI offers a number of options to format the BLAST result page: they are presented from a link at the top of the BLAST results page: "Formatting options": the principal options for the format are:
- Pairwise: the default
- Pairwise with identities: showing only differences to the query sequence
- query anchored with/without identities: looks something like a multiple sequence alignment, hyphens for gaps, insertions relative to the query are displayed below the sequence
- flat-query anchored with/without identitites: This now looks like a multiple sequence alignment (in fact it is one - all sequences aligned to the profile).
- hit-table: this gives only the numerical parameters describing the quality of the matches.
When we select the Flat-query anchored with letters for identitites option, it is reasonably straightforward to obtain the aligned sequences, copy and paste them into a Word document and convert that into a multi-FASTA format with a few Edit > Replace commands.
Renaming sequences
To make the interpretation of alignments and gene trees easier, all Saccharomyces cerevisiaea sequences were labelled with their gene name (e.g. Sok2_SACCE). Sequences that are presumed to be functionally equivalent orthologues to Mbp1 were identified through the Reciprocal Best Match (RBM) criterion and labeled as Mbp1_NNNNN. All other sequences were named APS1_, APS2_, APS3_ ... - as required. (e.g. APS1_USTMA). There is no further significance in the numbers, i.e. APS1_USTMA is not necessarily an RBM to APS1_SCHPO. Note that such relabeling of sequences does not change the data or its interpretation, it is just helpful to interpret the tree.
The final 27 APSES domain reference sequences
>KILA_ESCCO ZP_07189117 KilA-N domain protein IDGEIIHLRAKDGYINATSMCRTAGKLLSDYTRLKTTQEFFDELSRDMGIPISELIQSFKGGRPENQGTW VHPDIAINLAQ >MBP1_SACCE NP_010227 Mbp1 IHSTGSIMKRKKDDWVNATHILKAANFAKAKRTRILEKEVLKETHEKVQGGFGKYQGTWVPLNIAKQLAE KFSVY >MBP1_USTMA XP_762343 UM06196 IINNVAVMRRRSDDWLNATQILKVVGLDKPQRTRVLEREIQKGIHEKVQGGYGKYQGTWIPLDVAIELAE RYNI >MBP1_NEUCR XP_955821 NCU07246 VMRRRHDDWVNATHILKAAGFDKPARTRILEREVQKDTHEKIQGGYGRYQGTWIPLEQAEALARRNNIY >MBP1_ASPNI XP_660758.1 AN3154 IGTDSVMRRRSDDWINATHILKVAGFDKPARTRILEREVQKGVHEKVQGGYGKYQGTWIPLQEGRQLAER NNI >MBP1_SCHPO NP_593032 MBF transcription factor complex subunit Res2 IKGVSVMRRRRDSWLNATQILKVADFDKPQRTRVLERQVQIGAHEKVQGGYGKYQGTWVPFQRGVDLATK YKV >MBP1_CANAL XP_723071 potential DNA binding component of MBF VTSEGPIMRRKKDSWINATHILKIAKFPKAKRTRILEKDVQTGIHEKVQGGYGKYQGTYVPLDLGAAIAR NFGVY >APS1_NEUCR XP_962967 NCU07587 VNNVAVMRRQKDGWVNATQILKVANIDKGRRTKILEKEIQIGEHEKVQGGYGKYQGTWIPFERGLEVCRQ YGV >APS1_CANAL XP_712970 potential DNA binding component of SBF MMNESSIMRRCKDDWVNATQILKCCNFPKAKRTKILEKGVQQGLHEKVQGGFGRFQGTWIPLEDARKLAK TYGV >APS1_SCHPO NP_595496 MBF transcription factor complex subunit Res1 INGFPLMKRCHDNWLNATQILKIAELDKPRRTRILEKFAQKGLHEKIQGGCGKYQGTWVPSERAVELAHE YNVF >APS2_ASPNI XP_664319 hypothetical protein AN6715 VNGVAVMKRRSDGWLNATQILKVAGVVKARRTKTLEKEIAAGEHEKVQGGYGKYQGTWVNYQRGVELCRE YHV >APS2_USTMA XP_761485 UM05338 VRGIAVMRRRGDGWLNATQILKIAGIEKTRRTKILEKSILTGEHEKIQGGYGKFQGTWIPLQRAQQVAAE YNV >SWI4_SACCE NP_011036 Swi4p TKIVMRRTKDDWINITQVFKIAQFSKTKRTKILEKESNDMQHEKVQGGYGRFQGTWIPLDSAKFLVNKYE I >APS3_SCHPO NP_596132 MBF transcription factor complex subunit Cdc10 GDNVALRRCPDSYFNISQILRLAGTSSSENAKELDDIIESGDYENVDSKHPQIDGVWVPYDRAISIAKR YGVY >APS3_CANAL XP_714237 potential DNA binding regulator of filamentous growth NNVSVVRRADNNMINGTKLLNVAQMTRGRRDGILKSEKVRHVVKIGSMHLKGVWIPFERALAMAQREQI >SOK2_SACCE NP_013729 Sok2p NGISVVRRADNDMVNGTKLLNVTKMTRGRRDGILKAEKIRHVVKIGSMHLKGVWIPFERALAIAQREKI >APS3_ASPNI XP_663440 STUA CELL PATTERN FORMATION-ASSOCIATED PROTEIN GVCVARREDNGMINGTKLLNVAGMTRGRRDGILKSEKVRNVVKIGPMHLKGVWIPFDRALEFANKEKI >PHD1_SACCE NP_012881 Phd1p NGISVVRRADNNMINGTKLLNVTKMTRGRRDGILRSEKVREVVKIGSMHLKGVWIPFERAYILAQREQI >APS4_CANAL XP_710918 CaO19.5210 LNNHWVIWDYETGWVHLTGIWKASLTIDGSNVSPSHLKADIVKLLESTPKEYQQYIKRIRGGFLKIQGTW LPYKLCKILARRFCYY >APS3_NEUCR XP_960837 NCU01414 GICVARREDNAMINGTKLLNVAGMTRGRRDGILKSEKVRHVVKIGPMHLKGVWIPFERALDFANKEKI >APS5_CANAL XP_711513 potential DNA binding protein NILVSRREDTNYINGTKLLNVIGMTRGKRDGILKTEKIKNVVKVGSMNLKGVWIPFDRAYEIARNEGV >APS4_ASPNI XP_663009 AN5405 TVMWDYNIGLVRTTHLFKCNDYSKTTPAKMLNQNPGLRDICHSITGGALAAQGYWMPYEAAKAIAATFC >APS3_USTMA XP_760925 UM04778 VRGHTMMIDVDTSFVRFTSITQALGKNKVNFGRLVKTCPALDPHITKLKGGYLSIQGTWLPFDLAKELSR R >APS4_SCHPO NP_596166 HFLMRMAKDSSISATSMFRSAFPKATQEEEDLEMRWIRDNLNPIEDKRVAGLWVPPADALALAKDYSM >APS6_CANAL XP_723412 potential transcriptional co-activator HGEIIVLRRVQDSFVNVTQLFQILIKLEVLPTSQVDNYFDNEILSNLKYFGSSSNTPQYLDLRKHQNIYL QGIWIPYDKAVNLALKFDIY >APS4_NEUCR XP_962267 NCU06560 FLMRRSQDGYISATGMFKATFPYASQEEEEAERKYIKSIPTTSSEETAGNVWIPPEQALILAEEYQI >APS5_ASPNI XP_657766 AN0162 TYFLMRRSKDGYVSATGMFKIAFPWAKLEEERSEREYLKTRPETSEDEIAGNVWISPVLALELAAEYKMY
Mbp1 orthologue reference alignment
This is a reference alignment of the APSES domains of those proteins that fulfilled the Reciprocal Best Match criterion with yeast Mbp1.
CLUSTAL format alignment by MAFFT L-INS-1 (v6.850b) MBP1_SACCE IHSTGSIMKRKKDDWVNATHILKAANFAKAKRTRILEKEVLKETHEKVQGGFGKYQGTWVPLNIAKQLAEKFSVY MBP1_CANAL VTSEGPIMRRKKDSWINATHILKIAKFPKAKRTRILEKDVQTGIHEKVQGGYGKYQGTYVPLDLGAAIARNFGVY MBP1_USTMA IINNVAVMRRRSDDWLNATQILKVVGLDKPQRTRVLEREIQKGIHEKVQGGYGKYQGTWIPLDVAIELAERYNI- MBP1_NEUCR ------VMRRRHDDWVNATHILKAAGFDKPARTRILEREVQKDTHEKIQGGYGRYQGTWIPLEQAEALARRNNIY MBP1_ASPNI -IGTDSVMRRRSDDWINATHILKVAGFDKPARTRILEREVQKGVHEKVQGGYGKYQGTWIPLQEGRQLAERNNI- MBP1_SCHPO -IKGVSVMRRRRDSWLNATQILKVADFDKPQRTRVLERQVQIGAHEKVQGGYGKYQGTWVPFQRGVDLATKYKV-
Sample Phylip format
Here is a sample set of the APSES domain sequences to illustrate the phylip format. Sequences were aligned with MAFFT and edited in JALVIEW to remove gapped regions and frayed termini. The FASTA sequences were converted with the Readseq server.
27 78
KILA_ESCCO DGEIIHLRAK DGYINATSMC RT-A-GKLLS DYTRLKLSRD M-GIPIS-IQ
MBP1_SACCE STGSIMKRKK DDWVNATHIL KA-A-NFAKA KRTRI-LEKE V-LKETH--E
MBP1_USTMA NNVAVMRRRS DDWLNATQIL KV-V-GLDKP QRTRV-LERE I-QKGIH--E
MBP1_NEUCR ----VMRRRH DDWVNATHIL KA-A-GFDKP ARTRI-LERE V-QKDTH--E
MBP1_ASPNI GTDSVMRRRS DDWINATHIL KV-A-GFDKP ARTRI-LERE V-QKGVH--E
MBP1_SCHPO KGVSVMRRRR DSWLNATQIL KV-A-DFDKP QRTRV-LERQ V-QIGAH--E
MBP1_CANAL SEGPIMRRKK DSWINATHIL KI-A-KFPKA KRTRI-LEKD V-QTGIH--E
APS1_NEUCR NNVAVMRRQK DGWVNATQIL KV-A-NIDKG RRTKI-LEKE I-QIGEH--E
APS1_CANAL NESSIMRRCK DDWVNATQIL KC-C-NFPKA KRTKI-LEKG V-QQGLH--E
APS1_SCHPO NGFPLMKRCH DNWLNATQIL KI-A-ELDKP RRTRI-LEKF A-QKGLH--E
APS2_ASPNI NGVAVMKRRS DGWLNATQIL KV-A-GVVKA RRTKT-LEKE I-AAGEH--E
APS2_USTMA RGIAVMRRRG DGWLNATQIL KI-A-GIEKT RRTKI-LEKS I-LTGEH--E
SWI4_SACCE -TKIVMRRTK DDWINITQVF KI-A-QFSKT KRTKI-LEKE S-NDMQH--E
APS3_SCHPO GDNVALRRCP DSYFNISQIL RL-A-GTSSS ENAKE-LDDI I-ESGDY--E
APS3_CANAL NNVSVVRRAD NNMINGTKLL NV-A-QMTRG RRDGI-LKSE ----KVR--H
SOK2_SACCE NGISVVRRAD NDMVNGTKLL NV-T-KMTRG RRDGI-LKAE ----KIR--H
APS3_ASPNI -GVCVARRED NGMINGTKLL NV-A-GMTRG RRDGI-LKSE ----KVR--N
PHD1_SACCE NGISVVRRAD NNMINGTKLL NV-T-KMTRG RRDGI-LRSE ----KVR--E
APS4_CANAL NNHWVIWDYE TGWVHLTGIW KA-SLSHLKA DIVKL-LEST PKEYQQY-IK
APS3_NEUCR -GICVARRED NAMINGTKLL NV-A-GMTRG RRDGI-LKSE ----KVR--H
APS5_CANAL -NILVSRRED TNYINGTKLL NV-I-GMTRG KRDGI-LKTE ----KIK--N
APS4_ASPNI ---TVMWDYN IGLVRTTHLF KC-N-DYSKT TPAKM-LNQN PGLRDIC--H
APS3_USTMA RGHTMMIDVD TSFVRFTSIT QA-L-GKNKV NFGRL-VKTC P-ALDPH-IT
APS4_SCHPO --HFLMRMAK DSSISATSMF RS-A-FPKAT QEEED-LEMR WIRDNLN---
APS6_CANAL GEIIVLRRVQ DSFVNVTQLF QILE-VLPTS QVDNY-FDNE I-LSNLKYLR
APS4_NEUCR ---FLMRRSQ DGYISATGMF KA-T-FPYAS QEEEE-AERK YIKSIPT---
APS5_ASPNI -TYFLMRRSK DGYVSATGMF KI-A-FPWAK LEEER-SERE YLKTRPE---
SFKGGRPENQ GTWVHPDIAI NLAQ----
KVQGGFGKYQ GTWVPLNIAK QLAEKFSV
KVQGGYGKYQ GTWIPLDVAI ELAERYNI
KIQGGYGRYQ GTWIPLEQAE ALARRNNI
KVQGGYGKYQ GTWIPLQEGR QLAERNNI
KVQGGYGKYQ GTWVPFQRGV DLATKYKV
KVQGGYGKYQ GTYVPLDLGA AIARNFGV
KVQGGYGKYQ GTWIPFERGL EVCRQYGV
KVQGGFGRFQ GTWIPLEDAR KLAKTYGV
KIQGGCGKYQ GTWVPSERAV ELAHEYNV
KVQGGYGKYQ GTWVNYQRGV ELCREYHV
KIQGGYGKFQ GTWIPLQRAQ QVAAEYNV
KVQGGYGRFQ GTWIPLDSAK FLVNKYEI
NVDSKHPQID GVWVPYDRAI SIAKRYGV
VVKIGSMHLK GVWIPFERAL AMAQREQI
VVKIGSMHLK GVWIPFERAL AIAQREKI
VVKIGPMHLK GVWIPFDRAL EFANKEKI
VVKIGSMHLK GVWIPFERAY ILAQREQI
RIRGGFLKIQ GTWLPYKLCK ILARRFCY
VVKIGPMHLK GVWIPFERAL DFANKEKI
VVKVGSMNLK GVWIPFDRAY EIARNEGV
SITGGALAAQ GYWMPYEAAK AIAATFC-
KLKGGYLSIQ GTWLPFDLAK ELSRR---
--PIEDKRVA GLWVPPADAL ALAKDYSM
KHQNIY--LQ GIWIPYDKAV NLALKFDI
--TSSEETAG NVWIPPEQAL ILAEEYQI
